Mon.Apr 08, 2024

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Psychiatry drugs finally have pharma’s attention. Can they keep it?

BioPharma Drive: Drug Pricing

Recent biotech company acquisitions have put emerging schizophrenia treatments in focus. But many development hurdles still stand in the way of new medicines for the brain.

Treatment 136
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Pregnancy accelerates biological aging in a healthy, young adult population

Science Daily: Pharmacology News

Pregnancy may carry a cost, reports a new study. The research shows that women who reported having been pregnant looked biologically older than women who had never been pregnant, and women who had been pregnant more often looked biologically older than those who reported fewer pregnancies.

Research 126
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Many Cancer Drugs Still Unproven 5 Years After Accelerated Approval

Drugs.com

MONDAY, April 8, 2024 -- New research questions the effectiveness of the U.S. Food and Drug Administration's accelerated drug approval program after finding that many cancer drugs remain unproven five years later.The study, published Sunday in the.

Drugs 116
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Engineers design soft and flexible 'skeletons' for muscle-powered robots

Science Daily: Pharmacology News

Engineers designed modular, spring-like devices to maximize the work of live muscle fibers so they can be harnessed to power biohybrid robots.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Therapeutic Vaccine Prevents Pancreatic Cancer's Recurrence in 3-Year Trial

Drugs.com

MONDAY, April 8, 2024 -- A pancreatic cancer vaccine has continued to protect a small group of patients from their cancer coming back, three years after receiving the jab, a new study says.Eight patients have not had their pancreatic cancer recur.

Vaccine 111
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New study highlights the benefit of touch on mental and physical health

Science Daily: Pharmacology News

Through a large-scale analysis, researchers have uncovered the ways in which consensual touch can benefit a person's physical and mental wellbeing.

Research 128

More Trending

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Telescope detects unprecedented behavior from nearby magnetar

Science Daily: Pharmacology News

Captured by cutting-edge radio telescope technology, a chance reactivation of a magnetar -- the Universe's most powerful magnets -- has revealed an unexpectedly complex environment.

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Even a Little Secondhand Smoke Ups Odds for A-Fib

Drugs.com

MONDAY, April 8, 2024 -- Just a little exposure to secondhand smoke may increase your risk for the heart rhythm disorder atrial fibrillation (A-Fib), a new, large study suggests.

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How the moon turned itself inside out

Science Daily: Pharmacology News

Linking analyses of the moon's gravity field with models of its earliest evolution, scientists tell a story of the moon turning itself inside out after it solidified from a primordial magma ocean. The process left behind a vestige of dense, titanium-rich material beneath its Earth-facing side that makes its presence known by gravity anomalies.

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Vaccine-by-Mouth Could Replace Antibiotics in Fighting UTIs

Drugs.com

MONDAY, April 8, 2024 -- A new oral vaccine could prove a potential alternative to antibiotics for people with recurring urinary tract infections, a new study says.More than half of patients with recurring UTIs (54%) wound up infection-free for.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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A friendly pat on the back can improve performance in basketball

Science Daily: Pharmacology News

A free throw in basketball will have every eye glued to one person. It's an intensely stressful situation. A research team studied whether a friendly tap on the shoulder increases the odds of making a shot.

Research 103
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How to move from diversity to inclusion in medical research

Antidote

Increasing racial diversity in clinical research is a common topic in the industry, and for good reason. The purpose of a clinical trial is to ensure that any new medications are safe and effective for the patient population, so it is of the utmost importance that studies have participant pools that reflect the diversity of real-world individuals.

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Urine Test Could Cut Need for Painful Bladder Cancer Procedure

Drugs.com

MONDAY, April 8, 2024 -- A new urine test could spare bladder cancer survivors from a painful follow-up procedure needed to ensure their cancer hasn’t come back, researchers report.People who’ve gotten surgery for high-risk bladder cancer.

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Climate change threatens Antarctic meteorites

Science Daily: Pharmacology News

Antarctica harbors a large concentration of meteorites imbuing the icy continent with an unparalleled wealth of information on our solar system. However, these precious meteorites are rapidly disappearing from the ice sheet surface due to global warming, according to a new study.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Immunotherapy Before Surgery Might Boost Pancreatic Cancer Survival

Drugs.com

MONDAY, April 8, 2024 -- Pancreatic cancer patients may do better if they receive an immunotherapy drug as well as chemotherapy in preparation for surgery, new research suggests.Pancreatic cancer is one of the toughest to treat. Only 12% of.

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Toothed whale echolocation organs evolved from jaw muscles

Science Daily: Pharmacology News

Genetic analysis finds evidence suggesting that acoustic fat bodies in the heads of toothed whales were once the muscles and bone marrow of the jaw.

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Scientists Develop Vaccine Against Lethal Xylazine, Often Mixed With Street Drugs

Drugs.com

MONDAY, April 8, 2024 (HealthDay news) -- A new vaccine might be able to block the toxic effects of the animal tranquilizer xylazine, which is being added to illicit drugs and increasing overdose risk.The vaccine trains the immune system to attack.

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Mediterranean marine worm has developed enormous eyes

Science Daily: Pharmacology News

Scientists are amazed at the discovery of a bristle worm with such sharp-seeing eyes that they can measure up to those of mammals and octopuses. The researchers suspect that these marine worms may have a secretive language, which uses UV light only seen by their own species. The advanced vision of such a primitive creature helps to finally settle an epic debate about the evolution of eyes.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Today's Young Adults Are Aging Faster, and That Might Help Spur Cancers

Drugs.com

MONDAY, April 8, 2024 -- Younger generations are aging more rapidly, and this could be leading to an increased risk of cancer, a new study says.People born in or after 1965 are 17% more likely to be experiencing accelerated aging compared to.

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Trial shows Wegovy can ease heart failure symptoms

BioPharma Drive: Drug Pricing

The results were the second time Novo has shown its weight loss treatment can help with the condition, and may help it secure broader use of the drug.

Trials 95
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Blood Test Spots Early Pancreatic Cancers With 97% Accuracy

Drugs.com

MONDAY, April 8, 2024 -- A blood test appears capable of detecting early-stage pancreatic cancers with up to 97% accuracy, a new study reports.

RNA 98
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Addgene's Website Update

addgene Blog

Starting today, you may notice some changes to our website ! Part of sharing science and making access to materials easier is improving the tools you use to share and access them. Addgene’s product, development, and content teams have made some changes to the look and feel of addgene.org. Some you’ll notice right away, while others may be less obvious — but every change is meant to make your experience on our website better so you can get the resources you need more easily.

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Enhancing Sponsor Outcomes: The Power of In-House Clinical Assessment Support

Conversations in Drug Development Trends

By Rolana Avrumson, MS, Vice President of Clinical Projects, Clinical Assessment Technologies In the intricate world of clinical trials, the precision and reliability of clinical assessments stand as pivotal factors in determining a trial’s success. Expertly managed clinical assessments by a team with fastidious attention to detail optimizes precision and reliability and helps you successfully navigate the complex terrain of clinical research.

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SAVE THE DATE: Drug Channels Leadership Forum, March 17-19, 2025

Drug Channels

I am pleased to announce the inaugural Drug Channels Leadership Forum ! This unique, new event will be held from March 17 to 19, 2025, at the Turnberry Resort and Spa in Miami. The Leadership Forum will be an executive gathering where drug channel leaders can network and discuss key issues and challenges facing the commercial healthcare system. We intend to bring together people from the entire drug channel: pharmaceutical manufacturers, pharmacy benefit managers (PBMs), health plans, insurers,

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Private biotech funding ticks up as venture firms deploy cash

BioPharma Drive: Drug Pricing

Twenty-six drugmakers closed private fundraising rounds worth more than $100 million, according to HSBC data shared with BioPharma Dive.

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3M PFAS settlement gains final court approval

Agency IQ

BY WALKER LIVINGSTON, ESQ Following a similar smaller settlement by DuPont, 3M has finalized a multibillion-dollar settlement with municipal water supplies over the release of PFAS into the environment. The finalized settlement sets the tone for the next stage of both PFAS-related litigation and remediation in the U.S. Per- and polyfluoroalkyl substances are a large group of synthetic organic chemicals used in many different industrial, commercial, and consumer applications since the 1940s.

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Perficient’s Salesforce Expertise Continues To Be Recognized

Perficient: Drug Development

In today’s competitive digital landscape, clients need to innovate faster, increase operational efficiency, and deliver customized, memorable customer experiences. They need to be more responsive, efficient, and relevant to better connect with customers and build lasting relationships. Salesforce enables clients to accelerate their digital transformation and unlock data across disparate systems, clouds, and devices to make smarter, faster decisions, and create highly differentiated, connected ex

Science 59
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New proposed cybersecurity framework would apply to certain life sciences companies

Agency IQ

BY LAURA DIANGELO, MPH A new proposed rule from the Cybersecurity and Infrastructure Security Agency (CISA) would establish cybersecurity reporting requirements for certain entities – including, as proposed, certain medical device companies that manufacture Class II and Class III products and the manufacturers of 86 “critical” drug products. CISA is an agency operating under the umbrella of the Department of Homeland Security (DHS).

Science 59
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Does the Drug Shortage White Paper Fall Short?

FDA Law Blog: Biosimilars

By Kalie E. Richardson — The U.S. Department of Health and Human Services (HHS) recently published a White Paper on Policy Considerations to Prevent Drug Shortages and Mitigate Supply Chain Vulnerabilities in the United States —with input from several HHS stakeholders, including FDA, CMS, and the Administration for Strategic Preparedness and Response.

Drugs 57
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CISA cybersecurity framework seeks to cover wide array of chemical facilities

Agency IQ

BY LAURA DIANGELO, MPH , WALKER LIVINGSTON, ESQ A newly proposed rule from the Cybersecurity and Infrastructure Security Agency (CISA) would establish cybersecurity reporting requirements for many chemical facilities in a bid to improve the speed and detail at which cyber incidents are reported. CISA is an agency operating under the umbrella of the Department of Homeland Security (DHS).

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OPQ’s 2023 Annual Report: an Upbeat Review of CDER’s Quality Efforts

FDA Law Blog: Biosimilars

By John W.M. Claud — CDER’s Office of Pharmaceutical Quality (OPQ) issued its 2023 Annual Report last week, and it’s an upbeat assessment of the Office’s policy and outreach efforts. Last year, OPQ saved a more quantitative analysis of its efforts for the other yearly publication it put out, on the State of Pharmaceutical Quality. Again this year, the Annual Report that was released last week did not feature much in the way of specific quality issues.

FDA 57
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FDA updates set the stage for broader use of harmonized standards for safety reporting

Agency IQ

BY RACHEL COE, MSC Though long considered a top priority by regulators, the process to standardize and harmonize the submission of individual case safety reports (ICSRs) has been slow. This week, the FDA announced it is finally ready to start accepting adverse event submissions in ICH E2B(R3) format and that the countdown to mandatory compliance with these requirements has begun.

FDA 59
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Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR

Covalent Modifiers

Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson, Jason G. Kettle, Jonathan P. Orme, and Richard A. Ward ACS Medicinal Chemistry Letters 2024 DOI: 10.1021/acsmedchemlett.3c00425 To further facilitate the discovery of cysteine reactive covalent inhibitors, there is a need to develop new reactive groups beyond the traditional acrylamide-type warheads.

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