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Merve Demir,*, Laura Koepping, Ya Li, Lynn Fujimoto, Andrey Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard Sergienko Structure, 2024 [link] Mitochondrial creatine kinases (MtCKs) are key players in maintaining energy homeostasis in cells that work with cytosolic creatine kinases for energy transport from mitochondria to cytoplasm. The inhibition of breast cancer growth by cyclocreatine targeting CKs indicates dependence of cancer cells on the energy shuttle for cell growth and survival.
Researchers have unveiled the precise brain mechanisms that enable animals to overcome instinctive fears. The study in mice could have implications for developing therapeutics for fear-related disorders such as phobias, anxiety and post-traumatic stress disorder (PTSD).
THURSDAY, Feb. 6, 2025 -- The U.S. Food and Drug Administration has approved Onapgo (apomorphine hydrochloride) injection as the first and only subcutaneous apomorphine infusion device for the treatment of motor fluctuations in patients with.
The biotech is evaluating several cystic fibrosis medicines that could either work alongside Vertex’s top-selling Trikafta or be used in new, multi-drug combinations.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a molecule. ABSTRACT Despite advancements in molecular design rules and understanding biochemical processes, the field of drug design and discovery seeks to minimize the number and duration of synthesis-testing cycles to convert lead compounds into drug candidates.
Astronomers have characterized the largest-ever early-Universe radio jet. Historically, such large radio jets have remained elusive in the distant Universe. With these observations, astronomers have valuable new insights into when the first jets formed in the Universe and how they impacted the evolution of galaxies.
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Astronomers have characterized the largest-ever early-Universe radio jet. Historically, such large radio jets have remained elusive in the distant Universe. With these observations, astronomers have valuable new insights into when the first jets formed in the Universe and how they impacted the evolution of galaxies.
THURSDAY, Feb. 6, 2025 -- A new strain of bird flu has infected dairy cows in Nevada, marking the second time the virus has jumped from birds to cattle. This latest infection — reported by the U.S. Department of Agriculture (USDA) Wednesday.
People's ability to interpret emotions or focus on performing a task is reduced by short-term exposure to particulate matter (PM) air pollution, potentially making everyday activities, such as the weekly supermarket shop, more challenging.
THURSDAY, Feb. 6, 2025 -- Many seniors suffer long-term health issues after a hip fracture, even after hip replacement surgeries. Now, research shows that a patient's mental health could be crucial to how well they bounce back in the years after.
Cobenfy, the main asset acquired through Bristol Myers’ $14 billion purchase of Karuna, had $10 million in sales in the fourth quarter and is around 1,000 prescriptions weekly by late January.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
New research finds some baleen whale species call at such deep frequencies that they're completely undetectable by killer whales, which cannot hear sounds below 100 hertz. These also tend to be the species of baleen whales that flee in the face of attack from killer whales.
THURSDAY, Feb. 6, 2025 -- When it comes to the potential of H5N1 avian flu, otherwise known as bird flu, picking up mutations that might lead to human-to-human spread, that "train has already left the station," warns one infectious disease.
THURSDAY, Feb. 6, 2025 -- Many women may opt for a breast reduction if they encounter issues such as recurrent neck, back and shoulder pain. However, a new study suggests a link between these procedures in teens and young adult women and later.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers.
The pharmaceutical company plans to cut $2 billion in annual expenses by the end of 2027 through “operational efficiencies across multiple areas of the business,” its CFO told analysts on a conference call.
A new study focusing on Enceladus, a moon of Saturn, shows that the physics of alien oceans could prevent evidence of deep-sea life from reaching places where we can detect it.
THURSDAY, Feb. 6, 2025 -- A small, early trial of a vaccine that mobilizes the immune system to battle advanced kidney cancers appears successful, researchers report.The "personalized cancer vaccines" (PCVs) used by the nine patients in the trial.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
The drugmaker’s financial forecasts topped Wall Street’s expectations, reassuring investors after it overestimated demand for its weight loss medicines in January.
THURSDAY, Feb 6, 2024 -- Getting enough vitamin D, the "sunshine vitamin," during early pregnancy could be important for infant health, new research suggests.Researchers at Penn State found that infants born to women deficient in the nutrient were.
THURSDAY, Feb. 6, 2025 -- Kids and teens can also get migraines, but Black and Hispanic children seen in ERs are more likely to have their condition go undiagnosed, new research shows.That's concerning, because without a proper diagnosis, m.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
The beginning of a new semester brings a fresh crop of aspiring researchers to institutions each fall and spring. Students learn how to navigate post-secondary education and gain knowledge around effective research methods, both practical and intangible. Student researchers, along with early career researchers (collectively referred to here as new researchers), begin to experience responsible conduct of research principles firsthand.
THURSDAY, Feb. 6, 2025 -- Set, hut! Super Bowl Sunday is almost here. But it's not just about big plays and bad calls, it's also a sodium tsunami. On average, foods advertised during NFL games contain 40% of the daily recommended sodium intake.
Electric sparks are used for welding, powering electronics, killing germs or for igniting the fuel in some car engines. Despite their usefulness, they are hard to control in open space, they split into chaotic branches that tend to go towards the closest metallic objects. A recent study uncovers a way of transporting electricity through air by ultrasonic waves.
Type 2 diabetes is a chronic condition that affects millions globally. Characterised by insulin resistance and elevated blood glucose levels, the disease can lead to severe complications such as heart disease, kidney failure and nerve damage. Over time, the bodys ability to regulate blood sugar deteriorates, causing long-term damage to various organ systems.
The Multi-Billion Dollar Opportunity in Generic Drugs: How to Seize the Moment As a business leader in the pharmaceutical industry, you're likely no stranger to the importance of staying ahead of the curve. One key trend that's been gaining momentum in recent years is the rise of generic drugs. With the patent expiration of many blockbuster medications, the generic drug market is poised for significant growth.
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