Drug Discovery World

SEPTEMBER 6, 2023

Phesi, a global provider of patient-centric data software and services, has partnered with Krystelis, a provider of medical writing and clinical trial transparency services, to launch its new Diversity, Equity, and Inclusion (DEI) Data Service. A 2022 Phesi data analysis discovered 42% of US cancer trial cohorts do not include African American patients, and almost half – 48% – have no Hispanic American patients.

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Broad Institute

SEPTEMBER 6, 2023

New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases By Allessandra DiCorato September 6, 2023 Breadcrumb Home New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases The collaboration aims to identify disease-modifying interventions, with the goal of improving standards of care for people living with type 2 diabetes and cardiac fibrosis By Broad Communications Sep

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Drug Discovery World

SEPTEMBER 6, 2023

The development of antibodies and associated technologies continues to drive high-value deals, according to a recent report in Nature. 1 Using data provided by DealForma for the period 1 January 2022 to 16 June 2023, Nature analysed the deal trends in the field. In 2022, there were 156 antibody-focused deals with a value of $57.3 billion, up 40% from 2021.

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Chemical Biology and Drug Design

SEPTEMBER 6, 2023

Matrine inhibits TNBC cell proliferation, migration and invasion, promotes apoptosis, and suppresses tumor growth through down-regulation of HN1 expression. Abstract The treatment of triple-negative breast cancer (TNBC) cannot meet medical needs, and it is urgent to find new drugs for intervention. This study aimed to investigate the anti-tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 6, 2023

AI drug discovery company Optibrium has acquired 3D drug design specialist BioPharmics. BioPharmics’ CEO, Dr Ajay Jain, and Director of Applied Science, Dr Ann Cleves, will join the Optibrium team, respectively focusing on R&D and Application Science in the newly-created BioPharmics Division. BioPharmics has developed a series of algorithms and software for 3D ligand-based and structure-based computational drug design, including software for 2D to 3D ligand conversion and conformer generatio

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BioPharma Drive: Drug Pricing

SEPTEMBER 6, 2023

Jane Grogan, an industry veteran who worked at Genentech for over 15 years, will take over the role starting Oct. 2. She’ll fill a seat that's lacked a permanent replacement since the departure of Al Sandrock.

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Research 122

Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Heat domes and extreme heat waves have been battering the United States for years now, and a new study shows that increasing temperatures are doing real harm to humans. A significant increase in heat-related illnesses.

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Hospitals 111

Drug Discovery World

SEPTEMBER 6, 2023

The eleventh eBook of the Hamilton series ‘Analytical Methods for Viral Vector Development and Manufacturing in Gene Therapy’ is now available. Download the eBook to learn about: Gene therapy: history, viral vectors and the role of CDMOs Automation of analytical assays during viral vector development and manufacturing The solutions that Hamilton offers to customers working in this field, both in research and GMP-regulated environments The post eBook: Analytical methods for viral vect

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Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Being fit doesn’t just help your body -- it also helps your mind, a new study reports. People in better physical condition appear to have less need for drugs to treat mood disorders, Norwegian researchers have.

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Drug Discovery World

SEPTEMBER 6, 2023

TherageniX and the University of Nottingham have been awarded a £995,000 ($1,252,585) grant from Innovate UK, the UK’s innovation agency. The funding will support the development of the company’s gene therapy in a powder, a non-viral gene delivery system to improve tissue regeneration following surgery. TherageniX will initially focus on orthopaedic applications, with the aim of improving the outcomes for patients undergoing bone grafting procedures.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Obesity taxes many parts of the body, but new research suggests the heart might take the hardest hit of all. Between 1999 and 2020, deaths from heart disease linked to obesity tripled in the United States, and some groups.

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NIOSH Science Blog: Drugs

SEPTEMBER 6, 2023

We’re back for another Respiratory Protection Week! This year we’re shining some light on our Respirator Approval Program’s efforts to fill in gaps related to respiratory protection and answering some of your remaining questions about NIOSH Approved® respirators. As you may know, the National Institute for Occupational Safety and Health (NIOSH) is the federal institute responsible for the evaluation and approval of respirators used in U.S. occupational settings.

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Laboratories Disease 103

Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- New research on a leading cause of foodborne illness has linked a large share of Michigan infections to antibiotic-resistant bacteria strains. More than 100 strains of Campylobacter jejuni circulating in Michigan are.

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keypoint

SEPTEMBER 6, 2023

Established in 2009, Keystone Symposia’s Fellows Program has become a premier professional advancement opportunity for rising scientists from diverse backgrounds. This unique one-year fellowship provides early-stage investigators (ESIs) (within 6 years of starting an independent research program) from underrepresented (UR) and other disadvantaged backgrounds with the support, skills and networking opportunities they need to successfully pursue research careers and leadership roles in academic, i

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Government Science Research 103

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Infants whose first year of life unfolded during the pandemic appear to have fewer types of bacteria in their gut than infants born before COVID-19 raced across the planet, a new study suggests. Specifically, these.

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BioPharma Drive: Drug Pricing

SEPTEMBER 6, 2023

The decision is the latest in a series of setbacks for the Actelion spinout and ends a lucrative partnership that began in 2017.

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Drugs 117

Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Just like adults, kids face daily stressors. Luckily, a new study suggests that teaching them creative thinking can help them manage it all. Researchers found that when school-age children learned some "narrative.

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Research 105

keypoint

SEPTEMBER 6, 2023

In June we concluded our 2023 season, which ran from August 2022 to June 2023, aligning with the academic year. It was a busy season, consisting of 60 meetings altogether, including 13 that had been rescheduled due to the pandemic. We hosted over 9,000 participants and c overed many exciting new topics, including Neurocircuitry of Social Behavior, Infections in Pregnancy, Computational Design and Modeling of Biomolecules and Multispecific Immune Cell Engagers for Cancer Immunotherapy.

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Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- As waters warm across the United States and hurricanes and flooding season begins, the odds of being infected by flesh-eating bacteria are also rising, U.S. health officials warn. According to a Sept. 1 health alert from.

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keypoint

SEPTEMBER 6, 2023

The September 2023 issue of the Keypoint Newsletter features the latest news and views from Keystone Symposia, including our new Climate Initiatives, the new KS Career Connect Job Posting Site, Launch of the Post-doc arm of the Fellows Program, Recap of the 50th Anniversary Gala Celebration, and upcoming program highlights like Long-COVID, Next-Generation Nanomedicine and AI in Biomedicine.

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SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

Australian patients with chronic health issues prescribed medical cannabis showed significant improvements in overall health-related quality of life and fatigue in the first three months of use, along with improvements in anxiety, depression, and pain.

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Therapies 89

Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Some good news for folks who are worried about the new, troublesome COVID variant known as BA.2.86: Moderna Inc. said Wednesday that its updated vaccine held its own against this highly mutated version of the virus. While.

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SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

Oral health deteriorates in morbidly obese people on a diet in preparation for bariatric surgery and patients who have undergone the procedure, with increasing caries, gingivitis and periodontitis. This is the conclusion of a study conducted by researchers at the Federal University of São Paulo (UNIFESP) in Brazil.

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Research 88

keypoint

SEPTEMBER 6, 2023

New this year we added new Health Equity Programming to select meetings, to raise awareness for health disparities in various fields, and initiate discussions on how to rectify these health inequities through scientific research and discovery. Our goal is to e mbed health equity content across our meeting portfolio via the addition of speakers, sessions, workshops/panels, and virtual content that specifically address health equity research goals and strategies.

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Research 78

SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

Barriers to accessing potentially life-saving support persist, according to new research into suicidality in the LGBTIQA+ community. Credit: Jacq Moon Barriers to accessing potentially life-saving support persist, according to new research into suicidality in the LGBTIQA+ community.

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Research 88

keypoint

SEPTEMBER 6, 2023

Many career transforming opportunities have been forged at Keystone Symposia conferences over the years, whether networking with field leaders at the breakfast buffet to secure a post-doc position, or connecting with industry representatives over cocktails to get a first job offer. We are pleased to extend these career-changing connections now online, through our new KS Career Connect platform, where the same high quality candidates and employers come to find talent and opportunity.

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SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

New “hypervirulent” strains of the bacterium Klebsiella pneumoniae have emerged in healthy people in community settings, prompting a National Institutes of Health research group to investigate how the human immune system defends against infection.

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Laboratories Research 87

Science Daily: Pharmacology News

SEPTEMBER 6, 2023

Astronomers have detected the magnetic field of a galaxy so far away that its light has taken more than 11 billion years to reach us: we see it as it was when the Universe was just 2.5 billion years old. The result provides astronomers with vital clues about how the magnetic fields of galaxies like our own Milky Way came to be.

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SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

PITTSBURGH – To reimagine existing preclinical trials for Alzheimer’s disease, University of Pittsburgh School of Medicine neuroscientists created the first non-human primate model of hereditary Alzheimer’s in marmoset monkeys, outlining their approach in Alzheimer’s & Dementia: Translational Research & Clinical Interventions.

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keypoint

SEPTEMBER 6, 2023

Please join us in welcoming our new Director of Philanthropy, Minda Mason , who will be working with individuals and foundations to support Keystone Symposia. Her efforts will help to support key initiatives including Emerging Minds, Emerging Topics and Diversity in Life Sciences programming.

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Science 75

SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

“Such knowledge on physiological decline throughout pregnancy and the remarkable rejuvenation right after delivery will assist with revolutionizing our approach to treating the elderly.” Credit: 2023 Andrawus et al. “Such knowledge on physiological decline throughout pregnancy and the remarkable rejuvenation right after delivery will assist with revolutionizing our approach to treating the elderly.

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keypoint

SEPTEMBER 6, 2023

Our fall line-up of conferences is off to a great start, featuring many emerging and hot topics, from longcovid to next-generation nanomedicines, regulatory RNAs, vaccinology and more! (see listing below) In particular, the Long COVID and Post-Acute Sequalae of SARS CoV-2: Pathogenesis and Treatment conference made a big splash in the news media, with NPR reporter Will Stone in attendance ( see NPR coverage below!

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SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

Autistic and neurodivergent workers report experiencing unique pressures to mask traits, to avoid negative reactions from colleagues and employers Credit: This image was created with the assistance of DALL·E by Open Ai.

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Drugs.com

SEPTEMBER 6, 2023

WEDNESDAY, Sept. 6, 2023 -- Cancer is surging among people under 50, a new global study reveals. Over the past 30 years, new cases have increased 79% worldwide in that age bracket, according to a report published Sept. 5 in BMJ Oncology. The fastest.

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