Wed.Aug 21, 2024

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Life from a drop of rain: New research suggests rainwater helped form the first protocell walls

Science Daily: Pharmacology News

New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.

RNA 341
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Congo Says First Vaccines to Fight Mpox Arriving Next Week

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- The first mpox vaccine doses from the United States are set to arrive next week in the Congo, the epicenter of an ongoing mpox outbreak in Africa.The doses come not a moment too soon: Just last week, the World Health.

Vaccine 299
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New heaviest exotic antimatter nucleus

Science Daily: Pharmacology News

Scientists studying the tracks of particles streaming from six billion collisions of atomic nuclei at the Relativistic Heavy Ion Collider (RHIC) -- an 'atom smasher' that recreates the conditions of the early universe -- have discovered a new kind of antimatter nucleus, the heaviest ever detected. Composed of four antimatter particles -- an antiproton, two antineutrons, and one antihyperon -- these exotic antinuclei are known as antihyperhydrogen-4.

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Therapeutic App Might Ease Anxiety in Young Adults

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- It's not a replacement for actual psychotherapy, but a newly designed app could help young adults with mental health issues lower their anxiety, researchers report.The app, dubbed Maya, "can be an accessible and.

Research 279
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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First visualization of valence electrons reveals fundamental nature of chemical bonding

Science Daily: Pharmacology News

The distribution of outermost shell electrons, known as valence electrons, of organic molecules was observed for the first time. As the interactions between atoms are governed by the valence electrons, the findings shine light on the fundamental nature of chemical bonds, with implications for pharmacy and chemical engineering.

Pharmacy 291

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Eco-friendly cooling device with record-breaking efficiency

Science Daily: Pharmacology News

Researchers have developed an eco-friendly refrigeration device with record-breaking cooling performance in the world, setting to transform industries reliant on cooling and reduce global energy use. With a boost in efficiency of over 48%, the new elastocaloric cooling technology opens a promising avenue for accelerating the commercialization of this disruptive technology and addressing the environmental challenges associated with traditional cooling systems.

Research 291
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Employers foresee higher health costs next year due to rising pharmacy spend

BioPharma Drive: Drug Pricing

Pharmaceuticals like the in-demand GLP-1 drugs for obesity are expected to drive increases in healthcare spending in 2025, per a new employer survey.

Pharmacy 272
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To kill mammoths in the Ice Age, people used planted pikes, not throwing spears, researchers say

Science Daily: Pharmacology News

Archeologists say new findings might help resolve the debate about Clovis points and reshape how we think about what life was like roughly 13,000 years ago. After an extensive review of writings and artwork -- and an experiment with replica Clovis point spears -- a team of archaeologists says humans may have braced the butt of their weapons against the ground in a way that would impale a charging animal.

Research 285
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Regeneron confirms FDA won’t approve myeloma drug over manufacturing issues

BioPharma Drive: Drug Pricing

Company executives had previously warned investors that a delay was likely due to issues at a facility run by third-party manufacturer.

FDA 272
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Highest prediction of sea-level rise unlikely

Science Daily: Pharmacology News

A new study challenges as highly unlikely an alarming prediction of sea-level rise that -- while designated as low likelihood --earned a spot in the latest UN climate report for its projection that the collapse of polar ice sheets could make the world's oceans up to 50 feet higher by 2300. But researchers found that the model is based on inaccurate physics of how ice sheets retreat and break apart, though they stress that the accelerating loss of ice from Greenland and Antarctica is still dire.

Research 277
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Obese Kids May Face Higher Odds for Eczema, Psoriasis

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- Obese kids are more likely to develop immune-based skin problems like eczema or psoriasis, a new study says.Analysis of more than 2.1 million Korean children between 2009 and 2020 revealed that children who became.

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Mobile species are 'glue' which connect different habitats together

Science Daily: Pharmacology News

A groundbreaking study conducted across 30 field sites in the southwest UK has revealed the importance of incorporating varied habitats into the landscape at large.

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New 'Platelet Score' Could Gauge Your Odds for Stroke, Heart Attack

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- An experimental genetic test can gauge a person’s risk of developing potentially deadly blood clots, researchers report.People who scored high on the test had more than double the rate of heart attack, stroke and major a.

Research 264
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Engineered Bacteria make thermally stable plastics similar to polystyrene and PET

Science Daily: Pharmacology News

Bioengineers around the world have been working to create plastic-producing microbes that could replace the petroleum-based plastics industry. Now, researchers have overcome a major hurdle: getting bacteria to produce polymers that contain ring-like structures, which make the plastics more rigid and thermally stable. Because these molecules are usually toxic to microorganisms, the researchers had to construct a novel metabolic pathway that would enable the E. coli bacteria to both produce and to

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Red Meat Linked to Higher Odds for Type 2 Diabetes

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- Eating red meat and processed meat can increase a person’s risk of developing type 2 diabetes, a new review finds.Regularly eating 50 grams of processed meat a day -- the equivalent of two slices of ham -- increased by 1.

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BioMarin taps Amgen, Roche vets in executive reshuffle

BioPharma Drive: Drug Pricing

Greg Friberg and James Sabry will take over, respectively, as heads of R&D and business development, less than a year after BioMarin named a new CEO.

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Free Meals at School May Boost Attendance, Lower Obesity Rates

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- A review of U.S. data from 2012 through 2024 finds that when kids get free school meals, there's a potential for a slight increase in attendance and a lowering of child obesity rates.Even kids from higher-income.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Mitigation of cisplatin-induced acute kidney injury through oral administration of FAAH Inhibitor PF-04457845 [Gastrointestinal, Hepatic, Pulmonary, and Renal]

ASPET

Fatty acid amide hydrolase (FAAH) serves as the primary enzyme responsible for degrading the endocannabinoid anandamide (AEA). Inhibition of FAAH, either through pharmacological means or genetic manipulation, can effectively reduce inflammation in various organs, including the brain, colon, heart, and kidneys. Infusion of a FAAH inhibitor into the kidney medulla has been shown to induce diuretic and natriuretic effects.

DNA 100
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Even 1 Cigarette a Day While Pregnant Can Harm Baby

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- Just a daily cigarette or two before or during pregnancy endangers the health of newborns, a new study warns.Infants are 16% more likely to suffer major health issues following delivery if their mothers engaged in “light.

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Inhibition of TTX-S Na+ currents by a novel blocker QLS-278 for antinociception [Behavioral Pharmacology]

ASPET

Genetic loss-of-function mutations of Nav1.7 channel, abundantly expressed in peripheral nociceptive neurons, cause congenital insensitivity to pain (CIP) in humans, indicating that selective inhibition of the channel may lead to potential therapy of pain disorders. In this study, we investigated a novel compound, 5-chloro-N-(cyclopropylsulfonyl)-2-fluoro-4-(2-(8-(furan-2-ylmethyl)-8-azaspiro [4.5] decan-2-yl) ethoxy) benzamide (QLS-278) that inhibits Nav1.7 channel and exhibits anti-nociceptive

Treatment 100
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PE Class: It Can Boost a Child's Body and Mind

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- A quality physical education program involves more than just getting kids to move for a set amount of time during the school day, experts say.PE classes can teach lessons not found in any other classroom, Erika Mundt, a.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Drug-induced long QT syndrome: Concept and non-clinical models for predicting the onset of drug-induced torsade de pointes in patients in compliance with ICH E14/S7B guidance [Minireview]

ASPET

ICH established S7B and E14 guidelines in 2005 to prevent drug-induced torsade de pointes (TdP), effectively preventing the development of high-risk drugs. However, those guidelines unfortunately hampered the development of some potentially valuable drug candidates despite not being proven to be proarrhythmic. In response, Comprehensive In Vitro Proarrhythmia Assay (CiPA) and Exposure-Response Modeling were proposed in 2013 to reinforce proarrhythmic risk assessment.

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'Mindful Breathing' Might Ease Cancer-Related Pain, Anxiety

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- A meditation technique called mindful breathing can help cancer patients manage their pain and anxiety, a new study finds.Cancer patients who engaged in 20 minutes of mindful breathing experienced a greater reduction in.

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A Biotech Midsummer’s Madness

LifeSciVC

By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC Greetings from Lake Winnipesaukee in NH where I am at this time every year. It’s midsummer and vacation time for me and the family. In order to try and maintain a healthy work/life balance, I try and lead by example, but we know that this rarely goes according to plan in biotech.

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COVID Vaccine Won't Trigger MS Relapse: Study

Drugs.com

WEDNESDAY, Aug. 21, 2024 -- Multiple sclerosis makes people vulnerable to more severe cases of COVID-19, but a new study finds that getting the COVID vaccine won't trigger a relapse of MS symptoms.“People with MS have an increased risk of severe C.

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How to Scale Up with Jessica Neal

BenchSci

We were thrilled to welcome back Jessica Neal, for our second Scale Up talk of the year. Jessica is not only a renowned culture builder and advisor to BenchSci, but she also played an instrumental role in shaping Netflix’s high-performing culture, completing two tours at Netflix as their Vice President of Talent and Chief Talent Officer. While Jessica first joined us in 2022 , it felt like the right time to welcome her back, as so much has changed since that conversation.