Science Daily: Pharmacology News
AUGUST 21, 2024
New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.
ASPET
AUGUST 21, 2024
Fatty acid amide hydrolase (FAAH) serves as the primary enzyme responsible for degrading the endocannabinoid anandamide (AEA). Inhibition of FAAH, either through pharmacological means or genetic manipulation, can effectively reduce inflammation in various organs, including the brain, colon, heart, and kidneys. Infusion of a FAAH inhibitor into the kidney medulla has been shown to induce diuretic and natriuretic effects.
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Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- The first mpox vaccine doses from the United States are set to arrive next week in the Congo, the epicenter of an ongoing mpox outbreak in Africa.The doses come not a moment too soon: Just last week, the World Health.
ASPET
AUGUST 21, 2024
Genetic loss-of-function mutations of Nav1.7 channel, abundantly expressed in peripheral nociceptive neurons, cause congenital insensitivity to pain (CIP) in humans, indicating that selective inhibition of the channel may lead to potential therapy of pain disorders. In this study, we investigated a novel compound, 5-chloro-N-(cyclopropylsulfonyl)-2-fluoro-4-(2-(8-(furan-2-ylmethyl)-8-azaspiro [4.5] decan-2-yl) ethoxy) benzamide (QLS-278) that inhibits Nav1.7 channel and exhibits anti-nociceptive
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
AUGUST 21, 2024
The distribution of outermost shell electrons, known as valence electrons, of organic molecules was observed for the first time. As the interactions between atoms are governed by the valence electrons, the findings shine light on the fundamental nature of chemical bonds, with implications for pharmacy and chemical engineering.
ASPET
AUGUST 21, 2024
ICH established S7B and E14 guidelines in 2005 to prevent drug-induced torsade de pointes (TdP), effectively preventing the development of high-risk drugs. However, those guidelines unfortunately hampered the development of some potentially valuable drug candidates despite not being proven to be proarrhythmic. In response, Comprehensive In Vitro Proarrhythmia Assay (CiPA) and Exposure-Response Modeling were proposed in 2013 to reinforce proarrhythmic risk assessment.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
AUGUST 21, 2024
Researchers have developed an eco-friendly refrigeration device with record-breaking cooling performance in the world, setting to transform industries reliant on cooling and reduce global energy use. With a boost in efficiency of over 48%, the new elastocaloric cooling technology opens a promising avenue for accelerating the commercialization of this disruptive technology and addressing the environmental challenges associated with traditional cooling systems.
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- An experimental genetic test can gauge a person’s risk of developing potentially deadly blood clots, researchers report.People who scored high on the test had more than double the rate of heart attack, stroke and major a.
Science Daily: Pharmacology News
AUGUST 21, 2024
Archeologists say new findings might help resolve the debate about Clovis points and reshape how we think about what life was like roughly 13,000 years ago. After an extensive review of writings and artwork -- and an experiment with replica Clovis point spears -- a team of archaeologists says humans may have braced the butt of their weapons against the ground in a way that would impale a charging animal.
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- Eating red meat and processed meat can increase a person’s risk of developing type 2 diabetes, a new review finds.Regularly eating 50 grams of processed meat a day -- the equivalent of two slices of ham -- increased by 1.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
AUGUST 21, 2024
Backed by $300 million from investors that include Viking Global Investors and Sequoia Capital, GondolaBio will inherit several BridgeBio drug programs.
Science Daily: Pharmacology News
AUGUST 21, 2024
Scientists studying the tracks of particles streaming from six billion collisions of atomic nuclei at the Relativistic Heavy Ion Collider (RHIC) -- an 'atom smasher' that recreates the conditions of the early universe -- have discovered a new kind of antimatter nucleus, the heaviest ever detected. Composed of four antimatter particles -- an antiproton, two antineutrons, and one antihyperon -- these exotic antinuclei are known as antihyperhydrogen-4.
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- A review of U.S. data from 2012 through 2024 finds that when kids get free school meals, there's a potential for a slight increase in attendance and a lowering of child obesity rates.Even kids from higher-income.
BioPharma Drive: Drug Pricing
AUGUST 21, 2024
Pharmaceuticals like the in-demand GLP-1 drugs for obesity are expected to drive increases in healthcare spending in 2025, per a new employer survey.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- Obese kids are more likely to develop immune-based skin problems like eczema or psoriasis, a new study says.Analysis of more than 2.1 million Korean children between 2009 and 2020 revealed that children who became.
BioPharma Drive: Drug Pricing
AUGUST 21, 2024
Company executives had previously warned investors that a delay was likely due to issues at a facility run by third-party manufacturer.
Science Daily: Pharmacology News
AUGUST 21, 2024
A new study challenges as highly unlikely an alarming prediction of sea-level rise that -- while designated as low likelihood --earned a spot in the latest UN climate report for its projection that the collapse of polar ice sheets could make the world's oceans up to 50 feet higher by 2300. But researchers found that the model is based on inaccurate physics of how ice sheets retreat and break apart, though they stress that the accelerating loss of ice from Greenland and Antarctica is still dire.
BenchSci
AUGUST 21, 2024
We were thrilled to welcome back Jessica Neal, for our second Scale Up talk of the year. Jessica is not only a renowned culture builder and advisor to BenchSci, but she also played an instrumental role in shaping Netflix’s high-performing culture, completing two tours at Netflix as their Vice President of Talent and Chief Talent Officer. While Jessica first joined us in 2022 , it felt like the right time to welcome her back, as so much has changed since that conversation.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
AUGUST 21, 2024
Bioengineers around the world have been working to create plastic-producing microbes that could replace the petroleum-based plastics industry. Now, researchers have overcome a major hurdle: getting bacteria to produce polymers that contain ring-like structures, which make the plastics more rigid and thermally stable. Because these molecules are usually toxic to microorganisms, the researchers had to construct a novel metabolic pathway that would enable the E. coli bacteria to both produce and to
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- A quality physical education program involves more than just getting kids to move for a set amount of time during the school day, experts say.PE classes can teach lessons not found in any other classroom, Erika Mundt, a.
Science Daily: Pharmacology News
AUGUST 21, 2024
A groundbreaking study conducted across 30 field sites in the southwest UK has revealed the importance of incorporating varied habitats into the landscape at large.
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- A meditation technique called mindful breathing can help cancer patients manage their pain and anxiety, a new study finds.Cancer patients who engaged in 20 minutes of mindful breathing experienced a greater reduction in.
LifeSciVC
AUGUST 21, 2024
By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC Greetings from Lake Winnipesaukee in NH where I am at this time every year. It’s midsummer and vacation time for me and the family. In order to try and maintain a healthy work/life balance, I try and lead by example, but we know that this rarely goes according to plan in biotech.
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- Multiple sclerosis makes people vulnerable to more severe cases of COVID-19, but a new study finds that getting the COVID vaccine won't trigger a relapse of MS symptoms.“People with MS have an increased risk of severe C.
Drug Patent Watch
AUGUST 21, 2024
The pharmaceutical industry has witnessed a significant surge in the availability of public disease and drug-related data, which has facilitated […] Source
Drugs.com
AUGUST 21, 2024
WEDNESDAY, Aug. 21, 2024 -- Just a daily cigarette or two before or during pregnancy endangers the health of newborns, a new study warns.Infants are 16% more likely to suffer major health issues following delivery if their mothers engaged in “light.
BioPharma Drive: Drug Pricing
AUGUST 21, 2024
Greg Friberg and James Sabry will take over, respectively, as heads of R&D and business development, less than a year after BioMarin named a new CEO.
Fierce BioTech
AUGUST 21, 2024
Global Perspective on Achieving Launch Excellence pesurya Wed, 08/21/2024 - 13:15 Wed, 10/09/2024 - 11:00 Resource Type Webinar Natalie Harb Sarah Rickwood Elyse Muñoz Duration 60 Minutes Join IQVIA in its Launch Excellence webinar, where we build on our Launch Excellence framework to explore challenges and key drivers of commercial success for new launches.
Perficient: Drug Development
AUGUST 21, 2024
As a Salesforce Developer, sending emails through Apex is a common task. One of the powerful methods you can use is setTargetObjectId(). This method allows you to specify the recipient using a Salesforce record ID, ensuring seamless integration and enhancing CRM data quality. In this blog, we’ll dive into how to use setTargetObjectId(), explore practical use cases, and address common issues along with debugging tips.
KIF1A
AUGUST 21, 2024
“He enjoys making others laugh with his quick wit and his smile is contagious. He loves being with family & friends.” A message from Kirt’s family in the USA: Kirt is a hardworking, happy, friendly young man! He enjoys making others laugh with his quick wit and his smile is contagious. He loves being with family & friends. He enjoys playing Skyjo, Uno, ping pong, swimming, horse-back riding and playing the Wii with his two older sisters or anyone that comes over.
Perficient: Drug Development
AUGUST 21, 2024
In some situations, we need to set a maximum zoom scale or disable zoom completely on our website. This blog explains how to achieve that behavior in Optimizely Spire. In Optimizely, the meta viewport tag rendered on the page comes from the srcFrontEndmodulesserver-frameworksrcPageRenderer.tsx file. However, since this file is part of the server framework, we cannot override it directly.
Drug Patent Watch
AUGUST 21, 2024
Clinical Trial Results Alnylam Pharmaceuticals reported positive Phase 3 results for vutrisiran in treating transthyretin amyloidosis cardiomyopathy, boosting the company’s […] Source
Perficient: Drug Development
AUGUST 21, 2024
Welcome to another installment of our UX in Universal Design series! In this edition, we’ll explore the significance of customizable gestures in health systems. As touchscreens and gesture-based interfaces become more prevalent in healthcare, it’s crucial to make these interactions adaptable to meet the diverse needs of users. Customizable gestures allow for greater accessibility, ensuring that patients, healthcare providers, and other users can interact with digital systems in a way that
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