Drug Discovery World

AUGUST 20, 2024

Mirit Eldor , Managing Director, Life Sciences Solutions, Elsevier, looks at how artificial intelligence (AI) can improve the hit-to-lead process for small molecules. Early drug discovery takes an average of three-to-six years and accounts for 42% of total costs 1 in the development of a new drug. It’s therefore no surprise that pharmaceutical companies are increasingly interested in using artificial intelligence (AI) to accelerate development and reduce costs.

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Small Molecule Pharmaceutical Companies Drugs Pharmaceuticals 275

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

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Drug Discovery World

AUGUST 20, 2024

Positive results from multiple in vivo studies have shown the impact of sphingosine kinase-2 (SPHK2) inhibition in various models of metabolic disease. RedHill Biopharma announced the positive study results, which show the effect of opaganib on weight gain and glucose tolerance in a high fat diet (HFD) model. The company says the data support the potential clinical use of opaganib for the prevention and therapy of Type 2 diabetes and other obesity-related disorders.

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Science Daily: Pharmacology News

AUGUST 20, 2024

Meat consumption, particularly consumption of processed meat and unprocessed red meat, is associated with a higher type 2 diabetes risk, an analysis of data from 1.97 million participants.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 20, 2024

Phanes Therapeutics’ PT217 has received orphan drug designation (ODD) for neuroendocrine carcinoma (NEC) from the US Food and Drug Administration (FDA). PT217 is a first-in-class bispecific antibody targeting delta-like ligand 3 (DLL3) and cluster of differentiation 47 (CD47) being developed for patients with NEC. NEC is known to be the most aggressive subgroup of neuroendocrine neoplasms and defined as cancers with poorly differentiated morphology and a high proliferation rate.

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Clinical Supply Clinical Trials Drugs FDA 147

Science Daily: Pharmacology News

AUGUST 20, 2024

Researchers have succeeded in something that has been pursued since the 1970s: explaining the X-ray radiation from the black hole surroundings. The radiation originates from the combined effect of the chaotic movements of magnetic fields and turbulent plasma gas.

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Research 120

Science Daily: Pharmacology News

AUGUST 20, 2024

Researchers suggest a new designation of the humpback whales they study: tool wielders. Researchers have known that humpback whales create "bubble-nets" to hunt, but they have learned that the animals don't just create the bubble-nets; they manipulate this unique tool in a variety of ways to maximize their food intake in Alaskan feeding grounds.

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Research 118

Drug Discovery World

AUGUST 20, 2024

Join DDW and Lonza for this free event ‘ Building advanced cell models for toxicity testing ’. The event will take place on 19 September at 3pm GMT / 4pm CET / 10am EST / 7am PST. Life sciences researchers need a host of tools to develop and test critical disease-treating drugs and therapies, from basic research to final product release. Primary cells, media, and reagents are all important for supporting preclinical and clinical pharmaceutical workflows for drug discovery and absorption, distrib

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Pharmacokinetics Production Science Pharmaceuticals 130

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Tirzepatide, the blockbuster GLP-1 medicine known as Mounjaro for diabetes and Zepbound for weight loss, cut the odds that an obese, prediabetic person will develop diabetes by 94%, a new trial shows. The three-year-long.

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Trials 116

Fierce BioTech

AUGUST 20, 2024

Alzheimer’s disease research and drug development is evolving at a rapid pace. Decades of research has led to the approval of the first disease-modifying drugs and new pathological discoveries.

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Disease Drug Development Research Drugs 116

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- AI can help predict which young kids are more likely to develop autism, a new study says.The AI looks for patterns in medical data that can be easily obtained from children 2 or younger without extensive assessments or.

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Science Daily: Pharmacology News

AUGUST 20, 2024

A new study shows how the mismatch between where fossils are preserved and where humans likely lived may influence our understanding of early human evolution.

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Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- The overdose-reversing drug naloxone can help save the lives of people whose hearts have stopped due to an opioid OD, a new study shows.Naloxone rapidly reverses opioid ODs by blocking the ability of opioids to bind with.

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Drugs 105

BioPharma Drive: Drug Pricing

AUGUST 20, 2024

Treatment with the GLP-1 drug, which Lilly sells as Mounjaro and Zepbound, lowered the risk of Type 2 diabetes progression by 94% versus placebo.

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Treatment Drugs 113

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Toxin from one of the most venomous animals on the planet – a deadly sea snail – could help researchers figure out new ways to treat diabetes and other hormone disorders, a new study suggests.A toxin in the venom of the geo.

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Research 105

Science Daily: Pharmacology News

AUGUST 20, 2024

Our understanding of Venus' water history and the potential that it was once habitable in the past is being challenged by recent observations.

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Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Tiny turtles are the cause of a outbreak of 51 cases of salmonella in 21 states, the U.S. Centers for Disease Control and Prevention announced Friday.In almost half of cases, the illness has been so severe as to require.

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Disease 105

addgene Blog

AUGUST 20, 2024

Now that you know how to read flow plots and have designed your first flow panel , you’ll load your samples into the cytometer and see one of two results for your antibody of interest: two clear populations or a huge smear across your FSH vs reporter plot. In this post, I’ll walk you through how to interpret the antibody readout on a flow plot.

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Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- An insect-borne virus that can cause birth defects and deaths has prompted warnings from the United States for travelers headed to locales in South America and the Caribbean.Oropouche virus has caused two deaths and five.

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Virus 105

DrugBank

AUGUST 20, 2024

The world of drug discovery is in a state of transformation, with advancements in biotechnology opening doors to new possibilities for targeting previously "undruggable" disease mechanisms. If you're a pharmaceutical researcher or drug developer, understanding these breakthroughs is critical to staying at the forefront of innovation. Our new eBook, Unlocking Undruggable Targets: Biotechnology’s Role in Expanding Drug Discovery , is your comprehensive guide to navigating this

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Pharmaceuticals Therapies Research Disease 73

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- One of the most abundant fatty acids in the body -- and a key ingredient in the Mediterranean diet -- could be a safe, easy and natural cure for bacterial vaginosis, a new lab study suggests.Oleic acid can inhibit the.

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Science Daily: Pharmacology News

AUGUST 20, 2024

High-resolution images show large spots on the surface of Polaris.

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Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Updated shots you could use this fall to shield against COVID-19 infection may receive approval this week.Two sources familiar with the issue told CNN that updated mRNA vaccines from Moderna and Pfizer that target a.

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BioPharma Drive: Drug Pricing

AUGUST 20, 2024

Approval of Rybrevant and Lazcluze was supported by results from a study that compared the regimen to AstraZeneca’s widely used drug Tagrisso.

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FDA Drugs 80

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Final government data finds the number of U.S. births falling by 2% last year compared to 2022, continuing a decades-long decline.Overall, annual U.S. birth numbers have fallen by 17% since peaking in 2007, according to.

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Government 104

Perficient: Drug Development

AUGUST 20, 2024

Let’s test a button color! I hear this alot with clients. While that can sometimes be a valid beginner AB test, your web designer and UX specialist likely chose the current color based on years of sound research. That likely makes it an unfavorable candidate for a good test. So, what makes a good test then? What’s the secret sauce? A good test has these attributes: It tests a component/page that influences conversion.

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Marketing Research 59

Drugs.com

AUGUST 20, 2024

TUESDAY, Aug. 20, 2024 -- Some seniors with end-stage kidney failure who are too sick for a transplant should probably skip dialysis because the health trade-offs aren't worth it, a new study says.Seniors who started dialysis immediately after.

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BioPharma Drive: Drug Pricing

AUGUST 20, 2024

In addition to new stock offerings, this week saw Merck license an antibody drug conjugate and BARDA further work trying to innovate remote clinical trials.

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Clinical Trials Licensing Licensing Trials 57

KIF1A

AUGUST 20, 2024

“Pauline is the joy of the family. She was the angel who came to bring us even closer together.” A message from Pauline’s family in Brazil: Pauline was born on 09/27/2023, with a smooth pregnancy, but in the last 2 months, observing the ultrasounds exams, it was identified that the measurements of the long-bones of the arms and legs were much lower than normal, but the doctor told us to wait until the birth to determine if she had or not dwarfism.

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Perficient: Drug Development

AUGUST 20, 2024

In the realm of modern business operations, efficient inventory management is paramount. Companies must keep track of a plethora of items, ensuring that they are properly categorized, tracked, and managed. Oracle Product Data Hub (PDH) Cloud and Oracle Inventory Management Cloud are two powerful tools that work in tandem to achieve these goals. A critical component of this system is item classification, which significantly impacts inventory management.

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Sygnature Discovery

AUGUST 20, 2024

World-leading contract research organization Sygnature Discovery has announced a major new addition to its leadership team, with the high-profile appointment of industry veteran Jade Dagher as General Manager, Canada. Jade Dagher – General Manager, Canada Jade is a “big hitter” in the sector and has over 35 years of experience in pharmaceuticals, including 25 years with Global pharma giant Merck.

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Perficient: Drug Development

AUGUST 20, 2024

The rapid advancement of artificial intelligence (AI) has led to the development of foundational models that form the bedrock of numerous AI applications. AWS Bedrock is Amazon Web Services’ comprehensive solution that leverages these models to provide robust AI and machine learning (ML) capabilities. This blog delves into the essentials of AI foundational models in AWS Bedrock, highlighting their significance and applications.

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Drug Patent Watch

AUGUST 20, 2024

Digital twins are revolutionizing the pharmaceutical and biopharmaceutical industries by integrating physical plants, data collection, data analysis, and system control.

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Pharmaceuticals Drugs 52

BioPharma Drive: Drug Pricing

AUGUST 20, 2024

J&J has agreed to pay $600 million upfront for the private company as it works to expand its portfolio of cardiovascular devices.

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