Drug Discovery World

SEPTEMBER 10, 2024

Boehringer Ingelheim has reported positive results from its Phase Ib primary analysis of Cohort 1 of the Beamion LUNG-1 trial evaluating zongertinib (BI 1810631) in pre-treated patients with advanced non-small cell lung cancer (NSCLC) with activating HER2 mutations. Zongertinib, an investigational oral HER2 tyrosine kinase inhibitor (TKI), demonstrated a meaningful objective response rate of 66.7%, and was generally well tolerated in the Cohort 1 setting.

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Science Daily: Pharmacology News

SEPTEMBER 10, 2024

When they become fathers, men who have an unhealthy, high-cholesterol diet can cause increased risk of cardiovascular disease, or CVD, in their daughters, a mouse study has found.

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Disease 119

Drug Discovery World

SEPTEMBER 10, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the release of clinical study results that led some media titles to ask if semaglutide could be a ‘fountain of youth’, this week our news highlights focus on clinical trials at a variety of different stages.

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Clinical Trials Trials Drugs 147

Science Daily: Pharmacology News

SEPTEMBER 10, 2024

Methane concentrations in Earth's atmosphere increased at record speed over the past five years. At least two-thirds of annual methane emissions now come from human activities, including fossil fuel use, agriculture, and landfills and other waste.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 10, 2024

The Francis Crick Institute and MSD have opened a new Skylab facility, extending the footprint of the Crick and expanding opportunities for collaboration between the two organisations. The new 11,800 square foot specialised life sciences laboratory is located on the roof space of the Crick and took 16 months to complete. Science Minister Patrick Vallance, who opened the facility, said: “The opening of Skylab represents a fantastic opportunity to advance UK science and is a vote of confiden

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Drug Research Research Laboratories Nurses 147

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- Taking steroids more than doubles a person’s risk of developing type 2 diabetes, a new study warns.Patients taking steroid pills, injections or infusions are 2.6 times more likely to develop diabetes than those not on s.

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Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- A European epilepsy drug could be an effective treatment for sleep apnea, a new study suggests. Patients who took sulthiame had few pauses in their breathing while asleep, as well as higher levels of blood oxygen.

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Treatment Drugs 104

Drug Discovery World

SEPTEMBER 10, 2024

Recently, the Novo Nordisk Foundation updated its strategy to include regenerative medicine. While regenerative medicine is not new to the Foundation, it is now an explicit part of the company’s strategy. DDW’s Megan Thomas caught up with Martin Ridderstråle, Senior Vice President and Head of Medical Science at the Novo Nordisk Foundation, to learn more about this strategic decision and the future of regenerative medicine at the Copenhagen-based charitable foundation.

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Clinical Trials Science Therapies Disease 147

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- A form of psychotherapy can help women whose libidos have suffered as they go through menopause, a new study finds.Cognitive behavioral therapy significantly improved sexual desire and satisfaction in a small group of.

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Therapies 98

Drug Discovery World

SEPTEMBER 10, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the release of clinical study results that led some media titles to ask if semaglutide could be a ‘fountain of youth’, this week our news highlights focus on clinical trials at a variety of different stages.

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Clinical Trials Trials Drugs 130

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Clinical Trials

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- New research uncovers a possible reason why teenaged girls struggled so mightily with their mental health during the pandemic: Scans showed their brains aged far faster than expected during that stressful time, even.

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Research 98

Drug Discovery World

SEPTEMBER 10, 2024

Join DDW and Lonza for this free event ‘ Building advanced cell models for toxicity testing ’. The event will take place on 19 September at 3pm GMT / 4pm CET / 10am EST / 7am PST. Life sciences researchers need a host of tools to develop and test critical disease-treating drugs and therapies, from basic research to final product release. Primary cells, media, and reagents are all important for supporting preclinical and clinical pharmaceutical workflows for drug discovery and absorption, distrib

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Pharmacokinetics Production Science Pharmaceuticals 130

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- A European epilepsy drug could be an effective treatment for sleep apnea, a new study suggests.Patients who took sulthiame had few pauses in their breathing while asleep, as well as higher levels of blood oxygen.

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Treatment Drugs 97

addgene Blog

SEPTEMBER 10, 2024

Antibody validation is to confirm (or refute) that the antibody is selectively detecting the target-of-interest in your assay and sample-of-interest. The approaches available broadly map onto the five pillars of antibody validation (see: Uhlen et al., 2016 ). In this post, we will describe the approaches that can be used to determine selectivity of an antibody for flow cytometry experiments.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- A flare-up in COPD can be predicted through changes in a person’s voice, a new study claims.Patients’ voices become higher-pitched, more breathy or hoarse when a flare-up is imminent, researchers found.Using those cues, re.

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Research 95

BioPharma Drive: Drug Pricing

SEPTEMBER 10, 2024

A small, early study produced what one analyst called “highly compelling” results that lifted the company’s shares by as much as 15% Tuesday.

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Drugs 78

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- Annoyed that you still have a bit of tummy even though you work out all the time?Exercise actually is helping you develop healthier belly fat tissue, a new study says.That means that even if you don’t obtain six-pack abs.

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NIOSH Science Blog: Drugs

SEPTEMBER 10, 2024

Where It Started As the Nanotechnology Research Center (NTRC) marks its 20th anniversary, we reflect on our achievements in the field of nanotoxicology. Within the National Institute for Occupational Safety and Health (NIOSH), one NTRC goal is to understand possible harm from nanomaterials in workplaces. Our work has its origins in earlier research.

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International Research 69

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- The latest AirPods from Apple will come with built-in hearing aids, the company announced Monday.Designed as an over-the-counter hearing aid feature for those with mild to moderate hearing loss, users take hearing tests.

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BioPharma Drive: Drug Pricing

SEPTEMBER 10, 2024

The Biosecure Act, which limits contracts with WuXi AppTec, WuXi Biologics and three other companies, still needs Senate support to advance.

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New Drug Approvals

SEPTEMBER 10, 2024

Zelatriazin, C 18 H 15 F 3 N 4 O 3 , 392.3 g/mol 1929519-13-0 NBI-1065846 or TAK-041 Phase 2 (S)-2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide Zelatriazin ( NBI-1065846 or TAK-041 ) is a small-molecule agonist of GPR139. It was developed for schizophrenia and anhedonia in depression but trials were unsuccessful and its development was discontinued in 2023. [1] [2] [3] [4] [5] [6] [7] SCHEME SYN WO2016081736 [link] Example 2: (S)-2-(4-oxobenzo[d][l,2,3]

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Drug Patent Watch

SEPTEMBER 10, 2024

The generic drug market has experienced significant growth over the past few decades, driven by the passage of the Hatch-Waxman Act in 1984 and subsequent legislation. Today, the market is more competitive than ever, with generic drugs accounting for over 90% of all prescriptions in the United States.

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Drug Development Drugs Marketing 59

New Drug Approvals

SEPTEMBER 10, 2024

Vorasidenib 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine CAS 1644545-52-7 , C 14 H 13 ClF 6 N 6 , 414.74 FDA APPROVED, 8/6/2024, Voranigo , To treat Grade 2 astrocytoma or oligodendroglioma UNII 789Q85GA8P AG 881 AG-881 AG881 Ingredient UNII CAS InChI Key Vorasidenib citrate X478M962XG 2316810-02-1 YOUTVRFNJAAFNS-DLVAHKFUSA-N Vorasidenib citrate anhydrous W4XG3EQK7B 2316810-00-9 OCEHQNOYRLHJCI-WPRTUUMNSA-N Vorasidenib , sold under the brand name

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BioPharma Drive: Drug Pricing

SEPTEMBER 10, 2024

The partners’ ADC didn’t significantly extend survival in lung cancer patients who were expected to benefit the most from treatment in a Phase 3 trial.

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Trials Treatment 62

New Drug Approvals

SEPTEMBER 10, 2024

Deuruxolitinib C 17 H 18 N 6 , 314.422 Fda approved Leqselvi , 7/25/2024, To treat severe alopecia areata C-21543, CTP 543, CTP-543, CTP543 (3r)-3-(2,2,3,3,4,4,5,5-d8)cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)propanenitrile 1h-pyrazole-1-propanenitrile,beta.-(cyclopentyl-2,2,3,3,4,4,5,5-d8)-4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-, (.beta.r)-D8-ruxolitinib Ingredient UNII CAS InChI Key Deuruxolitinib phosphate 8VJ43S4LCM 2147706-60-1 JFMWPOCYMYGEDM-NTVOUFPTSA-N unii 0CA0VSF9

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FDA Approval FDA Treatment Clinical Trials 52

Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- An analysis of where suicides are occurring in the United States shows that, tragically, location matters. People living in poorer areas with fewer resources are significantly more likely to fall victim to suicide versus.

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Perficient: Drug Development

SEPTEMBER 10, 2024

The healthcare and life sciences industries are rapidly evolving, fueled by the demand for innovation, efficiency, and patient-centric care. Emerging technologies like AI and cloud platforms are reshaping how healthcare organizations operate. Kristen Quick , Director at Perficient and HLS Industry Lead within the Salesforce practice, brings 15 years of expertise to guide transformative initiatives.

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Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- Brain changes that signal Alzheimer's disease even before symptoms appear are linked to an increased vulnerability to financial scams, new research shows.“Assessing financial vulnerability in older adults could help i.

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Fierce BioTech

SEPTEMBER 10, 2024

Unique Solutions for Drug Discovery and Development Today's drug development teams need solutions that push discovery, de-risk development, and trim timelines. But each project comes with a unique set of challenges. Cell Signaling Technology (CST) is a company founded and led by active research scientists, so our approach to helping you solve those challenges is different.

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Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- People with type 2 diabetes are nearly twice as likely to develop asthma, a new review has concluded.Type 2 diabetics are 83% more likely to develop asthma, compared to those without diabetes, researchers found.The.

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Research 52

Drug Channels

SEPTEMBER 10, 2024

I am pleased to announce the full agenda for the inaugural Drug Channels Leadership Forum , which will be held from March 17 to 19, 2025, at the Turnberry Resort and Spa in Miami. Everyone here at Drug Channels Institute (DCI) is excited to bring this novel event to the drug channels community. I personally assembled the agenda. As you can see, it’s filled with senior industry executives who will participate in fireside chats with me as well as topical panel discussions moderated by a diverse se

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Drugs.com

SEPTEMBER 10, 2024

TUESDAY, Sept. 10, 2024 -- Having asthma appears linked to raised odds for miscarriage and troubles with fertility among women, new Danish research shows.“We found that women fulfilling the definition of asthma had a higher rate of fetal loss and a.

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Research 52

BioPharma Drive: Drug Pricing

SEPTEMBER 10, 2024

The fund is Bain’s fourth and follows several recent acquisitions of some of its portfolio companies, among them Jnana Therapeutics and EyeBio.

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Quanticate

SEPTEMBER 10, 2024

Discover what Health Economics and Outcomes Research (HEOR) is and how it’s applied in programming to analyse healthcare data and improve patient outcomes.

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Research 52