Tue.Nov 12, 2024

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Beta Blockers Unnecessary for Folks Without Heart Failure; May Be Linked to Depression

Drugs.com

TUESDAY, Nov. 12, 2024 -- Beta blockers are go-to meds for many people who've survived a heart attack.However, new Swedish research has found that they might not be needed for heart attack survivors whose hearts have retained a normal pumping.

Research 108
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One genomic test can diagnose nearly any infection

Science Daily: Pharmacology News

A genomic test developed by researchers to rapidly detect almost any kind of pathogen -- virus, bacteria, fungus or parasite -- has proved successful after a decade of use.

Virus 109
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Vitamin D Supplements Could Help Lower Blood Pressure in Obese People

Drugs.com

TUESDAY, Nov. 12, 2024 -- Vitamin D supplements might lower blood pressure in seniors who are obese, reducing their heart health risk, a new study says.But taking more than the recommended daily dose will not provide additional health benefits.

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Intelligently Automating Prior Authorization to Build Consumer Trust in Healthcare

Perficient: Drug Development

Healthcare leaders are engaging us in a variety of discussions to explore intelligent automation’s role for complex business challenges, ranging from efforts to enhance consumer trust and use artificial intelligence (AI) in effective ways, to navigating change that comes with prior authorization mandates. This series shares key insights coming from those discussions.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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A formula for life? New model calculates chances of intelligent beings in our Universe and beyond

Science Daily: Pharmacology News

The chances of intelligent life emerging in our Universe -- and in any hypothetical ones beyond it -- can be estimated by a new theoretical model which has echoes of the famous Drake Equation. This was the formula that American astronomer Dr Frank Drake came up with in the 1960s to calculate the number of detectable extraterrestrial civilizations in our Milky Way galaxy.

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Kids Still Find It Easy to Buy Flavored Vapes Online

Drugs.com

TUESDAY, Nov. 12, 2024 -- If you think that federal restrictions on the sale of tobacco products make it nearly impossible for your teen to buy vapes online, new research suggests you're mistaken.In 2020, the Preventing Online Sales of E-Cigarettes.

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Bird Flu Is Decimating Elephant Seal Colonies

Drugs.com

TUESDAY, Nov. 12, 2024 -- The H5N1 strain of avian flu is now passing easily among South America's elephant seals and drastically cutting herd populations, a new report finds."It is likely that more than half of the reproductive population died due.

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Giving robots superhuman vision using radio signals

Science Daily: Pharmacology News

Researchers have developed PanoRadar, a new tool to give robots superhuman vision by transforming simple radio waves into detailed, 3D views of the environment.

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Genomic Test Might Quickly Diagnose Any Type of Infection

Drugs.com

TUESDAY, Nov. 12, 2024 -- A cutting-edge genetic test can rapidly detect and identify almost any kind of disease-causing microorganism in the human body, whether it’s a virus, bacteria, fungus or parasite, researchers say.Doctors have been using t.

Virus 96
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Astronomers' theory of how galaxies formed may be upended

Science Daily: Pharmacology News

The standard model for how galaxies formed in the early universe predicted that the James Webb Space Telescope (JWST) would see dim signals from small, primitive galaxies. But data are not confirming the popular hypothesis that invisible dark matter helped the earliest stars and galaxies clump together.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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America's Epidemic of STDs May Finally Be Slowing

Drugs.com

TUESDAY, Nov. 11, 2024 -- The epidemic of sexually transmitted infections (STIs) in the United States appears to be cooling off after more than two decades, a new Centers for Disease Control and Prevention (CDC) study says. Gonorrhea cases dropped.

Disease 95
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Time alone heightens 'threat alert' in teenagers -- even when connecting on social media

Science Daily: Pharmacology News

Scientists detect a heightened 'threat vigilance' reaction in adolescents after a few hours of isolation, which socializing online doesn't appear to ameliorate. They say the findings might shed light on the link between loneliness and mental health conditions such as anxiety disorders, which are on the rise in young people.

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Grandparents & Grandkids: Poll Shows Them Helping Each Other

Drugs.com

TUESDAY, Nov. 12, 2024 -- Grandchildren are a true blessing for seniors, helping them avoid loneliness and keeping them on their toes, a new poll reports.Overall, 72% of people with grandkids say they hardly ever feel isolated, compared with 62% of.

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Fossil fuel CO2 emissions increase again in 2024

Science Daily: Pharmacology News

Global carbon emissions from fossil fuels have reached a record high in 2024, according to new research.

Research 114
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Understanding Cybercrime-as-a-Service: A Growing Threat in the Digital World

Perficient: Drug Development

With just a cryptocurrency wallet, cybercriminals can now execute complex cyberattacks without advanced technical knowledge or sophisticated software. This alarming trend is a byproduct of the growing popularity of cloud computing and the “as-a-service” model, where services like infrastructure, recovery, and cybersecurity are now accessible on demand.

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Breakthrough in photonic time crystals could change how we use and control light

Science Daily: Pharmacology News

An international research team has for the first time designed realistic photonic time crystals - exotic materials that exponentially amplify light. The breakthrough opens up exciting possibilities across fields such as communication, imaging and sensing by laying the foundations for faster and more compact lasers, sensors and other optical devices.

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U.S. Alcohol Intake Rose During Pandemic, and for Years After

Drugs.com

TUESDAY, Nov. 12, 2024 -- Even as the pressures of the pandemic began to ebb, Americans' growing dependence on alcohol did not, a troubling new study shows.Two years into the globe-altering health crisis, the percentage of Americans who consumed.

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Remarkable new swimming sea slug in the deep sea

Science Daily: Pharmacology News

Researchers have discovered a remarkable new species of sea slug that lives in the deep sea. Nicknamed the 'mystery mollusc,' the nudibranch Bathydevius caudactylus swims through the ocean's midnight zone with a large gelatinous hood and paddle-like tail, and lights up with brilliant bioluminescence.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Recent changes to ELN

Collaborative Drug

Updates to ELN annotation tool, ELN insert link hotkey, auto generated sample IDs, list searching in inventory, flag outliers during imports

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Synthetic cells emulate natural cellular communication

Science Daily: Pharmacology News

A research team has succeeded in synthesizing simple, environmentally sensitive cells complete with artificial organelles. For the first time, the researchers have also been able to emulate natural cell-cell communication using these proto-cells -- based on the model of photoreceptors in the eye. This opens up new possibilities for basic research and applications in medicine.

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Biotech investors, including Third Rock, pump $100M into a startup’s genetic medicine for ALS

BioPharma Drive: Drug Pricing

Trace Neuroscience aims to advance an RNA-binding therapy designed to preserve — and potentially improve — muscle function in people living with the nerve-destroying disorder.

RNA 67
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New solar composition ratios that could reconcile longstanding questions

Science Daily: Pharmacology News

A team combined compositional data of primitive bodies like Kuiper Belt objects, asteroids and comets with new solar data sets to develop a revised solar composition that potentially reconciles spectroscopy and helioseismology measurements for the first time. Helioseismology probes the Sun's interior by analyzing the waves that travel through it, while spectroscopy reveals the surface composition based on the spectral signature produced by each chemical element.

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Top 10 Challenges in Generic Drug Development

Drug Patent Watch

Generic drug development is a crucial aspect of the pharmaceutical industry, providing cost-effective alternatives to brand-name medications. However, this process is not without its challenges. Here are the top 10 challenges faced by generic drug developers: Generic drug development involves navigating complex regulatory frameworks, including the U.S.

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Possible to limit climate change to 1.5°C, if EU and 17 other countries go beyond their own targets

Science Daily: Pharmacology News

A new study finds that limiting global warming to 1.5 degrees Celsius is still possible, but some countries require support to meet their climate responsibilities. An 'additional carbon accountability' indicator is introduced, revealing that the EU and 17 other countries must exceed their own current targets to achieve this global goal.

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Transforming Construction: Automation and Robotics for a Safer Future

NIOSH Science Blog: Drugs

Introduction At its core, automation is the use of technology to perform tasks that were once done by humans. Technology includes software, tools to automate workflows, and machinery. Some of the early examples of automation in construction are power tools. As technology progresses, construction automation has seen rapid progress over the last decade with the introduction of robots.

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Earliest ancient Maya salt works excavated

Science Daily: Pharmacology News

A team of archaeologists has excavated the earliest known ancient Maya salt works in southern Belize.

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AstraZeneca, Daiichi revise approval plans for Enhertu successor

BioPharma Drive: Drug Pricing

Following mixed study results, the partners have backed away from seeking broad clearance of dato-dxd in lung cancer and instead are aiming for a narrower approval.

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Early Deaths From Heart Disease Rising in Rural U.S.

Drugs.com

TUESDAY, Nov. 11, 2024 -- More people in rural America are dying from heart disease, a new study says.Heart disease deaths increased among 25- to 64-year-olds in U.S. rural areas by about 21% between 2010 and 2022, researchers report in the Journal.

Disease 59
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Neurogene hits a setback in the clinic, one week after raising funds

BioPharma Drive: Drug Pricing

The company, which secured $200 million from investors in a private funding deal last week, learned Tuesday of a serious side effect experienced by one participant on a high dose of its Rett therapy.

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Act Now! Navigating the Windsor Framework in the UK

thought leadership

A New Era for Pharmaceutical Development and Licensing in the UK The Windsor Framework , set to be implemented from January 1, 2025, marks a significant shift in the regulatory landscape for pharmaceutical development and licensing in the United Kingdom (UK). This framework aims to streamline the licensing process, ensuring that medicines are authorized across the entire UK, including Northern Ireland, under a unified system managed by the Medicines and Healthcare products Regulatory Agency (MHR

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GSK partners with a Flagship startup to hunt for Parkinson’s drugs

BioPharma Drive: Drug Pricing

Under deal terms, GSK will give Vesalius Therapeutics $80 million in upfront and equity payments to identify treatments for Parkinson’s and another neurodegenerative condition.

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Logistics in Focus: Orchestrating the Challenges of Cell Therapy

Conversations in Drug Development Trends

By Amy Raymond, PhD, PMP, Executive Director, Therapeutic Strategy Lead, Rare Disease Cell and gene therapies (CGTs) include cutting-edge approaches that offer the hope of a healthier, happier, and better tomorrow for a wide range of patient populations. CGTs address rare and complex diseases at the root cause with increasing use in cancer, genetic disorders, and autoimmune diseases.

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Market Access for 505(b)(2) Drugs: Interview with US Payers Reveals a Better Approach

The Premier Consulting Blog

For drug developers the 505(b)(2) pathway presents an expedited pathway to FDA approval. In our experience, the conversation on 505(b)(2) pathways commonly focuses on predicate data or bridging strategies to accelerate FDA approval but lacks dialogue on the needs of US payers. This often leads to a major disconnect at the time of launch. The 505(b)(2) developer may expect broader access and lower patient out of pocket cost (copay) than the payer is willing to give.