Chemical Biology and Drug Design

FEBRUARY 22, 2024

TMEM97 knockdown re-sensitized HCT116/R and SW480/R cells to 5-FU by inhibiting EMT and ABC transporter expression through inactivation of Akt/mTOR pathway. These results indicate that TMEM97 may be a promising therapeutic target to combat 5-FU resistance in CRC. Abstract Resistance to 5-fluorouracil (5-FU) is still a primary setback to the success of colorectal cancer (CRC) chemotherapy.

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Regulations Research 100

BioPharma Drive: Drug Pricing

FEBRUARY 22, 2024

The startup’s Series C round will support a clinical-stage drug the company thinks could address some of the weaknesses of other KRAS-targeting medicines.

Drugs 125

Drugs 125

Perficient: Drug Development

FEBRUARY 22, 2024

We’re in Our #GrowthEra It’s a new year, and with that, there is always change. One of those changes is that I’m now leading Perficient’s Salesforce business unit as the Managing Director. I’ve had the opportunity to work in the Salesforce ecosystem for 8+ years with top-notch talent. Our team continues to do amazing work for our clients, maximizing the value they’ve invested in the Salesforce platform, bringing innovation to life, and driving business outcomes.

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Production 114

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- Former talk show host Wendy Williams has been diagnosed with primary progressive aphasia and frontotemporal dementia, her representatives announced in a statement on Thursday.The conditions are the same diagnoses actor.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

FEBRUARY 22, 2024

Nearly 30 years ago, scientists discovered a unique class of anticancer molecules in a family of bryozoans, a phylum of marine invertebrates found in tropical waters. The chemical structures of these molecules, which consist of a dense, highly complex knot of oxidized rings and nitrogen atoms, has attracted the interest of organic chemists worldwide, who aimed to recreate these structures from scratch in the laboratory.

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Small Molecule Laboratories 123

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- The common hair-loss drug in Propecia and Proscar might lower men’s risk of heart disease by lowering cholesterol levels, a new study suggests.Finasteride is used to treat male pattern baldness, and it’s also been.

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Drugs Disease 111

Drugs.com

FEBRUARY 22, 2024

THURSDAY. Feb. 22, 2024 -- First Lady Jill Biden on Wednesday announced $100 million in federal funding to fuel research into women's health.“We will build a health care system that puts women and their lived experiences at its center,” Biden.

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Research 111

Science Daily: Pharmacology News

FEBRUARY 22, 2024

Scientists have announced a major discovery that has profound importance for our understanding of brain fog and cognitive decline seen in some patients with Long COVID. The findings showed that there was disruption to the integrity of the blood vessels in the brains of patients suffering from Long COVID and brain fog. This blood vessel 'leakiness' was able to objectively distinguish those patients with brain fog and cognitive decline compared to patients suffering from Long-COVID but not with br

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Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- Television has been wryly referred to as the “electronic babysitter,” but a new study argues TV or other media could stunt a child’s language development.Children plopped in front of videos for hours on end tend to.

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addgene Blog

FEBRUARY 22, 2024

Ready to learn about antibodies? Our latest animation is here to help! Join Abi as they explain what antibodies are, their role in the immune response, and the different antibody isotypes found in mammals.

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Immune Response 86

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 21, 2024 -- Infection with the COVID-19 virus triggers the production of an immune system protein that's long been associated with fatigue, muscle ache and depression.Trouble is, for folks suffering from Long COVID this protein.

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Virus Production 105

SCIENMAG: Medicine & Health

FEBRUARY 22, 2024

Increased use of Paxlovid, the antiviral drug used to treat COVID-19, could prevent hundreds of thousands of hospitalizations and save tens of billions of dollars a year, according to a new epidemiological model published by researchers at The University of Texas at Austin.

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Hospitals Research Drugs 84

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- Rigorous safety protocols prevented an outbreak of tuberculosis last year in lab monkeys imported to the United States from spreading to humans, a new report shows.Overall, 26 cynomolgus macaque monkeys flown in from.

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SCIENMAG: Medicine & Health

FEBRUARY 22, 2024

t’s official. Getting the recommended 7-9 hours of sleep a night is currently out of reach for almost one-third of the population as Flinders University experts found 31% of adults had average sleep durations outside the recommended range. Credit: Flinders University t’s official.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 21, 2024 -- Talking about the “good old days” might elicit eye rolls from teenagers, but it could be the key to boosting a preschooler’s language skills, a new study finds.Reminiscing about past events with preschoolers.

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Science Daily: Pharmacology News

FEBRUARY 22, 2024

Astronomers have characterized a bright quasar, finding it to be not only the brightest of its kind, but also the most luminous object ever observed. Quasars are the bright cores of distant galaxies and they are powered by supermassive black holes. The black hole in this record-breaking quasar is growing in mass by the equivalent of one Sun per day, making it the fastest-growing black hole to date.

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Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- Burnout: It's a common enough concept, but how do you know if you're experiencing it at work and at home?According to experts at Baylor College of Medicine in Houston, a myriad of daily pressures placed on individuals can.

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Science Daily: Pharmacology News

FEBRUARY 22, 2024

How did cooperative behavior prevail in human evolution? Researchers have challenged two prevailing explanations -- repeated interactions on the one hand or group competition on the other. Instead, both mechanisms synergistically contribute to fostering cooperation effectively.

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Research 89

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- Some Americans living with diabetes are using smartwatches and smart rings that claim to be able to track their blood sugar.However, such claims from any device that does not pierce the skin are fraudulent and potentially.

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FDA 89

Common Sense for Drug Policy Blog

FEBRUARY 22, 2024

Safe Supply and Non-Fatal Overdose "In this study involving 47 individuals who were admitted to an unsanctioned compassion club, we found that enrolment in the program was associated with a reduction in any type of non-fatal overdose as well as non-fatal overdose involving naloxone administration. These findings, suggesting that enrollment in DULF's intervention likely decreased overdose rates, appear to be amongst the first in a growing body of research on the impacts of a safer drug supply tha

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Hospitals International Drugs Research 75

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 22, 2024 -- A deficiency or absence of viable sperm in a man's semen could spell danger for him and those closely related to him, new research suggests.Cancers are more likely to occur in these men and their families, reports a team.

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Research 98

Science Daily: Pharmacology News

FEBRUARY 22, 2024

The side effects of large-scale forestation initiatives could reduce the CO2 removal benefits by up to a third, a pioneering study has found.

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SCIENMAG: Medicine & Health

FEBRUARY 22, 2024

Three Virginia health systems together will serve as one of eight groups in the U.S. to conduct groundbreaking research for the Cancer Screening Research Network (CSRN), launched this week by the National Cancer Institute (NCI), part of the National Institutes of Health.

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Research Clinical Trials Trials 74

Science Daily: Pharmacology News

FEBRUARY 22, 2024

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

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Therapies Clinical Trials Treatment Disease 87

SCIENMAG: Medicine & Health

FEBRUARY 22, 2024

A new study from Vanderbilt University Medical Center demonstrates the promise of artificial intelligence to help refine and target the myriad computerized alerts intended to assist doctors and other team members in day-to-day clinical decision-making.

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Doctors 73

Science Daily: Pharmacology News

FEBRUARY 22, 2024

Scientists suspect Mars once had long-lived rivers, lakes and streams. Today, water on Mars is found in ice at the poles and trapped below the Martian surface. Researchers now reveal that Mars also may have had hydrothermal systems based on the hydrated magnesium sulfate the rover identified in the volcanic rocks.

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Research 89

SCIENMAG: Medicine & Health

FEBRUARY 22, 2024

BOSTON, February 22, 2024: CureLab Oncology, a clinical-stage, pre-IPO biotech company, announced that its novel biological agent, Elenagen, has been shown to significantly enhance standard chemotherapy and provides clinical benefits for the patients with the deadliest form ovarian cancer. Elenagen belongs to a novel class of biological agents, supercoiled circular DNA (plasmids).

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DNA Disease 71

BioPharma Drive: Drug Pricing

FEBRUARY 22, 2024

The commitment is part of a new initiative led by First Lady Jill Biden to change how research into diseases that predominantly affect women gets funded in the U.S.

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Research Disease 73

Science Daily: Pharmacology News

FEBRUARY 22, 2024

A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.

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Antidote

FEBRUARY 22, 2024

Behind every new treatment is the incredible team of doctors, researchers, patients, and clinical trial specialists who worked on the research that made it possible. Because every therapy must be rigorously tested through clinical trials before it can be approved, the process from creation to entering the market can be an arduous one — but it’s one that makes medical breakthroughs possible.

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Clinical Trials Trials Doctors Therapies 69

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Feb. 21, 2024 -- More than two in every five Americans know someone who’s died from a drug overdose, a new study shows.The study highlights the heavy toll that the U.S. opioid epidemic has taken on the nation, researchers say.“The.

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Drugs Research 91

Science Daily: Pharmacology News

FEBRUARY 22, 2024

Researchers have unveiled a novel concept termed 'supercritical coupling' that enables several folds increase in photon upconversion efficiency. This discovery not only challenges existing paradigms, but also opens a new direction in the control of light emission.

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Research 88

BioPharma Drive: Drug Pricing

FEBRUARY 22, 2024

The $260 million fund will be used to back startups working on new drugmaking approaches like protein degraders and RNA therapies.

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RNA Therapies 73

Drugs.com

FEBRUARY 22, 2024

THURSDAY, Dec. 22, 2024 -- Falls, frostbite, fractures: They are all potential hazards of icy winter conditions. But experts say there's a lot you can do to avoid injury when snowflakes fall. First, stay warm. According to the New York City.

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