ASPET

APRIL 16, 2024

Organic anions (OA) are compounds including drugs or toxicants that are negatively charged at physiological pH and are typically transported by Organic Anion Transporters (OATs). Human OAT4 (SLC22A11) is expressed in the apical membrane of renal proximal tubules. Although there is no rodent ortholog of hOAT4, rodents express Oat5 (Slc22a19), an anion exchanger that is also localized to the apical membrane of renal proximal tubule cells.

Pharmacogenetics 100

Pharmacogenetics Drugs 100

Science Daily: Pharmacology News

APRIL 16, 2024

For the first time, scientists have managed to create sheets of gold only a single atom layer thick. The material has been termed goldene. According to researchers, this has given the gold new properties that can make it suitable for use in applications such as carbon dioxide conversion, hydrogen production, and production of value-added chemicals.

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Research Production 127

The ChEMBL-og

APRIL 16, 2024

We are delighted to announce the release of ChEMBL 34, which includes a full update to drug and clinical candidate drug data. This version of the database, prepared on 28/03/2024 contains: 2,431,025 compounds (of which 2,409,270 have mol files) 3,106,257 compound records (non-unique compounds) 20,772,701 activities 1,644,390 assays 15,598 targets 89,892 documents Data can be downloaded from the ChEMBL FTP site: [link] Please see ChEMBL_34 release notes for full details of all changes in this rel

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Clinical Trials FDA Cell Based Assays Compound Screening 108

Science Daily: Pharmacology News

APRIL 16, 2024

Astronomers have identified the most massive stellar black hole yet discovered in the Milky Way galaxy. This black hole was spotted in data from the European Space Agency's Gaia mission because it imposes an odd 'wobbling' motion on the companion star orbiting it. Astronomers have verified the mass of the black hole, putting it at an impressive 33 times that of the Sun.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Perficient: Drug Development

APRIL 16, 2024

Health insurers today are facing a rapidly evolving landscape of complex expectations and requirements. Whether it’s responding to government mandates regarding interoperability and data privacy or customer demand for a seamless digital experience, constant evolution is key to staying at the forefront of industry standards. Your future success will be determined by the investments you make now in your capabilities and technology.

Marketing 107

Marketing Government 107

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- In the wake of a sharp rise in the number of young children accidentally eating melatonin supplements, an industry group has called for tougher safety guidelines for packaging and labeling the sleep-aid.

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Packaging 105

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Genetics-based “one-and-done” vaccines for the flu and COVID could prove more effective and easier to craft than current jabs, researchers report.These new vaccines would target viruses using a different response to.

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Vaccine Virus Research 98

Science Daily: Pharmacology News

APRIL 16, 2024

High levels of plastic pollution can kill the embryos of a wide range of ocean animals, new research shows.

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Research 118

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Want to feel happier?Live in or near a place with a rich diversity of nature, a new study says.Environments with plentiful natural features -- trees, birds, plants and rivers -- are associated with better mental.

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Drug Patent Watch

APRIL 16, 2024

The pharmaceutical industry in China is undergoing a significant transformation with the adoption of artificial intelligence (AI) technology.

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Pharmaceuticals Research Science Drugs 94

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- The nose appears to know when it comes to why children typically have milder cases of COVID-19 than seniors, a new study finds.Cells lining the inside of the nose are more likely to have a prompt immune response to COVID.

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Immune Response 98

keypoint

APRIL 16, 2024

On May 14, 2024, Keystone Symposia will host a live ePanel event featuring the recipients of the Michelson Prizes: Next-Generation Grants , an international prize that provides $150,000 in funding to young investigators at a time in their careers when it is most difficult to secure funding for innovative work. These Next-Generation Grants aim to encourage and support early-career researchers who are applying disruptive concepts and inventive processes to advance human immunology, vaccine discove

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Vaccine International Research 81

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Walking is one of the best exercises available to average folks, and it can be as easy as stepping out your front door, experts say.“It is something you can easily fit into your lifestyle,” said Dr.

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Drug Channels

APRIL 16, 2024

Drug Channels Institute’s (DCI’s) latest analysis finds that participants in the specialty pharmacy market continue to get more diverse—although revenues remain highly concentrated. We have identified nearly 1,800 dispensing sites with specialty pharmacy accreditation—about 40% of which are owned by hospitals, physician practices, and other healthcare providers.

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Specialty Pharmacies Pharmacy Marketing Hospitals 71

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Artificial intelligence can serve as a helpful backup editor to radiologists, making sure their reports are accurate and reliable, a new study says.The OpenAI program GPT-4 performed about as well as a group of.

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BioPharma Drive: Drug Pricing

APRIL 16, 2024

Shares of the biotech rose 25% after a large trial found adding its drug Caplyta onto antidepressant therapy significantly helped people with major depression.

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Trials Drugs Therapies 77

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Women who experience common complications during a pregnancy could face heightened odds for early death for decades to come, new research shows.In the largest such study to date, "women who experienced any of five major.

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Research 97

addgene Blog

APRIL 16, 2024

If you take a look in a typical lab freezer, you’ll probably find lots of different plasmids containing the same protein of interest tagged with different fusion proteins for different experiments over the years — a green fluorescent protein, a red fluorescent protein, a fancy new green fluorescent protein, some affinity purification tags, another version with that same red fluorescent protein somebody made because they forgot it was already in the freezer… you get the idea.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Tapping the power of the small brain region called the cerebellum could improve patients’ ability to move cutting-edge robotic limbs, a new study suggests.

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Codon

APRIL 16, 2024

Stage 1: Planning As soon as I’m spun up, a face fills my vision, and I realize that something’s changed. The humans evaluating my performance over the last few weeks had all been young unknowns, mostly Ph.D. students eager for extra cash. This guy is older, and I recognize him from my early training data: he’s a team lead at Magma, the company developing me.

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International Engineering Research Production 68

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Counterfeit or mishandled Botox shots have triggered harmful reactions in 19 people in nine states, U.S. health officials warned Monday.In its alert, the U.S. Centers for Disease Control and Prevention said nine people.

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Disease 85

BioPharma Drive: Drug Pricing

APRIL 16, 2024

The biotech says a dual-pronged antibody it’s developing could become an “off-the-shelf” alternative to cell therapies in development for lupus and other inflammatory conditions.

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Disease Therapies 69

FDA Law Blog: Biosimilars

APRIL 16, 2024

By Sophia R. Gaulkin — On April 10, the Fourth Circuit unanimously affirmed a summary judgment ruling for the Centers for Medicare & Medicaid Services (CMS) regarding the agency’s definitions of “line-extension drug” and “new formulation” for purposes of determining rebates that drug manufacturers may owe the Medicaid Drug Rebate Program (MDRP).

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Drugs Pharmaceuticals Regulations 57

Drug Patent Watch

APRIL 16, 2024

Annual Drug Patent Expirations for RAVICTI Ravicti is a drug marketed by Horizon Therap Us and is included in one NDA. It is available from one supplier.

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Drugs Marketing 59

Fierce BioTech

APRIL 16, 2024

Patient-Centered or Patient-Driven? Exploring New Ways of Patient Collaboration in Modern Healthcare Publishing swheeler Tue, 04/16/2024 - 13:20 Thu, 05/23/2024 - 11:00 Resource Type Webinar Bob Perry Heather Gorse Catherine Richards Golini Paul Lavender Duration 60 minutes This webinar focuses on the growing significance and value of co-creation in healthcare education, particularly in the creation of patient information resources.

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Drug Patent Watch

APRIL 16, 2024

Annual Drug Patent Expirations for ELIGARD+KIT Eligard Kit is a drug marketed by Tolmar and is included in four NDAs. It is available from one supplier.

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Drugs Marketing 59

Perficient: Drug Development

APRIL 16, 2024

Testing applications hosted locally or in private environments presents a unique challenge for testers. Accessing these applications for testing purposes requires setting up a secure connection, commonly known as a tunnel. This detailed guide will explore the concept of test cloud tunnels and provide a step-by-step configuration process to enable test execution in a private domain.

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Compliance 52

Drug Patent Watch

APRIL 16, 2024

Annual Drug Patent Expirations for LODOCO Lodoco is a drug marketed by Agepha Pharma Fz and is included in one NDA. It is available from one supplier.

Drugs 59

Drugs Marketing 59

Perficient: Drug Development

APRIL 16, 2024

Take Over Begins On April 7th, the Perficient LDC Colleagues embarked on a heartfelt mission at St. Joseph’s Diner in Lafayette, Louisiana. With six eager hearts, we took over the kitchen at 613 W. Simcoe St., ready to serve those in need. St. Joseph’s Diner, a beacon of hope in the community, opens its doors daily from 11 am to 1 pm, providing free, freshly prepared, nutritious meals to individuals experiencing homelessness and hunger.

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Hospitals 52

Alta Sciences

APRIL 16, 2024

Inside The Altascientist: The Benefits of PCR for Your Gene Therapy Programs pmjackson Tue, 04/16/2024 - 19:04 The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. The goal is to safely incorporate genetic alterations to restore and repair the proteins of missing and/or faulty genes.

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Therapies DNA RNA Laboratories 52

Drugs.com

APRIL 16, 2024

TUESDAY, April 16, 2024 -- Keeping blood pressure under control could be crucial for women in preventing uterine fibroids, new research shows.Middle-aged women tracked for up to 17 years in a new study were 37% less likely to develop these painful.

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Research 52

Perficient: Drug Development

APRIL 16, 2024

Welcome back to the second installment of our three-part series on Cypress, the premier tool for testing web applications. Having covered the basics in our first article, we now turn our focus to advanced testing techniques that can further enhance your testing strategy. This article aims to explore the depths of Cypress’s capabilities, helping you leverage its full potential for more complex testing scenarios.

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Antidote

APRIL 16, 2024

Effectively recruiting patients for clinical trials is one of the most integral parts of conducting research, and difficulties in the process are often responsible for delays. Not only can delays result in a costly waste of resources, but they can also result in a negative patient experience that can discourage volunteers from continuing the process.

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Clinical Trials Trials Research 52