Drug Hunter
AUGUST 15, 2023
LRRK2 has been a hotly pursued drug target for Parkinson’s Disease based on human genetics. Clinical advancement of LRRK2 inhibitors was initially stalled by concerns about on-target lung findings in primates, but these were ameliorated by a Merck/Genentech/Pfizer/MJFF study showing that these lung changes were reversible, and Biogen/Denali has currently a small molecule (BIIB122/DNL151) in Ph.
Drug Discovery World
AUGUST 15, 2023
Researchers have shown that a group of novel molecules inspired by our own immune system inactivates viruses like Zika and chikungunya, and could help overcome antiviral resistance. “We found an Achilles heel of many viruses: their bubble-like membranes. Exploiting this vulnerability and disrupting the membrane is a promising mechanism of action for developing new antivirals,” said Kent Kirshenbaum, Professor of Chemistry at New York University (NYU) and the study’s senior author.
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BioPharma Drive: Drug Pricing
AUGUST 15, 2023
More than a dozen startups have joined a few publicly traded biotechs and larger pharmaceutical firms in what’s become one of the most competitive areas in drug research.
Drug Discovery World
AUGUST 15, 2023
Recombinant lentiviral vectors are used for ex vivo transgene delivery in several gene-modified cell therapies, such as chimeric antigen receptor (CAR) T cell therapy. Reliable analytical methods such as digital PCR to characterise lentiviral vectors and the cells transduced with them are critical to helping ensure the safety and efficacy of these biologics.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- The famous Pink Floyd lyrics emerge from sound that is muddy, yet musical: “All in all, it was just a brick in the wall.” But this particular recording didn’t come from the 1979 album "The Wall," or from.
Drug Discovery World
AUGUST 15, 2023
A new Whitepaper is available from Thermo Fisher Scientific, entitled ‘Lentiviral vector characterization for cell and gene therapy manufacturing using the QuantStudio Absolute Q Digital PCR System’ Recombinant lentiviral vectors are used for ex vivo transgene delivery in several gene-modified cell therapies, such as chimeric antigen receptor (CAR) T cell therapy.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drug Discovery World
AUGUST 15, 2023
Researchers have shown that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells, paving the way for personalised medicine and targeted drug discovery. The work, by the Francis Crick Institute, UCL Queen Square Institute of Neurology, and technology company Faculty AI, has shown that computer models can accurately classify four subtypes of Parkinson’s disease, with one reaching an accuracy of 95%.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- Millions of Americans are addicted to drugs or alcohol, and millions more struggle with an addicted family member or friend, a new poll finds. Two-thirds of those surveyed said either they or a family member have been.
Drug Channels
AUGUST 15, 2023
Hi, Barbie! The likelihood of major national legislation over the pharmacy benefit management (PBM) industry has never been greater. A serious effort exists to require greater transparency into PBMs’ activities and mandate full pass-through of rebates to plan sponsors. Today, I review some surprising new data on a crucial aspect of the drug channel: how employer-sponsored health plans access the billions of dollars in manufacturer rebates that are negotiated by their PBMs.
Drug Target Review
AUGUST 15, 2023
In a recent peer-reviewed study published in Cell Reports , the team, led by Dr Edward V. Prochownik, delved into the dual role of the Myc gene in both cancer development and ageing. The findings highlight the gene’s complex functions, opening up new avenues for cancer therapy and raising important considerations for future drug development. Myc: a crucial cancer driver with a mysterious side Myc , a gene widely recognised for its pivotal role in driving cancer progression in both mice and
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drug Patent Watch
AUGUST 15, 2023
A recent paper in Expert Opinion on Biological Therapy studies failed fillings for biosimilar drugs. Over the past three decades, biotherapeutics have revolutionized healthcare by providing effective treatments for complex diseases… The post Unsuccessful Regulatory Filings for Biosimilar Approval: A Comprehensive Review appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- What researchers call 'social factors' are largely responsible for Black Americans having a greater risk of death from heart disease than whites, according to a new study. Among the social factors that contribute to this.
Conversations in Drug Development Trends
AUGUST 15, 2023
Selecting the right CRO to partner with on your development program is a pivotal decision that can shape the trajectory of your product’s development. At Worldwide, we understand the significance of this collaboration and are dedicated to becoming an extension of your team, providing personalized clinical development solutions that align with your corporate objectives and milestones.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- Mosquitoes can be a big pest, leaving behind itchy bumps on skin and potentially spreading serious diseases, such as West Nile virus. Sam Telford III is a professor of infectious disease and global health at Cummings School.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Perficient: Drug Development
AUGUST 15, 2023
In part 1 of this two-part blog series on securing your local development with HTTPS and Self-Signed Certificates, I described how to create a local self-signed certificate. In this part, I’ll explain how to use that certificate to safeguard your development environment and make it even more similar to QA & Production. Bind the certificate to HTTPS in IIS When creating a site in IIS, you can bind the site to several protocols: http, https, ftp, etc.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- While vast quantities of peels from the aloe vera plant are thrown out every year as agricultural waste, this natural ingredient has potential to be a powerful insecticide, new research suggests. “It’s likely that.
Codon
AUGUST 15, 2023
Writing is a way to will ideas into the world. A good idea — presented clearly, backed by evidence, and packaged in a story — can help you raise money for a cause, rally people to an idea, or shift the directions of a field. But too many promising ideas are filed away on dusty hard drives, doomed to an eternity of damp, cardboard boxes. And that’s a real shame.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 (American Heart Association News) -- Sure, the end of summer vacation makes many kids groan. But many will also be cheering the return of fall sports. That's a good thing, experts say. Exercise habits form early and pay off.
BioPharma Drive: Drug Pricing
AUGUST 15, 2023
San Diego-based Tentarix will receive $66 million in cash and equity from Gilead, which holds an option to acquire up to three of the company’s subsidiaries.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- People who daily breathe in air pollution, particularly from wildfires or agricultural sources, might need to add a heightened risk of dementia to their list of health concerns. New research looked at the potential effects.
SCIENMAG: Medicine & Health
AUGUST 15, 2023
In a study published in the journal Genes & Diseases, researchers from Naval Medical University and Soochow University conducted an in-depth investigation into the genomic landscape of schistosomiasis-associated colorectal cancer (SA-CRC).
BioPharma Drive: Drug Pricing
AUGUST 15, 2023
The agency had paused testing after a patient death, but is now permitting more types of bridging treatment to help keep participants’ disease at bay.
SCIENMAG: Medicine & Health
AUGUST 15, 2023
BINGHAMTON, N.Y. — Credit: Nature Communications BINGHAMTON, N.Y. — Nanovesicles can be bioengineered to target cancer cells and deliver treatments directly, according to research at Binghamton University, State University of New York.
sptlabtech
AUGUST 15, 2023
Biological samples are invaluable in pharmaceutical research, enabling scientists to gain a better understanding of human health and disease. Correctly handling and storing these precious samples is essential for maintaining sample integrity , ensuring accurate results, and facilitating future research. Doing this efficiently is needed to ensure lab operations run smoothly and productively.
SCIENMAG: Medicine & Health
AUGUST 15, 2023
SAN FRANCISCO, Aug. 15, 2023 — Young vegetables known as microgreens are reputed to be particularly good for health. Now, researchers are trying to find out if microgreens — which can easily be grown at home — are the superfood they’re claimed to be, and how they compare to mature veggies.
Collaborative Drug
AUGUST 15, 2023
Company Named as a Sample Vendor for SaaS Electronic Lab Notebook San Francisco, CA - August 15, 2023 - Collaborative Drug Discovery (CDD) is proud to announce its recent recognition as a Sample Vendor for Software-as-a-Service (SaaS) Electronic Laboratory Notebook (ELN) in the Gartner Hype Cycle for Life Science Discovery Research, 2023 report. Gartner Hype Cycles provide a graphic representation of the maturity and adoption of technologies and applications, and how they are potentially relevan
SCIENMAG: Medicine & Health
AUGUST 15, 2023
The new project creates opportunities for researchers from historically underrepresented groups to develop technology that will help us understand the forces behind an expanding universe. Credit: (Image by Argonne National Laboratory.
NIOSH Science Blog: Drugs
AUGUST 15, 2023
Workers who are exposed to occupational heat stress (i.e., the combination of heat from environment factors, metabolic heat, and clothing/PPE) may be at risk for heat-related illnesses and injuries. Heat-related illnesses may include heat stroke, heat exhaustion, heat cramps, heat rashes, and rhabdomyolysis. Injuries with heat as a factor may also occur, such as falls when someone becomes dizzy or slips on sweat puddles on floors.
SCIENMAG: Medicine & Health
AUGUST 15, 2023
Since the scientists at Bell Labs invented the world’s first transistor in December 1947, a revolution in microelectronics technology has profoundly affected lifestyles worldwide. As electronics get smaller and smaller, it is a challenge to find an easy, fast, and low-cost way to fabricate micro-nano components.
Collaborative Drug
AUGUST 15, 2023
Company Named as a Sample Vendor for SaaS Electronic Lab Notebook San Francisco, CA - August 15, 2023 - Collaborative Drug Discovery (CDD) is proud to announce its recent recognition as a Sample Vendor for Software-as-a-Service (SaaS) Electronic Laboratory Notebook (ELN) in the Gartner Hype Cycle for Life Science Discovery Research, 2023 report. Gartner Hype Cycles provide a graphic representation of the maturity and adoption of technologies and applications, and how they are potentially relevan
SCIENMAG: Medicine & Health
AUGUST 15, 2023
Researchers have announced an important step in the development of a next-gen technology for making X-ray free-electron laser pulses brighter and more stable: They used precisely aligned mirrors made of high-quality synthetic diamond to steer X-ray laser pulses around a rectangular racetrack inside a vacuum chamber.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- As experts begin preparing for another season of viruses, they now know that even healthy infants with no underlying health issues are at risk for severe respiratory syncytial virus (RSV). New research finds that most.
SCIENMAG: Medicine & Health
AUGUST 15, 2023
HOUSTON – (Aug. 15, 2023) – Bioengineers can tailor the genomes of cells to create “cellular therapies” that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch on bioengineered genes without occasionally turning on some of the cell’s naturally occurring genes.
Drugs.com
AUGUST 15, 2023
TUESDAY, Aug. 15, 2023 -- “She’s cheer captain and I’m on the bleachers,” Taylor Swift laments to her popular crush in the song “You Belong With Me.” The lyrics of longing to fit in at school reflect an old trope.
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