National Institute on Drug Abuse: Nora's Blog

AUGUST 28, 2024

Older Black Men Are Disproportionately Affected by the Overdose Crisis mfleming Wed, 08/28/2024 - 16:08 Nora's Blog August 30, 2024 Image ©Getty Images/ xavierarnau Saturday, August 31, is International Overdose Awareness Day , when we collectively remember those who have lost their lives to drug overdose, support those who grieve those losses, and offer encouragement to those who seek recovery from addiction.

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Treatment Research Disease Drugs 117

Science Daily: Pharmacology News

AUGUST 28, 2024

New research explores music's impact on learning, memory, and emotions in two studies. One reveals that familiar music can enhance concentration and learning, while the other demonstrates that music with a strong emotional tone can reshape the quality of existing memories. These findings suggest that music could be used for therapeutic interventions for cognitive function, or in conditions like PTSD and depression.

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Research 124

Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years. This is caused by the high amounts of inflammation and fibrosis (scarring) in the liver, suppressing the liver’s natural ability to regenerate or perform its functi

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Therapies Disease Engineering Medical Schools 115

BioPharma Drive: Drug Pricing

AUGUST 28, 2024

Under a collaboration with NextRNA Therapeutics, Bayer will access the biotech’s platform to target long, non-coding RNA interactions with small molecule drugs.

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RNA Small Molecule Therapies Drugs 117

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Perficient: Drug Development

AUGUST 28, 2024

This post is the first in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Coming Soon: Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion Estimating is a precarious business – part science, a lot of guesswork, and a bit of psychic magic! The goal is to forecast the effort, time, and cost of a project with enough accuracy to avoid disaster.

Science 110

Science Production 110

BioPharma Drive: Drug Pricing

AUGUST 28, 2024

Despite “positive” results, shares of the biotech slid by 20%. Analysts cautioned that Neurocrine shouldn’t get “the benefit of the doubt” with its data.

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Perficient: Drug Development

AUGUST 28, 2024

Perficient continues to make strategic investments to grow our global footprint. This is great for our clients because we span time zones, cultures and capabilities. However, it can present a challenge fostering a cohesive company culture and opportunities for colleagues to connect. That is why Perficient invests in its people by supporting Employee Resource Groups (ERGs), Special Interest Groups (SIGs), and Innovation Groups (IGs).

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Marketing International 104

Science Daily: Pharmacology News

AUGUST 28, 2024

Bacterial cells can 'remember' brief, temporary changes to their bodies and immediate surroundings, a new study has found. And, although these changes are not encoded in the cell's genetics, the cell still passes memories of them to its offspring -- for multiple generations.

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Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- Recreational drug users are three times more likely to have repeated heart health emergencies than people who don’t use, a new study has found.About 11% of patients admitted to intensive cardiac care units have been u.

Drugs 105

Drugs 105

Science Daily: Pharmacology News

AUGUST 28, 2024

When taken at the first signs of a migraine, before headache pain begins, a drug called ubrogepant may be effective in helping people with migraine go about their daily lives with little or no symptoms, according to a new study. The study focused on people with migraine who could tell when an attack was about to happen, due to early symptoms such as sensitivity to light and sound, fatigue, neck pain or stiffness, or dizziness.

Drugs 112

Drugs 112

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- An improved test for Lyme disease could provide accurate results within 20 minutes, researchers report.The test -- which resembles an AI-guided form of the at-home COVID-19 test -- would be a vast improvement over the.

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Disease Research 110

Science Daily: Pharmacology News

AUGUST 28, 2024

The system combines an activated carbon filter with a special, patented catalyst that traps harmful chemicals and breaks them down into harmless components on the filter material.

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Engineering 112

Perficient: Drug Development

AUGUST 28, 2024

Next-level personalization strategies will undoubtedly be a key topic at Salesforce’s largest event this year. Dreamforce is right around the corner taking place in San Francisco on September 17 to 19, and learning how to get the most out of your customer data with AI-powered tools is top of mind. Whether you’re attending in person or virtually, the conference boasts numerous opportunities to hear how some of the world’s largest brands are using data and AI to create personalized journeys and pr

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Marketing 98

Science Daily: Pharmacology News

AUGUST 28, 2024

A new study sheds light on how Viking Age societies in Norway and Denmark differed in their experiences with violence and the role social structures played in shaping those patterns.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- Diabetes can age the brain by up to four years, a new study based on MRI scans shows.There was one silver lining: Healthy lifestyle changes could help prevent that neurological aging, the Swedish researchers said.“Having.

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Research 98

Science Daily: Pharmacology News

AUGUST 28, 2024

A new study reveals that dogs trained with soundboard buttons can indeed comprehend specific words, producing contextually appropriate responses.

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Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- The trees and shrubs in your neighborhood could be giving you a big health boost, a new study finds.People have lower levels of inflammation in neighborhoods where the number of trees and shrubs is more than doubled.

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Science Daily: Pharmacology News

AUGUST 28, 2024

Supermassive black holes typically take billions of years to form. But the James Webb Space Telescope is finding them not that long after the Big Bang -- before they should have had time to form. Astrophysicists have discovered that if dark matter decays, the photons it emits keep the hydrogen gas hot enough for gravity to gather it into giant clouds and eventually condense it into a supermassive black hole.

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Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- The risk of death associated with donating a kidney is at an all-time low, a new study finds.A kidney donor’s risk -- already small a decade ago -- is now lower by more than half, researchers found.Fewer than one death o.

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Research 98

Science Daily: Pharmacology News

AUGUST 28, 2024

Researchers have used vinegar vapor to dramatically improve UV sensors in a cheap, room-temperature process leading to better wearable devices.

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Research 106

Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- Almost half of American parents surveyed say they face "overwhelming" levels of stress on a daily basis, and in an advisory issued on Wednesday U.S. Surgeon General Dr. Vivek Murthy called parental stress an urgent.

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Science Daily: Pharmacology News

AUGUST 28, 2024

A research team developed an innovative method to quantify stress using Integrated Information Theory. This approach comprehensively evaluates biological signals and has demonstrated a strong correlation with subjective stress reports, especially in relation to feelings of boredom. This suggests that the method may serve as a comprehensive measure of stress, encompassing objective and subjective aspects.

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Research 93

Collaborative Drug

AUGUST 28, 2024

Nanome and Collaborative Drug Discovery (CDD) are excited to announce a partnership that streamlines cheminformatic workflows for drug discovery Together, Nanome and Collaborative Drug Discovery (CDD) are committed to enhancing the efficiency and innovation of drug discovery teams by providing an integrated solution for molecular visualization, design, and data analysis.

Drugs 82

Drugs 82

Science Daily: Pharmacology News

AUGUST 28, 2024

An archaeogenetic study sheds new light on the isolated medieval community Las Gobas in northern Spain. Besides isolation and endogamy, the researchers have also identified the variola virus which can offer a new explanation on how smallpox entered Iberia.

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Virus Research 90

Drugs.com

AUGUST 28, 2024

WEDNESDAY, Aug. 28, 2024 -- A new study supports the notion that women age 40 and older get a mammogram each year rather than every two years, to help catch breast cancers early.The rate at which mammograms revealed a tumor in its later stages was.

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Science Daily: Pharmacology News

AUGUST 28, 2024

New research has found limits to how quickly we can scale up technology to store gigatons of carbon dioxide under the Earth's surface.

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Research 96

Chemical Biology and Drug Design

AUGUST 28, 2024

Cover Image © molekuul_be/Shutterstock.

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PPD

AUGUST 28, 2024

For pharmaceutical innovators and drug developers working to bring oncology therapies to market, patients are the “why” behind it all. For many patients, involvement in oncology clinical trials represents a last hope for an effective therapy. This is why oncology trials must be built around patient needs, and sponsors need to balance the complexity of oncology trials with a patient-centric mindset.

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Trials Clinical Trials Drug Development Therapies 64

Drug Patent Watch

AUGUST 28, 2024

The European Union (EU) has implemented a robust regulatory framework to ensure the quality and safety of active pharmaceutical ingredients (APIs) used in medicines. The EU’s Good Manufacturing Practice (GMP) guidelines provide the minimum standards for API manufacturing, and compliance with these guidelines is mandatory for all manufacturers and importers of APIs intended for the EU market.

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Compliance Pharmaceuticals Marketing 59

Broad Institute

AUGUST 28, 2024

Interactive mapping of functional data on structure to explore PPIs in E. coli Mla complex By admin August 28, 2024 Breadcrumb Home Interactive mapping of functional data on structure to explore PPIs in E. coli Mla complex This video demonstrates how to use the Interactive Mapping module in the G2P portal to upload your own protein structures. As a case study, the tutorial explains the use of non-human proteins such as the MlaC crystal structure from the Protein Data Bank and the AlphaFold3-pred

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Common Sense for Drug Policy Blog

AUGUST 28, 2024

Laboratory Evaluation of Nitazene Test Strips "This study presents an independent, laboratory-based assessment of the potential of the first commercially available NTS for drug checking applications. The NTS displayed limited lot-to-lot variability, with an experimental limit of detection for isotonitazene of 2000 or 3000 ng/mL. Twenty-four of the 33 evaluated nitazene analogues cross-reacted with the NTS at concentrations at or below 9000 ng/mL.

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Laboratories Drugs 52

Perficient: Drug Development

AUGUST 28, 2024

JavaScript is a language that has become an essential part of web development, powering everything from simple interactions to complex applications. One of the core concepts that every JavaScript developer eventually encounters is lexical scoping. But what exactly is lexical scoping, and why is it important? Let’s dive into this concept in a way that’s easy to understand, complete with examples, common pitfalls, and some handy debugging tips.

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KIF1A

AUGUST 28, 2024

Hello KIF1A Families, Sloane received her third dose of the ASO on August 1st. We had pre-dose bloodwork, PT evaluation, and research EEG and then post-dose bloodwork, EKG, and research EEG. No substantial motor changes from what we were already seeing with this dose, but we did have one huge milestone this month…Sloane’s first day of school! Right now we are focused on how to maximize what insurance is paying.

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Research Treatment Trials 52

Perficient: Drug Development

AUGUST 28, 2024

In our ongoing exploration of UX in Universal Design, we turn our attention to a critical area of healthcare: supporting individuals with chronic conditions. Chronic conditions, such as diabetes, heart disease, and arthritis, require long-term management and frequent interaction with healthcare systems. Ensuring that these systems are accessible and user-friendly for individuals with chronic conditions is vital for improving their quality of life, health outcomes, and overall patient experience.

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Treatment Disease Drugs 52