Wed.Sep 27, 2023

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The epigenetic edge: Harnessing precision medicine’s potential 

Drug Discovery World

HKG Epitherapeutics is a biotechnology company developing novel tools for the early detection of cancer and promoting healthy aging. Founder Dr Moshe Szyf Founder shares the potential of harnessing precision medicine. Embarking on a new era of medicine The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the genetic makeup of individuals with unprecedented accuracy.

DNA 290
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FDA Adds Warning to Ozempic Label About Risk for Blocked Intestines

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Ozempic, a type 2 diabetes drug that has increasingly been used to help with weight loss, will now be labeled as having the potential to block intestines. The U.S. Food and Drug Administration recently made the label.

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DDW Fall issue out now

Drug Discovery World

The Fall issue of Drug Discovery World (DDW) is out now featuring expertise on what spatial biology tells us about drug discovery and disease. Read the digital version free here. Other features in the Fall issue include: How biomarkers can help discover new treatments for women’s health A market report on the innovation taking place across UK drug discovery Exclusive Neuroscience Guide DDW has published the latest addition to its Guide Series, ‘Unlocking neuroscience drug discovery’.

Marketing 174
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Just 23% of U.S. Adults 'Definitely' Plan to Get New COVID Shot

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Just 23% of American adults say they 'definitely' will get the new COVID-19 vaccine, while another 23% say they will 'probably' get it, according to a new poll, which also finds interest in the shot falls along partisan.

Vaccine 119
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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EC approves Erwinia-derived asparaginase for leukaemia

Drug Discovery World

The European Commission (EC) has granted marketing authorisation for Jazz Pharmaceuticals’ Enrylaze as part of a multi-agent regimen for acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma (LBL). The treatment is approved in adult and paediatric patients who developed hypersensitivity or silent inactivation to E. coli-derived asparaginase.

Treatment 163
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Former Novartis executive Tsai to lead UK heart drug startup

BioPharma Drive: Drug Pricing

John Tsai, previously Novartis’ chief medical officer, has been named CEO of Forcefield Therapeutics, an 18-month-old biotech working on a treatment for heart attacks.

Treatment 113

More Trending

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Fast-Acting Investigational Nasal Spray May Ease Rapid Heartbeat

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Up to 2 million people in the U.S. experience rapid-fire heartbeats from time to time, and many end up in the hospital for treatment. But an investigational nasal spray may help folks with paroxysmal supraventricular.

Hospitals 111
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UK regulator gives green light to combination for multiple myeloma

Drug Discovery World

The National Institute for Health and Care Excellence (NICE) has recommended Darzalex (daratumumab) in combination with lenalidomide and dexamethasone (DLd) for untreated multiple myeloma (MM) for routine use on the NHS in England and Wales. The therapy is now recommended within an NHS setting for the treatment of adults with newly diagnosed MM where an autologous stem cell transplant (ASCT) is unsuitable.

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More Women Using Cannabis to Help Ease Menopause Symptoms

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Women over 50 are turning to weed in droves, and menopause symptoms may be one big reason why, new research suggests These women may not necessarily be getting the results they’re looking for, however. That's according.

Research 111
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ProQR sale of eye drugs comes undone over employment contracts

BioPharma Drive: Drug Pricing

Laboratoires Théa terminated its planned purchase of ProQR’s sepofarsen after certain ProQR personnel opted against working for the French company.

Drugs 117
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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What Is 'Sexsomnia'? And 'Sleep Eating'? Can They Be Treated?

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Everyone’s seen a movie or TV show featuring someone sleepwalking -- eyes half-lidded, bumbling around, tripping over furniture. But sleepwalkers are actually capable of much more complex behaviors during their.

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BrainStorm’s ALS therapy not effective, FDA panel finds

BioPharma Drive: Drug Pricing

Expert advisers to the agency voted 17-1 that Brainstorm's clinical trial data did not show the company's stem cell treatment was effective for treating ALS.

Therapies 113
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Timing of Hot Flashes Could Give Clues to Alzheimer's Risk

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Hot flashes and night sweats top the list of bothersome symptoms for women going through menopause. Now, a new study suggests that hot flashes, especially during sleep, may be more than a nuisance: They may foreshadow.

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Roche bets on Ionis RNA medicines with neuroscience deal

BioPharma Drive: Drug Pricing

The Swiss drugmaker is restocking its pipeline by buying into preclinical Ionis medicines for Alzheimer’s and Huntington’s diseases.

RNA 120
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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In Mice, Gene Therapy Helps Restore Movement After Spinal Cord Injury

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Gene therapy has restored mobility in mice with completely severed spinal cords, researchers report. The mice regained the ability to walk, with gait patterns resembling those of mice that resumed walking naturally after.

Therapies 105
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BrainStorm’s ALS therapy not effective, FDA panel finds

BioPharma Drive: Drug Pricing

Expert advisers to the agency voted 17-1 that Brainstorm's clinical trial data did not show the company's stem cell treatment was effective for treating ALS.

Therapies 109
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Five days in Vermont

Molecular Design

A couple of months ago I enjoyed a visit to the US (my first for eight years) on which I caught up with old friends before and after six days spent in Vermont (where a trip to the golf course can rapidly become a National Geographic Moment). One highlight of the trip was randomly meeting my friend and fellow blogger Ash Jogalekar for the first time in real life (we’ve actually known each other for about fifteen years) on the Boston T Red Line.

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Safety Culture in Healthcare Settings

NIOSH Science Blog: Drugs

As of 2019, more than 18 million people, 11.5 % of the United States workforce, were employed in healthcare settings. Everyday healthcare workers face hazardous work conditions due to exposures to infectious agents and hazardous drugs and chemicals.

Drugs 97
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Down goes antimatter! Gravity's effect on matter's elusive twin is revealed

Science Daily: Pharmacology News

For the first time, in a unique laboratory experiment at CERN, researchers have observed individual atoms of antihydrogen fall under the effects of gravity. In confirming antimatter and regular matter are gravitationally attracted, the finding rules out gravitational repulsion as the reason why antimatter is largely missing from the observable universe.

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Stem Cell Treatment Halts MS for Some Patients

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- A new study is strengthening the evidence that stem cell transplants can be highly effective for some people with multiple sclerosis -- sending the disease into remission for years, and sometimes reversing.

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Strength is in this glass's DNA

Science Daily: Pharmacology News

Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.

DNA 91
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Increasing R&D productivity: “Bullseye, Aim, Fire!”

Plenge Gen

At the beginning of the summer, I had the opportunity to join the team at Royalty Pharma for a great event at MIT (link here ). It was an interesting time for me as I was thinking about the new role I was about to take at Bristol Myers Squibb. While I had certainly been “a leader” for several years now, I was pushing myself to think through and question my perspectives on R&D now that I was taking on increasing responsibilities as “the leader” of the research organization.

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Desalination system could produce freshwater that is cheaper than tap water

Science Daily: Pharmacology News

Researchers have designed a new solar desalination system that takes in saltwater and heats it with natural sunlight. The system flushes out accumulated salt, so replacement parts aren't needed often, meaning the system could potentially produce drinking water at a rate and price that is cheaper than tap water.

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Black Patients More Likely to Be Physically Restrained During ER Visits

Drugs.com

WEDNESDAY, Sept. 27, 2023 – It seemed to some that patients of color were being restrained in the emergency room more often than others, so researchers decided to investigate.

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Whales Around the World Play With Kelp Clumps

Science Daily: Pharmacology News

A new article has analyzed another understudied behavior in baleen (filter-feeding) whales such as humpback whales in different populations across the northern and southern hemispheres. They appeared to roll around and 'play' with clumps of kelp and seaweed at the water's surface. The research also emphasizes that the behavior was similar in different individuals, regardless of where in the world it occurred.

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Emotional Issues Could Be Early Sign of MS

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- A newer understanding of multiple sclerosis (MS) suggests that psychiatric conditions like anxiety and depression may emerge long before classic MS symptoms. “For a long time, it was thought that MS only really began.

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Drug Channels News Roundup, September 2023: PBM Profits, Specialty Rx Markups, CVS Spending Trends, Pharmacy Pricing Secrets, and Deductibles 101

Drug Channels

Autumn is here! Curl up with your favorite pumpkin-spiced blog and savor these stories harvested from the great Drug Channels patch: A must-read report on hidden sources of PBMs’ profits How generic drugs drive specialty pharmacy profits CVS Health’s unadvertised 2022 drug trend report A shocking look at how PBMs set prescription prices Plus, Dr. Glaucomflecken teaches us about our insurance benefits.

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Inside Bavarian Nordic’s late-stage stumbles — and drive to become a vaccine giant

BioPharma Drive: Drug Pricing

Despite the company's recent Phase 3 setbacks in RSV and COVID, CEO Paul Chaplin sees a path forward for the Dutch biotech in the travel vaccine market.

Vaccine 67
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New proof for black hole spin

Science Daily: Pharmacology News

The supermassive black hole at the heart of galaxy M87, made famous by the first picture of a black hole shadow, has yielded another first: the jet shooting out from the black hole has been confirmed to wobble, providing direct proof that the black hole is spinning.

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New patent for Pfizer drug NURTEC ODT

Drug Patent Watch

Annual Drug Patent Expirations for NURTEC+ODT Nurtec Odt is a drug marketed by Pfizer and is included in one NDA. It is available from one supplier. There are three patents… The post New patent for Pfizer drug NURTEC ODT appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59
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Separating molecules requires lots of energy. This new, heat-resistant membrane could change that

Science Daily: Pharmacology News

A research team has created a new, heat-resistant membrane that can withstand harsh environments -- high temperatures, high pressure and complex chemical solvents -- associated with industrial separation processes. It could eventually be used as a less energy intensive alternative to distillation and other industrial processes that separate molecules that ultimately serve as ingredients in medicine, chemicals and other products.

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Drug Patent Expirations for the Week of September 24, 2023

Drug Patent Watch

NUZYRA (omadacycline tosylate) Paratek pharms inc Patent: 7,326,696 Expiration: Sep 24, 2023 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact… The post Drug Patent Expirations for the Week of September 24, 2023 appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59
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Origin of cultural learning: Babies imitate because they are imitated

Science Daily: Pharmacology News

A new study shows that babies learn to imitate others because they themselves are imitated by caregivers.

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Art & Graphic Design in the Broad Discovery Center

Broad Institute

Art & Graphic Design in the Broad Discovery Center By Rose Circeo September 27, 2023 Breadcrumb Home Art & Graphic Design in the Broad Discovery Center Meet some of the artists behind the art, illustration, and graphic design in the Broad Discovery Center. Museum staff offer a behind-the-scenes look at some of visitors' favorite aspects of the museum, while sharing what happens when art and science collide.

Science 52