Drug Discovery World
JANUARY 11, 2024
Verge Genomics has initiated a Phase Ib proof-of-concept study for the treatment of sporadic and familial forms of amyotrophic lateral sclerosis (ALS) with VRG50635. VRG50635 is a small molecule PIKfyve inhibitor and is reportedly one of the first drugs to enter clinical trials that was entirely discovered and developed using an AI-enabled platform.
Forbes: Drug Truths
JANUARY 11, 2024
The FDA had been previously reluctant to approve such a plan for safety concerns.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Drug Discovery World
JANUARY 11, 2024
This is the latest episode of the free DDW narrated podcast, titled “Revolutionary technology for drug discovery and development” which covers three written for Volume 23 – Issue 4, Fall 2022 of DDW. They are called: mRNA technology may hold the future for a cytomegalovirus vaccine ; Predictive diagnostics: closing the precision medicine gap ; and FAIR Game: making data work harder in the race to market.
Science Daily: Pharmacology News
JANUARY 11, 2024
Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Scientists have now uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.
Advertisement
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JANUARY 11, 2024
Researchers have used messenger RNA (mRNA) to create an effective therapy for a rare liver disease in preclinical studies, demonstrating the technology’s potential therapeutic use in people. The team, led by University College London (UCL), King’s College London and Moderna scientists, found that mRNA could be used to correct a rare genetic liver disease known as argininosuccinic aciduria in a mouse model.
addgene Blog
JANUARY 11, 2024
Addgene is announcing we have chosen to stop all activity on X, formerly Twitter. If you are interested in engaging with us on social media, you can find us on Bluesky: @addgene.bsky.social; or @addgene on Instagram, TikTok, Facebook, and LinkedIn. We are also exploring other social media platforms with active scientific communities and welcome suggestions in the comments.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- U.S. doctors are prescribing antifungal creams to patients with skin complaints at rates so high they could be contributing to the rise of drug-resistant infections, new research shows.These are "severe.
Drug Discovery World
JANUARY 11, 2024
SandboxAQ has acquired Good Chemistry, a computational chemistry company that leverages AI, quantum and other advanced technologies to accelerate drug discovery. Good Chemistry, which spun out of 1Qbit in 2021, is SandboxAQ’s second acquisition and its first in the AI simulation sector. “Good Chemistry’s software and existing partnerships will enable us to rapidly accelerate how we bring the benefits of advanced simulation and AI tools to more customers,” said Dr Nadia Ca
Science Daily: Pharmacology News
JANUARY 11, 2024
Scientists have developed a way to convert carbon dioxide (CO2), a potent greenhouse gas, into carbon nanofibers, materials with a wide range of unique properties and many potential long-term uses. Their strategy uses tandem electrochemical and thermochemical reactions run at relatively low temperatures and ambient pressure and could successfully lock carbon away to offset or even achieve negative carbon emissions.
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- Amid an ongoing shortage of the first-line treatment for syphilis in the United States, the U.S. Food and Drug Administration will allow the importation of a different syphilis drug from a French drugmaker. In a.
Advertisement
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
JANUARY 11, 2024
Record heat across the world profoundly impacted the global water cycle in 2023, contributing to severe storms, floods, megadroughts and bushfires, new research shows.
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- Amid an ongoing shortage of the first-line treatment for syphilis in the United States, the U.S. Food and Drug Administration will allow the importation of a different syphilis drug from a French drugmaker.In a.
Science Daily: Pharmacology News
JANUARY 11, 2024
Researchers have developed a neural implant that provides information about activity deep inside the brain while sitting on its surface. The implant is made up of a thin, transparent and flexible polymer strip that is packed with a dense array of graphene electrodes. The technology, tested in transgenic mice, brings the researchers a step closer to building a minimally invasive brain-computer interface (BCI) that provides high-resolution data about deep neural activity by using recordings from t
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- Black Americans have strokes nearly a decade younger on average than white people, a new study has found.The study also revealed that Black people consistently had a higher rate of stroke than white folks over a 22-year.
Advertisement
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
JANUARY 11, 2024
Credit: City of Hope Journal Cell Method of Research Experimental study Subject of Research Cells Article Title Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death Article Publication Date 10-Jan-2024
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- DNA locked in the bones and teeth of more than 5,000 humans who lived in Asia and Europe up to 34,000 years ago are providing vital clues to a myriad of present-day medical conditions.The descendants of these ancient.
SCIENMAG: Medicine & Health
JANUARY 11, 2024
Reston, VA (January 11, 2024)—A newly developed PET imaging agent has been found to be effective in identifying medullary thyroid cancer (MTC) in preclinical and clinical studies, according to research published in the January issue of The Journal of Nuclear Medicine.
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- Pain can present itself in many forms for people battling multiple sclerosis, and one type can interfere with exercising, new research shows.One class of pain experienced by MS patients is what the authors of the new.
BioPharma Drive: Drug Pricing
JANUARY 11, 2024
Investors and executives interviewed by BioPharma Dive at J.P. Morgan say new companies have to be leaner, hire more conservatively and focus on their first medicines quickly.
Drugs.com
JANUARY 11, 2024
THURSDAY, Jan. 11, 2024 -- A biorobotic heart that combines a biological pig heart with a silicone robotic pump is providing researchers with a new tool to understand and potentially treat heart disease.Scientists built the heart by replacing the.
SCIENMAG: Medicine & Health
JANUARY 11, 2024
The effects of aging and external factors like UV exposure on skin are well documented. As people age or spend more time in the sun, their skin tends to become drier and more wrinkled, Credit: University of California San Diego The effects of aging and external factors like UV exposure on skin are well documented.
Science Daily: Pharmacology News
JANUARY 11, 2024
Researchers have identified a 3D fragment of fossilized skin that is at least 21 million years than previously described skin fossils. The skin, which belonged to an early species of Paleozoic reptile, has a pebbled surface and most closely resembles crocodile skin. It's the oldest example of preserved epidermis, the outermost layer of skin in terrestrial reptiles, birds, and mammals, which was an important evolutionary adaptation in the transition to life on land.
SCIENMAG: Medicine & Health
JANUARY 11, 2024
The dissolution of the Soviet Union in 1991 marked the start of a period ripe with political, economic, and societal changes. In many former Soviet countries, these abrupt and turbulent transformations posed massive challenges to healthcare systems.
Science Daily: Pharmacology News
JANUARY 11, 2024
Recent findings have identified a potential new link to signs of skin aging -- the skin microbiome, the collection of microorganisms that inhabits our skin.
Covalent Modifiers
JANUARY 11, 2024
Aaron B. Keeley, Aleksandra Kopranovic, Vincenzo Di Lorenzo, Péter Ábrányi-Balogh, Niklas Jänsch, Linh N. Lai, László Petri, Zoltán Orgován, Daniel Pölöske, Anna Orlova, András György Németh, Charlotte Desczyk, Tímea Imre, Dávid Bajusz, Richard Moriggl, Franz-Josef Meyer-Almes, and György M. Keserü Journal of Medicinal Chemistry 2024 67 (1), 572-585 [link] Screening of ultra-low-molecular weight ligands (MiniFrags) successfully identified viable chemical starting points for a variety of drug tar
Science Daily: Pharmacology News
JANUARY 11, 2024
Astronomers have made the rare discovery of a small, cold exoplanet and its massive outer companion -- shedding light on the formation of planets like Earth.
The ChEMBL-og
JANUARY 11, 2024
(Generated with DALL-E 3 ∙ 11 Janvier 2024 at 11:50 am) Happy New Year everyone! You already know that we have been working extensively in the last few years to offer a new version of SureChEMBL that can deliver a better user experience. If you did not have the opportunity yet, you can still test the new UI and underlying system. Obviously it is still a beta version but new improvements are deployed weekly and 2024 should be exciting.
Science Daily: Pharmacology News
JANUARY 11, 2024
A team of astronomers has created the first-ever map of magnetic field structures within a spiral arm of our Milky Way galaxy. Previous studies on galactic magnetic fields only gave a very general picture, but the new study reveals that magnetic fields in the spiral arms of our galaxy break away from this general picture significantly and are tilted away from the galactic average by a high degree.
Covalent Modifiers
JANUARY 11, 2024
Eric W. J. Gates, Adrien Prince-Hallée, Yasaman Heidari, Abootaleb Sedighi, and Jeffrey W. Keillor Biochemistry 2023 62 (21), 3085-3095 DOI: 10.1021/acs.biochem.3c00337 Transglutaminases (TGases) are a family of calcium-dependent enzymes primarily known for their ability to cross-link proteins. Transglutaminase 2 (TG2) is one isozyme in this family whose role is multifaceted.
Science Daily: Pharmacology News
JANUARY 11, 2024
Hummingbirds use two distinct sensory strategies to control their flight, depending on whether they're hovering or in forward motion, according to new research.
BioPharma Drive: Drug Pricing
JANUARY 11, 2024
Though the number of financings from private investors is down year over year, the size of those rounds has remained high, especially for drugmakers with human data in hand.
Science Daily: Pharmacology News
JANUARY 11, 2024
ChatGPT and other solutions built on Machine Learning are surging. But even the most successful algorithms have limitations. Researchers have now proven mathematically that apart from simple problems it is not possible to create algorithms for AI that will always be stable. The study may lead to guidelines on how to better test algorithms and reminds us that machines do not have human intelligence after all.
Drug Patent Watch
JANUARY 11, 2024
Annual Drug Patent Expirations for WELIREG Welireg is a drug marketed by Merck Sharp Dohme and is included in one NDA. It is available from one supplier. There are two… The post New patent for Merck Sharp drug WELIREG appeared first on DrugPatentWatch - Make Better Decisions.
FDA Law Blog: Biosimilars
JANUARY 11, 2024
Two Hyman, Phelps & McNamara, P.C. (HPM) Directors, Karla Palmer and Dara Levy , will present at the Puerto Rico Pharmaceutical Summit 2024, February 6, 2024, at the La Concha Renaissance San Juan Resort in San Juan, Puerto Rico. This day-long (FREE) seminar is a must-attend event for anyone in the pharmaceutical sector interested in understanding the “ins and outs” of doing business in the Territory, as well as an opportunity to interact with those who already have a keen understanding of
Expert insights. Personalized for you.
246 
Let's personalize your content