Mon.Jul 29, 2024

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Virus that causes COVID-19 is widespread in wildlife, scientists find

Science Daily: Pharmacology News

SARS-CoV-2, the virus responsible for COVID-19, is widespread among wildlife species, according to new research. The virus was detected in six common backyard species, and antibodies indicating prior exposure to the virus were found in five species, with rates of exposure ranging from 40 to 60 percent depending on the species.

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FDA Approves Another Blood Test for Colon Cancer Screening

Drugs.com

MONDAY, July 29, 2024 -- The U.S. Food and Drug Administration on Monday approved a new blood test that can spot colon cancer.In late May, an FDA advisory panel had voted 7-2 that the benefits outweigh the risks when using the Guardant Health's.

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NASA data shows July 22, 2024 was Earth's hottest day on record

Science Daily: Pharmacology News

July 22, 2024, was the hottest day on record, according to a NASA analysis of global daily temperature data. July 21 and 23 of this year also exceeded the previous daily record, set in July 2023. These record-breaking temperatures are part of a long-term warming trend driven by human activities, primarily the emission of greenhouse gases.

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U.S. Measles Cases Are Already Triple Those of Last Year

Drugs.com

MONDAY, July 25, 2024 -- With five months still to go, the number of U.S. measles cases reported so far this year already triple that of all the cases seen in the country last year, federal health officials report.A total of 188 cases have been.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Winter breeding offers lifeline for monarch butterflies in Northern California

Science Daily: Pharmacology News

Monarch butterflies in Northern California are adapting to a changing climate by embracing an unexpected strategy: breeding in the winter. The shift could be key to the survival of the iconic insect, according to a new study.

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Blood Test 91% Accurate at Predicting Alzheimer's, Outperforming Doctors

Drugs.com

MONDAY, July 29, 2024 -- A new test gauging levels of key proteins in the blood was far more accurate than doctor assessments in spotting Alzheimer's disease in people with early-stage illness.The test, called APS2 (the amyloid probability score.

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Superhero Evan

KIF1A

“He really keeps us on our toes but he always has a smile on his face no matter the challenges he’s faced with.” A message from Evan’s family: Evan was diagnosed with KIF1A in May this year after a lot of tests, he’s been so brave and been put through it. It was scary at first as life would look alot different to how we thought it would but we are lucky as Evan is so happy, cheeky and energetic.

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A Guide to CDISC SDTM Standards and Domains

Quanticate

The Clinical Data Interchange Standards Consortium (CDISC) creates standards that are now mandatory for a regulatory submission to the FDA and PMDA. Study Data Tabulation Model (SDTM) is one of the standards which provides a standard for streamlined data in collection, management, analysis and reporting. If your data is not using SDTM standards then a you will have to perform SDTM mapping to the latest version of SDTM standards as you prepare for your regulatory submission.

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Applying Artificial Intelligence to Transform the Patient Enrollment Paradigm in Clinical Research

PPD

Artificial Intelligence (AI) imitates human cognitive functions using computer science, algorithms, machine learning and data sciences. Simply put, AI refers to systems having the capability to perceive their surroundings, make logical deductions, interact with humans and acquire knowledge. These systems can be utilized for tasks resembling human abilities, such as recognizing images, understanding spoken words, planning and organizing.

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Avoiding One Nutrient Can Keep Your Cells Young

Drugs.com

MONDAY, July 29, 2024 -- Added sugar can cause your cells to prematurely age, a new study warns.Each gram of added sugar is associated with an increase in a person’s cellular age, even when they eat healthy otherwise, researchers found.On the other.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Scientists untangle interactions between the Earth's early life forms and the environment over 500 million years

Science Daily: Pharmacology News

The atmosphere, the ocean and life on Earth interacted over the past 500-plus million years in ways that improved conditions for early organisms to thrive. Now, an interdisciplinary team of scientists has produced a perspective article of this co-evolutionary history.

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Women Often Misled by Claims About Common Fertility Test

Drugs.com

MONDAY, July 29, 2024 -- Women are often being sold a fertility test that paints a misleading picture of their ability to conceive a child, a new study warns.The anti-Mullerian hormone (AMH) test uses a blood sample to estimate the number of eggs.

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Safe 3D Printing is for Everyone, Everywhere

NIOSH Science Blog: Drugs

Three-dimensional (3D) printing has become more popular in recent years. These printers can create objects by building them layer by layer from a digital design. 3D printing is an important part of modern inno­vation because it speeds up the design and testing of new ideas. It can also help produce complex and precise parts. The National Institute for Occupational Safety and Health (NIOSH) is working to minimize the potential health and safety risks from using 3D printers.

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A Little Drinking Won't Help You Live Longer, New Research Shows

Drugs.com

MONDAY, July 29, 2024 -- A new review challenges the long-held belief that moderate drinking can have health benefits. The analysis, conducted by a team of researchers in Canada, points out flaws in several studies that seemed to support moderate.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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GSK leans on Flagship for help finding new drugs, vaccines

BioPharma Drive: Drug Pricing

The deal resembles recent Flagship alliances with Pfizer and Novo Nordisk, allowing the British pharma to comb through the company creator’s portfolio to unearth up to 10 therapies.

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Surgery Overused for 'Tongue Tie' Issue That Stops Babies From Breastfeeding, Experts Say

Drugs.com

MONDAY, July 29, 2024 -- Surgery is being overused to correct breastfeeding difficulties in infants, a new report says.A growing number of newborns are being diagnosed with ankyloglossia, also called “tongue-tie.”Tongue-tie restricts the tongue’s ra.

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Enforcing Your Drug Patent: Innovative Strategies

Drug Patent Watch

In the fiercely competitive pharmaceutical industry, securing and enforcing patents is crucial for recouping the massive investments required to bring […] Source

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Mom's Type 1 Diabetes Might Shield Her Children From the Disease

Drugs.com

MONDAY, July 29, 2024 -- Having a mom with type 1 diabetes might provide long-term protection against the condition in children, a new review finds.This protective effect is suggested by that fact that a child is almost twice as likely to develop.

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Cover Image

Chemical Biology and Drug Design

Cover Image © molekuul_be/Shutterstock.

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COVID-19 Virus Is Widespread in U.S. Wildlife

Drugs.com

MONDAY, July 29, 2024 -- The virus responsible for COVID-19 is widespread among wildlife, a new study finds.SARS-CoV-2 was detected in six common backyard species, including deer mice, opossums, raccoons, groundhogs, cottontail rabbits and red.

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Draft Guidance on Biosimilars and Interchangeables Tries to Smooth Path for Post-Approval Changes

FDA Law Blog: Biosimilars

By John W.M. Claud — There is a growing consensus among legal experts that after Loper Bright, FDA may rely on non-binding guidance to instruct industry with hopes of charting regulatory pathways that avoid litigation. In areas like biologics, biosimilars, and interchangeable biosimilars, where emerging technologies meet regulatory complexities, this is perhaps a wise strategy.

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Grief Can Truly Age People, Study Finds

Drugs.com

MONDAY, July 29, 2024 -- Losing someone close to you can make you age faster, a new study finds.People who lost a parent, partner, sibling or child showed signs of older biological age compared with those who hadn’t experienced such a loss, r.

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Ventyx’s TYK2 drug suffers second setback

BioPharma Drive: Drug Pricing

The company claimed “higher than anticipated” scores from trial volunteers on placebo led to the disappointing data, prompting it to halt internal trials.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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How a Mubadala partner views investing in biotech’s new normal

BioPharma Drive: Drug Pricing

Ayman AlAbdallah spoke with PharmaVoice about some of the inroads the sector has made towards a recovery and the traits he looks for in a startup.

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New patent expiration for Helsinn Hlthcare drug ALOXI

Drug Patent Watch

Annual Drug Patent Expirations for ALOXI Aloxi is a drug marketed by Helsinn Hlthcare and is included in two NDAs. It is available from one supplier. There are thirteen patents protecting this drug.

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Boehringer adds to cancer drug pipeline with deal for startup Nerio

BioPharma Drive: Drug Pricing

The pharma company will pay up to $1.3 billion to acquire San Diego-based Nerio and its research into novel immune checkpoint inhibitors.

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New patent for IPSEN drug SOHONOS

Drug Patent Watch

Annual Drug Patent Expirations for SOHONOS Sohonos is a drug marketed by Ipsen and is included in one NDA. It is available from one supplier. There are five patents protecting this drug.

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NewAmsterdam heart drug hits trial goal, but data disappoint investors

BioPharma Drive: Drug Pricing

The study is the latest test of a class of cholesterol medicines known as CETP inhibitors, which were abandoned by several large drugmakers last decade.

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New patent for TEVA drug AUSTEDO XR

Drug Patent Watch

Annual Drug Patent Expirations for AUSTEDO+XR Austedo Xr is a drug marketed by Teva and is included in one NDA. It is available from one supplier. There are ten patents protecting this drug.

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Who are ELRIG’s Red Shirts Volunteers?

Elrig

Who are ELRIG's Red Shirt Volunteers? Alex Powell shares his insights. Curious about our Red Shirt Volunteers? Meet Alex Powell, a neuroscience master’s student from the University of Exeter and one of our Red Shirt Volunteers. He’s sharing his experiences as a Red Shirt Volunteer at Research & Innovation 2024 & AI in Drug Discovery Forum with us.

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Will Olympians Soon Be Swimming in the Seine? Paris Officials Track Water Quality

Drugs.com

MONDAY, July 29, 2024 -- Paris officials said Sunday they are confident the Seine will be clean enough for Olympic triathletes to swim in the storied river this week, despite the fact that officials had to cancel a practice run Sunday over worries.

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Understanding Encryption Algorithms: AES, DES, and Blowfish

Perficient: Drug Development

In our previous blog, we discussed how to encrypt and decrypt passwords in Java using the AES algorithm. In this follow-up post, we’ll delve deeper into various encryption algorithms, specifically AES, DES, and Blowfish. We’ll explain each algorithm in detail and provide code examples for their implementation. Types of Encryption Algorithms AES (Advanced Encryption Standard) AES is a symmetric encryption algorithm widely used across the globe.

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Digital Transformation in Life Sciences: The Importance of Data Strategy

thought leadership

What is Digital Transformation? While there are many different definitions of digital transformation in life sciences, the core concepts they all have in common are digital technology and creating new, or modifying existing, ways of working. The underlying business driver is that digital transformation can help organizations evolve and stay competitive in the race to create value for customers/stakeholders.

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