Drug Discovery World
JANUARY 3, 2024
Swedish company IRLAB Therapeutics has been awarded funding of over $2 million from The Michael J Fox Foundation for Parkinson’s Research (MJFF). The grant will be used to conduct a Phase I clinical study of IRL757, a drug candidate in development as a novel treatment of apathy. The grant was awarded under MJFF’s program ‘Parkinson’s Disease Therapeutics Pipeline Program.
Science Daily: Pharmacology News
JANUARY 3, 2024
Fossils of a new group of animal predators have been located in the Early Cambrian Sirius Passet fossil locality in North Greenland. These large worms may be some of the earliest carnivorous animals to have colonized the water column more than 518 million years ago, revealing a past dynasty of predators that scientists didn't know existed.
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Drug Discovery World
JANUARY 3, 2024
The SLAS Ignite Theater ‘ Innovation & technology: from lab to patient ’ will take place at SLAS2024 in Boston on 5 and 6 February 2024. The event will be curated by DDW and sponsored by Integra Biosciences and Hamamatsu Corporation, providing leading research from experts in academia, government agencies and industry. On Monday 5 February at 3pm , Andrea Bortolato, Director of Drug Discovery at SandboxAQ, will share his insights on the topic ‘Combining physics-based methods with AI to maxim
Science Daily: Pharmacology News
JANUARY 3, 2024
Mount Sinai researchers have shown for the first time that a person's beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JANUARY 3, 2024
The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has approved Bristol Myers Squibb’s advanced melanoma drug Opdualag (nivolumab-relatlimab) for patients from the age of 12. Opdualag was authorised through Project Orbis, a global partnership between the MHRA, the Therapeutics Goods Administration in Australia, Health Canada, the Health Sciences Authority in Singapore, Swissmedic, Agência Nacional de Vigilância Sanitária in Brazil and Israel’s Ministry of Health, coordinated by
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- A diet laden with omega-3 fatty acids found in nuts and oily fish might help slow the progression of pulmonary fibrosis, researchers report.Pulmonary fibrosis is a relentless, potentially fatal disease where lung tissue.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- You may think that artificial sweeteners can help you lose some weight, but a new study finds they are no good for your gut’s microbiome.
NIOSH Science Blog: Drugs
JANUARY 3, 2024
NIOSH has been at the forefront of research on engineered nanomaterials since the early 2000’s. As the NIOSH Nanotechnology Research Center (NTRC) celebrates its 20th anniversary, we look back over two decades of NIOSH NTRC published guidance to help reduce worker exposures to engineered nanomaterials (ENMs). Both companies and workers use this guidance to keep workers safer.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- Golden news for a new year: Scientists now know why urine is yellow. It's only taken 100 years, but researchers say they've pinpointed the enzyme in urine behind its buttery hue.“This enzyme discovery finally unravels.
SCIENMAG: Medicine & Health
JANUARY 3, 2024
A UC Riverside study to motivate your new year’s resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- There are so many New Year’s resolutions from which to choose, but an important one could be to schedule a memory screening, experts say.Memory screenings consist of a series of questions that gauge memory and brain.
SCIENMAG: Medicine & Health
JANUARY 3, 2024
An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- The average cost of hospital care for COVID-19 patients skyrocketed during the pandemic, outstripping what might be expected under inflation, a new study shows.Average hospital costs for COVID patients increased five.
NIOSH Science Blog: Drugs
JANUARY 3, 2024
Among U.S. workers, driving a motor vehicle or being exposed to traffic hazards as a pedestrian while at work is a significant risk. In fact, motor vehicle crashes (MVCs) are the leading cause death at work in the United States [1]. Many factors can play a role in work-related MVCs, but have you considered how these factors may have different impacts on workers, depending on their social or demographic characteristics?
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- A regularly prescribed class of heart medications might be capable of treating one of the most common forms of muscular dystrophy, a new study in mice suggests.Myotonic dystrophy type 1 (DM1) is caused by abnormal RNA.
SCIENMAG: Medicine & Health
JANUARY 3, 2024
CLEVELAND, Ohio – Jonathan Stamler, MD, has been named a Fellow of the National Academy of Inventors (NAI). Dr. Stamler is the co-founder and president of Harrington Discovery Institute at University Hospitals (UH), and the Robert S. and Sylvia K.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- Some people might be prone to low back pain because of specific cells contained in their spinal disks, a new study suggests.The research could explain why only certain people develop back pain due to the degeneration of.
Science Daily: Pharmacology News
JANUARY 3, 2024
A new study shows that adults with hearing loss who regularly used hearing aids had a 24% lower risk of mortality than those who never wore them.
SCIENMAG: Medicine & Health
JANUARY 3, 2024
A team of Virginia Tech researchers was awarded nearly $2 million from the National Institute of Diabetes and Digestive and Kidney Disease, part of the National Institutes of Health, to explore novel approaches for treating Type 2 diabetes and obesity. Credit: Photo courtesy of Dongmin Liu.
Covalent Modifiers
JANUARY 3, 2024
Mathilde Goullieux, Vincent Zoete, and Ute F. Röhrig Journal of Chemical Information and Modeling 2023 63 (24), 7847-7859 DOI: 10.1021/acs.jcim.3c01055 Due to their various advantages, interest in the development of covalent drugs has been renewed in the past few years. It is therefore important to accurately describe and predict their interactions with biological targets by computer-aided drug design tools such as docking algorithms.
SCIENMAG: Medicine & Health
JANUARY 3, 2024
DETROIT (January 3, 2024) – Findings from a published case series research letter by the Henry Ford Health Structural Heart Disease team show that severe mitral stenosis, due to a build-up of calcium deposits in the mitral valve common in elderly patients, can be safely and successfully treated using Intravascular lithotripsy (IVL)-enabled percutaneous balloon mitral […]
BioPharma Drive: Drug Pricing
JANUARY 3, 2024
The $650 million fund exceeded Goldman’s target and comes amid cautious optimism that biotech could rebound from a lengthy downturn.
SCIENMAG: Medicine & Health
JANUARY 3, 2024
LOS ANGELES — Hearing loss affects approximately 40 million American adults, yet only one in 10 people who need hearing aids use them, research shows. Credit: Ricardo Carrasco III LOS ANGELES — Hearing loss affects approximately 40 million American adults, yet only one in 10 people who need hearing aids use them, research shows.
BioPharma Drive: Drug Pricing
JANUARY 3, 2024
The hemophilia B therapy, which Pfizer will sell in Canada as Beqvez, is also under review in the U.S., where the FDA expects to make a decision by the second quarter.
Cytel
JANUARY 3, 2024
Ten years ago this month, in January 2014, the FDA issued the first version of its Technical Conformance Guide (by chance I also found comments provided by my friend Jozef Aerts already complaining about the use of SAS XPORT). 1 The following December, a second version was released after public comments and, on December 16, 2014, the FDA stopped the clock, providing sponsors with a pivotal two-year window to adapt their methods of creating clinical dataset packages to comply with the FDA’s new r
Perficient: Drug Development
JANUARY 3, 2024
One of my favorite memories as a kid was going to the car dealership with my dad and watching him beat up (figuratively, of course) the sales associate who was trying to sell him a new truck. The sales associate wanted one price; my father wanted a very different price. Round and round they went, spending hours and oxygen as they both attempted to get to a place where they felt good about the deal.
Drug Target Review
JANUARY 3, 2024
Researchers from the Baylor College of Medicine have discovered that antibodies produced by llamas, called nanobodies, could be developed as a therapeutic agent to neutralise human norovirus. Nanobodies are a novel and unique class of antigen-binding fragments, derived from naturally occurring heavy-chain-only antibodies present in the serum of camelids.
BioPharma Drive: Drug Pricing
JANUARY 3, 2024
The deal is the third Roche has formed with startups developing pills that target RNA, following similar pacts with Arrakis and Ribometrix.
Drug Patent Watch
JANUARY 3, 2024
Annual Drug Patent Expirations for TASIGNA Tasigna is a drug marketed by Novartis and is included in one NDA. It is available from one supplier. There are seven patents protecting… The post New patent expiration for Novartis drug TASIGNA appeared first on DrugPatentWatch - Make Better Decisions.
FDA Law Blog: Biosimilars
JANUARY 3, 2024
By Sara W. Koblitz & Karla L. Palmer & Riëtte van Laack — Most of us love our furry friends, and with the boom in pet ownership during the pandemic, it is no surprise that the market for pet products has become enormous. With the growth in pet ownership, the pet health product market has also exploded; a Bloomberg article from March 2023 noting that the growth in the pet industry market “is driven by an increase in spending on pet-related healthcare—including veterinary care, diagnostic
Drug Patent Watch
JANUARY 3, 2024
Annual Drug Patent Expirations for YUPELRI Yupelri is a drug marketed by Mylan Ireland Ltd and is included in one NDA. It is available from one supplier. There are eighteen… The post New patent for Mylan Ireland drug YUPELRI appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
JANUARY 3, 2024
WEDNESDAY, Jan. 3, 2024 -- A tasty vegetarian salad could be the fresh meal that fuels a space flight to Mars, a new study contends.Researchers came up with the salad while searching for the optimal “space meal” that would supplement.
Perficient: Drug Development
JANUARY 3, 2024
The COVID-19 pandemic prompted several unprecedented shifts in society, notably impacting the workplace and necessitating the adoption of innovative technologies that facilitate collaboration and efficiency in a work-from-home (WFH) environment. For brokers, in the financial services sector, remote work became especially difficult due to the requirement for firms to register and supervise all home office “branches.
Antidote
JANUARY 3, 2024
While the primary goal of clinical trials is to help identify potential new treatments that improve people's health and save lives, it's the unfortunate truth that the patient experience is often not prioritized. This discrepancy becomes evident in industry findings, highlighting a substantial disparity between the services patients want from pharmaceutical companies compared to what they actually receive.
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