Wed.Jan 03, 2024

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'Giant' predator worms more than half a billion years old discovered in North Greenland

Science Daily: Pharmacology News

Fossils of a new group of animal predators have been located in the Early Cambrian Sirius Passet fossil locality in North Greenland. These large worms may be some of the earliest carnivorous animals to have colonized the water column more than 518 million years ago, revealing a past dynasty of predators that scientists didn't know existed.

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Healthy Omega-3 Fatty Acids Could Slow a Deadly Lung Disease

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- A diet laden with omega-3 fatty acids found in nuts and oily fish might help slow the progression of pulmonary fibrosis, researchers report.Pulmonary fibrosis is a relentless, potentially fatal disease where lung tissue.

Disease 111
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Human beliefs about drugs could have dose-dependent effects on the brain

Science Daily: Pharmacology News

Mount Sinai researchers have shown for the first time that a person's beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.

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Could Artificial Sweeteners Alter Your Microbiome?

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- You may think that artificial sweeteners can help you lose some weight, but a new study finds they are no good for your gut’s microbiome.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Looking to the Past and the Future of NIOSH Nanotechnology Guidance

NIOSH Science Blog: Drugs

NIOSH has been at the forefront of research on engineered nanomaterials since the early 2000’s. As the NIOSH Nanotechnology Research Center (NTRC) celebrates its 20th anniversary, we look back over two decades of NIOSH NTRC published guidance to help reduce worker exposures to engineered nanomaterials (ENMs). Both companies and workers use this guidance to keep workers safer.

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Functional semiconductor made from graphene

Science Daily: Pharmacology News

Researchers have created the first functional semiconductor made from graphene, a single sheet of carbon atoms held together by the strongest bonds known. The breakthrough throws open the door to a new way of doing electronics.

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Health Equity, Work, and Motor Vehicle Safety

NIOSH Science Blog: Drugs

Among U.S. workers, driving a motor vehicle or being exposed to traffic hazards as a pedestrian while at work is a significant risk. In fact, motor vehicle crashes (MVCs) are the leading cause death at work in the United States [1]. Many factors can play a role in work-related MVCs, but have you considered how these factors may have different impacts on workers, depending on their social or demographic characteristics?

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Signaling Complexes: A Ripe Opportunity for Drug Development

LifeSciVC

By Jonathan Montagu, CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used by nature to control almost all forms of cell activity – growth, response to stimuli, adaptation, replication, cell death. At its most fundamental, a signaling pathway is a cascade of activity, whereby a single stimulus triggers a precise sequence, resulting in specific ce

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New reasons eating less fat should be one of your resolutions

SCIENMAG: Medicine & Health

A UC Riverside study to motivate your new year’s resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk.

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Resolve to Get a Free Memory Screening in 2024

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- There are so many New Year’s resolutions from which to choose, but an important one could be to schedule a memory screening, experts say.Memory screenings consist of a series of questions that gauge memory and brain.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Study reveals clues to how Eastern equine encephalitis virus invades brain cells

SCIENMAG: Medicine & Health

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

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Hospital Costs Soared for COVID Patients During Pandemic

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- The average cost of hospital care for COVID-19 patients skyrocketed during the pandemic, outstripping what might be expected under inflation, a new study shows.Average hospital costs for COVID patients increased five.

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Jonathan Stamler, MD, named fellow of the 2023 National Academy of Inventors

SCIENMAG: Medicine & Health

CLEVELAND, Ohio – Jonathan Stamler, MD, has been named a Fellow of the National Academy of Inventors (NAI). Dr. Stamler is the co-founder and president of Harrington Discovery Institute at University Hospitals (UH), and the Robert S. and Sylvia K.

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Two-Step Covalent Docking with Attracting Cavities

Covalent Modifiers

Mathilde Goullieux, Vincent Zoete, and Ute F. Röhrig Journal of Chemical Information and Modeling 2023 63 (24), 7847-7859 DOI: 10.1021/acs.jcim.3c01055 Due to their various advantages, interest in the development of covalent drugs has been renewed in the past few years. It is therefore important to accurately describe and predict their interactions with biological targets by computer-aided drug design tools such as docking algorithms.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Hearing aids may help people live longer

Science Daily: Pharmacology News

A new study shows that adults with hearing loss who regularly used hearing aids had a 24% lower risk of mortality than those who never wore them.

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In Early Research, Heart Drugs Show Promise in Fighting Muscular Dystrophy

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- A regularly prescribed class of heart medications might be capable of treating one of the most common forms of muscular dystrophy, a new study in mice suggests.Myotonic dystrophy type 1 (DM1) is caused by abnormal RNA.

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Virginia Tech researchers awarded nearly $2 million to explore new treatment for Type 2 diabetes and obesity

SCIENMAG: Medicine & Health

A team of Virginia Tech researchers was awarded nearly $2 million from the National Institute of Diabetes and Digestive and Kidney Disease, part of the National Institutes of Health, to explore novel approaches for treating Type 2 diabetes and obesity. Credit: Photo courtesy of Dongmin Liu.

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New Clues To Origins of Lower Back Pain

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- Some people might be prone to low back pain because of specific cells contained in their spinal disks, a new study suggests.The research could explain why only certain people develop back pain due to the degeneration of.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Henry Ford Health cardiologists publish case series study on heart valve procedure

SCIENMAG: Medicine & Health

DETROIT (January 3, 2024) – Findings from a published case series research letter by the Henry Ford Health Structural Heart Disease team show that severe mitral stenosis, due to a build-up of calcium deposits in the mitral valve common in elderly patients, can be safely and successfully treated using Intravascular lithotripsy (IVL)-enabled percutaneous balloon mitral […]

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Goldman Sachs gets into biotech investing with new venture fund

BioPharma Drive: Drug Pricing

The $650 million fund exceeded Goldman’s target and comes amid cautious optimism that biotech could rebound from a lengthy downturn.

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Tales of the Unsurprised: U.S. Brand-Name Drug Prices Fell for an Unprecedented Sixth Consecutive Year (And Will Fall Further in 2024)

Drug Channels

It's time for Drug Channels ’ annual reality check on U.S. drug pricing. For 2023, brand-name drugs’ list prices again grew at mid-single-digit rates. However, net prices dropped for an unprecedented sixth consecutive year. What’s more, after adjusting for overall inflation, brand-name drug net prices plunged by more than 7%. Details below. Employers, health plans, and PBMs determine whether patients share in this ongoing deflation.

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Hearing aids may help people live longer

SCIENMAG: Medicine & Health

LOS ANGELES — Hearing loss affects approximately 40 million American adults, yet only one in 10 people who need hearing aids use them, research shows. Credit: Ricardo Carrasco III LOS ANGELES — Hearing loss affects approximately 40 million American adults, yet only one in 10 people who need hearing aids use them, research shows.

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Have You Missed Any FDA Data Submission Requirements? A Look at Substantial Changes and New Requirements

Cytel

Ten years ago this month, in January 2014, the FDA issued the first version of its Technical Conformance Guide (by chance I also found comments provided by my friend Jozef Aerts already complaining about the use of SAS XPORT). 1 The following December, a second version was released after public comments and, on December 16, 2014, the FDA stopped the clock, providing sponsors with a pivotal two-year window to adapt their methods of creating clinical dataset packages to comply with the FDA’s new r

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The Future of the Automotive Shopping Landscape Powered by Unified, Immersive, Frictionless Buying

Perficient: Drug Development

One of my favorite memories as a kid was going to the car dealership with my dad and watching him beat up (figuratively, of course) the sales associate who was trying to sell him a new truck. The sales associate wanted one price; my father wanted a very different price. Round and round they went, spending hours and oxygen as they both attempted to get to a place where they felt good about the deal.

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The promise of nanobodies to neutralise the human norovirus

Drug Target Review

Researchers from the Baylor College of Medicine have discovered that antibodies produced by llamas, called nanobodies, could be developed as a therapeutic agent to neutralise human norovirus. Nanobodies are a novel and unique class of antigen-binding fragments, derived from naturally occurring heavy-chain-only antibodies present in the serum of camelids.

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Roche joins startup Remix in bet on another way to drug RNA

BioPharma Drive: Drug Pricing

The deal is the third Roche has formed with startups developing pills that target RNA, following similar pacts with Arrakis and Ribometrix.

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Which pharmaceutical companies have the most capsule dosed drugs?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most capsule dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most capsule dosed drugs… The post Which pharmaceutical companies have the most capsule dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.

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Animals Need Drugs Too, But Not Without CVM Approval

FDA Law Blog: Biosimilars

By Sara W. Koblitz & Karla L. Palmer & Riëtte van Laack — Most of us love our furry friends, and with the boom in pet ownership during the pandemic, it is no surprise that the market for pet products has become enormous. With the growth in pet ownership, the pet health product market has also exploded; a Bloomberg article from March 2023 noting that the growth in the pet industry market “is driven by an increase in spending on pet-related healthcare—including veterinary care, diagnostic

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New patent expiration for Novartis drug TASIGNA

Drug Patent Watch

Annual Drug Patent Expirations for TASIGNA Tasigna is a drug marketed by Novartis and is included in one NDA. It is available from one supplier. There are seven patents protecting… The post New patent expiration for Novartis drug TASIGNA appeared first on DrugPatentWatch - Make Better Decisions.

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Adobe AEMaaCS integration with OpenAI Assistants API

Perficient: Drug Development

About the OpenAI Assistants API The OpenAI Assistants API allows you to build AI assistants within your own applications. An Assistant has instructions and can leverage models, tools, and knowledge to respond to user queries. The Assistants API is designed to help developers build powerful AI assistants capable of performing a variety of tasks. Different from OpenAI’s Chat Completions API, Assistants API is an agent framework.

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New patent for Mylan Ireland drug YUPELRI

Drug Patent Watch

Annual Drug Patent Expirations for YUPELRI Yupelri is a drug marketed by Mylan Ireland Ltd and is included in one NDA. It is available from one supplier. There are eighteen… The post New patent for Mylan Ireland drug YUPELRI appeared first on DrugPatentWatch - Make Better Decisions.

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A crash course of Next.js: Routing and Middleware (part 3)

Perficient: Drug Development

This series is my Next.js study resume, and despite it’s keen to a vanilla Next.js, all the features are applicable with Sitecore SDK. It is similar to the guide I recently wrote about GraphQL and aims to reduce the learning curve for those switching to it from other tech stacks. In part 1 we covered some fundamentals of Next.js – rendering strategies along with the nuances of getStaticProps, getStaticPaths, getServerSideProps as well as data fetching.

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Here's the Ideal Salad for Men on Long Spaceflights

Drugs.com

WEDNESDAY, Jan. 3, 2024 -- A tasty vegetarian salad could be the fresh meal that fuels a space flight to Mars, a new study contends.Researchers came up with the salad while searching for the optimal “space meal” that would supplement.

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