Tue.Jan 16, 2024

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Antibody cocktail effective against emerging Covid-19 Omicron variants

Drug Discovery World

Biotech company ExeVir Bio has revealed new data demonstrating that its antibodies are effective in neutralising currently circulating Covid-19 Omicron variants. The company says that all authorised SARS-CoV-2 therapeutic antibodies that have been used in the clinic show severe to complete loss of virus neutralisation potency against the currently circulating variants.

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Sentiment & Themes Emerging From JPM 2024

LifeSciVC

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. 2023 was a stellar year for M&A, comeback stories, burgeoning “hot” spaces, and for re-learning the basics of belt-tightening and careful capital allocation.

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SLAS2024 update: The technology behind nanoparticle-based vaccines

Drug Discovery World

Will you be attending SLAS2024 in Boston? This year the programme will feature a track curated by DDW taking place in the Ignite Theater ‘ Innovation & technology: from lab to patient ’. Co-sponsored by Integra Biosciences and Hamamatsu Corporation, the Ignite Theater will be live on 5 and 6 February 2024 in the SLAS2024 exhibition hall. Dr Masaru Kanekiyo On Tuesday 6 February at 11.30am, the speaker will be Masaru Kanekiyo, DVM, PhD, Investigator and Chief of Molecular Immunoengineering Se

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AI in Drug Discovery - A Highly Opinionated Literature Review (Part III)

Practical Cheminformatics

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Clinical trial will test novel inhaled TB vaccine

Drug Discovery World

A new study will compare whether giving tuberculosis vaccine by inhalation is better at protecting against tuberculosis (TB) than injection into the skin. The Jenner Institute at the University of Oxford is conducting the study using Bacille Calmette-Guérin (BCG), the current licensed vaccine against TB. As the natural route of infection with TB is through inhalation of droplets into the lungs, it is hoped that delivering BCG by the same route will be more effective at stimulating the immune sys

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FDA widens approval of Vertex’s CRISPR medicine to treat beta thalassemia

BioPharma Drive: Drug Pricing

The agency’s decision to expand use of Casgey, which won a landmark OK for sickle cell disease in December, comes more than two months ahead of schedule.

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An AI Approach to Generate Novel Pharmaceuticals using Patent Data

Drug Patent Watch

A recent article published in the Journal of Cheminformatics addresses the challenge of confirming the patent status of newly developed compounds, particularly in the pharmaceutical industry, where generating novel structures… The post An AI Approach to Generate Novel Pharmaceuticals using Patent Data appeared first on DrugPatentWatch - Make Better Decisions.

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Pacific kelp forests are far older that we thought

Science Daily: Pharmacology News

Fossils of kelp along the Pacific Coast are rare. Until now, the oldest fossil dated from 14 million years ago, leading to the view that today's denizens of the kelp forest -- marine mammals, urchins, sea birds -- coevolved with kelp. A recent amateur discovery pushes back the origin of kelp to 32 million years ago, long before these creatures appeared.

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MRI-Guided Brain Zaps Ease Severe Depression for 6 Months

Drugs.com

TUESDAY, Jan. 16, 2024 -- Magnetic zaps to the brain can significantly help people with severe depression, if the procedure is guided using MRI brain scans, a new clinical trial has concluded.On average, patients showed substantial improvements in.

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'Feel good' hormone could explain why exercise helps boost your brain

Science Daily: Pharmacology News

A study exploring the mechanisms behind why cognitive performance improves in response to exercise, has found that dopamine plays a key role.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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How Obamacare Boosted Lung Cancer Survival

Drugs.com

TUESDAY, Jan. 16, 2024 -- As more Americans with lung cancer gained access to quality care after passage of the Affordable Care Act (ACA), their post-surgical survival rates rose, new data shows. The ACA (often called Obamacare) triggered the.

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Anti-Obesity Drugs and The Coming Battle Over Utilization Management (video)

Drug Channels

My recent Drug Channels Outlook 2024 webinar covered 12 key trends that will shape the commercial environment this year. The video excerpt below highlights my commentary on trend #2: the rapid growth of anti-obesity GLP-1 agonist drugs. As I explain, this growth will challenge payer and channel economics, while boosting profits for patient reimbursement hub businesses and pharmacy benefit managers (PBMs).

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Marijuana Has No Role in Taking Up or Quitting Opioids: Study

Drugs.com

TUESDAY, Jan. 16, 2024 -- There’s no link at all between weed use and a person’s use of illicit opioids, one way or the other, a new review concludes.Cannabis isn’t a gateway drug that can spark a person’s desire to try narcotics, results.

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Amnesia caused by head injury reversed in early mouse study

Science Daily: Pharmacology News

A mouse study designed to shed light on memory loss in people who experience repeated head impacts, such as athletes, suggests the condition could potentially be reversed. The research in mice finds that amnesia and poor memory following head injury is due to inadequate reactivation of neurons involved in forming memories.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Vaccination Cuts Odds for Long COVID in Kids

Drugs.com

TUESDAY, Jan. 16, 2024 -- Vaccination can protect young people -- particularly teenagers-- against long COVID, a new study finds.Records of more than 1 million U.S. kids showed that the COVID jab can effectively shield kids from long-term health.

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Innovative COVID-19 analysis supports prevention protocols in health care settings

SCIENMAG: Medicine & Health

In early 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly contagious and pathogenic virus, made its alarming debut and quickly spread worldwide, causing the novel coronavirus (COVID-19) pandemic that threatened human health and public safety.

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Defense Secretary Austin Leaves Hospital After Prostate Cancer Surgery Complications

Drugs.com

TUESDAY, Jan. 16, 2024 -- Following two weeks of hospital care for complications from prostate cancer surgery, U.S. Defense Secretary Lloyd Austin has been released from Walter Reed National Military Medical Center, the Pentagon announced.

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St. Jude Home Care, LLC is first US pediatric home health agency to earn new category of industry certification

SCIENMAG: Medicine & Health

St. Jude Children’s Research Hospital announces today that St. Jude Home Care LLC, a home health agency for the hospital’s patients, earned dual certifications in both pediatrics and home health from Community Health Accreditation Partners (CHAP), an independent, non-profit, accrediting body for home and community-based healthcare organizations. St.

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Higher Premiums for Employer-Sponsored Insurance Keep Wages Low: Study

Drugs.com

TUESDAY, Jan. 16, 2024 -- Ever glance at your paycheck and wonder why your take-home pay is so much less than you’d expect?The rising cost of employer-sponsored health insurance is a major reason why, a new study argues.The cost of.

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New study aims to unlock secrets of the human brain

SCIENMAG: Medicine & Health

The inner workings of the human brain are a gradually unraveling mystery and Dr. Richard Naud of the University of Ottawa’s Faculty of Medicine has led a highly compelling new study that brings us closer to answering these big questions.

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Dopamine Hit Could Drive Mental Boost From Exercise

Drugs.com

TUESDAY, Jan. 16, 2024 (HeathDay News) -- Folks often feel more alert and savvy after a great workout, and dopamine might be the reason why.A small, new study by British and Japanese researchers found higher levels of the "feel good" brain.

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Researchers examine accuracy of adult body weight estimates in the emergency department

SCIENMAG: Medicine & Health

Knowing a patient’s weight is necessary for many weight-based medications such as thrombolytics, anticoagulants and numerous cardiovascular medications. Scaling drugs to a patient’s weight prevents adverse events from overtreatment and treatment failure due to underdosing. Inaccurate weight estimations may lead to inaccurate drug doses, which could cause patient harm.

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Simplifying speaker engagement in Pharma: A holistic approach

BioPharma Drive: Drug Pricing

Relationships with Speaker Bureau faculty are among the most important that a biopharmaceutical company nurtures.

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Novel drug for fatal type of heart failure proves safe and effective in phase 3 trial

SCIENMAG: Medicine & Health

Pumping over 100,000 times a day, the heart is a critical muscle needed to deliver oxygen and nutrients to our organs to sustain healthy bodily function. Unfortunately, heart failure affects an estimated 6.2 million people in the U.S. and a staggering 64 million worldwide. Credit: Medical University of South Carolina. Photograph by Sarah Pack.

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Women’s health companies, battling under-investment in research, see growing opportunity

BioPharma Drive: Drug Pricing

While investment remains lower than in other areas of drug R&D, executives and VCs speak of growing momentum for a field that’s been overlooked in the past.

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USC Stem Cell study throws our understanding of gene regulation for a loop

SCIENMAG: Medicine & Health

The blueprint for human life lies within the DNA in the nucleus of each of our cells. In human cells, around six and a half feet of this genetic material must be condensed to fit inside the nucleus. DNA condensation is not random.

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New map shows where damaging earthquakes are most likely to occur in US

Science Daily: Pharmacology News

Scientists recently revealed the latest National Seismic Hazard Model, showing that nearly 75% of the United States could experience a damaging earthquake, emphasizing seismic hazards span a significant part of the country.

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X-CHIME: Context Dependent Germline Knockout in Immune Cells

addgene Blog

Annotation of genes in immune cells typically involves the creation of germline knockout mice, which is time-consuming, as it only changes one gene at a time. CRISPR-based systems enable gene knockout in immune cells in a high-throughput manner, but these systems have not been widely employed in vivo. The CHIME and new X-CHIME systems, developed and deposited at Addgene by Arlene Sharpe’s lab , allow for wide deployment of in vivo gene knockout in immune systems.

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Cryo-microscopy reveals nano-sized copy machine implicated in origin of life

Science Daily: Pharmacology News

RNA is thought to have sparked the origin of life by self-copying. Researchers have now revealed the atomic structure of an 'RNA copy machine' through cryo-EM. This breakthrough sheds light on a primordial RNA world and fuels advancements in RNA nanotechnology and medicine.

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What if cows could talk?

SCIENMAG: Medicine & Health

You may not know it, but cows share information every time they burp, moo, and chew that speaks volumes about their health and welfare. Credit: Photo by Madi Hahn for Virginia Tech.

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Do violent video games numb us towards real violence?

Science Daily: Pharmacology News

Neuroscientists have investigated whether playing violent video games leads to a reduction in human empathy. To do this, they had adult test subjects play a violent video game repeatedly over the course of an experiment lasting several weeks. Before and after, their empathic responses to the pain of another person were measured. It was found that the violent video game had no discernible effect on empathy and underlying brain activity.

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We need a staph vaccine: here’s why we don’t have one

SCIENMAG: Medicine & Health

Staphylococcus aureus (SA) is an extremely common bacterial infection; about 30% of people have colonies of SA living in their nose. SA is often harmless, but it is also a leading cause of hospital-acquired and community-associated infections.

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Does More Outdoor Light at Night Help Cause Macular Degeneration?

Drugs.com

TUESDAY, Jan. 16, 2024 -- As levels of nighttime artificial outdoor light rise, so do the odds for a leading cause of vision loss, age-related macular degeneration (AMD).South Korean researchers found that people living in areas of that country.

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Researchers find that using patients’ own blood, rather than saline, helps preserve veins in coronary bypass grafts

SCIENMAG: Medicine & Health

In a collaboration between the Fralin Biomedical Research Institute at VTC and Carilion Clinic, researchers learned that by preserving large superficial leg veins intended for coronary bypass grafting in a mixture of the anticoagulant heparin and blood, rather than heparin and saline, the veins were better protected from cell and tissue damage.