Drug Discovery World

FEBRUARY 7, 2024

Professor Jonathan Blackburn, Chief Scientific Officer (CSO) of Sengenics, featured in a sponsored DDW Sitting Down With podcast to discuss the advantages of functional protein microarrays, challenges to overcome for biomarker discovery, Sengenics’ new i-Ome Discovery chip, and more. Professor Blackburn began by sharing an overview of his current research, including the work he does with Sengenics.

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FDA Approval Disease DNA FDA 148

Science Daily: Pharmacology News

FEBRUARY 7, 2024

Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.

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Drug Discovery World

FEBRUARY 7, 2024

For this year’s SLAS2024 conference in Boston (which takes place 3-7 February), DDW’s Megan Thomas narrates articles from the DDW SLAS2024 supplement as part of the DDW Events podcast series. This is episode three, The building blocks of AI success stories. Erin Welsh, PhD, is a disease ecologist and epidemiologist now working full-time as a science communicator.

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Science Disease Drugs 130

BioPharma Drive: Drug Pricing

FEBRUARY 7, 2024

The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.

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Science 128

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 7, 2024

For this year’s SLAS2024 conference in Boston (which takes place 3-7 February), DDW’s Megan Thomas narrates articles from the DDW SLAS2024 supplement as part of the DDW Events podcast series. This is episode three, The building blocks of AI success stories. Erin Welsh, PhD, is a disease ecologist and epidemiologist now working full-time as a science communicator.

Science 130

Science Disease Drugs 130

Chemical Biology and Drug Design

FEBRUARY 7, 2024

We obtained a total of 14 new compounds from peiminine and found that compound 1c has strong cytotoxicity and can inhibit cell proliferation. qRT-PCR and western blot showed that compound 1c exhibits an inhibitory effect on lung cancer, which was found to occur via inhibition of the PI3K/AKT/mTOR/NF-κB signaling pathway. Abstract To seek an effective anti-lung cancer drug, a total of 14 derivatives were synthesized and characterized.

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Therapies Treatment Drugs Research 100

Chemical Biology and Drug Design

FEBRUARY 7, 2024

HSYA has been found to inhibit the expression of MMP13, COL2A1, SOX9, IL-6, and TNF-α in IL-1β-induced osteoarthritis. Additionally, HSYA exhibits anti-inflammatory effects, potentially by inhibiting the activation of the NF-κB signaling pathway induced by IL-1β. Abstract The progression of osteoarthritis (OA) requires the involvement of inflammation, in which chondrocyte damage plays a significant role.

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Bioinformatics Production Treatment Disease 100

FDA Law Blog: Biosimilars

FEBRUARY 7, 2024

By John A. Gilbert — Last week, DEA and DOJ announced a $59 million civil penalty settlement with eBay related to the failure to comply with Controlled Substances Act (CSA) requirements for identifying purchasers, maintaining records, and filing reports of individuals selling/purchasing pill presses and encapsulating machines. As stated in the press release , this was the fourth largest civil penalty settlement under the CSA and, ironically, did not involve the sale or distribution of any contr

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Regulations Compliance Government Production 116

Chemical Biology and Drug Design

FEBRUARY 7, 2024

Schematic diagram of mitirone-inhibited ESCC. Mitirone inhibits the RSPO-mediated ZNRF3/RNF43 degradation mechanism by reducing the expression of RSPO1 and RSPO2 in ESCC cell lines K30 and K150. The red box indicates the ubiquitination and degradation mechanism of FZD2 under the action of mitirone. Abstract Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer and lacks effective treatment.

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Regulations Treatment Drugs Research 100

Fierce BioTech

FEBRUARY 7, 2024

In this digital interview hosted at Fierce JPM Week, Gaurav Marya of Cognizant is joined by Samer Ansari of Takeda to discuss what digital transformation means in today’s biopharma world. | Cognizant's Gaurav Marya and Takeda's Samer Ansari discuss what digital transformation means in today’s biopharma world and how key technological advances, such as generative AI, will help create elevated human experiences.

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Science 111

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- Ohio resident Erica Hutson was in her 20s when she found out she had high cholesterol through a health check required by insurance. Because she was young and fit, Hutson shrugged off the test result. But Hutson changed.

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Science Daily: Pharmacology News

FEBRUARY 7, 2024

Scientists may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself. By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to engineered T cells. Inserting a gene encoding this unique mutation into normal human T cells made them more than 100 times more potent at killing cancer cells without any signs of becoming toxic.

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Engineering 103

Drug Channels

FEBRUARY 7, 2024

The boffins at the Centers for Medicare & Medicaid Services (CMS) recently dropped the latest National Health Expenditure (NHE) data, which measures all U.S. spending on healthcare. (Links below.) As you will see, retail and mail prescription drug spending remain a consistently small share of the $4.5 trillion that we spend on U.S. healthcare. And contrary to what you might read, drug spending growth was *not* driven by purportedly “skyrocketing” drug prices.

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Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- A company in Ecuador that processed the cinnamon used in flavored applesauce pouches destined for the American market is the likely source of lead contamination in those products, U.S. investigators said.In an update to.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

SCIENMAG: Medicine & Health

FEBRUARY 7, 2024

Whether it’s singing in a choir, playing the living room piano, joining in hymns at church, or just whistling along with the radio, a new poll finds that nearly all older adults say music brings them far more than just entertainment.

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Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- Music may be good medicine for older adults, boosting both their mental and physical health, a new survey finds.Virtually all people between the ages of 50 and 80 (98%) say they benefit in at least one health-related way.

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BioPharma Drive: Drug Pricing

FEBRUARY 7, 2024

The company, a leading developer of cell therapies for autoimmune diseases, is the fifth drug startup to go public in 2024. All of them raised at least $100 million.

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Therapies Disease Drugs 90

Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- Depression and a rise in body temperature appear linked, although researchers say it's not yet clear which causes which. Still, the findings offer a hint that manipulating body temperature might be a new form of therapy.

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Therapies Research 98

SCIENMAG: Medicine & Health

FEBRUARY 7, 2024

More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents^ of nuts and seeds per week.1 Credit: American Pistachio Growers More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents^ of nuts and seeds per week.

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Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- Preterm births linked to “hormone-disruptor” chemicals in plastics cost the U.S. health care system billions of dollars, a new study claims.Daily exposure to phthalates -- chemicals used to manufacture plastics --.

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SCIENMAG: Medicine & Health

FEBRUARY 7, 2024

UNIVERSITY PARK, Pa. — Predicting the trajectory of neurodevelopmental and psychiatric disorders like autism or schizophrenia is difficult because they can be influenced by many different genetic and environmental factors.

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Disease Research 81

Science Daily: Pharmacology News

FEBRUARY 7, 2024

Saturn's moon Mimas harbors a global ocean beneath its icy shell, discovered through analysis of its orbit by Cassini spacecraft data. This ocean formed just 5-15 million years ago, making Mimas a prime candidate for studying early ocean formation and potential for life. This discovery suggests life-essential conditions might exist on seemingly inactive moons, expanding our search for life beyond Earth.

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SCIENMAG: Medicine & Health

FEBRUARY 7, 2024

More biodiverse nature landscapes may better buffer against stress – but only if you notice the difference, per experiment using videos of urban woodland Credit: Farris et al., 2024, PLOS ONE, CC-BY 4.

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Collaborative Drug

FEBRUARY 7, 2024

Upcoming Webinar 3-21 24: Interdisciplinary Pathways in Medicine: Neurodegenerative Research and Drug Discovery

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Research Disease Drugs 94

SCIENMAG: Medicine & Health

FEBRUARY 7, 2024

Geographic sorting along ideological lines is on the rise. Counties and regions of the United States differ in political ideology. But do they differ in personality as well? Further, are people who ‘fit’ their communities healthier, happier, or more highly achieving than those who do not?

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Science Daily: Pharmacology News

FEBRUARY 7, 2024

A new study illuminates the cultural evolution that took place approximately 50,000 to 40,000 years ago, coinciding with the dispersals of Homo sapiens across Eurasia. The insights gleaned from their examination of stone tool technology challenge the widely held notion of a rapid cultural and technological 'revolution' that enabled anatomically modern humans to surpass Neanderthals and other archaic humans.

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Research 79

SCIENMAG: Medicine & Health

FEBRUARY 7, 2024

The Michael J. Fox Foundation for Parkinson’s Research has chosen MUSC as one of four sites for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) research study, a part of the Global Parkinson’s Genetics Program. Credit: Medical University of South Carolina. Photo by Sarah Pack. The Michael J.

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Disease Research 75

Drug Target Review

FEBRUARY 7, 2024

How does the Artificial Intelligence (AI) system developed by the research team contribute to understanding the interactions between SARS-CoV-2 viral protein fragments and the immune system? We had built a machine learning classifier that has been trained to identify amino acid sequences that have the potential to mimic ‘host defense peptides’ from the human innate immune system.

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RNA Virus Immune Response Engineering 69

Science Daily: Pharmacology News

FEBRUARY 7, 2024

A more accurate way of identifying underground nuclear tests, including those conducted in secret, has been developed.

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Drug Patent Watch

FEBRUARY 7, 2024

Annual Drug Patent Expirations for APONVIE Aponvie is a drug marketed by Heron Theraps Inc and is included in one NDA. It is available from one supplier. There are ten… The post New patent for Heron Theraps drug APONVIE appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Drugs.com

FEBRUARY 7, 2024

WEDNESDAY, Feb. 7, 2024 -- Pulmonary rehabilitation can be a lifeline for millions of Americans coping with COPD or other chronic lung ailments. However, new research finds that travel time and cost issues put pulmonary rehab programs out of reach.

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Research 59

Drug Patent Watch

FEBRUARY 7, 2024

Annual Drug Patent Expirations for NALOXONE+HYDROCHLORIDE+%28AUTOINJECTOR%29 Naloxone Hydrochloride (autoinjector) is a drug marketed by Kaleo Inc and is included in one NDA. It is available from one supplier. There are… The post New patent for Kaleo Inc drug NALOXONE HYDROCHLORIDE (AUTOINJECTOR) appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

BioPharma Drive: Drug Pricing

FEBRUARY 7, 2024

The deal hands Kyowa Kirin rights in Japan to the drug, which is emerging as a potential rival to BioMarin’s marketed medicine Voxzogo.

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Drugs Marketing 62

Drug Patent Watch

FEBRUARY 7, 2024

Annual Drug Patent Expirations for AUVI-Q Auvi-q is a drug marketed by Kaleo Inc and is included in one NDA. It is available from three suppliers. There are twenty-four patents… The post New patent for Kaleo Inc drug AUVI-Q appeared first on DrugPatentWatch - Make Better Decisions.

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