Science Daily: Pharmacology News
FEBRUARY 7, 2024
Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.
BioPharma Drive: Drug Pricing
FEBRUARY 7, 2024
The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.
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Chemical Biology and Drug Design
FEBRUARY 7, 2024
We obtained a total of 14 new compounds from peiminine and found that compound 1c has strong cytotoxicity and can inhibit cell proliferation. qRT-PCR and western blot showed that compound 1c exhibits an inhibitory effect on lung cancer, which was found to occur via inhibition of the PI3K/AKT/mTOR/NF-κB signaling pathway. Abstract To seek an effective anti-lung cancer drug, a total of 14 derivatives were synthesized and characterized.
FDA Law Blog: Biosimilars
FEBRUARY 7, 2024
By John A. Gilbert — Last week, DEA and DOJ announced a $59 million civil penalty settlement with eBay related to the failure to comply with Controlled Substances Act (CSA) requirements for identifying purchasers, maintaining records, and filing reports of individuals selling/purchasing pill presses and encapsulating machines. As stated in the press release , this was the fourth largest civil penalty settlement under the CSA and, ironically, did not involve the sale or distribution of any contr
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Chemical Biology and Drug Design
FEBRUARY 7, 2024
HSYA has been found to inhibit the expression of MMP13, COL2A1, SOX9, IL-6, and TNF-α in IL-1β-induced osteoarthritis. Additionally, HSYA exhibits anti-inflammatory effects, potentially by inhibiting the activation of the NF-κB signaling pathway induced by IL-1β. Abstract The progression of osteoarthritis (OA) requires the involvement of inflammation, in which chondrocyte damage plays a significant role.
Fierce BioTech
FEBRUARY 7, 2024
In this digital interview hosted at Fierce JPM Week, Gaurav Marya of Cognizant is joined by Samer Ansari of Takeda to discuss what digital transformation means in today’s biopharma world. | Cognizant's Gaurav Marya and Takeda's Samer Ansari discuss what digital transformation means in today’s biopharma world and how key technological advances, such as generative AI, will help create elevated human experiences.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- Ohio resident Erica Hutson was in her 20s when she found out she had high cholesterol through a health check required by insurance. Because she was young and fit, Hutson shrugged off the test result. But Hutson changed.
Broad Institute
FEBRUARY 7, 2024
Study reveals links between blood vessel biology and heart disease risk By Tom Ulrich February 7, 2024 Breadcrumb Home Study reveals links between blood vessel biology and heart disease risk Genetic alterations in cells lining blood vessels contribute to coronary artery disease, with implications for diagnostic and treatment strategies By Brigham and Women's Hospital Communications February 7, 2024 Credit: Christopher V.
Perficient: Drug Development
FEBRUARY 7, 2024
The content editor and experience editor modes may seem similar at first glance, but they operate with different controls. In simpler terms, even though they look alike, the tools and functions they use are not the same, which can be a source of confusion for those working with them. We have already seen the content editor part in the Extending General Link for Content Editor article.
Science Daily: Pharmacology News
FEBRUARY 7, 2024
Scientists may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself. By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to engineered T cells. Inserting a gene encoding this unique mutation into normal human T cells made them more than 100 times more potent at killing cancer cells without any signs of becoming toxic.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- A company in Ecuador that processed the cinnamon used in flavored applesauce pouches destined for the American market is the likely source of lead contamination in those products, U.S. investigators said.In an update to.
Drug Channels
FEBRUARY 7, 2024
The boffins at the Centers for Medicare & Medicaid Services (CMS) recently dropped the latest National Health Expenditure (NHE) data, which measures all U.S. spending on healthcare. (Links below.) As you will see, retail and mail prescription drug spending remain a consistently small share of the $4.5 trillion that we spend on U.S. healthcare. And contrary to what you might read, drug spending growth was *not* driven by purportedly “skyrocketing” drug prices.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- Music may be good medicine for older adults, boosting both their mental and physical health, a new survey finds.Virtually all people between the ages of 50 and 80 (98%) say they benefit in at least one health-related way.
SCIENMAG: Medicine & Health
FEBRUARY 7, 2024
Whether it’s singing in a choir, playing the living room piano, joining in hymns at church, or just whistling along with the radio, a new poll finds that nearly all older adults say music brings them far more than just entertainment.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- Depression and a rise in body temperature appear linked, although researchers say it's not yet clear which causes which. Still, the findings offer a hint that manipulating body temperature might be a new form of therapy.
Science Daily: Pharmacology News
FEBRUARY 7, 2024
Engineers apply electron beam technology to develop an integrated silicon-gel electrolyte system.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- Preterm births linked to “hormone-disruptor” chemicals in plastics cost the U.S. health care system billions of dollars, a new study claims.Daily exposure to phthalates -- chemicals used to manufacture plastics --.
BioPharma Drive: Drug Pricing
FEBRUARY 7, 2024
The company, a leading developer of cell therapies for autoimmune diseases, is the fifth drug startup to go public in 2024. All of them raised at least $100 million.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
FEBRUARY 7, 2024
More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents^ of nuts and seeds per week.1 Credit: American Pistachio Growers More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents^ of nuts and seeds per week.
Science Daily: Pharmacology News
FEBRUARY 7, 2024
Saturn's moon Mimas harbors a global ocean beneath its icy shell, discovered through analysis of its orbit by Cassini spacecraft data. This ocean formed just 5-15 million years ago, making Mimas a prime candidate for studying early ocean formation and potential for life. This discovery suggests life-essential conditions might exist on seemingly inactive moons, expanding our search for life beyond Earth.
SCIENMAG: Medicine & Health
FEBRUARY 7, 2024
UNIVERSITY PARK, Pa. — Predicting the trajectory of neurodevelopmental and psychiatric disorders like autism or schizophrenia is difficult because they can be influenced by many different genetic and environmental factors.
Collaborative Drug
FEBRUARY 7, 2024
Upcoming Webinar 3-21 24: Interdisciplinary Pathways in Medicine: Neurodegenerative Research and Drug Discovery
SCIENMAG: Medicine & Health
FEBRUARY 7, 2024
More biodiverse nature landscapes may better buffer against stress – but only if you notice the difference, per experiment using videos of urban woodland Credit: Farris et al., 2024, PLOS ONE, CC-BY 4.
Science Daily: Pharmacology News
FEBRUARY 7, 2024
A new study illuminates the cultural evolution that took place approximately 50,000 to 40,000 years ago, coinciding with the dispersals of Homo sapiens across Eurasia. The insights gleaned from their examination of stone tool technology challenge the widely held notion of a rapid cultural and technological 'revolution' that enabled anatomically modern humans to surpass Neanderthals and other archaic humans.
SCIENMAG: Medicine & Health
FEBRUARY 7, 2024
Geographic sorting along ideological lines is on the rise. Counties and regions of the United States differ in political ideology. But do they differ in personality as well? Further, are people who ‘fit’ their communities healthier, happier, or more highly achieving than those who do not?
Drug Target Review
FEBRUARY 7, 2024
How does the Artificial Intelligence (AI) system developed by the research team contribute to understanding the interactions between SARS-CoV-2 viral protein fragments and the immune system? We had built a machine learning classifier that has been trained to identify amino acid sequences that have the potential to mimic ‘host defense peptides’ from the human innate immune system.
SCIENMAG: Medicine & Health
FEBRUARY 7, 2024
The Michael J. Fox Foundation for Parkinson’s Research has chosen MUSC as one of four sites for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) research study, a part of the Global Parkinson’s Genetics Program. Credit: Medical University of South Carolina. Photo by Sarah Pack. The Michael J.
Science Daily: Pharmacology News
FEBRUARY 7, 2024
A more accurate way of identifying underground nuclear tests, including those conducted in secret, has been developed.
Drug Patent Watch
FEBRUARY 7, 2024
This chart shows the pharmaceutical companies with the most concentrate dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most concentrate dosed drugs… The post Which pharmaceutical companies have the most concentrate dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.
Covalent Modifiers
FEBRUARY 7, 2024
John M. Bennett, Sunil K. Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L. Li, Ryan K. Muir, Franco F. Faucher, Scott Lovell, Michael J. Blackman, Alexander Adibekian, Ellen Yeh, David A. Fidock, Matthew Bogyo bioRxiv 2024.01.11.575224; doi: [link] Malaria, caused by Plasmodium falciparum, remains a significant health burden.
Drug Patent Watch
FEBRUARY 7, 2024
Annual Drug Patent Expirations for APONVIE Aponvie is a drug marketed by Heron Theraps Inc and is included in one NDA. It is available from one supplier. There are ten… The post New patent for Heron Theraps drug APONVIE appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
FEBRUARY 7, 2024
WEDNESDAY, Feb. 7, 2024 -- Pulmonary rehabilitation can be a lifeline for millions of Americans coping with COPD or other chronic lung ailments. However, new research finds that travel time and cost issues put pulmonary rehab programs out of reach.
Drug Patent Watch
FEBRUARY 7, 2024
Annual Drug Patent Expirations for NALOXONE+HYDROCHLORIDE+%28AUTOINJECTOR%29 Naloxone Hydrochloride (autoinjector) is a drug marketed by Kaleo Inc and is included in one NDA. It is available from one supplier. There are… The post New patent for Kaleo Inc drug NALOXONE HYDROCHLORIDE (AUTOINJECTOR) appeared first on DrugPatentWatch - Make Better Decisions.
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