Wed.Mar 12, 2025

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More Children Accidentally Poisoned By Fentanyl

Drugs.com

WEDNESDAY, March 12, 2025 -- The number of children poisoned through exposure to fentanyl, a powerful synthetic opioid, has skyrocketed in recent years, researchers have reported.Fentanyl poisonings increased by 924% among children 12 and younger.

Research 261
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First operating system for quantum networks

Science Daily: Pharmacology News

Researchers have announced the creation of the first operating system designed for quantum networks: QNodeOS. The research marks a major step forward in transforming quantum networking from a theoretical concept to a practical technology that could revolutionize the future of the internet.

Research 177
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Dozens of Laid-Off CDC Workers Push to Get Their Jobs Back

Drugs.com

WEDNESDAY, March 12, 2025 -- A group of former U.S. Centers for Disease Control and Prevention (CDC) employees is fighting to get their jobs back after being abruptly laid off last month. In a letter sent Monday to Health and Human Services (HHS).

Disease 227
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How climate change affects rain and floods

Science Daily: Pharmacology News

Climate change may lead to more precipitation and more intense floods. A new study shows that to understand the details of this relationship, it is important to distinguish between different types of rainfall and flood events -- namely, between short-term events that occur on a time scale of hours, and longer-term events that last several days. In each case, climate change has a different impact.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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RFK Jr. Pushes for Stricter Oversight of Chemicals in Food

Drugs.com

WEDNESDAY, March 12, 2025 -- The nation's top health official, Robert F. Kennedy Jr., is taking steps to tighten oversight of chemicals in the U.S. food supply, a key component of his Make America Healthy Again agenda.On March 10, Kennedy dir.

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Poll Reveals Only 17 Percent Think Medicaid Funding Should Be Cut

Drugs.com

WEDNESDAY, March 12, 2025 -- Only 17 percent of adults say they want to see Medicaid funding decreased, while 42 percent think funding should increase and 40 percent think it should be kept about the same, according to results of the February 2025.

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Flagship startup raises $200M in pursuit of ‘scientific superintelligence’

BioPharma Drive: Drug Pricing

Funded by investors such as Flagship and General Catalyst, the AI startup claims its platform will help scientists speed up the experimentation process.

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Pickleballers Bounce Back After Joint Replacement

Drugs.com

WEDNESDAY, March 12, 2025 -- Love pickleball, but facing a knee or hip replacement?Odds are youll return to the court in no time, a new study suggests.More than 7 of 10 regular pickleball players pick up their paddle promptly following joint r.

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Roche broadens obesity drug plans with $1.65B Zealand deal

BioPharma Drive: Drug Pricing

The deal gives the Swiss pharma access to an experimental amylin-targeting treatment it will test in combination with drugs it acquired from Carmot.

Drugs 144
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Spouses Also Benefit From Partner's Knee/Hip Replacement

Drugs.com

WEDNESDAY, March 12, 2025 -- Knee or hip replacement is a major surgery, and many people must lean hard on their spouses to care for them during weeks to months of recuperation.But all that hassle is absolutely worthwhile for the one providing care.

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Ono pays $280M to license Ionis rare disease drug

BioPharma Drive: Drug Pricing

Ionis’ drug, sapablursen, is currently being tested in a Phase 2 trial in patients with polycythemia vera.

Licensing 144
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Responsive Parenting Can Help Counter Childhood Obesity

Drugs.com

WEDNESDAY, March 12, 2025 -- Kids are more likely to maintain a healthy weight if their parents adopt a responsive style while theyre babies and toddlers, a new study suggests.Children had a significantly lower average body mass index (BMI) t.

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IRA reforms could be on the table. Will Trump and the GOP pursue them?

BioPharma Drive: Drug Pricing

Industry insiders are pushing to fix the small molecule ‘penalty’ by setting their hopes on a Republican majority.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Splash Your Way To Weight Loss Through Water Aerobics

Drugs.com

WEDNESDAY, March 12, 2025 -- Purposeful splishing and splashing can help you trim your waist size and drop excess pounds, a new evidence review has concluded.Water aerobics led to about 6 pounds of weight loss and more than an inch off the waists.

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Machine Learning‐Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent

Chemical Biology and Drug Design

We have discovered a novel non-covalent MurA inhibitor as an antibacterial agent through machine learning and bioactivity testing. This is the first to use machine learning for virtual screening of non-covalent inhibitors of MurA. ABSTRACT The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis.

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America's Well-To-Do Have Less Heart Disease Risk

Drugs.com

WEDNESDAY, March 12, 2025 -- Well-to-do and better-educated Americans have far lower rates of heart disease than the rest of the population, a new study says.The top 20% of high-income, college-educated Americans have less heart disease risk than.

Disease 130
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New technology puts a spatial lens on CRISPR screening

Broad Institute

New technology puts a spatial lens on CRISPR screening By Leah Eisenstadt March 12, 2025 Breadcrumb Home New technology puts a spatial lens on CRISPR screening Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells. By Leah Eisenstadt March 12, 2025 Credit: Broad Communications Scientists in the Spatial Technology Platform at the Broad develop, use, and share spatial -omics approaches

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Disabling Cookies in Sitecore SDKs

Perficient: Drug Development

Intro In this post, we’ll take a look at a couple Sitecore SDKs commonly used to build XM Cloud head applications. Specifically, we’ll be looking at how to disable cookies used by these SDKs. This can be useful for data privacy and/or regulatory compliance reasons. These SDKs allow your application to integrate with other composable Sitecore services like analytics, personalization, and search.

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German Pharmaceutical Compliance: The Role of Medical Information

thought leadership

When a pharmaceutical company completes clinical trials and prepares to launch a medical product, the focus often shifts to regulatory approvals, market access, and commercialization. However, one crucial aspect that must not be overlooked is Medical Information (MI) the vital bridge between pharmaceutical companies and healthcare professionals (HCPs) or patients.

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Want to preserve biodiversity? Go big

Science Daily: Pharmacology News

Large, undisturbed forests are better for harboring biodiversity than fragmented landscapes, according to recent research. Ecologists agree that habitat loss and the fragmentation of forests reduces biodiversity in the remaining fragments. But ecologists don't agree whether it's better to focus on preserving many smaller, fragmented tracts of land or larger, continuous landscapes.

Research 155
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Identification of Potential PBP2a Inhibitors Against Methicillin‐Resistant Staphylococcus aureus via Drug Repurposing and Combination Therapy

Chemical Biology and Drug Design

This study first employed molecular docking to identify potential allosteric inhibitors of PBP2a from FDA-approved drugs. Subsequent invitro experiments demonstrated that these identified inhibitors, when combined with cefazolin, synergistically enhanced the killing of methicillin-resistant Staphylococcus aureus (MRSA), effectively restoring MRSA's sensitivity to cefazolin.

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ACI’s 21st Annual Paragraph IV Disputes

FDA Law Blog: Biosimilars

The American Conference Institutes 21st Annual Paragraph IV Disputes is scheduled to take place from April 29-30, 2025 at The Altman Building in New York, NY. Widely recognized as the industry gold standard, the conference unites leaders from brand-name and generic drug companies, alongside federal judges, the U.S. PTOs PTAB, the FTC, and the FDA, to tackle the critical legal, regulatory, and business issues shaping pharmaceutical patent litigation.

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Targeting Blood‐Stage Malaria: Design, Synthesis, Characterization, In Vitro, and In Silico Evaluation of Pyrrolidinodiazenyl Chalcones

Chemical Biology and Drug Design

The study outlines the design and synthesis of 25 pyrrolidinodiazenyl chalcones using covalent bitherapy to explore their potential invitro blood stage antimalarial activity against the mixed-blood stage culture (ring, trophozoites, and schizonts) of Plasmodium falciparum 3D7. ABSTRACT Malaria is a pervasive and deadly threat to the global population, and the resources available to treat this disease are limited.

Disease 100
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Activate to SFTP from Salesforce Data Cloud

Perficient: Drug Development

SFTP? Isn’t that old? It is an oldie, but a goodie. With Data Cloud we can send data to a lot of external data sources like Marketing Cloud Engagement or Amazon S3 through Activation Targets. But there are times we are working with a destination system like Eloqua or Marketo that has solid support for SFTP. SFTP and Data Cloud work well together!

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Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK–STAT Signaling Pathway

Chemical Biology and Drug Design

This study validated the therapeutic potential of moscatilin for renal clear cell carcinoma by combining network pharmacology methods and invitro experiments. ABSTRACT Moscatilin, a biphenyl compound derived from Dendrobium nobile , exhibits significant anti-tumor activity. However, the specific role of moscatilin in clear cell renal cell carcinoma (ccRCC) and its underlying molecular mechanisms have not been fully studied.

Treatment 100
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Key Considerations for Generic Drug Stability Testing

Drug Patent Watch

The Unseen Heroes of Generic Drugs: Stability Testing 101 As a consumer, have you ever stopped to think about the rigorous process that goes into bringing a generic version of your favorite medication to market? It's not just a matter of copying a formula and slapping a new label on it. Behind the scenes, generic drug manufacturers are working tirelessly to ensure that their products are safe, effective, and identical to their branded counterparts.

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How to Activate to SFTP from Salesforce Data Cloud

Perficient: Drug Development

SFTP? Isn’t that old? It is an oldie but a goodie. With Data Cloud we can send data to a lot of external data sources like Marketing Cloud Engagement or Amazon S3 through Activation Targets. But there are times we are working with a destination system like Eloqua or Marketo that has solid support for SFTP. Even with Marketing Cloud Engagement you might want to get data flowing into Automation Studio instead of pushing directly to a Data Extension or Journey.