Thu.Apr 18, 2024

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One third of China's urban population at risk of city sinking, new satellite data shows

Science Daily: Pharmacology News

Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.

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Antipsychotics May Do Great Harm to People With Dementia: Report

Drugs.com

THURSDAY, April 18, 2024 -- Antipsychotics can substantially increase dementia patients’ risk of many serious health problems, a new study warns.

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Octopus inspires new suction mechanism for robots

Science Daily: Pharmacology News

A new robotic suction cup which can grasp rough, curved and heavy stone, has been developed by scientists.

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Cerevel, in ‘major surprise,’ finds success in late-stage Parkinson’s study

BioPharma Drive: Drug Pricing

Analysts had low expectations for Cerevel’s drug tavapadon, which was something of an afterthought in AbbVie’s proposed buyout of the biotech.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Report Finds High Levels of Pesticides in 20% of Fruits, Veggies

Drugs.com

THURSDAY, April 18, 2024 -- Nearly 20% of fresh, frozen and canned fruits and vegetables that Americans eat contain concerning levels of pesticides, a new report finds.

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More Trending

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Two-Drug Combo Curbs Drinking for People Battling Severe Alcoholism

Drugs.com

THURSDAY, April 18, 2024 -- A combo of an allergy drug and a blood pressure med appears to lower daily drinking in folks battling severe alcoholism, French researchers report.

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Vertex begins bid for US approval of non-opioid painkiller

BioPharma Drive: Drug Pricing

The start of a so-called rolling review formally begins an FDA evaluation of a closely watched drug that’s important to the biotech’s future, but faces questions about its sales potential.

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Check Your Fridge for Trader Joe's Fresh Basil, Linked to Salmonella

Drugs.com

THURSDAY, April 18, 2024 -- Fresh organic basil tainted with salmonella and sold by Trader Joe's in 29 states has sickened at least 12 people, according to an alert issued Wednesday by the U.S. Centers for Disease Control and Prevention. One.

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23andMe CEO plans to take company private

BioPharma Drive: Drug Pricing

Company head Anne Wojcicki is considering buying all outstanding shares of the DNA testing firm, which has seen its stock slump in recent years.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Many Seniors Are Overmedicated, But ChatGPT Might Prevent That

Drugs.com

THURSDAY, April 18, 2024 -- AI could help doctors cut back on the bewildering variety of medications that seniors frequently are prescribed, a new study suggests.More than 40% of seniors are prescribed five or more meds, and this increases a.

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Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy

Covalent Modifiers

Tonia Kirschner, Matthias P. Müller, and Daniel Rauh Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c02403 The GTPase KRAS acts as a switch in cellular signaling, transitioning between inactive GDP-bound and active GTP-bound states. In about 20% of human cancers, oncogenic RAS mutations disrupt this balance, favoring the active form and promoting proliferative signaling, thus rendering KRAS an appealing target for precision medicine in oncology.

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Rising Number of Americans Sent to ERs Last Year During Heat Waves

Drugs.com

THURSDAY, April 18, 2024 -- As climate change threatens another long hot summer for Americans, new data shows last summer's record-breaking temperatures sent a rising number of people to emergency departments. At special risk of heatstroke and.

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Low-Efficacy Mu Opioid Agonists as Candidate Analgesics:Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]

ASPET

Low efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compar

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Work That Challenges Your Brain Helps You Stay Sharp With Age

Drugs.com

THURSDAY, April 18, 2024 -- Jobs that challenge your mind could help your brain age more gracefully, a new study suggests.

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Twenty Years of Addgene Sharing: CRISPR

addgene Blog

As we celebrate twenty years at Addgene, we are sharing stories of our repository’s positive impact on science and scientists around the globe. Our first story focuses on a technology that has changed virtually all of biology…CRISPR.

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Big Health Care Disparities Persist Across the U.S., New Report Finds

Drugs.com

THURSDAY, April 18, 2024 -- Deep-seated racial and ethnic disparities persist in health care across the United States, even in states considered the most progressive, a new report shows.For example, California received a score of 45 for the care.

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Mutations in Three Genes Protect Against Alzheimer’s

PLOS: DNA Science

Clues to combatting a devastating disease can come from identifying people who have gene variants – mutations – that protect them, by slowing the illness or lowering the risk that it develops in the first place. Understanding how they do this may inspire treatment strategies for the wider patient population. Rare variants of three well-studied genes appear to delay inherited forms of Alzheimer’s disease – by decades.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Urine Test Might Spot Head-and-Neck Cancers Early

Drugs.com

THURSDAY, April 18, 2024 -- A newly developed at-home urine test could potentially help doctors catch head and neck cancers earlier, a new study suggests.The test looks for tiny DNA fragments sloughed off by tumor cells, which pass from the.

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Cloud-Based Technology Supports Complex Supply Chains

Fierce BioTech

In today’s fiercely competitive biotech industry, managing tight margins and evolving regulatory environments present major challenges. | NSF TraQtion software combines decades of quality expertise with real-time digital insight in one trusted, cloud-based digital solution.

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Urine Test Might Help Men Skip Prostate Biopsies

Drugs.com

THURSDAY, April 18, 2024 -- When prostate cancer strikes, one question is paramount: Is it aggressive and requiring immediate treatment, or slow-growing and worthy of monitoring only?Right now, an invasive biopsy is the only way to answer that.

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Which pharmaceutical companies have the most drug patents in Czech Republic?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Czech Republic.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Teens Often Bullied Online About Their Weight: Study

Drugs.com

THURSDAY, April 18, 2024 -- Teenagers are frequently bullied about their weight on social media, and the bullying increases with each hour they spend on these sites, a new study reveals.Nearly one in five teens (17%) said they’d experienced.

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New patent expiration for Azurity drug EVEKEO ODT

Drug Patent Watch

Annual Drug Patent Expirations for EVEKEO+ODT Evekeo Odt is a drug marketed by Azurity and is included in one NDA. There are four patents protecting this drug.

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Advisory Committee

Broad Institute

Advisory Committee By Rose Circeo April 18, 2024 Breadcrumb Home Machine Learning in Drug Discovery Symposium Advisory Committee Anne Carpenter Anne Carpenter is senior director of the Imaging Platform at Broad Institute of MIT and Harvard, where she is also an institute scientist. Learn more. Pat Walters Pat Walters is chief data officer at Relay Therapeutics.

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New patent for Tolmar drug ELIGARD KIT

Drug Patent Watch

Annual Drug Patent Expirations for ELIGARD+KIT Eligard Kit is a drug marketed by Tolmar and is included in four NDAs. It is available from one supplier.

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Agenda

Broad Institute

Agenda By Rose Circeo April 18, 2024 Breadcrumb Home Machine Learning in Drug Discovery Symposium Agenda 08:00 - 08:50 am Registration/breakfast 08:50 - 09:00 AM Opening Remarks Keynote 09:00 - 10:00 am Jennifer Listgarten Professor University of California, Berkeley Morning session 10:00 - 10:40 am Broad talk 10:40 - 11:00 am Break and poster viewing 11:00 - 11:40 am Broad talk 11:40 - 12:00 noon TBD, Lightning talks from selected poster presenters 12:00 - 1:30 pm Lunch and poster v

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