Thu.Jun 20, 2024

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Six advances in drug discovery for MND / ALS

Drug Discovery World

Ahead of Motor Neurone Disease (MND) Awareness Day on 21 June, we take a look back over the latest developments in the treatment of MND and amyotrophic lateral sclerosis (ALS). A new UK research partnership In June, UK charity LifeArc pledged £1.5 million to fund a new two-year collaborative partnership with King’s College London (KCL) to validate a portfolio of human genetic driven therapeutic targets for MND.

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Walking brings huge benefits for low back pain

Science Daily: Pharmacology News

Adults with a history of low back pain went nearly twice as long without a recurrence of their back pain if they walked regularly, a world-first study has found.

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Could auto-antibodies be linked to severe Covid-19?

Drug Discovery World

Researchers have revealed that auto-antibodies block interferon signalling, contributing to severe Covid-19 by impairing the patient’s immune response. Scientists have found that some people who suffered from Covid-19 had auto-antibodies targeting their own type 1 interferons, which are important immune signalling proteins. Factors such as age and underlying medical conditions can increase vulnerability to severe Covid-19.

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New genetic cause of obesity could help guide treatment

Science Daily: Pharmacology News

Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Silencing RNA causes moles to self-destruct in rare condition

Drug Discovery World

UK researchers have designed a new genetic therapy that could alleviate debilitating giant moles in a rare skin condition. The treatment could be used to reverse moles, and therefore prevent cancer. It could also potentially reverse other types of at-risk moles as an alternative to surgery. In congenital melanocytic naevus syndrome (CMN), children are born with up to 80% of their body covered in big, painful or itchy moles.

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Microplastics Found in Human Penises

Drugs.com

THURSDAY, June 20, 2024 -- Seven different kinds of microplastics have been discovered in human penises for the first time.The tiny fragments, formed when plastic products break down in the environment, were found in four of five samples of penis.

More Trending

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New catalyst unveils the hidden power of water for green hydrogen generation

Science Daily: Pharmacology News

A team of scientists reports a new milestone for the sustainable production of green hydrogen through water electrolysis. Their new catalyst design harnesses so far unexplored properties of water to achieve, for the first time, an alternative to critical raw materials for water electrolysis at industrial-relevant conditions.

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Colombian Family's Genes Could Hold Key to Delaying Alzheimer's

Drugs.com

THURSDAY, June 20, 2024 -- A Colombian family’s genetics are shining a spotlight on a gene that might help protect people from the ravages of Alzheimer’s disease.About 1,200 out of 6,000 family members carry a genetic variant called the “Paisa mutat.

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FDA lifts hold on PTC Huntington’s disease trial

BioPharma Drive: Drug Pricing

The agency has lifted a partial trial suspension based on one-year data showing PTC’s pill suppressed a key protein associated with the disorder.

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Certain Prostate Meds Might Help Prevent Dementia

Drugs.com

WEDNESDAY, June 20, 2024 -- Prostate medications might help reduce the risk of a specific type of dementia, a new study suggests.People were less likely to develop Lewy body dementia when taking drugs designed to treat urinary symptoms caused by an.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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The Intricate Journey of Drug Patents: From Filing to Expiry

Drug Patent Watch

In the high-stakes world of pharmaceuticals, patents play a pivotal role in safeguarding intellectual property and ensuring a return on investment for drug developers. The journey of a drug patent is a complex and intricate one, spanning from the initial filing to its eventual expiry.

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Obesity drug from Zealand shows potential in early trial

BioPharma Drive: Drug Pricing

Interim study data suggest the Danish drugmaker can remain in the race to develop new kinds of weight loss drugs as doctors seek alternatives to the now dominant GLP-1s.

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Sweat health monitor measures levels of disease markers

Science Daily: Pharmacology News

A wearable health monitor can reliably measure levels of important biochemicals in sweat during physical exercise. The 3D-printed monitor could someday provide a simple and non-invasive way to track health conditions and diagnose common diseases, such as diabetes, gout, kidney disease or heart disease. The monitor was able to accurately monitor the levels of volunteers' glucose, lactate and uric acid as well as the rate of sweating during exercise.

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Twice-yearly shots of Gilead HIV drug effective in large prevention study

BioPharma Drive: Drug Pricing

Researchers recommended Gilead end testing early as lenacapavir proved 100% effective in protecting cisgender women in the Phase 3 trial.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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First conclusive evidence that a terrestrial leech species can jump

Science Daily: Pharmacology News

A new study presents video evidence that at least one species of terrestrial leech can jump, behavior that scientists have debated for more than a century.

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Looking for Weight Loss? Go Nuts

Drugs.com

THURSDAY, June 20, 2024 -- Folks dieting to drop pounds should consider eating a fistful of nuts here and there, a new review suggests.People who ate 1.5 to 3 ounces of almonds, peanuts, pistachios or walnuts daily as part of a calorie-cutting diet.

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Climate models underestimate carbon cycling through plants

Science Daily: Pharmacology News

The carbon stored globally by plants is shorter-lived and more vulnerable to climate change than previously thought, according to a new study.

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Walking May Do Wonders for Back Pain, Study Finds

Drugs.com

THURSDAY, June 20, 2024 -- If you've recovered from lower back pain, try walking away from a recurrence.New research out of Australia shows that folks who started a walking regimen kept recurrent back pain episodes at bay for much longer than.

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Hurricane changed 'rules of the game' in monkey society

Science Daily: Pharmacology News

A devastating hurricane transformed a monkey society by changing the pros and cons of interacting with others, new research shows.

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1 in 4 U.S. Yards May Have Unsafe Levels of Lead

Drugs.com

THURSDAY, June 20, 2024 -- The yards of 1 in every 4 U.S. households have soil lead levels that exceed new federal lead screening levels of 200 parts per million (ppm), a new study finds.“I was shocked at how many households were above the new 200.

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Iron meteorites hint that our infant solar system was more doughnut than dartboard

Science Daily: Pharmacology News

Iron meteorites are remnants of the metallic cores of the earliest asteroids in our solar system. Iron meteorites contain refractory metals, such as iridium and platinum, that formed near the sun but were transported to the outer solar system. New research shows that for this to have happened, the protoplanetary disk of our solar system had to have been doughnut-shaped because the refractory metals could not have crossed the large gaps in a target-shaped disk of concentric rings.

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High Rates of Loneliness Seen Among Bisexual and Transgender People

Drugs.com

THURSDAY, June 20, 2024 -- Transgender and bisexual adults have rates of loneliness that are much higher than that of cisgender and heterosexual people, new data shows.Federal health data on U.S. adults from 2022 finds the highest rates of.

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Newly discovered dinosaur boasts big, blade-like horns

Science Daily: Pharmacology News

A new dinosaur has been identified and named. The dinosaur's name, Lokiceratops rangiformis, translates roughly to 'Loki's horned face that looks like a caribou.

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Could Blood Pressure Meds Help Prevent Adult Epilepsy?

Drugs.com

THURSDAY, June 20, 2024 -- A class of blood pressure medications appears to also help lower seniors’ risk of developing epilepsy, a new study finds.The drugs, called angiotensin receptor blockers (ARBs), might prevent epilepsy in people at highest r.

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New study finds dinosaur fossils did not inspire the mythological griffin

Science Daily: Pharmacology News

For centuries, scientists thought they knew where the griffin legend came from. A new study takes a closer look at the data and folklore's influence on science.

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Cyberbullying Common in the World of Online Gaming

Drugs.com

THURSDAY, June 20, 2024 -- Cyberbullying and sexual harassment are rampant in the world of professional video gaming and online gaming, a new study reports.Nearly 96% of 145 video game players from 14 countries said they had been targeted online in.

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Supermassive black hole appears to grow like a baby star

Science Daily: Pharmacology News

Supermassive black holes pose unanswered questions for astronomers around the world, not least 'How do they grow so big?' Now, an international team of astronomers has discovered a powerful rotating, magnetic wind that they believe is helping a galaxy's central supermassive black hole to grow. The swirling wind, revealed with the help of the ALMA telescope in nearby galaxy ESO320-G030, suggests that similar processes are involved both in black hole growth and the birth of stars.

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Sarepta Duchenne gene therapy wins broader use from FDA

BioPharma Drive: Drug Pricing

The decision makes Elevidys available to Duchenne patients at least 4 years of age, despite mixed trial results that have led to skepticism about its effectiveness.

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Guiding humanity beyond the moon

Science Daily: Pharmacology News

What actually happens to the human body in space? While scientists and researchers have heavily researched how various factors impact the human body here on Earth, the amount of information available about changes that occur in the body in space is not as well-known. Scientists have been studying for years how the body, specifically on the molecular side, changes in space.

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Plasmids 101: Stringent Regulation of Replication

addgene Blog

All plasmids rely on their host cell's replication machinery in order to replicate—but not always to the same extent. As described in our previous Origin of Replication post, DNA replication is initiated at the ori and may or may not be synchronized with the replication of the host cell's chromosomal DNA.

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Kickstarting the use of AI for biotechs: part three

Drug Target Review

Early-stage biotechs are focused on survival until wet lab and/or animal data is generated that excites investors. Many biotech CEOs and CSOs are asking, often sceptically, whether computational methods (dry lab) can help them gain the required data faster and more cheaply. Algorithms could substitute for parts of the wet lab workflows, helping to reduce the number of experiments conducted by contract research organisations (CROs), by qualifying and prioritising them.

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Amazon expands drug subscription program to Medicare members

BioPharma Drive: Drug Pricing

RxPass, which fills prescriptions for generic drugs, is now available to more than 50 million Medicare members after Amazon brought it into compliance with the insurance program’s regulatory standards.

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2024 Life Sciences Industry Outlook

Fierce BioTech

2024 Life Sciences Industry Outlook The definitive report on the state of our industry. Readers will gain an understanding of key indicators to monitor, future predictions, and guidance for investors and founders navigating the therapeutic enabling tools and services, healthtech and techbio sectors through 2024 and beyond. lbarrick Thu, 06/20/2024 - 13:16 The definitive report on the state of our industry.

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Hacking for the Future: How BenchSci Unleashes Innovation with GenAI Tech

BenchSci

At BenchSci, we're not just building world-class AI to accelerate scientific research; we're doing something that’s never been done, which requires us to constantly push the boundaries of what's possible. And what better way to spark innovation than with a company-wide hackathon?