Tue.Jun 11, 2024

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Would astronauts' kidneys survive a roundtrip to Mars?

Science Daily: Pharmacology News

The structure and function of the kidneys is altered by space flight, with galactic radiation causing permanent damage that would jeopardise any mission to Mars, according to a new study led by researchers from UCL.

Research 131
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Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Chemical Biology and Drug Design

In this study, we explored the mechanism of action of brusatol in hepatocellular carcinoma. Using RNA-seq and through in vitro and in vivo studies, we determined that brusatol suppresses hepatocellular carcinoma progression by inducing ATF3-mediated ferroptosis. Therefore, our research revealed the biological effect of brusatol treatment and provided ATF3 as a novel therapeutic target and prognostic biomarker for HCC therapy.

RNA 100
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3D-printed mini-actuators can move small soft robots, lock them into new shapes

Science Daily: Pharmacology News

Researchers have demonstrated miniature soft hydraulic actuators that can be used to control the deformation and motion of soft robots that are less than a millimeter thick. The researchers have also demonstrated that this technique works with shape memory materials, allowing users to repeatedly lock the soft robots into a desired shape and return to the original shape as needed.

Research 117
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Ipsen drug for rare liver disease approved by FDA

BioPharma Drive: Drug Pricing

The medicine will join Intercept’s Ocaliva as a treatment option for primary biliary cholangitis. Another drug, from the now Gilead-owned CymaBay, could be cleared for the condition by August.

Disease 111
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Trash-sorting robot mimics complex human sense of touch

Science Daily: Pharmacology News

Researchers are breaking through the difficulties of robotic recognition of various common, yet complex, items. Their layered sensor is equipped with material detection at the surface and pressure sensitivity at the bottom, with a porous middle layer sensitive to thermal changes. An efficient cascade classification algorithm rules out object types in order, from easy to hard, starting with simple categories like empty cartons before moving on to orange peels or scraps of cloth.

Research 113
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FDA Advisors Support New Alzheimer's Drug, Donanemab

Drugs.com

TUESDAY, June 11, 2024 -- A U.S. Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding. Eli Lilly's.

FDA 110

More Trending

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Many Louisiana Residents May Be Exposed to Sky-High Levels of Toxic Gas

Drugs.com

TUESDAY, June 11, 2024 -- Many Louisiana residents are being exposed to a cancer-causing toxic gas that’s used in industrial settings, researchers report.A cutting-edge mobile air-testing lab found dangerous levels of ethylene oxide along large s.

Research 105
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From seashells to cement, nature inspires tougher building material

Science Daily: Pharmacology News

Inspired by the material that makes up oyster and abalone shells, engineers have created a new cement composite that is 17 times more crack-resistant than standard cement and 19 times more able to stretch and deform without breaking. The findings could eventually help increase the crack resistance of a wide range of brittle ceramic materials from concrete to porcelain.

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Study Casts Doubt on Standard Test for Athletes' Concussion

Drugs.com

TUESDAY, June 11, 2024 -- A test used to gauge whether a college athlete has suffered a concussion is right only half the time and may be useless, new research finds.The test used by the NCAA, which oversees college sports, measures an athlete's.

Research 104
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How do supermassive black holes get super massive?

Science Daily: Pharmacology News

By combining forefront X-ray observations with state-of-the-art supercomputer simulations of the buildup of galaxies over cosmic history, researchers have provided the best modeling to date of the growth of the supermassive black holes found in the centers of galaxies.

Research 109
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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FDA Warns of Paralyzing Poison Danger From Pacific Northwest Shellfish

Drugs.com

TUESDAY, June 11, 2024 -- Seafood lovers should steer clear of shellfish from Oregon and Washington state because of possible contamination with a paralyzing toxin, the U.S. Food and Drug Administration has warned.In an advisory, the FDA told.

FDA 98
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Origins of fast radio bursts come into focus through polarized light

Science Daily: Pharmacology News

What scientists previously thought about where Fast Radio Bursts (FRBs) come from is just the tip of the iceberg. A new study details the properties of polarized light from 128 non-repeating FRBs and reveals mysterious cosmic explosions that originated in far-away galaxies, similar to our own Milky Way.

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Space Travel Can Upset Human Immune Systems

Drugs.com

TUESDAY, June 11, 2024 -- Astronauts orbiting the Earth tend to suffer from immune system problems such as infections and the reactivation of dormant viruses, even on short-term space flights.That appears to be because a lack of gravity causes the.

Virus 98
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How did a satellite galaxy of the Milky Way come to be?

Science Daily: Pharmacology News

Crater 2, located approximately 380,000 light years from Earth, is one of the largest satellite galaxies of the Milky Way. Extremely cold and with slow-moving stars, Crater 2 has low surface brightness. How this galaxy originated remains unclear. A team of physicists now offers an explanation.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Glowing Dye Helps Surgeons Track & Destroy Prostate Cancer

Drugs.com

TUESDAY, June 11, 2024 -- British retiree David Butler was surprised to find that he had prostate cancer, and that it had spread to the lymph nodes and other places near the prostate.“I had literally no symptoms apart from needing to pee more q.

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New discovery reveals unexpected ocean algae help cool Earth

Science Daily: Pharmacology News

A common type of ocean algae plays a significant role in producing a massively abundant compound that helps cool the Earth's climate, new research has discovered.

Research 107
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Short Commercial Space Flights May Not Have Big Impact on Health

Drugs.com

TUESDAY, June 11, 2024 — The first all-civilian space mission is shedding light on the potential health risks facing private astronauts.The takeaway: Short-duration spaceflights appear to pose none that are significant.The study sample was small — f.

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Detecting early linguistic signs of dementia by studying the natural speech of seniors

Science Daily: Pharmacology News

A study led by linguists has found that early linguistic signs of dementia can be detected through the study of the natural speech of senior Singaporeans. The novel study revealed that participants with memory-related mild cognitive impairment spoke less and used fewer, but more abstract, nouns that is consistent with the speech pattern of Alzheimer's patients.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Advisors Support New Alzheimer's Drug

Drugs.com

TUESDAY, June 11, 2024 -- A U.S. Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding.Eli Lilly's.

FDA 98
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Scientists spot more Milky Way-like galaxies in early universe

Science Daily: Pharmacology News

Scientists are peering into the past and uncovering new clues about the early universe. Since light takes a long time to travel through space, they are now able to see how galaxies looked billions of years ago. The astronomers have discovered that spiral galaxies were more common in the early universe than previously thought. The scientists found that nearly 30% of galaxies have a spiral structure about 2 billion years after the universe formed.

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Failure's 'Benefits' Might Be Overrated

Drugs.com

TUESDAY, June 11, 2024 -- Winston Churchill once said, “Success consists of going from failure to failure without loss of enthusiasm.”It’s one of countless platitudes claiming that failure leads to success.But there’s strong evidence that such a not.

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Addgene's 20th Anniversary Party

addgene Blog

This year marks Addgene's 20th anniversary! We've been celebrating throughout the year, and on Sunday, June 9th, we hosted our 20th anniversary party for all Addgenies to celebrate together. We were even able to have many of our remote workers travel to Addgene's headquarters in Watertown, Massachusetts, for the occasion!

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Moving Off the Couch Brings Healthy Aging: Study Finds Benefit

Drugs.com

TUESDAY, June 11, 2024 -- It's tempting to binge-watch TV, but yet another study finds that when it comes to healthy aging, the less time on your sofa, the better.The study looked at 20 years of data on more than 45,000 people taking part in the.

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Major milestone in cutting harmful gases that deplete ozone layer and worsen global warming

Science Daily: Pharmacology News

A new study has revealed significant progress in the drive to reduce levels in the atmosphere of chemicals that destroy Earth's ozone layer, confirming the success of historic regulations limiting their production.

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Expert Panel Develops New Definition of Long COVID

Drugs.com

TUESDAY, June 11, 2024 -- A new proposed definition for Long COVID could help patients get the help they need, a new report from the National Academies of Sciences, Engineering and Medicine says.Long COVID is a chronic condition that occurs after.

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ADCs are in focus. Here’s where AstraZeneca, AbbVie hope to take the field next.

BioPharma Drive: Drug Pricing

Newer components and drug combinations could expand use of the targeted cancer medicines, according to company executives.

Drugs 107
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Wind from black holes may influence development of surrounding galaxies

Science Daily: Pharmacology News

Clouds of gas in a distant galaxy are being pushed faster and faster -- at more than 10,000 miles per second -- out among neighboring stars by blasts of radiation from the supermassive black hole at the galaxy's center. It's a discovery that helps illuminate the way active black holes can continuously shape their galaxies by spurring on or snuffing out the development of new stars.

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#WhyIScience Q&A: A biochemist uses mass spectrometry to find proteins involved in cancer

Broad Institute

#WhyIScience Q&A: A biochemist uses mass spectrometry to find proteins involved in cancer By Corie Lok June 11, 2024 Breadcrumb Home #WhyIScience Q&A: A biochemist uses mass spectrometry to find proteins involved in cancer Moe Haines talks about how his open-minded approach to science led him to pursue a career in proteomics. By Claire Hendershot June 11, 2024 Credit: Allison Colorado, Broad Communications Moe Haines is a senior research associate in the Proteomics Platform at Broad.

Science 105
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Driving Toward Nanopores

Codon

An organism’s entire genome can be sequenced today using little more than a laptop and a $1,000 device, slightly larger than a smartphone, called a nanopore sequencer. The smallest of these measures just four by one-and-a-half inches across and one inch thick. Such a device seems implausible. But these little machines, small enough to fit inside a pocket, have become commonplace.

DNA 71
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Celebrating Pride Across the World: A Reflection on the 10 10 10s Event

Perficient: Drug Development

In many places around the world, June is considered Pride Month. We kicked off Pride Month by celebrating the launch of PRISM, Perficient’s newest ERG dedicated to creating safe spaces for understanding, education, and culture focused on respect, recognition, and learning for the LGBT+ community and allies. PRIDE Month Realness For our first event, we proudly launched our inaugural Perficient Ball, “10 10 10 ‘ s – Celebrating Pride Across the World.” This event was an epic

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Taking a GLP-1 Medicine? Here's What Experts Say You Should Eat

Drugs.com

TUESDAY, June 11, 2024 -- Folks using a weight-loss drugs like Ozempic, Wegovy or Zepbound still have nutritional requirements for good health, even if they’re eating less.A new set of nutritional recommendations are expected to help people remain h.

Drugs 64
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Women in Stem with Joanne Kanaan

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I knew I’d be heading into STEM from a very young age. When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology.

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Donanemab approval would fuel growth of amyloid-blocking Alzheimer’s drugs, analysts say

BioPharma Drive: Drug Pricing

After an FDA panel backed the experimental Lilly drug, Wall Street analysts see its likely clearance as benefiting Eisai and Biogen’s rival Leqembi.

FDA 67