Drug Discovery World
JUNE 11, 2024
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting concluding this week, the headline news has all focused on breakthrough cancer research shared at the event.
Science Daily: Pharmacology News
JUNE 11, 2024
The structure and function of the kidneys is altered by space flight, with galactic radiation causing permanent damage that would jeopardise any mission to Mars, according to a new study led by researchers from UCL.
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Drug Discovery World
JUNE 11, 2024
Researchers have discovered a new biological pathway in inflammatory bowel disease (IBD) and related conditions that can be targeted using existing drugs. About 5% of the world’s population are currently affected by an autoimmune disease, such as IBD, the umbrella term for Crohn’s disease and ulcerative colitis. These diseases are also becoming more common, with over half a million people living with IBD in the UK as of 2022, nearly double the 300,000 previously estimated.
Chemical Biology and Drug Design
JUNE 11, 2024
In this study, we explored the mechanism of action of brusatol in hepatocellular carcinoma. Using RNA-seq and through in vitro and in vivo studies, we determined that brusatol suppresses hepatocellular carcinoma progression by inducing ATF3-mediated ferroptosis. Therefore, our research revealed the biological effect of brusatol treatment and provided ATF3 as a novel therapeutic target and prognostic biomarker for HCC therapy.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
JUNE 11, 2024
Read this whitepaper to: Gain insights into the diverse and complex structures of new molecular formats, often encompassing multiple chains and multiple domains Understand the unique challenges faced during the process development and manufacture of these advanced proteins Explore how characterising these products and developing robust manufacturing processes can help to usher them to market and provide new treatment options for diseases which are currently challenging to treat The post A compre
Science Daily: Pharmacology News
JUNE 11, 2024
Researchers have demonstrated miniature soft hydraulic actuators that can be used to control the deformation and motion of soft robots that are less than a millimeter thick. The researchers have also demonstrated that this technique works with shape memory materials, allowing users to repeatedly lock the soft robots into a desired shape and return to the original shape as needed.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
JUNE 11, 2024
The medicine will join Intercept’s Ocaliva as a treatment option for primary biliary cholangitis. Another drug, from the now Gilead-owned CymaBay, could be cleared for the condition by August.
Drug Discovery World
JUNE 11, 2024
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting concluding this week, the headline news has all focused on breakthrough cancer research shared at the event.
Science Daily: Pharmacology News
JUNE 11, 2024
Researchers are breaking through the difficulties of robotic recognition of various common, yet complex, items. Their layered sensor is equipped with material detection at the surface and pressure sensitivity at the bottom, with a porous middle layer sensitive to thermal changes. An efficient cascade classification algorithm rules out object types in order, from easy to hard, starting with simple categories like empty cartons before moving on to orange peels or scraps of cloth.
Drug Discovery World
JUNE 11, 2024
Biotech Nuclera has been awarded two Innovate UK grants totalling £1.14 ($1.4) million to further develop its eProtein Discovery platform. The funding is made up of a flexible, agile, scalable, and sustainable technologies (FASST) grant awarded in collaboration with DeepMirror, and an Engineering Biology grant. The FASST grant is part of the Innovate UK Transforming Medicines Manufacturing (TMM) programme and has been designed to support and grow the UK’s capabilities in manufacturing medicines
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- A U.S. Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding. Eli Lilly's.
Drug Discovery World
JUNE 11, 2024
The European Medicines Agency has approved a Type II variation to the Summary of Product Characteristics (SmPC) for Kite’s chimeric antigen receptor (CAR)-T cell therapies, Yescarta (axicabtagene ciloleucel) and Tecartus (brexucabtagene autoleucel). The variation includes a reduction in daily hospital safety monitoring for patients following CAR-T cell therapy infusion from 10 to seven days.
Science Daily: Pharmacology News
JUNE 11, 2024
The need to transition away from fossil fuels to more sustainable energy production is critical. That's why a team of researchers is looking at a potential power source that not only produces no carbon emissions but removes carbon as it works: algae.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- Many Louisiana residents are being exposed to a cancer-causing toxic gas that’s used in industrial settings, researchers report.A cutting-edge mobile air-testing lab found dangerous levels of ethylene oxide along large s.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
JUNE 11, 2024
Inspired by the material that makes up oyster and abalone shells, engineers have created a new cement composite that is 17 times more crack-resistant than standard cement and 19 times more able to stretch and deform without breaking. The findings could eventually help increase the crack resistance of a wide range of brittle ceramic materials from concrete to porcelain.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- A test used to gauge whether a college athlete has suffered a concussion is right only half the time and may be useless, new research finds.The test used by the NCAA, which oversees college sports, measures an athlete's.
Science Daily: Pharmacology News
JUNE 11, 2024
By combining forefront X-ray observations with state-of-the-art supercomputer simulations of the buildup of galaxies over cosmic history, researchers have provided the best modeling to date of the growth of the supermassive black holes found in the centers of galaxies.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- Seafood lovers should steer clear of shellfish from Oregon and Washington state because of possible contamination with a paralyzing toxin, the U.S. Food and Drug Administration has warned.In an advisory, the FDA told.
Science Daily: Pharmacology News
JUNE 11, 2024
What scientists previously thought about where Fast Radio Bursts (FRBs) come from is just the tip of the iceberg. A new study details the properties of polarized light from 128 non-repeating FRBs and reveals mysterious cosmic explosions that originated in far-away galaxies, similar to our own Milky Way.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- Astronauts orbiting the Earth tend to suffer from immune system problems such as infections and the reactivation of dormant viruses, even on short-term space flights.That appears to be because a lack of gravity causes the.
Science Daily: Pharmacology News
JUNE 11, 2024
Crater 2, located approximately 380,000 light years from Earth, is one of the largest satellite galaxies of the Milky Way. Extremely cold and with slow-moving stars, Crater 2 has low surface brightness. How this galaxy originated remains unclear. A team of physicists now offers an explanation.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- British retiree David Butler was surprised to find that he had prostate cancer, and that it had spread to the lymph nodes and other places near the prostate.“I had literally no symptoms apart from needing to pee more q.
Science Daily: Pharmacology News
JUNE 11, 2024
A common type of ocean algae plays a significant role in producing a massively abundant compound that helps cool the Earth's climate, new research has discovered.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 — The first all-civilian space mission is shedding light on the potential health risks facing private astronauts.The takeaway: Short-duration spaceflights appear to pose none that are significant.The study sample was small — f.
Science Daily: Pharmacology News
JUNE 11, 2024
A study led by linguists has found that early linguistic signs of dementia can be detected through the study of the natural speech of senior Singaporeans. The novel study revealed that participants with memory-related mild cognitive impairment spoke less and used fewer, but more abstract, nouns that is consistent with the speech pattern of Alzheimer's patients.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- A U.S. Food and Drug Administration advisory panel voted unanimously on Monday to recommend that the benefits of a new drug for Alzheimer's outweigh its harms, which can include brain swelling and bleeding.Eli Lilly's.
Science Daily: Pharmacology News
JUNE 11, 2024
Scientists are peering into the past and uncovering new clues about the early universe. Since light takes a long time to travel through space, they are now able to see how galaxies looked billions of years ago. The astronomers have discovered that spiral galaxies were more common in the early universe than previously thought. The scientists found that nearly 30% of galaxies have a spiral structure about 2 billion years after the universe formed.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- Winston Churchill once said, “Success consists of going from failure to failure without loss of enthusiasm.”It’s one of countless platitudes claiming that failure leads to success.But there’s strong evidence that such a not.
addgene Blog
JUNE 11, 2024
This year marks Addgene's 20th anniversary! We've been celebrating throughout the year, and on Sunday, June 9th, we hosted our 20th anniversary party for all Addgenies to celebrate together. We were even able to have many of our remote workers travel to Addgene's headquarters in Watertown, Massachusetts, for the occasion!
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- It's tempting to binge-watch TV, but yet another study finds that when it comes to healthy aging, the less time on your sofa, the better.The study looked at 20 years of data on more than 45,000 people taking part in the.
BioPharma Drive: Drug Pricing
JUNE 11, 2024
Newer components and drug combinations could expand use of the targeted cancer medicines, according to company executives.
Drugs.com
JUNE 11, 2024
TUESDAY, June 11, 2024 -- A new proposed definition for Long COVID could help patients get the help they need, a new report from the National Academies of Sciences, Engineering and Medicine says.Long COVID is a chronic condition that occurs after.
Science Daily: Pharmacology News
JUNE 11, 2024
A new study has revealed significant progress in the drive to reduce levels in the atmosphere of chemicals that destroy Earth's ozone layer, confirming the success of historic regulations limiting their production.
Broad Institute
JUNE 11, 2024
#WhyIScience Q&A: A biochemist uses mass spectrometry to find proteins involved in cancer By Corie Lok June 11, 2024 Breadcrumb Home #WhyIScience Q&A: A biochemist uses mass spectrometry to find proteins involved in cancer Moe Haines talks about how his open-minded approach to science led him to pursue a career in proteomics. By Claire Hendershot June 11, 2024 Credit: Allison Colorado, Broad Communications Moe Haines is a senior research associate in the Proteomics Platform at Broad.
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