Drug Discovery World

JULY 10, 2024

Aptamer Group and AstraZeneca have entered a collaboration agreement to evaluate Aptamer’s Optimer fibrotic liver delivery vehicles for the targeted delivery of small interfering RNA (siRNA). Following the encouraging results achieved to-date with Aptamer’s fibrotic liver delivery vehicles, the next phase of the research will explore the potential of the non-viral delivery vehicle and its applicability with a tool siRNA.

RNA 162

RNA International Therapies Marketing 162

Broad Institute

JULY 10, 2024

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.

Engineering 145

Engineering Packaging DNA Treatment 145

Drug Discovery World

JULY 10, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The ‘dark matter’ behind cancer and Could this ‘Goldilocks’ drug be a non-toxic way to treat breast cancer? In the first article, DDW Editor Reece Armstrong looks into recent research which may explain why cancers can become more aggressive.

Research 147

Research Clinical Trials Trials Drugs 147

Science Daily: Pharmacology News

JULY 10, 2024

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

Immune Response 127

Immune Response Disease 127

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JULY 10, 2024

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: The ‘dark matter’ behind cancer and Could this ‘Goldilocks’ drug be a non-toxic way to treat breast cancer? In the first article, DDW Editor Reece Armstrong looks into recent research which may explain why cancers can become more aggressive.

Research 130

Research Clinical Trials Trials Drugs 130

Science Daily: Pharmacology News

JULY 10, 2024

Engineers have developed a new soft, flexible device that makes robots move by expanding and contracting -- just like a human muscle. To demonstrate their new device, called an actuator, the researchers used it to create a cylindrical, worm-like soft robot and an artificial bicep. In experiments, the cylindrical soft robot navigated the tight, hairpin curves of a narrow pipe-like environment, and the bicep was able to lift a 500-gram weight 5,000 times in a row without failing.

Engineering 127

Engineering Research 127

Science Daily: Pharmacology News

JULY 10, 2024

Researchers have achieved a significant breakthrough in quantum materials, potentially setting the stage for advancements in topological superconductivity and robust quantum computing.

Research 120

Research 120

Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- Colorado health officials on Tuesday confirmed a case of human plague in that state.The infection -- which occurred in Pueblo County, in the southern part of the state -- was first reported Friday based on preliminary.

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Science Daily: Pharmacology News

JULY 10, 2024

The surprising discovery of a new species of extinct crocodile relative from the Triassic Favret Formation of Nevada, USA, rewrites the story of life along the coasts during the first act of the Age of Dinosaurs. The new species Benggwigwishingasuchus eremicarminis reveals that while giant ichthyosaurs ruled the oceans, the ancient crocodile kin known as pseudosuchian archosaurs ruled the shores across the Middle Triassic globe between 247.2 and 237 million years ago.

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Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- A newly discovered hormone could help fight osteoporosis and quickly heal broken bones, researchers say. The research team identified Maternal Brain Hormone while trying to figure out why the bones of breastfeeding women.

Research 94

Research 94

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

JULY 10, 2024

In preclinical studies, a team of researchers report new findings on a therapeutic combination that regenerated human insulin-producing beta cells, providing a possible new treatment for diabetes.

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Treatment Research 113

Drug Patent Watch

JULY 10, 2024

This is an example from the DrugPatentWatch AI Research Assistant, which is available with DrugPatentWatch subscriptions.

Marketing 105

Marketing Pharmaceuticals Research 105

Science Daily: Pharmacology News

JULY 10, 2024

Cystic fibrosis is one of the most common genetic disorders, causing thick mucus build-up in the lungs and other parts of the body, breathing problems, and infection. Now, researchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. With further development, it could pave the way for treatments that are administered only once and have fewer side effects.

Treatment 102

Treatment Research 102

Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- Many Americans like the idea of receiving hospital-level care at home, believing they'd recover from their ills faster and without safety risks. "Patients of course want the best-quality care, but often prefer to be at.

Hospitals 84

Hospitals 84

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JULY 10, 2024

A record-breaking swim by two lion brothers across a predator-infested African river has been documented in a new study. The researchers say the 1km swim is another example of iconic wildlife species having to make tough decisions to find homes and mates in a human-dominated world.

Research 100

Research 100

Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- Few Americans understand the health risks of drinking raw milk, a new survey shows, so experts are redoubling efforts to get the word out on its dangers.The push dovetails with the discovery this spring of bird flu virus.

Virus 81

Virus 81

Science Daily: Pharmacology News

JULY 10, 2024

Most known black holes are either extremely massive, like the supermassive black holes that lie at the cores of large galaxies, or relatively lightweight, with a mass of under 100 times that of the Sun. Intermediate-mass black holes (IMBHs) are scarce, however, and are considered rare 'missing links' in black hole evolution.

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BioPharma Drive: Drug Pricing

JULY 10, 2024

Having recently withdrawn its only product from the market, Amylyx hopes to rebound with a drug that regulates GLP-1 activity and is poised to enter pivotal testing early next year.

Regulations 78

Regulations Drugs Production Marketing 78

Science Daily: Pharmacology News

JULY 10, 2024

The most complete dinosaur discovered in the UK in the last 100 years, with a pubic hip bone the size of a 'dinner plate', has been described in a new article.

Research 103

Research 103

Drugs.com

JULY 10, 2024

TUESDAY, July 10, 2024 -- An experimental “air mask” could help ward off infectious diseases while people are on the job, researchers report.The mask uses an air curtain blowing down from the brim of a hard hat to prevent airborne viruses from rea.

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Virus Disease Research 76

Science Daily: Pharmacology News

JULY 10, 2024

New evidence of changes to the Gulf Stream during the last ice age could indicate additional sensitivity to future climatic changes, finds a new study.

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Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- Osteoarthritis could nearly triple a person’s risk of developing a multitude of other chronic illnesses, a new two-decade study finds.People with osteoarthritis (OA) -- where cartilage breaks down, allowing bones to rub a.

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Science Daily: Pharmacology News

JULY 10, 2024

New research indicates that babies can begin grasping complex language and ideas.

Research 128

Research 128

Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- While exposure to raw cow's milk infected with the H5N1 avian influenza virus can make you sick, a new study suggests the virus may not spread quickly to other people.Researchers at the University of Wisconsin-Madison.

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Virus 67

Science Daily: Pharmacology News

JULY 10, 2024

Up to 60% of near-Earth objects could be dark comets, mysterious asteroids that orbit the sun in our solar system that likely contain or previously contained ice and could have been one route for delivering water to Earth, according to a new study.

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Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- The second person to receive a kidney from a genetically modified pig has died, surgeons at NYU Langone Health announced Tuesday.The 54-year-old patient, Lisa Pisano, had both kidney failure and heart failure. She.

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Science Daily: Pharmacology News

JULY 10, 2024

Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe's populations long before the major plague outbreaks of the Middle Ages, new research shows.

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DNA Research 84

BioPharma Drive: Drug Pricing

JULY 10, 2024

Antitrust regulators are set to file suit against CVS Caremark, Express Scripts and Optum Rx over how they negotiate discounts for drugs, including insulin, per the report.

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Regulations Drugs 67

Science Daily: Pharmacology News

JULY 10, 2024

The question of whether Mars ever supported life has captivated the imagination of scientists and the public for decades. Central to the discovery is gaining insight into the past climate of Earth's neighbor: was the planet warm and wet, with seas and rivers much like those found on our own planet? Or was it frigid and icy, and therefore potentially less prone to supporting life as we know it?

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Drugs.com

JULY 10, 2024

WEDNESDAY, July 10, 2024 -- For years, Marty Kedian had been without a voice.Kedian, who hails from Haverhill, Mass., has undergone dozens of surgeries while being treated for a rare form of laryngeal cancer.As a result, he was robbed of his voice.

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Doctors 64

Science Daily: Pharmacology News

JULY 10, 2024

An unexpected find has enabled important progress to be made in the battle against harmful bacteria.

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BioPharma Drive: Drug Pricing

JULY 10, 2024

With more Americans taking obesity medications, adjacent businesses are offering supportive services to offset side effects, collect data and document new health benefits.

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Drugs 60

Quanticate

JULY 10, 2024

Bayesian Optimal Interval (BOIN) design are growing in popularity due to their statistical robustness, practical applicability and simplicity. Learn more.

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Clinical Trials Trials 64

BioPharma Drive: Drug Pricing

JULY 10, 2024

The latest round of funding comes as biotech company creator adds executives and prepares to grow more life sciences startups.

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Science 73