Wed.Jul 10, 2024

article thumbnail

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

Broad Institute

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.

article thumbnail

A new twist on artificial 'muscles' for safer, softer robots

Science Daily: Pharmacology News

Engineers have developed a new soft, flexible device that makes robots move by expanding and contracting -- just like a human muscle. To demonstrate their new device, called an actuator, the researchers used it to create a cylindrical, worm-like soft robot and an artificial bicep. In experiments, the cylindrical soft robot navigated the tight, hairpin curves of a narrow pipe-like environment, and the bicep was able to lift a 500-gram weight 5,000 times in a row without failing.

article thumbnail

Case of Human Plague Confirmed in Colorado

Drugs.com

WEDNESDAY, July 10, 2024 -- Colorado health officials on Tuesday confirmed a case of human plague in that state.The infection -- which occurred in Pueblo County, in the southern part of the state -- was first reported Friday based on preliminary.

111
111
article thumbnail

Scientists discover a cause of lupus and a possible way to reverse it

Science Daily: Pharmacology News

Scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Most Americans Would Welcome Hospital Care at Home, Survey Shows

Drugs.com

WEDNESDAY, July 10, 2024 -- Many Americans like the idea of receiving hospital-level care at home, believing they'd recover from their ills faster and without safety risks. "Patients of course want the best-quality care, but often prefer to be at.

Hospitals 104
article thumbnail

A breakthrough on the edge: One step closer to topological quantum computing

Science Daily: Pharmacology News

Researchers have achieved a significant breakthrough in quantum materials, potentially setting the stage for advancements in topological superconductivity and robust quantum computing.

Research 119

More Trending

article thumbnail

A new species of extinct crocodile relative rewrites life on the Triassic coastline

Science Daily: Pharmacology News

The surprising discovery of a new species of extinct crocodile relative from the Triassic Favret Formation of Nevada, USA, rewrites the story of life along the coasts during the first act of the Age of Dinosaurs. The new species Benggwigwishingasuchus eremicarminis reveals that while giant ichthyosaurs ruled the oceans, the ancient crocodile kin known as pseudosuchian archosaurs ruled the shores across the Middle Triassic globe between 247.2 and 237 million years ago.

113
113
article thumbnail

Researchers Discover New Hormone That Builds Strong Bones

Drugs.com

WEDNESDAY, July 10, 2024 -- A newly discovered hormone could help fight osteoporosis and quickly heal broken bones, researchers say. The research team identified Maternal Brain Hormone while trying to figure out why the bones of breastfeeding women.

article thumbnail

Combination treatment can increase human insulin-producing cells in vivo

Science Daily: Pharmacology News

In preclinical studies, a team of researchers report new findings on a therapeutic combination that regenerated human insulin-producing beta cells, providing a possible new treatment for diabetes.

Treatment 113
article thumbnail

Scientists Develop High-Tech 'Air Mask' to Ward Off Viruses

Drugs.com

TUESDAY, July 10, 2024 -- An experimental “air mask” could help ward off infectious diseases while people are on the job, researchers report.The mask uses an air curtain blowing down from the brim of a hard hat to prevent airborne viruses from rea.

Virus 97
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

Science Daily: Pharmacology News

Cystic fibrosis is one of the most common genetic disorders, causing thick mucus build-up in the lungs and other parts of the body, breathing problems, and infection. Now, researchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. With further development, it could pave the way for treatments that are administered only once and have fewer side effects.

Treatment 102
article thumbnail

Osteoarthritis Raises Risk of Other Chronic Health Conditions

Drugs.com

WEDNESDAY, July 10, 2024 -- Osteoarthritis could nearly triple a person’s risk of developing a multitude of other chronic illnesses, a new two-decade study finds.People with osteoarthritis (OA) -- where cartilage breaks down, allowing bones to rub a.

95
article thumbnail

Lion with nine lives breaks record with longest swim in predator-infested waters

Science Daily: Pharmacology News

A record-breaking swim by two lion brothers across a predator-infested African river has been documented in a new study. The researchers say the 1km swim is another example of iconic wildlife species having to make tough decisions to find homes and mates in a human-dominated world.

article thumbnail

Raw Milk Exposure a Real Bird Flu Risk for Humans, but Fast Spread Unlikely

Drugs.com

WEDNESDAY, July 10, 2024 -- While exposure to raw cow's milk infected with the H5N1 avian influenza virus can make you sick, a new study suggests the virus may not spread quickly to other people.Researchers at the University of Wisconsin-Madison.

Virus 94
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Strong evidence for intermediate-mass black hole in Omega Centauri

Science Daily: Pharmacology News

Most known black holes are either extremely massive, like the supermassive black holes that lie at the cores of large galaxies, or relatively lightweight, with a mass of under 100 times that of the Sun. Intermediate-mass black holes (IMBHs) are scarce, however, and are considered rare 'missing links' in black hole evolution.

99
article thumbnail

Second Recipient of Genetically Modified Pig Kidney Has Died

Drugs.com

WEDNESDAY, July 10, 2024 -- The second person to receive a kidney from a genetically modified pig has died, surgeons at NYU Langone Health announced Tuesday.The 54-year-old patient, Lisa Pisano, had both kidney failure and heart failure. She.

94
article thumbnail

Research reveals the most complete dinosaur discovered in the UK in a century

Science Daily: Pharmacology News

The most complete dinosaur discovered in the UK in the last 100 years, with a pubic hip bone the size of a 'dinner plate', has been described in a new article.

Research 102
article thumbnail

Doctors Perform Larynx Transplant in Cancer Patient

Drugs.com

WEDNESDAY, July 10, 2024 -- For years, Marty Kedian had been without a voice.Kedian, who hails from Haverhill, Mass., has undergone dozens of surgeries while being treated for a rare form of laryngeal cancer.As a result, he was robbed of his voice.

Doctors 91
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

The Gulf Stream is wind-powered and could weaken from climate change

Science Daily: Pharmacology News

New evidence of changes to the Gulf Stream during the last ice age could indicate additional sensitivity to future climatic changes, finds a new study.

98
article thumbnail

Amylyx, with GLP-1 buy, doubles down on blood sugar drugs

BioPharma Drive: Drug Pricing

Having recently withdrawn its only product from the market, Amylyx hopes to rebound with a drug that regulates GLP-1 activity and is poised to enter pivotal testing early next year.

article thumbnail

The origins of dark comets

Science Daily: Pharmacology News

Up to 60% of near-Earth objects could be dark comets, mysterious asteroids that orbit the sun in our solar system that likely contain or previously contained ice and could have been one route for delivering water to Earth, according to a new study.

86
article thumbnail

Viagra’s Resilience in the Face of Generic Competition: A Pharmaceutical Market Analysis

Drug Patent Watch

This is an example from the DrugPatentWatch AI Research Assistant, which is available with DrugPatentWatch subscriptions.

article thumbnail

Creativity starts in the cradle, new research shows

Science Daily: Pharmacology News

New research indicates that babies can begin grasping complex language and ideas.

Research 129
article thumbnail

FTC to sue three largest PBMs over drug price practices: WSJ

BioPharma Drive: Drug Pricing

Antitrust regulators are set to file suit against CVS Caremark, Express Scripts and Optum Rx over how they negotiate discounts for drugs, including insulin, per the report.

article thumbnail

The plague may have caused the downfall of the Stone Age farmers

Science Daily: Pharmacology News

Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe's populations long before the major plague outbreaks of the Middle Ages, new research shows.

DNA 84
article thumbnail

As GLP-1 drugs boom, other healthcare companies are cashing in

BioPharma Drive: Drug Pricing

With more Americans taking obesity medications, adjacent businesses are offering supportive services to offset side effects, collect data and document new health benefits.

Drugs 60
article thumbnail

Molecular atlas of blood vessel pathways in the human brain, across early brain development, adulthood and disease

Science Daily: Pharmacology News

Researchers have built the first-ever molecular atlas of the human brain vasculature at single-cell resolution, spanning from early development to adulthood and through disease stages such as brain tumors and brain vascular malformations.

Disease 85
article thumbnail

Flagship raises $3.6B for biotech investing

BioPharma Drive: Drug Pricing

The latest round of funding comes as biotech company creator adds executives and prepares to grow more life sciences startups.

Science 73
article thumbnail

Big gain in battle against harmful bacteria

Science Daily: Pharmacology News

An unexpected find has enabled important progress to be made in the battle against harmful bacteria.

94
article thumbnail

BOIN Design in Early Phase Clinical Trials

Quanticate

Bayesian Optimal Interval (BOIN) design are growing in popularity due to their statistical robustness, practical applicability and simplicity. Learn more.

article thumbnail

The molecule that could alleviate stroke-related brain injury

Science Daily: Pharmacology News

New research identifies novel path to protecting the brain from stroke-induced damage.

article thumbnail

Which pharmaceutical drugs have the most drug patents in Chile?

Drug Patent Watch

This chart shows the drugs with the most patents in Chile. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

article thumbnail

Power to the Patient with Patient Generated Health Data

FDA Law Blog: Biosimilars

By Adrienne R. Lenz, Principal Medical Device Regulation Expert — FDA’s Center for Devices and Radiological Health (CDRH) recently partnered with the Digital Medicine Society (DiMe) to host a two-day workshop to help advance the use of patient-generated health data (PGHD) to support improved clinical trials, medical device development, and regulatory science.