Chemical Biology and Drug Design

AUGUST 19, 2024

A series of quinoline(quinolinone) derivatives were designed and synthesized based on pharmacophore. Among them, 19d exhibits potent antiproliferative and NOXs inhibitory activities, suggesting its potential value for further research. ABSTRACT NADPH oxidases (NOXs) are the sole enzyme in the human body that can directly produce reactive oxygen species.

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Treatment Research 100

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections. By Ari Navetta August 19, 2024 Credit: Meilin Zhu Lactobacillus iners after treatment with oleic acid Related people Paul Blainey Related programs Metabolomi

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Hospitals Treatment Medical Schools Science 121

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Iron deficiency isn’t being effectively treated in the United States, with low iron levels persisting for years in most patients, a new study finds.Almost 3 of 5 (58%) patients with iron deficiency still had low iron levels.

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Treatment 116

Science Daily: Pharmacology News

AUGUST 19, 2024

Fireflies rely on flashing signals to communicate to other fireflies using light-emitting lanterns on their abdomens. In fireflies of the species Abscondita terminalis, males make multi-pulse flashes with two lanterns to attract females, while females make single-pulse flashes with their one lantern to attract males. Now researchers have evidence that an orb-weaving spider (Araneus ventricosus) manipulates the flashing signals of male fireflies ensnared in its web such that they mimic the typica

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Research 108

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Perficient: Drug Development

AUGUST 19, 2024

We are witnessing a sea-change in the way data is managed by banks and financial institutions all over the world. Data being commoditized and, in some cases, even monetized by banks is the order of the day. Though this seems to be at a stage where some more push is required in terms of adoption in the risk management function. Traditional risk managers, by their job definition, are highly cautious of the result sets provided by the analytics teams.

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Regulations Government Marketing Compliance 109

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- The crowded microbial space of the human gut is revealing potential routes to new antibiotics, scientists report.Molecules isolated from studying the gut's microbiome have yielded unexpected results that could lead to new.

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Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- A brain implant guided by AI could provide around-the-clock personalized care for people with Parkinson’s disease, a new study suggests.The implant uses AI to monitor a patient’s brain activity for changes that can cause mov.

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Disease 105

Science Daily: Pharmacology News

AUGUST 19, 2024

Two new studies are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and insomnia at night.

Disease 101

Disease 101

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- A fish might hold clues to healing spinal cord injuries in humans, researchers report.The damaged nerve cells of zebrafish can survive a spinal cord injury, eventually restoring full movement in the fish.That’s very unlike h.

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Research 105

Science Daily: Pharmacology News

AUGUST 19, 2024

Finding the next groundbreaking polymer is always a challenge, but now researchers are using artificial intelligence (AI) to shape and transform the future of the field.

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Research 98

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- "Stealth" foods are sneaking saturated fat and added sugars into even the strictest diets, a new study shows.Most saturated fats and added sugars come from well-known sources – soft drinks, cheese, pizza, ice cream, cakes a.

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Science Daily: Pharmacology News

AUGUST 19, 2024

The avian influenza virus needs to mutate to cross the species barrier and to infect and replicate within mammalian cells. Scientists have now deciphered the structure of the avian influenza virus's polymerase when it interacts with a human protein essential for the virus to replicate within the cell. The structure of this replication complex provides important information about the mutations that avian influenza polymerase must undergo to adapt to mammals, including humans.

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Virus 95

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Millions of Americans -- mostly younger adults -- could be unable to work due to the lingering symptoms of Long COVID, a new study says.About 14% of working-age people with Long COVID symptoms hadn’t returned to their jobs w.

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BioPharma Drive: Drug Pricing

AUGUST 19, 2024

A new wave of antipsychotics could improve patient adherence. The race to corner this large projected market is already getting tight.

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Marketing Drugs 113

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Bored?Zipping through online videos isn’t going to help you, a new study shows.Watching short snippets of videos or fast-forwarding through them makes people more bored rather than less, according to the results of seven e.

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Science Daily: Pharmacology News

AUGUST 19, 2024

The design of streets and layout of buildings have an impact on a city's resilience in the face of increasingly severe floods brought on by climate change. Researchers look at buildings and other urban structures as physicists consider elements in complex material systems. With this insight, the researchers have developed a new approach to urban flood modelling and found their results helpful in analyzing city-to-city variations in flood risk globally.

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Research 90

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- All 23 known species of the bacteria that cause Lyme disease have now been genetically mapped, providing an aid to better diagnosis and research."This comprehensive, high-quality sequencing investigation of Lyme disease and.

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Disease Research 104

Science Daily: Pharmacology News

AUGUST 19, 2024

The sea anemone Nematostella vectensis is potentially immortal. Using molecular genetic methods, developmental biologists have now identified possible candidates for multipotent stem cells in the sea anemone for the first time. These stem cells are regulated by evolutionary highly conserved genes.

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Regulations 80

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Covalent Modifiers

AUGUST 19, 2024

Isabel Mathiesen, Ewen Calder, Simone Kunzelmann, Louise Walport ChemRxiv , 2024 [link] Covalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity. Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weakly reactive warhead proximal to a suitable residue in the target.

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Drugs 81

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Perdue Foods has recalled over 167,000 pounds of chicken nuggets and tenders after consumers complained of finding bits of metal in the products.The recall covers select lots of Perdue Breaded Chicken Tenders, Butcher Box.

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Production 85

Science Daily: Pharmacology News

AUGUST 19, 2024

A view into how nanoscale building blocks can rearrange into different organized structures on command is now possible with an approach that combines an electron microscope, a small sample holder with microscopic channels, and computer simulations, according to a new study.

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Research 72

Drugs.com

AUGUST 19, 2024

MONDAY, Aug. 19, 2024 -- Across rural America, the increased presence of loaded guns in homes and vehicles could lead to a spike in gun injuries and homicides at the start of every deer hunting season, a new study warns.In fact, in the U.S. rural.

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BioPharma Drive: Drug Pricing

AUGUST 19, 2024

The new factory, which Novo is committing some $220 million to build, will supply raw materials for the company’s chronic disease medicines.

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Disease Drugs 60

keypoint

AUGUST 19, 2024

We have some big news to share, with the announcement of our new President and Chief Executive Officer, Dr. James Baumgartner! James (Jamie) Baumgartner, PhD, has spent the majority of his career in pharmaceutical drug discovery and development with a focus on accelerating timelines and success probability for moving drug candidates into human clinical trials.

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Clinical Trials Drug Development Science Pharmaceuticals 52

Fierce BioTech

AUGUST 19, 2024

As advancements in medical science progress, clinical research and development (R&D) are subject to more sophisticated and complex study designs and protocols that require precise global coordi | Market Insights: What’s Driving the Shift Toward FSP Models in Clinical Development?

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Clinical Development Marketing Clinical Research Science 52

Drug Patent Watch

AUGUST 19, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs Marketing 52

Perficient: Drug Development

AUGUST 19, 2024

Introduction In the realm of software testing, managing and executing test cases efficiently is crucial for maintaining high-quality standards. Katalon Studio’s dynamic test suite collection feature offers a sophisticated approach to organizing and executing test cases based on various criteria. By integrating tags with dynamic test suite collection, you can create highly flexible and targeted test suites that adapt to evolving testing needs.

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Government 52

Quanticate

AUGUST 19, 2024

In recent years the requirement for maintaining a robust audit trail has become crucial for ensuring data integrity, transparency, and compliance with regulatory requirements. An audit trail is a comprehensive log that records all activities, including modifications, additions, and deletions of data, within a clinical trial. It acts as a chronological record that helps trace the path of data, providing evidence that the data collected was performed in accordance with the protocol and regulatory

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Regulations Clinical Research Clinical Trials Compliance 52

Perficient: Drug Development

AUGUST 19, 2024

Introduction Efficient test management is essential in software testing, and Katalon Studio’s tagging feature offers a powerful way to categorize and manage your test cases. This advanced guide delves into the nuances of using tags in Katalon Studio, providing insights to help you optimize your test management strategies, including examples from Salesforce testing.

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Government 52

thought leadership

AUGUST 19, 2024

Importance of Quality Assurance in Clinical-Phase Drug Manufacturing Quality Assurance (QA) is a critical function in the pharmaceutical industry , ensuring that every aspect of drug manufacturing meets predefined standards of quality. In the context of clinical-phase drug manufacturing, QA encompasses a range of activities designed to ensure that investigational drugs are produced consistently and meet the stringent requirements necessary for clinical trials.

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Compliance Clinical Trials Drugs Drug Development 52

Perficient: Drug Development

AUGUST 19, 2024

This holiday season, what difference will 3.6 seconds make? For your e-commerce site’s load time, it will mean a significant difference in revenue. Slow page load times directly correlate to decreased profitability and conversions. For example, a page loading in 2.4 seconds converts at 2%, while a page taking 6 seconds to load will only convert at 0.6%.

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BioPharma Drive: Drug Pricing

AUGUST 19, 2024

Partner MediLink Therapeutics is limiting the drug’s dosing after reports of lowered white blood cell counts and inflammation of the digestive tract.

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FDA Drugs 56

Perficient: Drug Development

AUGUST 19, 2024

Hello Trailblazers! Salesforce Experience Cloud (formerly Community Cloud) is a powerful platform that allows businesses to create engaging and personalized online communities, portals, and websites for their customers, partners, and employees. Activating an Experience Cloud site is a crucial step in harnessing the platform’s potential to enhance customer experience and drive business success.

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Licensing Licensing 52