Wed.Oct 23, 2024

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Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.

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Aerobic Exercise May Ease 'Brain Fog' of Breast Cancer Chemo

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Women fighting breast cancer can relieve some of their chemotherapy “brain fog” through aerobic exercise, a new clinical trial in Canada suggests.Breast cancer patients on chemo who participated in a regular aerobics cla.

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What standing on one leg can tell you: Biological age

Science Daily: Pharmacology News

How long a person can stand -- on one leg -- is a more telltale measure of aging than changes in strength or gait, according to new research.

Research 335
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Cutting Back on Carbs Could Help Folks With Type 2 Diabetes

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Type 2 diabetes is caused in part by the failure of pancreatic beta cells to respond as they should to blood sugar.Now, new research suggests that switching to a low-carbohydrate diet might correct that beta cell.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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With 'electro-agriculture,' plants can produce food in the dark and with 94% less land, bioengineers say

Science Daily: Pharmacology News

Photosynthesis, the chemical reaction that enables almost all life on Earth, is extremely inefficient at capturing energy -- only around 1% of light energy that a plant absorbs is converted into chemical energy within the plant. Bioengineers propose a radical new method of food production that they call 'electro-agriculture.' The method essentially replaces photosynthesis with a solar-powered chemical reaction that more efficiently converts CO2 into an organic molecule that plants would be genet

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Capturing carbon from the air just got easier

Science Daily: Pharmacology News

In the face of rising CO2 levels, scientists are searching for sustainable ways of pulling carbon dioxide out of the air, so-called direct air capture. A new type of porous material, a covalent organic framework (COF) with attached amines, stands out because of its durability and efficient adsorption and desorption of CO2 at relatively low temperatures.

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Poll Finds Most Americans Stressed Over Election, Future of Nation

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Most Americans say they’re stressed out over the future of the United States and the presidential election, a new poll shows.The Stress in America poll, conducted by the American Psychological Association (APA), found t.

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Physicists discover first 'black hole triple'

Science Daily: Pharmacology News

A surprising discovery about the black hole V404 Cygnus is expanding our understanding of black holes, the objects they can host, and the way they form.

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FDA Appoints New Head of Medical Devices

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- The U.S. Food and Drug Administration announced Tuesday that it has appointed Dr. Michelle Tarver to head its division that oversees medical devices.The appointment of a new director for the Center for Devices and.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Paleontologists discover Colorado 'swamp dweller' that lived alongside dinosaurs

Science Daily: Pharmacology News

The new mammal lived in Colorado 70 to 75 million years ago -- a time when a vast inland sea covered large portions of the state, and animals like sharks, turtles and giant crocodiles abounded.

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MRI Might Spare Rectal Cancer Patients Surgery and Colostomy

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Some rectal cancer patients might be spared surgery and the lifelong need for a colostomy bag if they undergo MRI screening, a new study finds.The scans might accurately predict which patients have a higher odds for.

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Saving the bats: Researchers find bacteria, fungi on bat wings that could help fight deadly white-nose syndrome

Science Daily: Pharmacology News

Bacteria and fungi from the wings of bats could play a significant role in saving them from white-nose syndrome (WNS), a fungal disease affecting the skin of wings and muzzle, which has nearly wiped out vulnerable bat populations across North America.

Research 292
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Election Stressing You Out? An Expert Has Coping Tips

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Stress is flooding the nation as the 2024 U.S. presidential election nears its climax.This stress is only natural, but it can be managed, said Eric Storch, vice chair of psychiatry and behavioral sciences with Baylor.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Researchers use the sounds of healthy coral reefs to encourage growth of a new species of coral larvae

Science Daily: Pharmacology News

Healthy coral reefs echo with a chorus of grunts and purrs from fish feeding, looking for mates, or defending their territories, underscored by the persistent crackling of snapping shrimp. Larval corals use these sounds as cues to decide where to choose a home. The researchers found that now a second species of coral larvae responded to the sounds of a healthy reef played through a speaker, indicating 'acoustic enrichment' encourages coral to settle has the potential to be a widely applicable me

Research 289
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Even at Low Levels, Arsenic in Drinking Water Could Raise Heart Risks

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Long-term exposure to even low levels of arsenic in drinking water can raise a person’s risk of heart disease, a new study warns.Even folks exposed to arsenic levels below the federal limit of 10 micrograms per liter (.

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Immunotherapy blocks scarring, improves heart function in mice with heart failure

Science Daily: Pharmacology News

Researchers have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment, similar to that approved by the FDA to treat other conditions. The findings point to the possibility of developing such immunotherapies for heart failure in patients who have experienced a heart attack or other injury.

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Merck acquires cancer drug startup; Elevidys ex-US sales rise

BioPharma Drive: Drug Pricing

Yale spinout Modifi agreed to sell to Merck for $30 million upfront. Elsewhere, Sangamo plotted a much faster path to market for its Fabry gene therapy.

Therapies 177
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Rocky planets orbiting small stars could have stable atmospheres needed to support life

Science Daily: Pharmacology News

A sequence of events during the evolution of certain rocky planets orbiting M-dwarfs, the most common stars in the universe, creates an atmosphere that would be stable over time. This is true for more temperate planets, orbiting a bit farther from the central star.

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Pfizer’s RSV vaccine cleared by FDA for use in some younger adults

BioPharma Drive: Drug Pricing

Approval of Pfizer's Abrysvo in certain adults aged 18 to 59 years old will expand the number of people eligible for vaccination with the shot.

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'Paleo-robots' to help scientists understand how fish started to walk on land

Science Daily: Pharmacology News

The transition from water to land is one of the most significant events in the history of life on Earth. Now, a team of roboticists, palaeontologists and biologists is using robots to study how the ancestors of modern land animals transitioned from swimming to walking, about 390 million years ago.

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Alto hits new low as depression drug flunks key test

BioPharma Drive: Drug Pricing

While analysts still see value in Alto’s approach to brain drugmaking, investors may have lost some faith, as the biotech’s shares were down by two-thirds Wednesday morning.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The decision to eat may come down to these three neurons

Science Daily: Pharmacology News

Manipulating a newly identified neural circuit can curb appetite -- or spur massive overeating.

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Amgen plans launch of Eylea biosimilar after court ruling

BioPharma Drive: Drug Pricing

With “nerves of steel,” Amgen is getting ready to sell a copycat of Regeneron’s top-selling eye drug Eylea, even as litigation continues.

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New parasite discovered amid decline of California's unique Channel Island fox

Science Daily: Pharmacology News

In the 1990s, the San Miguel Island fox nearly went extinct, with numbers dropping to just 15. A recovery program increased their population by 2010, but from 2014 to 2018, it fell to 30% of its peak due to a new acanthocephalan parasite, exacerbated by a prolonged drought. A research effort employed morphological and molecular methods, alongside necropsy records, to identify the parasite and assess its health impacts on the foxes.

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Common Post-Injury Action by Players Signals Concussion, Study Shows

Drugs.com

WEDNESDAY, Oct. 23, 2024 -- Maybe you've seen a cartoon character shake their head back and forth following a sharp blow -- clearing away whatever stars or birds are circling their noggins.Turns out, that same move might help coaches and physical.

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Machine learning guides researchers to new synthetic genetic switches

Broad Institute

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P. Williams October 23, 2024 Credit: Natalie Velez, Broad Communications, from Gosai and Castro et al 2024.

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