Science Daily: Pharmacology News
OCTOBER 23, 2024
Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.
Broad Institute
OCTOBER 23, 2024
Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P. Williams October 23, 2024 Credit: Natalie Velez, Broad Communications, from Gosai and Castro et al 2024.
Nvidia Developer: Drug Discovery
OCTOBER 23, 2024
Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer technology engineer at NVIDIA, and Ellery Russell, tech lead for the Desmond engine at Schrödinger, explore advanced GPU optimization techniques designed to accelerate molecular dynamics simulati
Broad Institute
OCTOBER 23, 2024
To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives By Leah Eisenstadt October 23, 2024 Breadcrumb Home To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives The Broadbent family worked closely with scientists to discover the unique genetic cause of their daughter’s disease, highlighting the need to examine noncoding parts of the genome when diagnosing rare genetic disorders.
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ASPET
OCTOBER 23, 2024
Previous studies indicated differing effects of dopamine D 1 -like and D 2 -like receptor (D 1 R and D 2 R, respectively) agonists on cocaine self-administration. Leftward shifts by D 2 R agonists in the cocaine self-administration dose-effect function contrast with decreases by D 1 R agonists in maximal cocaine self-administration without rightward or leftward displacement.
The ChEMBL-og
OCTOBER 23, 2024
In the quest to develop new drugs, understanding the 3D structure of molecules is crucial. Resources like the Protein Data Bank in Europe (PDBe) and the Cambridge Structural Database (CSD) provide these 3D blueprints for many biological molecules. However, researchers also need to know how these molecules interact with their biological target – their bioactivity.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
OCTOBER 23, 2024
How long a person can stand -- on one leg -- is a more telltale measure of aging than changes in strength or gait, according to new research.
ASPET
OCTOBER 23, 2024
The Neuropeptide S receptor (NPSR) has been identified as a potential therapeutic target for anxiety and post-traumatic stress disorder. Central administration of Neuropeptide S (NPS) in male mice produces anxiolytic-like effects, hyperlocomotion, and memory enhancement. Currently, the literature is limited in the number of studies investigating the effects of NPS in female test subjects despite females facing a higher prevalence of anxiety-related pathology, as well as greater risk for adverse
Science Daily: Pharmacology News
OCTOBER 23, 2024
In the face of rising CO2 levels, scientists are searching for sustainable ways of pulling carbon dioxide out of the air, so-called direct air capture. A new type of porous material, a covalent organic framework (COF) with attached amines, stands out because of its durability and efficient adsorption and desorption of CO2 at relatively low temperatures.
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- Type 2 diabetes is caused in part by the failure of pancreatic beta cells to respond as they should to blood sugar.Now, new research suggests that switching to a low-carbohydrate diet might correct that beta cell.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
OCTOBER 23, 2024
The new mammal lived in Colorado 70 to 75 million years ago -- a time when a vast inland sea covered large portions of the state, and animals like sharks, turtles and giant crocodiles abounded.
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- An E. coli outbreak tied to McDonald's Quarter Pounders has sickened 49 people in 10 states, killing one and landing 10 more in the hospital.Most of the illnesses have been reported in Colorado and Nebraska, and one.
Science Daily: Pharmacology News
OCTOBER 23, 2024
Photosynthesis, the chemical reaction that enables almost all life on Earth, is extremely inefficient at capturing energy -- only around 1% of light energy that a plant absorbs is converted into chemical energy within the plant. Bioengineers propose a radical new method of food production that they call 'electro-agriculture.' The method essentially replaces photosynthesis with a solar-powered chemical reaction that more efficiently converts CO2 into an organic molecule that plants would be genet
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- Most Americans say they’re stressed out over the future of the United States and the presidential election, a new poll shows.The Stress in America poll, conducted by the American Psychological Association (APA), found t.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
OCTOBER 23, 2024
Bacteria and fungi from the wings of bats could play a significant role in saving them from white-nose syndrome (WNS), a fungal disease affecting the skin of wings and muzzle, which has nearly wiped out vulnerable bat populations across North America.
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- Stress is flooding the nation as the 2024 U.S. presidential election nears its climax.This stress is only natural, but it can be managed, said Eric Storch, vice chair of psychiatry and behavioral sciences with Baylor.
Science Daily: Pharmacology News
OCTOBER 23, 2024
A surprising discovery about the black hole V404 Cygnus is expanding our understanding of black holes, the objects they can host, and the way they form.
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- Long-term exposure to even low levels of arsenic in drinking water can raise a person’s risk of heart disease, a new study warns.Even folks exposed to arsenic levels below the federal limit of 10 micrograms per liter (.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
OCTOBER 23, 2024
Researchers have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment, similar to that approved by the FDA to treat other conditions. The findings point to the possibility of developing such immunotherapies for heart failure in patients who have experienced a heart attack or other injury.
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- The U.S. Food and Drug Administration announced Tuesday that it has appointed Dr. Michelle Tarver to head its division that oversees medical devices.The appointment of a new director for the Center for Devices and.
Science Daily: Pharmacology News
OCTOBER 23, 2024
A sequence of events during the evolution of certain rocky planets orbiting M-dwarfs, the most common stars in the universe, creates an atmosphere that would be stable over time. This is true for more temperate planets, orbiting a bit farther from the central star.
Drugs.com
OCTOBER 23, 2024
WEDNESDAY, Oct. 23, 2024 -- Some rectal cancer patients might be spared surgery and the lifelong need for a colostomy bag if they undergo MRI screening, a new study finds.The scans might accurately predict which patients have a higher odds for.
Fierce BioTech
OCTOBER 23, 2024
In this episode, we dive into the revolutionary work at Turbine Simulated Cell Technologies, where the intersection of artificial intelligence and biology is paving the way for a new era in drug de | Join us on the latest Top Line podcast as we dive into how Turbine Simulated Cell Technologies is reshaping drug development. Discover their innovative approaches to combatting biases in data, leading to more effective cancer treatments.
Science Daily: Pharmacology News
OCTOBER 23, 2024
The transition from water to land is one of the most significant events in the history of life on Earth. Now, a team of roboticists, palaeontologists and biologists is using robots to study how the ancestors of modern land animals transitioned from swimming to walking, about 390 million years ago.
NIOSH Science Blog: Drugs
OCTOBER 23, 2024
Working alone is common in many industries and may introduce safety and health risks for workers. In 2023, the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) formed a partnership to improve safety and health for lone workers by developing and disseminating information about the risks of working alone and promising prevention strategies.
Drug Patent Watch
OCTOBER 23, 2024
When it comes to patent searches, especially in the pharmaceutical industry, accuracy and comprehensiveness are crucial. While Google Patents is a popular tool due to its accessibility and user-friendly interface, it may not be the best resource for finding drug patents. Let’s explore why.
Science Daily: Pharmacology News
OCTOBER 23, 2024
Healthy coral reefs echo with a chorus of grunts and purrs from fish feeding, looking for mates, or defending their territories, underscored by the persistent crackling of snapping shrimp. Larval corals use these sounds as cues to decide where to choose a home. The researchers found that now a second species of coral larvae responded to the sounds of a healthy reef played through a speaker, indicating 'acoustic enrichment' encourages coral to settle has the potential to be a widely applicable me
Drug Patent Watch
OCTOBER 23, 2024
The pharmaceutical industry has faced significant challenges in recent years, including the loss of patents, increased regulatory scrutiny, and rising research and development costs. Amidst these challenges, the concept of patient centricity has gained prominence as a key strategy for improving the drug development process and enhancing patient outcomes.
BioPharma Drive: Drug Pricing
OCTOBER 23, 2024
Yale spinout Modifi agreed to sell to Merck for $30 million upfront. Elsewhere, Sangamo plotted a much faster path to market for its Fabry gene therapy.
Science Daily: Pharmacology News
OCTOBER 23, 2024
Manipulating a newly identified neural circuit can curb appetite -- or spur massive overeating.
BioPharma Drive: Drug Pricing
OCTOBER 23, 2024
Approval of Pfizer's Abrysvo in certain adults aged 18 to 59 years old will expand the number of people eligible for vaccination with the shot.
Drug Target Review
OCTOBER 23, 2024
Technologies for the rapid and efficient testing of small molecules and biologics have greatly accelerated drug discovery. However, many pharmaceutically relelvant targets remain ‘undruggable’. In particular, targeting intracellular protein-protein interactions is a challenge, as biologics have difficulty entering cells and small molecules often do not exhibit sufficient binding affinity and specificity to extended protein surfaces.
BioPharma Drive: Drug Pricing
OCTOBER 23, 2024
While analysts still see value in Alto’s approach to brain drugmaking, investors may have lost some faith, as the biotech’s shares were down by two-thirds Wednesday morning.
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