Fri.Dec 13, 2024

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Tectorigenin Reduces Dabie bandavirus‐Induced Cytokine Storm by Regulating Toll‐Like Receptor 7/Extracellular Signal–Regulated Kinase Pathway

Chemical Biology and Drug Design

Tectorigenin could reduce the expression levels of inflammatory cytokines in both DBV-infected THP-1 cells and plasma samples of IFNAR / mice infected with DBV. ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is a severe emerging infectious disease caused by Dabie bandavirus (DBV). Tectorigenin has been demonstrated to exert anti-inflammatory effect.

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Who Will Pay for Prescription Drugs in 2032: Four Takeaways from the New Government Forecasts (rerun)

Drug Channels

This week, Im rerunning some popular posts while I prepare for todays Drug Channels Outlook 2025 live video webinar. (If you sign up before 12 p.m. ET, you can attend the live event.) Click here to see the original post. The econowonks at the Centers for Medicare & Medicaid Services (CMS) recently released the latest projections for U.S. spending on healthcare.

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Discovery of Voreloxin as a Dual‐Selective Stabilizer for c‐Myc/Bcl‐2 G‐Quadruplexes in Leukemia

Chemical Biology and Drug Design

The stabilization of the G-quadruplex region in the c-Myc and Bcl-2 promoter genes by voreloxin leads to the downregulation of c-Myc and Bcl-2 expression, resulting in apoptosis of leukemia cells. ABSTRACT Overexpression of c-Myc is a key factor in the development of leukemia and other malignancies, highlighting the urgent need for novel drugs to inhibit c-Myc protein levels.

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Vault Snack #27 - Hazard Codes

Collaborative Drug

Vault Snack #27 - Hazard Codes

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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A New Normal: Developer Productivity with Amazon Q Developer

Perficient: Drug Development

Amazon Q was front and center at AWS re:Invent last week. Q Developer is emerging as required tooling for development teams focused on custom development, cloud-native services, and the wide range of legacy modernizations, stack conversions and migrations required of engineers. Q Developer is evolving beyond just code generation and is timing its maturity well alongside the rise of agentic workflows with dedicated agents playing specific roles within a process a familiar metaphor for enterprise

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Vault Snack #26 - Using Saved Searches to Automate Screening

Collaborative Drug

Vault Snack #26 - Using Saved Searches to Automate Screening

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New targeted therapies show promise in lung cancer treatment

Drug Target Review

Lung cancer is the most commonly diagnosed cancer worldwide, representing 12.4 percent of all cases. It is also the leading cause of cancer-related deaths, accounting for 18.7 percent of total cancer fatalities. 1 Lung cancer is primarily classified into two types based on histological examination: Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC).

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Title: Navigating the Generative AI Journey: A Strategic Roadmap for Healthcare Organizations

Perficient: Drug Development

Doctor creating artificial intelligence interface 3D rendering Introduction The healthcare industry stands at a transformative crossroads with generative AI (GenAI) poised to revolutionize care delivery, operational efficiency, and patient outcomes. Recent MIT Technology Review research indicates that while 88% of organizations are using or experimenting with GenAI, healthcare organizations face unique challenges in implementation.

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Newer Drug Imlunestrant Could Be Advance Against Tough-to-Treat Breast Cancers

Drugs.com

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Universal Design for Visual Disabilities in Healthcare – Understanding Visual Disabilities -1

Perficient: Drug Development

Creating a healthcare system that caters to the needs of individuals with visual disabilities is essential for providing inclusive and equitable care. Understanding visual disabilities is the first step towards implementing effective universal design principles in healthcare settings. Here’s a detailed look at visual disabilities and how they impact healthcare access and delivery.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.