Drug Discovery World

FEBRUARY 27, 2024

New studies have demonstrated that Vaxxinity’s vaccine VXX-401 reproducibly lowers low-density lipoprotein cholesterol (LDL-C) in non-human primates. The results support the continued clinical development of VXX-401 as a candidate for the treatment of hypercholesterolemia and prevention of atherosclerotic cardiovascular disease. VXX-401 is a synthetic peptide vaccine designed to stimulate the immune system to produce antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), whi

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BioPharma Drive: Drug Pricing

FEBRUARY 27, 2024

The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.

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Drugs Trials 125

Drug Discovery World

FEBRUARY 27, 2024

CAR-T Therapies have revolutionised the field of personalised medicine, especially in oncology. DDW’s Megan Thomas speaks with Dr Blythe Sather, Vice President and Head of Research at Tune Therapeutics, about how genetic tuning will transform the reach for CAR-T therapies, the different diseases that can benefit, and the disruptive technology making this happen.

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DNA Engineering Therapies Regulations 148

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- Eye ointment products made in India and sold in the United States at Walmart, CVS and other retailers are being recalled due to a danger of infection.Brassica Pharma Pvt. Ltd., of Maharastra, India, said it is recalling.

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Production 119

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 27, 2024

Arvinas has commenced dosing in the Phase I clinical trial of ARV-102, its first oral PROTAC (PROteolysis-TArgeting Chimera) protein degrader in development to treat neurodegenerative diseases. In preclinical studies, ARV-102 has been shown to cross the blood-brain barrier and degrade leucine-rich repeat kinase 2 (LRRK2), which is a large multidomain scaffolding kinase.

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Perficient: Drug Development

FEBRUARY 27, 2024

This time of year, I like to talk about updating the data strategy for the new year to include new business goals and new technology and in doing so I sometimes forget that there are still many companies that do not have a data strategy to update. What is a Data Strategy and why do I need one? Most organizations have multiple data management initiatives underway including master data management, data governance, data migration, data modernization, OLTP operational data cleanup, data ingestion, a

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Government 115

Science Daily: Pharmacology News

FEBRUARY 27, 2024

A new study shows oxygenation levels in the placenta, formed during the last three months of fetal development, are an important predictor of cortical growth (development of the outermost layer of the brain or cerebral cortex) and is likely a predictor of childhood cognition and behavior.

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Drug Discovery World

FEBRUARY 27, 2024

Curve Therapeutics, a company developing an intracellular screening platform to address disease targets, has completed a £40.5 million ($51.37 million) Series A financing round. Pfizer Ventures led the round with participation from Columbus Venture Partners and British Patient Capital, which join founding investor Advent Life Sciences and co-lead from the seed round, Epidarex Capital.

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Clinical Development Disease Science Drugs 130

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- Stuffy, sneezing, miserable: folks plagued by chronic sinusitis know the feeling all too well.Experts at University of Cincinnati Health say it's also an all-too-common affliction, affecting an estimated 14.6% of.

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Antidote

FEBRUARY 27, 2024

We’re here with Antidote’s tenth installment of Talk of the Towne, and it’s a very special one! We recently attended SCOPE 2024, where we met up with our partners at Rare Patient Voice and recorded our first Talk of the Towne episode live and in person.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 2, 2024 -- For nearly a week, prescription drug orders have been disrupted at thousands of pharmacies as the largest health insurer in the United States tries to fully restore services following a cyberattack. The security breach was.

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Pharmacy Drugs 105

Science Daily: Pharmacology News

FEBRUARY 27, 2024

Researchers have not only succeeded in using blue-green algae as a surrogate mother for a new protein -- they have even coaxed the microalgae to produce 'meat fiber-like' protein strands. The achievement may be the key to sustainable foods that have both the 'right' texture and require minimal processing.

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Research 96

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- Weather disasters driven by climate change are stressing out U.S. teenagers, a new study warns.Teens with the most firsthand experience of events like hurricanes, floods, tornadoes, droughts and wildfires were more likely.

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Drug Channels

FEBRUARY 27, 2024

February is longer than usual this year, which means that you’ll have extra time to leap into our monthly curated selection of noteworthy news. In this issue: An update on the retail pharmacy shakeout Arguing for high drug prices A leading researcher provides a 340B reality check Physicians don’t want pharmacists getting uppity Plus, Dave Grohl fights for your right to…have healthcare price transparency?

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- The mind is alert to relaxing words spoken by others when you're asleep, so much so that your heart beat slows down, new research shows.Hearing words like "relax" and "easy" spoken while asleep appeared to help put study.

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Research 98

SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

PITTSBURGH, Feb. 27, 2024 – Bariatric surgery is more effective than medical and lifestyle modifications for achieving long-term Type 2 diabetes control and remission, according to new research led by a University of Pittsburgh School of Medicine surgeon-scientist and published today in JAMA. Credit: UPMC PITTSBURGH, Feb.

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Research 91

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- Tattoos are a trendy way to decorate your body, but a new study reveals that the inks used in the process often contain unlisted substances that could cause health problems. An analysis of tattoo inks from nine.

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SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

A new study shows oxygenation levels in the placenta, formed during the last three months of fetal development, are an important predictor of cortical growth (development of the outermost layer of the brain or cerebral cortex) and is likely a predictor of childhood cognition and behaviour.

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Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- Well-to-do American families are more likely than poorer families to increase their children’s risk of cervical cancer by skipping the human papillomavirus (HPV) vaccine, a new study has found.Nearly two-thirds of.

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Vaccine 98

SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

Bridging precision engineering and precision medicine to create personalized physiology avatars. Pursuing on-demand tissue and organ engineering for human health. Revolutionizing neuroscience by using AI to engineer advanced brain interface systems. Engineering the immune system for health and wellness. Designing and engineering genomes for organism repurposing and genomic perturbations.

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Engineering 87

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- Excess fat around your pancreas could bode ill for the health of your aging brain, new research shows.But maybe only if you're male: The relationship wasn't observed among women, noted the team from Rutgers University in.

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Research 98

SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

Cells actively rely on maintaining an appropriate acid-base balance to support optimal function. Under normal physiological settings, the pH inside cells remains within a controlled range. However, disruptions in this equilibrium have been linked to a wide range of health conditions, both minor and catastrophic.

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Therapies 87

Drugs.com

FEBRUARY 27, 2024

TUESDAY, Feb. 27, 2024 -- One out of every five adults who attempt suicide never met the criteria for a mental illness by the time the attempt happened, new research shows.“This finding challenges clinical notions of who is at risk for suicidal.

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Research 98

SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens, according to researchers at Weill Cornell Medicine in New York and GHESKIO Centers in Haiti.

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Therapies Drugs Research 84

addgene Blog

FEBRUARY 27, 2024

At Addgene, it is our mission to make it easy for you to share plasmids. To achieve this goal, we will archive any plasmids you've deposited with us and distribute them to scientists worldwide. What's more, depositing is free! We've written this post as a step-by-step guide to the online deposit process.

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SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

Every year, over 100 million people worldwide suffer a stroke. Ischemic strokes (cerebral infarction) are the most common, but they can also occur “silently” and therefore often go undetected. This can result in serious illnesses such as dementia, depression or even suicide. In order to determine the risk of stroke at an early stage, Prof.

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BioPharma Drive: Drug Pricing

FEBRUARY 27, 2024

Analysts viewed results for one of Janux’s drug, a T cell engager aimed at metastatic prostate cancer, as potentially best-in-class in a field that’s crowded with competitors.

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Drugs 113

SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

Amyotrophic Lateral Sclerosis (ALS) is a fatal type of motor neuron disease characterized by progressive degeneration of nerve cells in the spinal cord and brain, resulting in muscle weakness and paralysis that can include the inability to walk and speak, or even swallow and breathe.

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NIOSH Science Blog: Drugs

FEBRUARY 27, 2024

The National Institute for Occupational Safety and Health’s (NIOSH) Hearing Loss Prevention Program has been an official member of the World Hearing Forum (WHF) since it was launched in 2019. The Forum was assembled by the Office of Ear and Hearing Care of the World Health Organization to promote ear and hearing care worldwide. NIOSH’s membership to the forum builds upon the Hearing Loss Prevention Program’s long-standing contributions to the prevention of work-related hearing loss.

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SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

BATON ROUGE – People with type 2 diabetes who underwent bariatric surgery achieved much better long-term blood glucose control compared to people who received medical management plus lifestyle interventions, according to a new study published in JAMA, or Journal of the American Medical Association, and funded by the National institute of Diabetes, Digestive and Kidney […]

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Covalent Modifiers

FEBRUARY 27, 2024

Jeyun Jo, Tulsi Upadhyay, Emily C. Woods, Ki Wan Park, Nichole J. Pedowitz, Joanna Jaworek-Korjakowska, Sijie Wang, Tulio A. Valdez, Matthias Fellner, and Matthew Bogyo Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c13974 Staphylococcus aureus (S. aureus) is a major human pathogen that is responsible for a wide range of systemic infections.

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Treatment 70

SCIENMAG: Medicine & Health

FEBRUARY 27, 2024

A study quantifies the emission of extremely tiny particles by gas stoves and finds that the particles could harm human health. Airborne nanoparticles between 1–3 nm, referred to as nanocluster aerosol or NCA, are known to be bioactive and toxic, but measuring such minute particles has been a challenge. Brandon E.

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Drug Patent Watch

FEBRUARY 27, 2024

Annual Drug Patent Expirations for QINLOCK Qinlock is a drug marketed by Deciphera Pharms and is included in one NDA. It is available from one supplier. There are twenty-two patents… The post New patent for Deciphera Pharms drug QINLOCK appeared first on DrugPatentWatch - Make Better Decisions.

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BioPharma Drive: Drug Pricing

FEBRUARY 27, 2024

The agency’s complete response letter knocks back Minerva’s attempt to secure approval of the drug over agency reviewers’ objections.

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FDA Drugs 62