Chemical Biology and Drug Design

FEBRUARY 18, 2024

Sinigrin Protects the Brain from CIR Injury by Reducing Oxidative Stress and Inhibiting the TLR4 Signaling Pathway. Abstract Cerebral ischaemia-reperfusion (CIR) injury occurs in stroke patients after the restoration of cerebral perfusion. Sinigrin, a phytochemical found in cruciferous vegetables, exhibits strong antioxidant activity. This study investigated the role of sinigrin in oxidative stress using a CIR injury model.

Treatment 100

Treatment Research 100

SCIENMAG: Medicine & Health

FEBRUARY 18, 2024

Niigata, Japan – Dr. Yamamoto et al. found the several uremic toxins as one of causes of itching in hemodialysis patients. Hemodialysis patients commonly experience itching on a daily basis, which is distributed throughout their bodies.

85

85

Covalent Modifiers

FEBRUARY 18, 2024

Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-min Zhang, Raquel Ortega, Xiaojing Lin, Adam V. Patterson, Jeff B. Smaill, Yongheng Chen, and Xiaoyun Lu Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01810 Fibroblast growth factor receptor 4 (FGFR4) has been considered as a potential anticancer target due to FGF19/FGFR4 mediated aberrant signaling in hepatocellular carcinoma (HCC).

Drugs 73

Drugs 73

KIF1A

FEBRUARY 18, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias What causes KAND?

Therapies 52

Therapies DNA Clinical Trials Trials 52

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Clinical Trials

Drug Patent Watch

FEBRUARY 18, 2024

This chart shows the pharmaceutical companies with the most patents in Croatia. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Croatia? appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies 59

Pharmaceutical Companies Pharmaceuticals Drugs 59