Fri.Oct 13, 2023

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AI tool predicts new viral variants and could improve vaccines

Drug Discovery World

The UK’s University of Oxford is taking the lead on two collaborative international projects to improve the response to new Covid-19 variants and contribute to future pandemic preparedness. Researchers at Harvard Medical School (HMS) in the US and the University of Oxford have developed a new artificial intelligence (AI) tool named EVEscape that can predict new viral variants before they emerge.

Vaccine 265
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Pfizer to cut costs, lay off staff on waning demand for COVID products

BioPharma Drive: Drug Pricing

Sales of Pfizer's antiviral Paxlovid and shot Comirnaty have been slower than it anticipated, while a shift to the commercial market for the antiviral has been delayed.

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Could a common antiviral treat long Covid?

Drug Discovery World

A UK-based study will investigate whether a common anti-viral medication could double up as a treatment for long Covid. The project involves teams from the University Hospitals of Derby and Burton NHS Foundation Trust and the University of Exeter, in collaboration with Gilead Sciences. Globally, estimates suggest that over 144 million people developed long Covid, with 22 million experiencing persistent symptoms at 12 months after the onset of their infection.

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Latest AI Has 100% Success Rate in Spotting Melanomas

Drugs.com

FRIDAY, Oct. 13, 2023 -- The ability to detect skin cancer using artificial intelligence (AI) software has rapidly improved. New research presented Wednesday at a medical conference in Berlin shows that this AI technology now has a 100% detection.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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This week in drug discovery (9-13 October)  

Drug Discovery World

News round-up for 9-13 October by DDW Digital Content Editor Diana Spencer. The buzz with week has been around Phase I trials, with new therapies for lung cancer, geographic atrophy, Parkinson’s, sarcopenia and long Covid demonstrating positive early results or entering clinical trials for the first time. The top stories: Non-viral gene therapy shows early efficacy in lung cancer Positive Phase I trial data indicates that Reqorsa (quaratusugene ozeplasmid) has shown early efficacy for the treatm

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Some Antidepressants Take Weeks to Kick In, and Scientists May Now Know Why

Drugs.com

THURSDAY, Oct. 12, 2023 -- Most folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay. Scientists have discovered this is because of physical.

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More Than 7 Million Americans Have Gotten the New COVID Shots

Drugs.com

FRIDAY, Oct. 13, 2023 -- Following a rocky rollout, more than 7 million Americans have now gotten the newly updated COVID vaccines. Unfortunately, that’s still lagging behind the number who sought booster shots last fall. For the the first.

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The inner workings of environmental bacterium

Drug Target Review

A team led by Professor Dr Ralf Rabus, a microbiologist at the University of Oldenburg, in collaboration with his doctoral student Patrick Becker, has achieved profound insights into the inner workings of a prevalent environmental bacterium. The scientists meticulously examined the entirety of the metabolic network within the bacterial strain Aromatoleum aromaticum EbN1T, and they utilised the findings to formulate a metabolic model capable of predicting the microorganisms’ growth across v

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Could Tissue-Zapping Procedure Be Non-Antibiotic Option for Recurrent UTIs?

Drugs.com

FRIDAY, Oct. 13, 2023 -- For some older women, recurring urinary tract infections — and the antibiotics typically prescribed for them — become a fact of life, but a new study offers a novel treatment that may deliver relief. Called.

Treatment 105
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GLP-1 drug demand leaves employers in a bind over coverage

BioPharma Drive: Drug Pricing

Employers face a difficult decision over whether to cover the popular weight loss therapies, which cost between $900 and $1,400 for a typical month’s supply at list price.

Therapies 104
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Treatment for Common Rotator Cuff Ailment May Be Useless

Drugs.com

THURSDAY, Oct. 12, 2023 -- Treating shoulder pain with steroid shots or removal of cartilage buildup yields the same result as no treatment at all, a Norwegian research team reports. They said their findings call into question treatment guidelines.

Treatment 105
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For Health Literacy Month, a look into effective patient communication

Antidote

For more than 20 years, October has been deemed Health Literacy Month , a designation aimed at highlighting the importance of health literacy in the United States. An individual's health literacy, including their ability to understand doctors’ guidelines, follow medication instructions, and discuss their symptoms, has a major impact on how individuals interact with the healthcare system — and for medical organizations, it is important to understand how to tailor messaging, collateral, and inform

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Human 'Brain Cell Atlas' Brings New Insight Into Brain Health, Illness

Drugs.com

THURSDAY, Oct. 12, 2023 -- After a massive five-year effort, researchers have unveiled an “atlas” that gives an unprecedented look at the intricacies of the human brain. The atlas, which will be available to researchers everywhere, can.

Research 105
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Pfizer wins FDA approval for its $7B colitis drug

BioPharma Drive: Drug Pricing

Acquired with the buyout of Arena Pharmaceuticals, Velsipity enters a competitive market for ulcerative colitis pills.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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A Bionic Hand Melds With Woman's Own Bone, Nervous System

Drugs.com

THURSDAY, Oct.12, 2023 -- Fifty years ago, the TV series “The Six Million Dollar Man” hyped a futuristic world of life-changing bionics with the stirring phrase: “We can rebuild him, we have the technology.” Cut to 2023, and.

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Not getting enough sleep? Your vascular cells are drowning in oxidants

SCIENMAG: Medicine & Health

NEW YORK, NY–Does this sound like you? You wake up at the same time each morning, get the kids out the door, and rush to catch the subway to work. But at night, maybe you stay up until midnight doing laundry or 1 a.m. to catch up on the bills.

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Hand, Foot & Mouth Disease: What Every Parent Needs to Know About This Common Illness

Drugs.com

THURSDAY, Oct. 12, 2023 - Hand, foot and mouth disease is an infectious disease that’s highly contagious. Common in children, it spreads quickly at day care centers and schools. This guide will tell you what you need to know about hand, foot.

Disease 105
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Amylyx’s ALS drug knocked back again in Europe

BioPharma Drive: Drug Pricing

Following a re-examination, the EMA again concluded that Albrioza — known as Relyvrio in the U.S. — should not be cleared for the European market.

Drugs 73
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Doctor's Group Pulls Paper on 'Excited Delirium,' Often Cited in Cases Involving Excessive Force by Police

Drugs.com

FRIDAY, Oct. 13, 2023 -- A paper that has been used in court cases to justify excessive police force was withdrawn Thursday by the American College of Emergency Physicians, a prominent doctor’s group. The paper, published in 2009, was on a.

Doctors 105
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Tanvex CDMO - Accelerating Biologics to Patients

Fierce BioTech

Many large biopharmaceutical companies have the means to develop their therapeutics, conduct the manufacturing and prepare the regulatory submissions needed to advance these products to the healthc | Reacting to the growth of biotherapeutics, Tanvex BioPharma USA, Inc., is set to launch Tanvex CDMO, a full-service CDMO specializing in mammalian- and microbial-derived biologics and biosimilars.

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Use of Hair Relaxers Raises Women's Odds for Uterine Cancer

Drugs.com

FRIDAY, Oct. 13, 2023 -- Older Black women who use chemical hair relaxers may be more likely to develop uterine cancer, new research suggests. Specifically, postmenopausal Black women who reported using hair relaxers more than twice a year or for.

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Looking to the Future — Improving Diagnosis and Prognosis of Eye Conditions with Artificial Intelligence

Cytel

Written by Alind Gupta, Cytel; Haridarshan Patel, Horizon Therapeutics; and Jason Simeone, Cytel Ophthalmology is well-suited to using artificial intelligence (AI) methods because clinical decisions often rely on complex data-rich information from medical images of the eye and patient health status. AI has revolutionized image data analysis over the last decade and is promising to improve healthcare delivery and clinical decision-making while reducing healthcare costs.

FDA 59
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When Health Care Access Is Equal, Race Gap in Prostate Cancer Survival Vanishes

Drugs.com

THURSDAY, Oct. 12, 2023 -- Men of all races and ethnic groups who have prostate cancer fare equally well when access to care is identical, a new study finds. The disparity in outcomes from prostate cancer between Black, Hispanic and white men.

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New patent for Ipsen Inc drug SOHONOS

Drug Patent Watch

Annual Drug Patent Expirations for SOHONOS Sohonos is a drug marketed by Ipsen Inc and is included in one NDA. It is available from one supplier. The generic ingredient in… The post New patent for Ipsen Inc drug SOHONOS appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59
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New Clues to How Inflammation in Young Children’s Brains Might Spur Autism

Drugs.com

THURSDAY, Oct. 12, 2023 -- Severe inflammation very early in childhood might hamper the development of key brain cells, perhaps setting the stage for conditions such as autism or schizophrenia, new research suggests. The origins of many.

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New patent for Indivior drug PERSERIS KIT

Drug Patent Watch

Annual Drug Patent Expirations for PERSERIS+KIT Perseris Kit is a drug marketed by Indivior and is included in one NDA. It is available from one supplier. There are nine patents… The post New patent for Indivior drug PERSERIS KIT appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59
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When Lung Cancer Strikes the Young, Women Face Higher Risks Than Men

Drugs.com

FRIDAY, Oct. 13, 2023 -- New research uncovers troubling trends for lung cancer in young and middle-aged women. Cancer incidence in young women is higher than it is in men, a continuing trend, and now that extends to women over age 50, reversing.

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New patent for Intra-cellular drug CAPLYTA

Drug Patent Watch

Annual Drug Patent Expirations for CAPLYTA Caplyta is a drug marketed by Intra-cellular and is included in one NDA. It is available from two suppliers. There are fifteen patents protecting… The post New patent for Intra-cellular drug CAPLYTA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59
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Kaiser Permanente Reaches Tentative Deal With 75,000 Health Care Workers

Drugs.com

FRIDAY, Oct. 13, 2023 -- A tentative deal has been reached between Kaiser Permanente and its 75,000 health care workers following a three-day strike last week. "The frontline health care workers of the Coalition of Kaiser Permanente Unions are.

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New patent for Abbvie drug UBRELVY

Drug Patent Watch

Annual Drug Patent Expirations for UBRELVY Ubrelvy is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. There are five patents protecting… The post New patent for Abbvie drug UBRELVY appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59
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Hispanics With Kidney Disease Face Higher Risk for Cardiac Arrest

Drugs.com

THURSDAY, Oct. 12, 2023 -- Hispanic folks with chronic kidney disease should have early heart health screenings, new research suggests, because they’re at high risk for sudden cardiac arrest. A team from the Smidt Heart Institute at.

Disease 59
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New patent for Karyopharm Theraps drug XPOVIO

Drug Patent Watch

Annual Drug Patent Expirations for XPOVIO Xpovio is a drug marketed by Karyopharm Theraps and is included in one NDA. It is available from one supplier. There are six patents… The post New patent for Karyopharm Theraps drug XPOVIO appeared first on DrugPatentWatch - Make Better Decisions.

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Women With Acne Bear Another Burden: Stigma

Drugs.com

THURSDAY, Oct. 12, 2023 -- Adult acne can significantly change how women are perceived in social settings, a new study finds. And where the acne is located on the face changes the onlooker’s perception. Researchers tracked eye movements of.

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Worldwide fertility crisis: Why men really need a hand from science

SCIENMAG: Medicine & Health

Montreal, October 13, 2023—Infertility now affects one in six couples of reproductive age according to the World Health Organisation. About half the time, it originates from men. As male infertility is increasing worldwide, researcher Sarah Kimmins and 25 international experts highlights that men have a right to meaningful diagnoses and targeted treatments.

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