Chemical Biology and Drug Design

NOVEMBER 4, 2024

Alzheimer's disease (AD) is a progressive age-related neurodegenerative brain disorder that destroys memory and other important mental functions. This review article comprehensively summarized the recent advancements in galantamine and its hybrid analogs as potential therapeutic agents for the management of AD. Furthermore, we also provided the design, synthesis, and SAR analysis of the galantamine-based compounds used in the last decades for the management of AD.

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Disease Therapies Research 100

ASPET

NOVEMBER 4, 2024

MK-8189 is a novel phosphodiesterase 10A (PDE10A) inhibitor being evaluated in clinical studies for the treatment of schizophrenia. PDE10A is a cyclic nucleotide phosphodiesterase enzyme highly expressed in medium spiny neurons of the striatum. MK-8189 exhibits sub-nanomolar potency on the PDE10A enzyme and has excellent pharmaceutical properties. Oral administration of MK-8189 significantly increased cGMP and pGluR1 in rat striatal tissues.

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Treatment Clinical Trials Trials Pharmaceuticals 100

Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- In what may be a first for the United States, a regional public health department in Idaho will no longer provide COVID-19 vaccines, following a close vote by its board.“I’m not aware of anything else like this,” said Adria.

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Vaccine 105

Science Daily: Pharmacology News

NOVEMBER 4, 2024

Researchers have developed synthetic genes that function like the genes in living cells. The artificial genes can build intracellular structures through a cascading sequence that builds self-assembling structures piece by piece. The discovery offers a path toward using a suite of simple building blocks that can be programmed to make complex biomolecular materials, such as nanoscale tubes from DNA tiles.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Alzheimer’s disease patients prescribed fistfuls of daily drugs are at greater risk of harm, a new study warns.Patients with Alzheimer’s prescribed five or more daily medications suffer from more symptoms, falls and hos.

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Disease Drugs 105

Science Daily: Pharmacology News

NOVEMBER 4, 2024

The unique properties of baseball's famed 'magic' mud, which MLB equipment managers applied to every ball in the World Series, have never been scientifically quantified -- until now. Researchers now reveal what makes the magic mud so special.

Research 100

Research 100

Science Daily: Pharmacology News

NOVEMBER 4, 2024

BiomedGPT is a new a new type of artificial intelligence (AI) designed to support a wide range of medical and scientific tasks. This new study is described in the article as 'the first open-source and lightweight vision -- language foundation model, designed as a generalist capable of performing various biomedical tasks.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- There's just something about sitting.New research shows that too much time on sofas and chairs harms the heart -- even among people who get the minimum recommended amount of daily exercise.“Taking a quick walk after work may.

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Research 97

Science Daily: Pharmacology News

NOVEMBER 4, 2024

Astronomers have discovered a supermassive black hole at the center of a galaxy just 1.5 billion years after the Big Bang that is consuming matter at a phenomenal rate -- over 40 times the theoretical limit. While short lived, this black hole's 'feast' could help astronomers explain how supermassive black holes grew so quickly in the early Universe.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- The home front hardships of World War II illustrate how too much sugar is harming people’s health today, a new study shows.British children who endured wartime rationing of sugar wound up with lifelong health benefits, r.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

NOVEMBER 4, 2024

The temperature of elementary particles has been observed in the radioactive glow following the collision of two neutron stars and the birth of a black hole. This has, for the first time, made it possible to measure the microscopic, physical properties in these cosmic events. Simultaneously, it reveals how snapshot observations made in an instant represents an object stretched out across time.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Although numerous studies have shown that marijuana use during pregnancy may harm both the fetus and a mom-to-be, almost 6% of women responding to a recent survey said they used weed while pregnant.That's more than one in.

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Science Daily: Pharmacology News

NOVEMBER 4, 2024

Evolutionary biologists report they have analyzed a fossil of an extinct giant meat-eating bird -- which they say could be the largest known member of its kind -- providing new information about animal life in northern South America millions of years ago.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Actor James Van Der Beek, perhaps best known for his role as Dawson Leery in the popular television series "Dawson's Creek," has announced that he has been diagnosed with colorectal cancer."I have colorectal cancer. I’ve b.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Broad Institute

NOVEMBER 4, 2024

A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity By Corie Lok November 4, 2024 Breadcrumb Home A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease brings together Danish and Broad scientists.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Huntington's disease is a devastating, fatal neurological illness with little means of treatment, but a new study in mice offers a glimmer of hope. Huntington's occurs when inherited genes cause key proteins to fold and.

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NIOSH Science Blog: Drugs

NOVEMBER 4, 2024

Respirable crystalline silica (RCS), most commonly in the form of quartz, is a known health hazard in many industries. Exposure to RCS can lead to debilitating and incurable diseases. To minimize the risk of health effects associated with exposure, the Mine Safety and Health Administration (MSHA) released a final rule for lowering miners’ exposure to RCS in April 2024.

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Disease 69

Science Daily: Pharmacology News

NOVEMBER 4, 2024

Fifteen minutes before the massive January 2022 eruption of the Hunga Tonga-Hunga Ha'apai volcano, a seismic wave was recorded by two distant seismic stations. The researchers propose that the seismic wave was caused by a fracture in a weak area of oceanic crust beneath the volcano's caldera wall. That fracture allowed seawater and magma to pour into and mix together in the space above the volcano's subsurface magma chamber, explosively kickstarting the eruption.

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Research 68

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

The ChEMBL-og

NOVEMBER 4, 2024

Dear SureChEMBL users, If you frequently rely on our "chemistry search" feature, today brings great news! We’ve recently implemented a major update that makes your search experience faster than ever. What's New? Last week, we upgraded our structure search engine by aligning it with the core code base used in ChEMBL. This update allows SureChEMBL to leverage our FPSim2 Python package , returning results in approximately one second.

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Packaging Engineering 67

BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

Wall Street analysts were impressed by data showing competitive rates of weight loss for Viking’s therapy, but shares in the company still slipped.

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Therapies Drugs 73

FDA Law Blog: Biosimilars

NOVEMBER 4, 2024

By Sara W. Koblitz & Charles D. Snow & Karla L. Palmer & John W.M. Claud — As we reported back in January, Phibro Animal Health Corporation challenged FDA’s decision to remove a drug called carbadox—used as an antimicrobial drug to treat gastrointestinal disease in food-producing pigs—from the market. More specifically, FDA rescinded approval of a “regulatory method” that Phibro used to establish that carbadox is safe and effective.

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Drug Patent Watch

NOVEMBER 4, 2024

The development and use of generic drugs have significant implications for healthcare systems and economies worldwide.

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Drug Development Drugs Pharmaceuticals Production 80

BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

Per terms, Novo could pay up to $285 million in upfront and milestone fees to Ascendis, which specializes in a kind of drug-enhancing technology.

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Drugs 70

Covalent Modifiers

NOVEMBER 4, 2024

Jinhyuk Kim, Hadong Kim, Jongwan Kim, Seon Yeon Cho, Sungho Moon, Youngki Yoo, Hanseong Kim, Jin Kwan Kim, Hyejin Jeon, Wan Namkung, Gyoonhee Han, and Kyoung Tai No Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c01393 I n the Hippo signaling pathway, the palmitoylated transcriptional enhanced associated domain (TEAD) protein interacts with the coactivator Yes-associated protein/PDZ-binding motif, leading to transcriptional upregulation of oncogenes such as Ctgf and Cyr61.

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Drugs 59

BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

The news led to a stock surge on expectations that forthcoming data for the company’s experimental gene therapy for Rett syndrome may turn out positive.

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Therapies 62

Drug Channels

NOVEMBER 4, 2024

Here on Drug Channels , we have long highlighted the boom in provider-administered biosimilars. In contrast to the pharmacy market, adoption of these biosimilars is growing, prices are dropping, and formulary barriers continue to fall. Novel transparency information reveals that this good news doesn’t always translate into savings. Below, we rely on a unique data set from Turquoise Health to examine how much four national commercial health plans—Aetna, Anthem, Cigna, and UnitedHealthcare—paid ho

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Biosimilars Hospitals Pharmacy Production 54

DrugBank

NOVEMBER 4, 2024

The World Health Organization (WHO) estimates that if current trends persist, antibiotic resistance could cause 10 million deaths annually by 2050. The pharmaceutical industry is the primary source of antibiotic innovation; therefore, it must lead the way in combating resistance.   Urgency of Antibiotic Resistance    The escalating threat of antibiotic resistance is an incoming global crisis projected to affect international health and the economy.

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Pharmaceutical Companies Government Pharmaceuticals DNA 52

PPD

NOVEMBER 4, 2024

The PPD clinical research business of Thermo Fisher Scientific has conducted a comprehensive survey involving 150 drug developers from around the world. This initiative, now in its third year, is designed to provide a detailed assessment of current drug development practices and shifts within the industry. This year’s findings reveal a nuanced landscape where rising clinical trial costs, complex protocol designs and patient recruitment issues have emerged as significant challenges.

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Drug Development Clinical Trials Clinical Research Trials 52

Alta Sciences

NOVEMBER 4, 2024

Case Study: How to Ensure Safety While Manufacturing Highly Potent APIs aasimakopoulos Mon, 11/04/2024 - 17:37 Highly potent active pharmaceutical ingredients (API) require careful attention to safety and handling during formulation and manufacturing. This blog explores the process required for manufacturing a highly potent API for an ophthalmic indication, based on a case study involving loteprednol etabonate, a topical corticosteroid used to treat eye inflammations.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Women who’ve had concussions are more likely to suffer severe mental health problems following childbirth, a new study shows.A history of concussion increased a new mother’s risk of severe mental illness by 25%, after adj.

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Perficient: Drug Development

NOVEMBER 4, 2024

The updateRecord function in Lightning Web Components (LWC) is a powerful tool for Salesforce developers, allowing for seamless data updates directly from the user interface. This feature enhances user experience by providing quick and efficient updates to Salesforce records without the need for page refreshes. In this guide, we’ll explore how the update record function works, its key benefits, and best practices for implementing it in your LWC projects.

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Drugs.com

NOVEMBER 4, 2024

MONDAY, Nov. 4, 2024 -- Text messages and other online feedback can help prevent obesity in very young children, a new study demonstrates.Kids had a healthier weight-for-height growth curve during their first two years if parents were offered.

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BioPharma Drive: Drug Pricing

NOVEMBER 4, 2024

As novel therapeutics become more complex — and costly — to bring to market, drug developers are looking to unified clinical development platforms to streamline operations.

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