Science Daily: Pharmacology News

FEBRUARY 9, 2024

A new study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Scientists now theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors.

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ASPET

FEBRUARY 9, 2024

Systemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity and associated metabolic impairment. While the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to obesity-associated inflammation, whether it contributes to the development or maintenance of obesity is unknown. We provide support for a direct role of saturated fatty acids, such as palmitic acid, as NLRP3 activating stimuli in obese states.

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Disease Regulations Drugs 100

Drug Target Review

FEBRUARY 9, 2024

What key findings about stem cell behaviour, differentiation and integration within host tissues impact the development of stem cell therapies? Adipose-derived stem cells (ADSCs) have garnered attention due to their remarkable ability to differentiate into various cell types crucial for tissue regeneration and repair. Their plasticity allows them to adapt to the microenvironment of host tissues, facilitating integration and functional restoration.

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ASPET

FEBRUARY 9, 2024

B cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young children and is associated with high levels of reactive oxygen species (ROS). The antioxidant N-acetylcysteine (NAC) was tested for its ability to alter disease progression in a mouse model of B-ALL. Mb1-CreDPB mice have deletions in genes encoding PU.1 and Spi-B in B cells and develop B-ALL at 100% incidence.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

FDA Law Blog: Biosimilars

FEBRUARY 9, 2024

By Adrienne R. Lenz, Principal Medical Device Regulation Expert & Lisa M. Baumhardt, Senior Medical Device Regulation Expert — As an end of the year gift, FDA finalized its guidance document, Digital Health Technologies for Remote Data Acquisition in Clinical Investigations , in late December. We previously blogged on the draft guidance ( here ) and on FDA’s broader framework for Digital Health Technologies (DHT) ( here and here ).

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Science Daily: Pharmacology News

FEBRUARY 9, 2024

Astronomers have uncovered evidence of how the enigmatic gap in the size distribution of exoplanets at around two Earth radii emerges. Their computer simulations demonstrate that the migration of icy, so-called sub-Neptunes into the inner regions of their planetary systems could account for this phenomenon. As they draw closer to the central star, evaporating water ice forms an atmosphere that makes the planets appear larger than in their frozen state.

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Science Daily: Pharmacology News

FEBRUARY 9, 2024

Beaked whales are among the least studied mammals in the world. Now, a new study reveals surprising information about the Baird's beaked whale species.

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SCIENMAG: Medicine & Health

FEBRUARY 9, 2024

Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a worldwide threat. The emergence of the BA.2.86 variant, a subvariant of Omicron, has raised significant concerns due to its substantial number of mutations. Discovered in August 2023, this variant differs markedly from other existing types such as Omicron XBB (including EG.5.

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Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- Fabrizio wasn’t sure what to expect of his newly outfitted prosthetic hand, until he touched one of the researchers who’d given it to him.“When one of the researchers placed the sensor on his own body, I could feel.

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Science Daily: Pharmacology News

FEBRUARY 9, 2024

A team of scientists has devised means for classical computing to mimic a quantum computing with far fewer resources than previously thought. The scientists' results show that classical computing can be reconfigured to perform faster and more accurate calculations than state-of-the-art quantum computers.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- Is 'practice makes perfect' true for the male erection, too? That's the suggestion from a Swedish study involving amorous male mice. It found that getting erections regularly was important to the rodents' overall erectile.

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Perficient: Drug Development

FEBRUARY 9, 2024

Perficient is revving up its commitment to the future of automotive initiative with the innovation of its Electrifying the Future of Automotive program , supporting college Formula SAE racing teams. The Formula SAE program empowers college students to design, build, and race formula-style racing cars, including electric vehicles (EVs), in national and global Formula SAE competitions.

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SCIENMAG: Medicine & Health

FEBRUARY 9, 2024

Humans are still evolving, and Tatum Simonson, PhD, founder and co-director of the Center for Physiological Genomics of Low Oxygen at University of California School of Medicine, plans to use evolution to improve healthcare for all.

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Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- Filling the day with simple activities could be the key to improving mood and well-being after a person has suffered the loss of a loved one, a new study finds.These “uplifts” -- activities that can improve a person’s.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

SCIENMAG: Medicine & Health

FEBRUARY 9, 2024

CLEVELAND—University Hospitals (UH) Brain Health & Memory Center is now treating patients with LEQEMBI® (lecanemab), a Food and Drug Administration-approved medication for the treatment of Alzheimer’s disease.

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Hospitals FDA Approval Treatment Disease 79

Drug Channels

FEBRUARY 9, 2024

Today’s guest post comes from Nasir Ali, Chief Product Officer at CareMetx. Nasir shares findings from CareMetx’s new 2024 Patient Services Report research study: Revealing Manufacturer Priorities: Patients Naturally Take Center Stage. As he explains, manufacturers want hub partners that can take a holistic approach and address each patient’s individual needs.

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Production Research Drugs 77

BioPharma Drive: Drug Pricing

FEBRUARY 9, 2024

Shortly after Kyverna priced one of the sector’s largest IPOs in recent years, Maag spoke with BioPharma Dive about what it takes to go public now.

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Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- While marriage can be hard work, a new survey suggests it can also be a powerful elixir for happiness.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

FEBRUARY 9, 2024

New results have convinced Takeda to “rapidly” pursue a late-stage program for its drug TAK-861 in one type of narcolepsy, while in another the company opted not to continue.

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Perficient: Drug Development

FEBRUARY 9, 2024

We’re thrilled to announce that this year, Sitecore has recognized nine of our Perficient colleagues the well-earned title of Sitecore Most Valuable Professional in all three categories- Strategy, Technology, and Ambassador. “Perficient’s commitment to encouraging their people to be active in the community is a model for what we’d like to see every partner doing.

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Collaborative Drug

FEBRUARY 9, 2024

Can AI and Digital Twins Make Drug Discovery “Cheaper Faster and More Successful.”? Results of Worlds-First Blood Test for Brain Cancer.

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Drugs 73

Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- Medical tourism to Mexico for cosmetic procedures exposed Americans to a deadly fungal infection last year, a new report shows.An outbreak of Fusarium solani meningitis occurred at two clinics in Matamoros specializing in.

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Drug Patent Watch

FEBRUARY 9, 2024

This chart shows the patent expirations for capsule dosed drugs over the next decade. The term of drug patents varies. The basic term for a patent is 20 years from… The post Capsule dosed drug patent expirations by year appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs 59

Perficient: Drug Development

FEBRUARY 9, 2024

In the wild world of artificial intelligence (AI), your vision of how to marry up systems and capabilities can get murky, quick. In fall of 2023, Salesforce hosted their annual expo, Dreamforce. At Dreamforce 2023 , it was all about Data + AI + CRM. The team re-launched their Data Cloud platform and ensured exciting, trusted capabilities were coming in the AI space.

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Drug Patent Watch

FEBRUARY 9, 2024

Annual Drug Patent Expirations for CAPLYTA Caplyta is a drug marketed by Intra-cellular and is included in one NDA. It is available from two suppliers. There are eighteen patents protecting… The post New patent for Intra-cellular drug CAPLYTA appeared first on DrugPatentWatch - Make Better Decisions.

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biobide

FEBRUARY 9, 2024

Bisphenol-A (BPA) is a chemical compound primarily used to produce polycarbonate plastics and epoxy resins. These plastics are part of water bottles, toys, sports equipment, or medical devices. Epoxy resins are used as coatings inside food and drink cans to prevent corrosion and breaking and to protect food from bacterial contamination. Thermal papers, such as the ones used for parking and train tickets, are also a source of BPA.

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Packaging 59

Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 (healthDay News) -- Super Bowl party spreads famously include nachos, wings, burgers, hot dogs and other unhealthy fare, but one expert offers some advice on how to make watching the game a healthy affair.“Think about what.

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Perficient: Drug Development

FEBRUARY 9, 2024

With thousands of skilled strategists from across the globe, Perficient accelerates growth and digital transformation for the world’s largest enterprises and biggest brands. Our team spans national, industry, and geographical business units to deliver compelling experiences for our clients and their customers. We bring an end-to-end digital approach through our comprehensive portfolio of capabilities, solutions, and strategic positions.

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International 52

Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- U.S. research into gun violence has started to expand following the ending of a two-decade drought of federal funding for such studies, a new report finds.Firearms violence studies had been stymied by severe restrictions on.

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Perficient: Drug Development

FEBRUARY 9, 2024

Sitecore Headless uses a service called the Layout Service to deliver content from Sitecore to the front-end application in a headless architecture. It is responsible for rendering the layout of a page or a component and delivering the associated content to the client-side application. The Layout Service constructs and delivers a JSON representation encompassing the context, route, placeholders, renderings (components), and data sources.

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Engineering 52

Drugs.com

FEBRUARY 9, 2024

FRIDAY, Feb. 9, 2024 -- American teenagers cite stress as the leading reason they might get drunk or high, a new report reveals.That only underscores the need for better adolescent mental health care, according to the research team behind the.

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Drugs Research 52

SCIENMAG: Medicine & Health

FEBRUARY 9, 2024

“A fundamental hypothesis we sought to test was whether biomarkers from the TGF-β signaling pathway might be of novel value in risk stratification of HCC in the clinical cirrhotic setting.” Credit: 2024 Xiang et al.

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Science Daily: Pharmacology News

FEBRUARY 9, 2024

Nearly 400 exceptionally well-preserved fossils dating back 470 million years have been discovered in the south of France by two amateur paleontologists. The discovery provides unprecedented information on the polar ecosystems of the Ordovician period.

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