Chemical Biology and Drug Design

DECEMBER 23, 2024

We have discovered a gefitinib derivative that can inhibit IDO1 enzyme activity in Hela cells, thereby inducing apoptosis in these cells. ABSTRACT Cervical cancer is the fourth most common cancer among women globally. Its development is closely linked to accelerated cell cycle progression and the inhibition of apoptosis in cervical cancer tissues. Gefitinib has demonstrated efficacy in inhibiting cervical cancer cells, and the 1,2,3-triazole structure is widely recognized for its role in inducin

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Autism ranks among the top ten health problems for young people under 20.A new study published recently in The Lancet Psychiatry says that nearly 62 million people in 2021 had autism spectrum disorder.We estimated one in 1.

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Science Daily: Pharmacology News

DECEMBER 23, 2024

Even highly realistic androids can cause unease when their facial expressions lack emotional consistency. Traditionally, a 'patchwork method' has been used for facial movements, but it comes with practical limitations. A team developed a new technology using 'waveform movements' to create real-time, complex expressions without unnatural transitions.

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- The U.S. Food and Drug Administration (FDA) has approved the first prescription medication specifically for treating obstructive sleep apnea (OSA): the weight-loss drug Zepbound. In a news release published Dec. 20, the FDA.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drug Target Review

DECEMBER 23, 2024

Antibody-drugconjugates (ADCs) represent a significant advancement in drug discovery, combining the precision of monoclonal antibodies with the cancer-killing power of cytotoxic drugs. While these therapies hold great promise for improving cancer treatment outcomes, their development presents significant challenges, especially in achieving the optimal balance between efficacy and safety.

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Drugs.com

DECEMBER 23, 2024

December 23, 2024 -- Today, the U.S. Food and Drug Administration approved the first generic referencing Victoza (liraglutide injection) 18 milligram/3 milliliter, a glucagon-like peptide-1 (GLP-1) receptor agonist indicated to improve glycemic.

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- The U.S. Food and Drug Administration (FDA) has approved the first prescription medication specifically for treating obstructive sleep apnea (OSA): the weight-loss drug Zepbound. In a news release published Dec. 20, the FDA.

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FDA Law Blog: Drug Discovery

DECEMBER 23, 2024

By Mark A. Tobolowsky & Frank J. Sasinowski The Winter Solstice, signifying the shortest day of the year, was Saturday, December 21. Although the earliest sunset of the year was actually in early December, this day also marked another premature sunset the beginning of the end of the rare pediatric disease priority review voucher program. As we blogged recently, the program has had scheduled sunset dates from its very beginning, which have been repeatedly extended.

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Drugs.com

DECEMBER 23, 2024

Dec. 23, 2024 -- Poison experts see it every winter holiday season: Parents rush kids to the emergency room or call hotlines, panicking that their child has ingested something dangerous.Between holiday breaks, visiting relatives' homes, attending.

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Alta Sciences

DECEMBER 23, 2024

Webinar-Nanomilling-Updated 2024 tchichekian Mon, 12/23/2024 - 20:39 Image Webinar_CDMO Nanosuspension Formulations.

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Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Predictably, flu season is in full swing, with cases surging across the United States, the Centers for Disease Control and Prevention (CDC) confirmed Friday in a report.Thirteen states, including Tennessee and Louisiana.

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Disease 52

Alta Sciences

DECEMBER 23, 2024

HPAPI Manufacturing Webinar_Updated 2024 tchichekian Mon, 12/23/2024 - 20:18 Image slide1.

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Dancing appears to lift the spirits of people with Parkinsons disease.Depression eased in Parkinsons patients who took months of dance classes, a new study published recently in the Journal of Medical Internet Research sho.

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Research 52

Alta Sciences

DECEMBER 23, 2024

HPAPI Manufacturing Webinar_Updated 2024 tchichekian Mon, 12/23/2024 - 20:18 Image High Potency Manufacturing Solutions.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Coffee provides a quick morning boost, but it might also protect the brain health of people with a common heart rhythm disorder.A study published recently in the Journal of the American Heart Association shows patients with.

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Alta Sciences

DECEMBER 23, 2024

HPAPI Manufacturing Webinar_Updated 2024 tchichekian Mon, 12/23/2024 - 20:18 Image High Potency Manufacturing Solutions_1.

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- What type of me-time is more restorative to a person -- hiking by yourself deep in a forest, or reading a book while sipping a latte in a coffee shop?Surprisingly, youll do best with a cup of joe and a good book, alone wi.

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Alta Sciences

DECEMBER 23, 2024

HPAPI Manufacturing Webinar_Updated 2024 tchichekian Mon, 12/23/2024 - 20:18 Image High Potency Manufacturing Solutions_2.

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Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Hundreds of beloved pet dogs and cats were reported as being unintentionally poisoned by cocaine and methamphetamine left out in their owners' homes, new data from one U.S. pet poison control hotline shows.When a dog or cat.

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Alta Sciences

DECEMBER 23, 2024

HPAPI Manufacturing Webinar_Updated 2024 tchichekian Mon, 12/23/2024 - 20:18 Image High Potency Manufacturing Solutions_3.

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Everyone needs to feel appreciated -- but especially someone whos caring for a spouse with dementia.A study published recently in the journal Comprehensive Psychoneuroendocrinology shows that the mental health of c.

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Perficient: Drug Development

DECEMBER 23, 2024

As your test automation skills grow, its crucial to implement advanced strategies that enhance the efficiency, reliability, and maintainability of your tests. In this post, well explore several techniques that can help you optimize your test automation framework using PyTest and Selenium. Custom Test Suites and Tags: Organizing tests into custom suites and using tags can help you manage your tests better, especially as the number of test cases grows.

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Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- Humans arent the only ones who lose a step or two brain-wise as they age.Artificial intelligence (AI) programs start to show signs of mild cognitive impairment as they grow older, a new study published Dec. 20 in the j.

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Perficient: Drug Development

DECEMBER 23, 2024

The release of Salesforce Agentforce 2.0 introduces a powerful AI-driven architecture that transforms how enterprises build, deploy, and manage intelligent agents. However, leveraging these advanced capabilities requires a well-structured DevOps strategy. Below are best practices for ensuring successful implementation and optimization of Agentforce 2.0.

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Perficient: Drug Development

DECEMBER 23, 2024

On December 10, 2024, the Perficient Towers in Chennai buzzed with energy and anticipation as we hosted the first-ever Perficient BrowserStack Partner Day event. This milestone event united colleagues from across Indiaincluding Bangalore, Hyderabad, Pune, and Nagpuras well as virtual participants, creating a hybrid experience that combined in-person dynamism with the inclusivity of online access.

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Perficient: Drug Development

DECEMBER 23, 2024

Hello Trailblazers! Salesforce Reports are a powerful way to analyze data, and one of their most useful features is the Bucket Field. This tool allows you to group report data into categories without creating custom fields or formula fields in your Salesforce objects. Whether youre working with large datasets or need a quick way to analyze trends, bucket field can save time and streamline your reporting.

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Perficient: Drug Development

DECEMBER 23, 2024

In this blog, we will walk through the process of creating a Team, adding Team Channels, and managing owners and members within Microsoft Teams using PowerShell scripts. Youll learn how to automate the creation of Teams, organize them with different channels, and efficiently manage user roles and permissions, such as assigning ownership or membership.

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Perficient: Drug Development

DECEMBER 23, 2024

Introduction Flaky teststhose that fail intermittentlyare a common headache for test automation teams. They can be especially frustrating in Selenium tests because of the dynamic nature of web applications. Elements might take time to load, page navigation could be slow, or JavaScript-heavy applications might delay interactions. These issues lead to false negatives in tests, where tests fail even though the application works fine.

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Perficient: Drug Development

DECEMBER 23, 2024

The Salesforce Winter ’25 Release introduces a significant enhancement: the integration of Knowledge and Unified Knowledge with Data Cloud. This update is set to revolutionize how businesses manage and utilize their knowledge bases. How to leverage the power of Data Cloud to improve generative AI features for Einstein for Service. In this blog, we will explore the key features of this integration.

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Perficient: Drug Development

DECEMBER 23, 2024

Salesforce has officially unveiled Agentforce 2.0, a groundbreaking update that redefines how enterprise AI solutions are developed, deployed, and managed. This new iteration introduces innovative features designed to streamline collaboration, enhance integration, and provide unmatched flexibility for building AI-powered workflows. Agentforce 2.0 focuses on three primary advancements: headless agents for seamless programmatic control, advanced Slack integration for improved teamwork, and a revam

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Perficient: Drug Development

DECEMBER 23, 2024

IAM Database Authentication lets you log in to your Amazon RDS database using your IAM credentials. This makes it easier to manage access, improves security, and provides more control over who can do what. Let’s look at how to set it up and use it effectively. Objective: IAM DB Authentication improves security, enables centralized user management, supports auditing, and ensures scalability for database access.

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Perficient: Drug Development

DECEMBER 23, 2024

1) Custom 404 Page Using React Router V6: React Router is a popular JavaScript library commonly used to create single-page applications in React. It offers a set of components and functions that allow you to define your app’s routing and navigation in a declarative way. In this blog post, well walk you through the process of designing and implementing a custom 404 page using React Router V6.

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