Chemical Biology and Drug Design

DECEMBER 11, 2024

The review discusses the systemic development of selective inhibitors for Mtb -DHFR as antitubercular agents and their designing strategies. The study also explores and compiles the latest patents and clinical trial data into a single platform to help develop selective Mtb -DHFR inhibitors for effective tuberculosis treatment. ABSTRACT Tuberculosis (TB) is an obstinate and infectious disease requiring a relatively longer treatment duration than other bacterial infections.

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Drug Target Review

DECEMBER 11, 2024

In recent years, regulatory focus has shifted from sensitivity to accuracy, marking a pivotal change in how we approach toxicological assessments. While sensitivity remains essential, our growing understanding of toxicology highlights the critical importance of precise target analysis. This shift in focus is especially critical in toxicology, where accurate target analysis plays a vital role in identifying toxic effects and ensuring patient safety, particularly as the field transitions from trad

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Drug Patent Watch

DECEMBER 11, 2024

The biopharmaceutical industry has witnessed a significant surge in the number of therapeutic molecules in development, leading to a corresponding increase in the number of contract development and manufacturing organizations (CDMOs). This growth has created a competitive landscape where pharmaceutical companies must carefully evaluate and select the right CDMO partner to ensure the success of their projects.

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Reprocell

DECEMBER 11, 2024

Inflammatory bowel disease (IBD) is rising in prevalence across the globe, as the number of individuals diagnosed with the condition has increased by 95% since 1990. 1 Despite the recent scientific advances in therapies for IBD, including ulcerative colitis and Crohns disease, there are still persistent unmet medical needs due to the complexity and chronic nature of these conditions.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Perficient: Drug Development

DECEMBER 11, 2024

Flutter’s versatility and powerful UI capabilities have made it a leading choice for building cross-platform mobile apps. However, its resource-intensive nature requires developers to fine-tune performance to create smooth, responsive, and memory-efficient apps. This guide compiles essential optimization techniques to help you craft a stellar Flutter experience. 1.

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Drug Patent Watch

DECEMBER 11, 2024

The pharmaceutical industry, particularly the generic drug sector, faces significant challenges in adopting sustainable practices. As the world grapples with the consequences of climate change, companies must adapt their operations to reduce environmental impacts while maintaining cost-effectiveness and regulatory compliance. This article outlines key considerations and strategies for developing a sustainable generic drug development strategy.

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Drug Patent Watch

DECEMBER 11, 2024

Generic drugs play a crucial role in providing affordable healthcare options to millions of patients worldwide. One of the key tools that generic drug manufacturers rely on to navigate the complex regulatory environment is the FDA’s Product Specific Guidances (PSGs). These guidances serve as a roadmap for companies looking to develop generic versions of brand-name drugs, offering invaluable insights into the FDA’s expectations for demonstrating bioequivalence and ensuring product qua

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Perficient: Drug Development

DECEMBER 11, 2024

Now is the time for retail giants to knock Santa off his pedestal and to do it, they can become reverse logistics experts. The younger generations have become accustomed to trying products before they buy them and being able to return them conveniently when products do not live up to their expectations. In both these areas, the good old Saint Nick, who has reigned over the holiday season for generations, is now falling short on customers demands.

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Drug Patent Watch

DECEMBER 11, 2024

Achieving operational excellence in a Contract Development and Manufacturing Organization (CDMO) is crucial to ensure the quality and consistency of products and services. This can be achieved by implementing robust controls, optimizing workflows, and fostering a culture of continuous improvement. Here are some key strategies to achieve operational excellence in a CDMO: Implementing Robust Controls Compliance with Regulatory Guidelines : Ensure compliance with strict regulatory standards set by

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Compliance Production FDA Science 52

Perficient: Drug Development

DECEMBER 11, 2024

Introduction Redux, a JavaScript application’s predictable state container, has emerged as a key component for React application state management. To make sure that your state management functions as intended, it is essential to test your Redux code. We’ll look at methods and resources for testing Redux apps in this extensive article. Why Test Redux?

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

FDA Law Blog: Biosimilars

DECEMBER 11, 2024

On Wednesday, December 11, Hyman, Phelps & McNamara, P.C. (HPM) and Riparian LLC will co-host a webinar on an important CMS rule imposing penalties for misclassification of drugs and other reporting errors under the Medicaid Drug Rebate Program. (See our post on this rule here.) The Webinar will explore the CMS rule and provide actionable recommendations for manufacturers on how to navigate the new requirements.

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Perficient: Drug Development

DECEMBER 11, 2024

Hello Trailblazers! Public Groups in Salesforce are a versatile and essential feature designed to streamline user management and data sharing across your organization. So these groups provide a convenient way to manage access permissions and ensure seamless collaboration among users, roles, and other groups. In this blog, we will explore what Public Groups are, their benefits, how to create and manage them, and best practices for their use.

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Drug Channels

DECEMBER 11, 2024

This week, Im rerunning some popular posts while I prepare for Fridays Drug Channels Outlook 2025 live video webinar. Click here to see the original post. In my recent The 340B Drug Pricing Program: Trends, Controversies, and Outlook video webinar, I provided an update on the economics of the 340B program, reviewed the multiple controversies surrounding the programs operations, discussed state and federal legislation, and analyzed how the Inflation Reduction Act of 2022 (IRA) will alter the 340B

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Perficient: Drug Development

DECEMBER 11, 2024

Introduction Deploying HCL Commerce involves setting up a network of Docker containers to run your e-commerce site. This guide will help you understand the deployment components, environments, and steps to effectively manage your HCL Commerce application. HCL Commerce provides a robust and scalable solution for e-commerce businesses. It supports multiple stores and environments, allowing for efficient management and deployment.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Target Review

DECEMBER 11, 2024

The impact of immunotherapy in oncology over recent years is undeniable. Novel therapeutic approaches have led to durable responses in some patients with metastatic disease, with some even experiencing results similar to a cure. Yet they do not work for everyone, and we still have a long way to go to fully harness the immune systems ability to fight cancer.

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Metabolite Tales Blog

DECEMBER 11, 2024

Hypha’s Q4 2024 Newsletter – Accessing glucuronides, a new UGT kit and our latest paper picks and blog article Focus topics for this edition: Accessing glucuronides New UGT kit – PolyUGTs TM Latest blog article Major biotransformation routes of aficamten involving hydroxylation, onwards glucuronidation and gut metabolism Latest Paper Picks Major circulating glucuronides of icenticaftor and Discovery of unprecedented human stercobilin conjugates of inavolisib Sign up at the bot

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FDA Law Blog: Biosimilars

DECEMBER 11, 2024

By Kurt R. Karst We learned earlier this week that an allision (a runner-up to Merriam-Websters 2024 Word of the Year, polarization) may be poised to occurperhaps within a fortnight (another runner-up to Merriam-Websters 2024 Word of the Year thanks to Taylor Swift)as Congress considers various pieces of healthcare legislation as part of its year-end package.

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