ASPET

MAY 21, 2024

Myocardial sarcoendoplasmic reticulum calcium ATPase 2 (SERCA2) activity is critical for heart function. We have demonstrated that inhaled halogen (chlorine or bromine) gases inactivate SERCA2, impair calcium homeostasis, increase proteolysis, and damage the myocardium ultimately leading to cardiac dysfunction. To further elucidate the mechanistic role of SERCA2 in halogen induced myocardial damage we utilized bromine exposed cardiac specific SERCA2 knockout (KO) mice (tamoxifen administered SER

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Production 100

Science Daily: Pharmacology News

MAY 21, 2024

Researchers have for the first time been able to pin down a prehistoric settlement of early farmers in northern Greece dating back more than 7,000 years to the year. For this they combined annual growth ring measurements on wooden building elements with the sudden spike of cosmogenic radiocarbon in 5259 BC. This provides a reliable chronological reference point for many other archaeological sites in Southeast Europe.

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Research 120

ASPET

MAY 21, 2024

The high prevalence of breast cancer is a global health concern, but there are no safe or effective treatments for it at its advanced stages. These facts urge the development of novel treatment strategies. Annexin A5 (ANXA5) is a natural human protein that binds with high specificity to phosphatidylserine, a phospholipid tightly maintained in the inner leaflet of the cell membrane on most healthy cells but externalized in tumor cells and the tumor vasculature.

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Therapies Treatment Immune Response 100

Science Daily: Pharmacology News

MAY 21, 2024

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.

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Virus Drugs 118

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Powerful COVID vaccines could be setting people’s immune systems up to successfully fight off not just future COVID variants, but other types of coronaviruses as well, a new study shows.People repeatedly vaccinated for.

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Vaccine Virus 111

Science Daily: Pharmacology News

MAY 21, 2024

Scientists discover 'zoned development' in dinosaur skin, with zones of reptile-style scales and zones of bird-like skin with feathers. A new dinosaur skin fossil has been found to be composed of silica -- the same as glass.

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Research 109

BioPharma Drive: Drug Pricing

MAY 21, 2024

The U.K. pharma expects to launch 20 new drugs by then, among them complex medicines for cancer as well as treatments for weight loss.

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Treatment Drugs 119

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Fetal exposure to fluoride from a mom-to-be's drinking water might raise the odds for physical and mental health issues in toddlers, new research suggests. The study, which was funded by the U.S. National Institutes of.

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Research 110

Science Daily: Pharmacology News

MAY 21, 2024

A new study suggests better nutrition might help prevent cognitive decline. Working with a group of 100 cognitively healthy participants aged 65 to 75, a research team combined neuroscience with nutritional science to identify a specific nutrient profile linked with better performance on cognitive tests. Nutrient biomarkers identified via blood tests revealed a combination of fatty acids, antioxidants and carotenoids, and two forms of Vitamin E and choline -- very similar to the Mediterranean di

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Science Research 103

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Gallbladder cancer rates are steadily increasing among Black Americans, even as they remain stable or decline for most other Americans, a new study warns.Further, growing numbers of cases among Black people are not being.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

MAY 21, 2024

Sudden, severe dry spells known as flash droughts are rising in intensity around the world, with a notable exception in mountainous Central Asia, where flash drought extent is shrinking, according to new research. Heat and changes to precipitation patterns caused by a warming climate are driving these trends, the study found.

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Research 102

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- The legalization of cannabis and the popularity of its edible versions is having an unexpected effect: More seniors landing in emergency departments with overdoses.A new Canadian study found "cannabis poisonings" in the.

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BioPharma Drive: Drug Pricing

MAY 21, 2024

Since pivoting from oncology, the startup has raised close to $300 million and advanced an ulcerative colitis drug into mid-stage testing.

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Drug Research Research Drugs 111

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Hip replacement is a major, arduous elective surgery, and rehabilitation afterwards takes time, according to an expert from Johns Hopkins Medicine in Baltimore.It'll also take coordinated planning between yourself, your.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

addgene Blog

MAY 21, 2024

If you are job searching, you may be wondering if you need to go to the effort of writing a cover letter. After all, they’re less common than they were ten years ago, and it does take a bit of time to craft one. We still think they're useful, so we've updated our cover letter blog post to help you write the best one possible!

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Science 96

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- You've watched others shed pounds in a matter of weeks after taking one of the new blockbuster weight-loss drugs, so you decide to try one of the medications yourself, only to discover the needle on your bathroom scale.

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Drugs 105

BioPharma Drive: Drug Pricing

MAY 21, 2024

The U.K. drugmaker aims to catch up in developing new tumor-fighting technologies — areas where it has lagged behind leaders like Novartis and J&J.

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Drugs 102

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Giving patients a choice between screening methods could help doctors detect colon cancer earlier, a new study shows.More than double the number of patients underwent colon cancer screening if they were given a choice of.

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Doctors 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

MAY 21, 2024

The analysis of fat traces in over one hundred pottery vessels reveals deep changes in food consumption and preparation by communities living in central Germany between the Early Neolithic and the Late Bronze Age, as well as in their relation with innovations in pottery styles and decorations. In a groundbreaking study, researchers identified a generalized inclusion of dairy products in prehistoric diets, a preference in consuming pork with the arrival of communities from the Eurasian Steppe, an

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Production Research 95

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- If you've quit smoking and have switched to vaping instead, your odds for lung cancer won't fall as steeply as if you quit nicotine altogether, new research suggests.“This is the first large population-based study to.

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Research 105

Science Daily: Pharmacology News

MAY 21, 2024

University of Copenhagen astrophysicists help explain a mysterious phenomenon, whereby stars suddenly vanish from the night sky. Their study of an unusual binary star system has resulted in convincing evidence that massive stars can completely collapse and become black holes without a supernova explosion.

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Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Matcha green tea has the potential to keep gum disease at bay, a new study finds.Lab experiments show that matcha can inhibit the growth of Porphyromonas gingivalis, one of the main bacterial culprits behind gum.

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Disease 110

Science Daily: Pharmacology News

MAY 21, 2024

See how an autonomous robot created a shock-absorbing shape no human ever could -- and what it means for designing safer helmets, packaging, car bumpers, and more.

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Packaging 96

Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Heat waves and heat domes are particularly dangerous to kids with asthma, a new study finds.Daytime heat waves are associated with 19% increased odds that a child with asthma will wind up in the hospital, researchers.

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Hospitals Research 104

Drug Patent Watch

MAY 21, 2024

Annual Drug Patent Expirations for BELSOMRA Belsomra is a drug marketed by Merck Sharp Dohme and is included in one NDA. It is available from one supplier.

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Drugs.com

MAY 21, 2024

TUESDAY, May 21, 2024 -- Many kids can get an occasional upset tummy, but what if your child's stomachaches are more persistent?Dr. David Ziring, associate director of the Pediatric Inflammatory Bowel Disease Program at Cedars-Sinai Guerin.

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Disease 98

Covalent Modifiers

MAY 21, 2024

Simon C. C. Lucas, J. Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G. Milbradt, Samiyah Ahmed, Mark J. Bostock, Carine Guerot, Andrea Gohlke, Olaf Kinzel, Michelle L. Lamb, Nidhal Selmi, Christopher J. Stubbs, Nancy Su, Qibin Su, Haiou Luo, Ting Xiong, Xiaoqian Zuo, Sana Bazzaz, Corey Bienstock, Paolo A. Centrella, Kyle E. Denton, Diana Gikunju, Marie-Aude Guié, John P.

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BioPharma Drive: Drug Pricing

MAY 21, 2024

CEO Cyrus Mozayeni said the company is taking a different approach than other developers of antibody-drug conjugates, though it’s keeping details close.

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Drugs 73

Science Daily: Pharmacology News

MAY 21, 2024

Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.

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Research 69

Drug Patent Watch

MAY 21, 2024

This chart shows the drugs with the most patents in Cyprus. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

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Pharmaceuticals Drugs 59

Science Daily: Pharmacology News

MAY 21, 2024

While humans feature a sophisticated sense of smell, insects have a much more basic olfactory system. Yet they depend upon smell to survive. Scientists have figured out how fruit flies use a simple but efficient system to recognize odors, and the answer lies at the edges of their antennae.

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Research 62

BioPharma Drive: Drug Pricing

MAY 21, 2024

The collaboration, which gives Lilly access to Aktis’ technology in return for $60 million, adds to a flurry of dealmaking in the radiopharma field.

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Perficient: Drug Development

MAY 21, 2024

Welcome to the world of JavaScript, where every line of code tells a story of efficiency and clarity. Today, we’re diving into a fascinating technique called short-circuiting. It’s like taking the express lane in coding – speeding up your journey while keeping things simple and easy to understand. Join us as we unravel the secrets of short-circuiting in JavaScript and discover how it can revolutionize your coding experience.

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