Drug Discovery World

AUGUST 16, 2024

News round-up for 12-16 August by DDW Senior Digital Content Editor Diana Spencer. The chosen news highlights this week all feature advances in drug development in oncology indications and reflect the breadth of therapeutic approaches to cancer treatment. The top stories: Genetic causes of colorectal cancer revealed in new study A new study has provided the most comprehensive analysis to date of the genetic makeup of colorectal cancer (CRC), providing unique understanding of its response to trea

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Science Daily: Pharmacology News

AUGUST 16, 2024

A zinc-air microbattery could enable the deployment of cell-sized, autonomous robots for drug delivery within in the human body, as well as other applications such as locating leaks in gas pipelines.

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Drug Discovery World

AUGUST 16, 2024

New published data have demonstrated positive monotherapy results for misetionamide as well as synergistic activity with PARP inhibitors (PARPis) and bevacizumab antineoplastic in ovarian cancer. Misetionamide is a tumour cell selective small molecule drug that is broadly active in multiple cancer models. Misetionamide’s inhibition of hexokinase-2 (HK-2), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and pyruvate dehydrogenase (PVD) in aerobic glycolysis inhibits ATP production for cancer ce

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Science Daily: Pharmacology News

AUGUST 16, 2024

Researchers are setting out to challenge our misconceptions about the Dodo, one of the most well-known but poorly understood species of bird. Researchers have undertaken the most comprehensive review of the taxonomy of the Dodo and its closest relative, the Rodriguez Island Solitaire.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Chemical Biology and Drug Design

AUGUST 16, 2024

Baicalein (BE) augments radiosensitivity in colorectal cancer (CRC) by inhibiting the JAK2/STAT3 pathway. In vitro and in vivo experiments demonstrate BE's ability to enhance apoptosis and suppress PD-L1 expression, suggesting its potential as a radiosensitizer in CRC therapy. ABSTRACT Radiation resistance is a crucial factor influencing therapeutic outcomes in colorectal cancer (CRC).

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Therapies Research 100

Science Daily: Pharmacology News

AUGUST 16, 2024

Barely audible to human ears, healthy soils produce a cacophony of sounds in many forms -- a bit like an underground rave concert of bubble pops and clicks. Special recordings made by ecologists show this chaotic mixture of soundscapes can be a measure of the diversity of tiny living animals in the soil, which create sounds as they move and interact with their environment.

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Science Daily: Pharmacology News

AUGUST 16, 2024

With new medications on the market or in the works for Alzheimer's disease and other kinds of dementia, a new study suggests that getting the diagnosis needed to access these new treatments may depend on where you live.

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BioPharma Drive: Drug Pricing

AUGUST 16, 2024

The vaccine didn’t spur a strong enough immune response against a particular flu strain in a Phase 3 trial, leading the companies to ponder adjustments.

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Science Daily: Pharmacology News

AUGUST 16, 2024

Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day. To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Their findings suggest a complex social history of dogs during the early colonial period.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- There are clues that red and processed meats could be driving the increased risk of colon cancer in young adults, a new study claims.Younger colon cancer patients typically have higher levels of metabolites created by the.

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Science Daily: Pharmacology News

AUGUST 16, 2024

On May 11, a gorgeous aurora surprised stargazers across the southern United States. That same weekend, a tractor guided by GPS missed its mark. What do the visibility of the northern lights have in common with compromised farming equipment in the Midwest? A uniquely powerful geomagnetic storm, according to new research.

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Drug Target Review

AUGUST 16, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I grew up in California where I developed a natural curiosity to understand how a living organism functions. Majoring in physiology in college allowed me to nourish this interest, and I knew medicine would be my path as it enabled me to learn the structure and function of the human body.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- A good night’s sleep is crucial for helping people make new memories, a new study says.Neurons that capture new memories during the day reset while you sleep, researchers reported Aug. 15 in the journal Science.“This mec.

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Collaborative Drug

AUGUST 16, 2024

Burlingame, CA (USA), Kyiv (Ukraine) – August 16, 2024 — Collaborative Drug Discovery (CDD), a leader in providing scientific informatics solutions, announced today that its flagship platform, CDD Vault , now includes the complete compound collection of Enamine , a leading provider of chemical compounds and early discovery services, within its AI module for structural similarity searches.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- As an outbreak of a new strain of mpox continues in Africa, Sweden announced Thursday that it has confirmed the first case in that country.Known as the clade I strain, this latest iteration of mpox appears to be spread.

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Science Daily: Pharmacology News

AUGUST 16, 2024

The asteroid that led to the extinction of the dinosaurs 66 million years ago probably came from the outer solar system.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Kids considering suicide after receiving mental health care at a hospital can be helped by automated text messages that help them feel hopeful and supported, a new study finds.Children receiving the texts as part of a.

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Hospitals 105

Science Daily: Pharmacology News

AUGUST 16, 2024

The dramatic dimming of a light source ~ 870 million light years away from Earth confirms the accuracy of a detailed model.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Where you live in the United States could play a role in whether you get a timely diagnosis of dementia, a new study says.The same person can have twice as much chance of getting a dementia diagnosis in some areas of the.

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BioPharma Drive: Drug Pricing

AUGUST 16, 2024

Some industry watchers described the level of price discounts announced by Medicare as a "relief," though they warned of bigger future implications for drug research.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Painting, woodworking, writing: Whatever you turn to creatively, it could equal or exceed work in terms of maintaining mental health, new research shows.“Crafting and other artistic activities showed a meaningful effect in p.

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Research 97

BioPharma Drive: Drug Pricing

AUGUST 16, 2024

Zealand is using a recent $1 billion equity raise to “accelerate” several would-be weight loss medicines. Meanwhile, Bluebird reworked a loan and Boundless Bio cut jobs only months after an IPO.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Uterine transplants are relatively rare and recent -- the first was performed in 2011, and to date a little more than 100 transplants have been conducted worldwide.However, a new study finds that these procedures are often.

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Agency IQ

AUGUST 16, 2024

By Rachel Coe, MSC Just over a year after it released the draft guidance, the FDA has finalized its guidance on dose optimization for oncology products. In this analysis, AgencyIQ has combed through the newly released final guidance document to tease out what’s new and what’s the same. We will discuss the context and implications of some of the changes in an upcoming second analysis.

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Production FDA 59

Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- A child at the dinner table talks about trouble at school or an argument with a friend, but parents aren't listening: They're checking their smartphones instead.It's a scenario that plays out millions of times per day.

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Agency IQ

AUGUST 16, 2024

By Amanda Conti On August 9, Lykos Therapeutics received a Complete Response Letter (CRL) from the FDA, stating the agency will not currently approve its application for midomafetamine (MDMA) to treat post-traumatic stress disorder. Here, AgencyIQ unpacks the announcement and analyzes potential implications throughout the psychedelic enterprise. A growing body of evidence suggests that psychedelics may provide clinical benefit for certain purposes, especially mental health conditions.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Back-to-school can feel like a rushed jumble, as kids leave behind summer fun for the next step in their education.But there are specific ways parents can help students show up sharper, get young athletes ready to compete.

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Drug Patent Watch

AUGUST 16, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs.com

AUGUST 16, 2024

FRIDAY, Aug. 16, 2024 -- Parents are worried that social media and technology will get in the way of schoolkids building meaningful connections with classmates and teachers during the upcoming school year, a new poll finds.Half of parents (50%) say.

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Perficient: Drug Development

AUGUST 16, 2024

In this series, we’re talking about why your healthcare organization (HCO) can and should support caregivers who are caring for the patients and members your organization serves. Supporting caregivers makes good business sense for your HCO. Remember, supported caregivers: Lead to more satisfied patients/members Demonstrate your HCO’s value proposition, which leads to more conversions Help your patients/members adhere to their care plans, which leads to healthier patients/members overall Let’s re

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Agency IQ

AUGUST 16, 2024

By Scott Stephens, MPA The European Commission has issued a call inviting companies to submit tenders for a 1.5-million-euro contract to deliver a pilot project setting up “substitution centers” envisioned to help companies negotiate the convoluted process of substituting hazardous substances with safer alternatives. Fill out the form to read the full article.

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Perficient: Drug Development

AUGUST 16, 2024

Meet Ryan Ambrose, a Portfolio Specialist at Perficient for our Salesforce practice, based in Chicago, Illinois. Ryan works closely with clients to optimize their use of Salesforce, ensuring that enterprises get the most value from the platform. The Dreamforce Experience Ryan is no stranger to Dreamforce, and one of his favorite memories from the event was in 2019 when he got to check a bucket-list item off his list—seeing Fleetwood Mac live in concert.

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Drug Channels

AUGUST 16, 2024

Today’s guest post comes from Benjamin Hinton II, Senior Market Access Solutions Analyst at MMIT. Benjamin reviews the growing trend of PBMs vertically integrating into the production of biosimilars. He shares data from an MMIT survey of 20 large national payers, independent plans, Blues affiliates and PBMs (excluding participants). The findings shed light on payers' view of biosimilar conpetition, contracting challenges, and other issues.

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Perficient: Drug Development

AUGUST 16, 2024

At Perficient, our team’s expertise and enthusiasm drive our success. Today, we’re excited to spotlight Cheryl Moore, Salesforce Portfolio Specialist, who’s eagerly anticipating Dreamforce 2024. An Experience Salesforce Expert Cheryl brings a wealth of experience to her role at Perficient. With over 5 years at our company and 9 years in the Salesforce ecosystem, she specializes in serving the CMT (Communications, Media & Technology), High Tech, and Life Sciences industries.

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