Chemical Biology and Drug Design

NOVEMBER 22, 2023

Imidazo[1,2-a]pyridine-chalcone conjugates with antikinetoplastid activity. Abstract A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using 1 H NMR, 13 C NMR and HRMS. The synthesized analogues were screened for their antikinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei brucei , Trypanosoma brucei rhodesiense and Leishmania infantum.

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Research 100

Science Daily: Pharmacology News

NOVEMBER 22, 2023

When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you'll regret it -- or so it's been thought.

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Drugs.com

NOVEMBER 22, 2023

WEDNESDAY, Nov. 22, 2023 -- The last thing a holiday host wants is to have guests get food poisoning from the feast they’ve set. That’s why food safety is particularly important as people prepare for holiday festivities, poison control.

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BioPharma Drive: Drug Pricing

NOVEMBER 22, 2023

The company said it had not found “a viable alternative” to closing down in the months since it hit a clinical setback and laid off staff.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

NOVEMBER 22, 2023

WEDNESDAY, Nov. 22, 2023 -- Artificial intelligence (AI) can help assess lung cancer risk in nonsmokers, a new study shows. The “CXR-Lung-Risk” AI program evaluates routine chest X-ray images, looking for patterns associated with lung.

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SCIENMAG: Medicine & Health

NOVEMBER 22, 2023

Anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease, according to a new observational study by researchers from Karolinska Institutet published in the Journal of Internal Medicine.

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Disease Drugs International Research 91

SCIENMAG: Medicine & Health

NOVEMBER 22, 2023

In Alzheimer’s disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau. Wherever tau builds up, nearby brain tissue starts to degenerate and die.

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Disease 86

Drugs.com

NOVEMBER 22, 2023

WEDNESDAY, Nov. 22, 2023 -- Abandoned animals, kids with cancer, disabled veterans: These and other pitches for charity can move your emotions and have you reaching for your credit card. But beware: Especially around the holidays, fake.

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SCIENMAG: Medicine & Health

NOVEMBER 22, 2023

Transplanting gut microbes from an obesity-resistant shrew can improve microbiome diversity and decrease the weight of obese mice Credit: Yi et al., 2023, PLOS ONE, CC-BY 4.

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Drugs.com

NOVEMBER 22, 2023

WEDNESDAY, Nov. 22, 2023 -- The risk of developing liver cancer appears to be rising with each successive generation of Mexican-Americans, especially men, a new report finds.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Covalent Modifiers

NOVEMBER 22, 2023

Masaharu Kawano, Syunsuke Murakawa, Kenji Higashiguchi, Kenji Matsuda, Tomonori Tamura, and Itaru Hamachi Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c08740 The covalent inhibition of a target protein has gained widespread attention in the field of drug discovery. Most of the current covalent drugs utilize the high reactivity of cysteines toward modest electrophiles.

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Drugs.com

NOVEMBER 22, 2023

WEDNESDAY, Nov. 22, 2023 -- A new type of bacterial infection could be the culprit behind a mysterious canine respiratory illness that has been infecting dogs from coast to coast, New Hampshire researchers say. Genetic sequencing of samples from 70.

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Research 89

SCIENMAG: Medicine & Health

NOVEMBER 22, 2023

Canadian First Nations houses in remote and isolated northern communities have strikingly high levels of CO2, mold damage and endotoxins, which could explain the high levels of respiratory illness in these communities Credit: Gary Mallach, CC-BY 4.

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Science Daily: Pharmacology News

NOVEMBER 22, 2023

Researchers create transistors combining silicon with biological silk, using common microprocessor manufacturing methods. The silk protein can be easily modified with other chemical and biological molecules to change its properties, leading to circuits that respond to biology and the environment.

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Research 83

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Clinical Trials

SCIENMAG: Medicine & Health

NOVEMBER 22, 2023

Paeonia ostii is a widely grown woody crop with up to 40% α-linolenic acid in its seed oil, which is beneficial to human health. Drought is a major environmental factor limiting the popularisation of P. ostii in hilly and mountainous areas, which may affect plant growth or lead to plant death.

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Drugs.com

NOVEMBER 22, 2023

WEDNESDAY, Nov. 22, 2023 -- Four of every 10 American seniors who suffer a fall and end up in the ER with head trauma get no follow-up care once they go home, a new study finds. “Only 59 percent of our study subjects had follow-up with their.

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Drug Patent Watch

NOVEMBER 22, 2023

This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Sweden. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Sweden? appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals 59

Drug Target Review

NOVEMBER 22, 2023

Can you elaborate on the central role that autotaxin plays in resistance to transforming growth factor-beta (TGF-β) pathway inhibition? How does the activation of alternative resistance pathways by the tumour hinder previous attempts to interrupt TGF-β pathway signalling in cancer? Whilst TGF-β is an attractive target for cancer therapy because of its critical role in promoting tumor aggressiveness, immune escape and resistance to therapy, activation of alternative resistance pathways has hinder

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Licensing Licensing Small Molecule Therapies 52

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Clinical Trials

Drug Patent Watch

NOVEMBER 22, 2023

Annual Drug Patent Expirations for OLUMIANT Olumiant is a drug marketed by Eli Lilly And Co and is included in one NDA. It is available from one supplier. There are… The post New patent for Eli Lilly drug OLUMIANT appeared first on DrugPatentWatch - Make Better Decisions.

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FDA Law Blog: Biosimilars

NOVEMBER 22, 2023

By Sophia R. Gaulkin & Riëtte van Laack — For any of our readers seeking recommendations on which drinks pair well with turkey this Thanksgiving, certain fruit-flavored beverages may be off the table. Earlier this month, FDA issued a proposed rule that would revoke 21 C.F.R. §  180.30 , its interim authorization of the use of brominated vegetable oil (BVO) in in fruit-flavored beverages.

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Drug Patent Watch

NOVEMBER 22, 2023

Annual Drug Patent Expirations for ZORYVE Zoryve is a drug marketed by Arcutis and is included in one NDA. It is available from one supplier. There are four patents protecting… The post New patent for Arcutis drug ZORYVE appeared first on DrugPatentWatch - Make Better Decisions.

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Perficient: Drug Development

NOVEMBER 22, 2023

Last week, Boston was a buzz with innovation, big announcements, and a shared vision for the future of digital experience at Acquia Engage 2023. Among the myriad of insightful sessions and keynotes, two emerging themes took hold: the evolution of AI and the imperative of accessibility. The event illuminated how these facets shape a more inclusive and impactful digital landscape.

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Marketing Production 52

Drug Patent Watch

NOVEMBER 22, 2023

Annual Drug Patent Expirations for NYMALIZE Nymalize is a drug marketed by Azurity and is included in one NDA. It is available from one supplier. There are eight patents protecting… The post New patent for Azurity drug NYMALIZE appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Antidote

NOVEMBER 22, 2023

One of the most crucial parts of running a clinical trial is managing randomization and drug supply levels. Ensuring that the right participants receive the right dosages of the right medication is essential to gathering accurate study results.

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Trials Clinical Trials Drugs 52

Perficient: Drug Development

NOVEMBER 22, 2023

I recently had the pleasure of attending HCIC – The Healthcare Internet Conference with Perficient’s Senior Healthcare Strategist, Kayla Brown. Kayla and I were both invited to speak at the conference, and, while we were there, we took full advantage of the great learning opportunities that always arise with the industry comes together. Kayla spoke about driving consumer centricity with enterprise digital experience platforms and I joined Bayhealth’s Digital Innovation and Cons

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Marketing International Regulations Government 52

BioPharma Drive: Drug Pricing

NOVEMBER 22, 2023

The planned acquisition adds to a string of bargain buyouts and reverse mergers in the gene therapy field.

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Therapies 67

Perficient: Drug Development

NOVEMBER 22, 2023

In March 2020, the student loan forgiveness program was initiated, providing relief to many borrowers. However, in October 2023, loan payments resumed, presenting new financial challenges. While the temporary pause was beneficial, it left numerous individuals still grappling with the task of managing their additional financial obligations. Borrowers now confront the daunting prospect of resuming loan payments alongside recurring bills and debts.

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Compliance 52

Alta Sciences

NOVEMBER 22, 2023

Fact-Sheet_Miniature-Swine_thumbnail ehdem Wed, 11/22/2023 - 15:00 Image Fact-Sheet_Miniature-Swine_thumbnail.

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Perficient: Drug Development

NOVEMBER 22, 2023

In the fast-changing world of automating tasks on the web, keeping up means getting really good at using tools that can easily handle the always-changing problems. Selenium 4 has a new feature called Relative Locators. It’s a big deal because it makes it easier to deal with complex connections between different parts of a website’s interface.

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Alta Sciences

NOVEMBER 22, 2023

Altascientist_issue11_thumbnail ehdem Wed, 11/22/2023 - 14:57 Image Altascientist_issue11_thumbnail.

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Perficient: Drug Development

NOVEMBER 22, 2023

When creating and testing websites or applications, mimicking real-life network situations is really important. Chrome DevTools offers a strong way to mimic various network conditions. It helps developers and testers imitate different networks and check how well their applications work in different situations. This guide will take you through the steps of simulating networks using Chrome DevTools, giving you a better idea of how well your application performs.

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Marketing 52

Alta Sciences

NOVEMBER 22, 2023

Altascientist_issue36_thumbnail ehdem Wed, 11/22/2023 - 14:59 Image Altascientist_issue36_thumbnail.

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Perficient: Drug Development

NOVEMBER 22, 2023

Introduction In this blog post, we will explore the benefits of Sitecore and Azure AD B2C integration and how its advanced authentication and authorization capabilities can help businesses provide a more secure and personalized digital experience for their customers. Sitecore first introduced Identity Server as a feature in Sitecore 9, which was released in October 2017.

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