Drug Discovery World

JUNE 19, 2024

KYV-101, a fully human anti-CD19 chimeric antigen receptor (CAR) T-cell product candidate, has been used to treat a 69-year-old patient suffering from treatment-refractory stiff-person syndrome (SPS). The therapy was given as part of a named-patient use in Germany for critically ill individuals who fail conventional therapies. SPS is a rare, progressive neurological autoimmune disorder causing debilitating muscle stiffness in the torso, arms, and legs, impacting the ability to walk or move.

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Chemical Biology and Drug Design

JUNE 19, 2024

Exploring the transformative impact of large language models (LLMs) in molecular biology and drug development, discussing potential areas of applications and breakthroughs in personalized therapies. LLMs, trained on vast datasets, can decode intricate biological information, from genomic sequences to clinical records, comprehending hidden patterns. While enhancing molecular biology aspects, we also address ethical concerns ensuring responsible application of these models.

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Drug Discovery World

JUNE 19, 2024

New research has uncovered how different people respond to sepsis based on their genetics, which could lead to the development of targeted therapies. The team from the Wellcome Sanger Institute, the University of Oxford, and collaborators built on their previous work that identified different subgroups of patients with sepsis. The new study, published in Cell Genomics , details the genetic basis of variability in sepsis response, and the different regulators and cell types involved in the differ

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Science Daily: Pharmacology News

JUNE 19, 2024

Roughly one in four U.S. households have soil exceeding the new U.S. Environmental Protection Agency's lead screening levels of 200 parts per million (ppm), halved from the previous level of 400 ppm, a new study found. For households with exposure from multiple sources, the EPA lowered the guidance to 100 ppm; nearly 40% of households exceed that level, the study also found.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JUNE 19, 2024

DDW Editor Reece Armstrong speaks to Jasminka Taleska , Director, RLT HCS Readiness and Policy at Novartis, about the opportunities radioligand therapies (RLTs) represent in treating cancer patients. RA: What are the potentials of RLTs across cancer? JT: Cancer is an incredibly complex and heterogeneous disease, and, devastatingly, around 10 million people worldwide lose their lives to it every year 1.

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Science Daily: Pharmacology News

JUNE 19, 2024

An international team of scientists has recently found that non-native species are expanding their ranges many orders of magnitude faster than native ones, in large part due to inadvertent human help. Even seemingly sedentary non-native plants are moving at three times the speed of their native counterparts in a race where, because of the rapid pace of climate change and its effect on habitat, speed matters.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- Only a third of outpatient mental health facilities offer medications essential for treating opioid addiction, a new study finds.Standard care for treating people with opioid use disorder involves drugs like.

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Drug Discovery World

JUNE 19, 2024

This is the latest episode of the free DDW narrated podcast, titled “Why drug repurposing is so significant for drug discovery” which covers three written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: AI use in repurposing drugs for Covid-19 and RRx-001: Jack of all trades, master of…many. In the first article, Imran Haque, VP Data Science at Recursion, describes the journey of the AI platform that predicted the efficacy of repurposed drugs for Covid-19 In the second arti

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Science Daily: Pharmacology News

JUNE 19, 2024

Geologists studied Titan's shorelines and showed through simulations that coastlines of the moon's methane- and ethane-filled seas have likely been shaped by waves. Until now, scientists have found indirect and conflicting signs of wave activity, based on Cassini images of Titan's surface.

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Drug Discovery World

JUNE 19, 2024

Researchers at the University of Turku in Finland have discovered that the protein TIMP-1 plays a critical role in the immune system’s defence against cancer. TIMP-1 is produced by dendritic cells, which are responsible for initiating immune responses and boosting the immune system’s ability to recognise and destroy cancer cells. The protein enhances antitumour immunity through self-stimulation and by activating surrounding immune cells.

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Clinical Trials

Drug Patent Watch

JUNE 19, 2024

In the ever-evolving pharmaceutical landscape, savvy businesses are constantly on the lookout for untapped markets and lucrative opportunities. One area that has garnered significant attention is the realm of low-competition generic drugs.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- After a recall was issued last year for lead-tainted applesauce pouches linked to illnesses in over 500 children, the discount retailer Dollar Tree failed to remove all products from store shelves for too long, federal.

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Science Daily: Pharmacology News

JUNE 19, 2024

Researchers have created a new class of materials called 'glassy gels' that are very hard and difficult to break despite containing more than 50% liquid. Coupled with the fact that glassy gels are simple to produce, the material holds promise for a variety of applications.

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Research 104

Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- A deadly bacterial infection known as streptococcal toxic shock syndrome (STSS) is spreading across Japan, officials in that country report.In March, Japan's National Institute of Infectious Diseases issued its first.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JUNE 19, 2024

Scientists have achieved a significant research milestone in the field of spinal cord injuries -- mapping out the cellular and molecular dynamics of paralysis in unprecedented detail with their open-source project 'Tabulae Paralytica'. Gr goire Courtine and his team have integrated cutting-edge cell and molecular mapping technologies with artificial intelligence to chart the complex molecular processes that unfold in each cell after spinal cord injuries (SCI).

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Therapies Research 101

Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- A new AI-driven blood test could improve detection of liver cancer, which is one of the most fatal cancers because early diagnosis is difficult.The test looks for “fusion genes” -- two different genes that have become bou.

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Science Daily: Pharmacology News

JUNE 19, 2024

Jupiter's iconic Great Red Spot has persisted for at least 190 years and is likely a different spot from the one observed by the astronomer Giovanni Domenico Cassini in 1665, a new study reports. The Great Red Spot we see today likely formed because of an instability in the planet's intense atmospheric winds, producing a long, persistent atmospheric cell, the study also finds.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- A record-breaking heat wave is spreading across the United States, baking the Northeast and Midwest with high temperatures and sweltering humidity.Everyone is at risk for heat-related illness as body temperatures rise.

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Drug Target Review

JUNE 19, 2024

Could you give us an overview of Lineage Cell Therapeutics’ mission? The mission of Lineage Cell Therapeutics is to deliver on some of the early promises of cell therapy. Cell therapy as a concept is a wonderful idea, but many of the early efforts never generated the kind of clinical data that gets people excited and leads to new medicines. Also, many companies never reached the point where they received validation from big pharmaceutical companies.

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Perficient: Drug Development

JUNE 19, 2024

In this episode of “What If? So What?” Jim talks with Neelima Sharma, SVP of ecommerce, digital, and technology at Lowe’s about the challenges and successes of transforming the retail industry through digital innovation. Neelima highlights the importance of teamwork, trust, and a customer-centric approach in driving the company’s growth and also emphasizes the significance of personalization and building long-term relationships with customers.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- Depression during or after a pregnancy could be tied to a heightened risk for heart trouble in women decades later, new research warns.This so-called "perinatal" depression was linked to a 36% higher odds of developing.

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Cytel

JUNE 19, 2024

Historically, many drugs have been prescribed to children even though this patient population have largely been excluded from clinical trials. Authorities worldwide have, therefore, implemented regulations to address the gap in drug research involving children and to promote efforts that can lead to increased knowledge of pediatric pharmaceutical use.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- Most seniors who survive a drug overdose often miss out on treatments that could help save them from a subsequent OD, a new study shows.Almost 24,000 Medicaid beneficiaries died from a follow-up overdose out of 137,000.

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The Open Targets Blog

JUNE 19, 2024

The latest release of the Platform — 24.06 — is now available at platform.opentargets.org. Key points In addition to our regular data updates: Users can now customise the associations view to explore evidence for a set list of entities We have updated our gene burden dataset with version 5 of the AstraZeneca PheWAS Portal and added new evidence for targets associated with prostate cancer Notable data updates include ChEMBL 34 and the Gene2Phenotype skeletal panel Key stats Metric C

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- As summers get hotter and hurricane seasons less predictable, more Americans now say that climate change affects their mental health, a new poll finds.In a survey conducted among more than 2,200 adults at the end of May.

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Perficient: Drug Development

JUNE 19, 2024

Our risk and regulatory compliance experts, Carl Aridas and Chandni Patel, have just returned from XLoD 2024 in New York. The event brought together the world’s top financial institutions and regulators to discuss the future of non-financial risk and control. With over 500 industry professionals in attendance, it showcased the unwavering commitment to practical innovation within the field.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- A new smartphone tool could help paramedics identify a stroke in seconds by scanning the patient’s face.The AI-driven tool analyzes facial symmetry and specific muscle movements to detect subtle signs of stroke, r.

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thought leadership

JUNE 19, 2024

Our “Meet the Expert” series introduces you to our team of experts around the world. This “behind the curtain” view will help you get to know who we are on a professional and personal level, and highlight how our colleagues work together on our higher purpose to improve patient health and safety throughout the complete product lifecycle.

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Production 52

Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- Folks nearing retirement shouldn’t skip leg days at the gym, a new study advises.One year of heavy strength training preserves vital leg strength up to at least four years later, researchers found.“This study provides evi.

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Perficient: Drug Development

JUNE 19, 2024

Data is the new oil. In today’s digital world, data is the new fuel. According to the latest estimates, 328 million terabytes of data are created each day. The age we live in is a digital age. As technology evolves, so has the use of the internet, which has skyrocketed in the last 10 years. Today, you can access information with one click. With the advent of the IoT and social media, data creation has skyrocketed.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- The number of people severely sickened after consuming mushroom edibles sold as Diamond Shruumz-brand chocolate bars, cones or gummies has risen, the U.S. Food and Drug Administration said Tuesday."As of June 17, 2024, a.

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Drug Patent Watch

JUNE 19, 2024

This chart shows the drugs with the most patents in Hungary. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

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Perficient: Drug Development

JUNE 19, 2024

(Pic Courtesy : Salesforce) 1. Enhanced Apex Capabilities Five-Level SOQL Relationship Queries: Salesforce now allows SOQL relationship queries to traverse up to five levels of parent-child records directly within Apex, aligning with previous support available through REST APIs. This enhancement is particularly useful for retrieving deeply nested data.

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Drugs.com

JUNE 19, 2024

WEDNESDAY, June 19, 2024 -- The discovery that the Epstein-Barr virus might be a major driver of multiple sclerosis has re-energized research into the autoimmune disease. Now, investigators in the U.K. and Sweden believe they might be closer to.

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