Wed.Mar 13, 2024

article thumbnail

Milk to the rescue for diabetics? Cow produces human insulin in milk

Science Daily: Pharmacology News

An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.

article thumbnail

Melatonin and its bioisosteres as potential therapeutic agents for the treatment of retinopathy of prematurity

Chemical Biology and Drug Design

Administration of melatonin and 3 its bioisosters efficiently normalize VEGF-A and total protein levels and antioxidant activity in vitreous body of newborn rat pups (in oxygen-induced retinopathy model). Novel melatonin analogues could be used as new metabolically stable therapeutic agents for the treatment of retinopathy of prematurity. Abstract We conducted a study on the impact of intraperitoneal injections of melatonin and its three bioisosteres (compounds 1 – 3 ) on the development of oxyg

Treatment 100
article thumbnail

Drought, soil desiccation cracking, and carbon dioxide emissions: an overlooked feedback loop exacerbating climate change

Science Daily: Pharmacology News

Soil stores 80 percent of carbon on earth, yet with increasing cycles of drought, that crucial reservoir is cracking and breaking down, releasing even more greenhouse gases creating an amplified feedback loop that could accelerate climate change.

125
125
article thumbnail

Women in Stem with Katherine Tran

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? To be honest, this is something I have never taken the time to reflect on until now. At first thought, I would say my journey in the field of STEM has been an exciting and rewarding experience. However, when I get to really think back on my journey throughout STEM, it has honestly been quite a rollercoaster ride with many bumps along the way.

Science 111
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Supply chain disruptions will further exacerbate economic losses from climate change

Science Daily: Pharmacology News

Global GDP loss from climate change will increase exponentially the warmer the planet gets when its cascading impact on global supply chains is factored in, finds a new study.

118
118
article thumbnail

Precautions Needed When Folks Taking Ozempic, Wegovy Undergo Anesthesia

Drugs.com

WEDNESDAY, March 13, 2024 — Nurses who specialize in anesthesia have issued new guidelines to reduce the risk that patients taking weight-loss drugs like Ozempic or Wegovy throw up during surgery."These medications have exploded in.

Nurses 111

More Trending

article thumbnail

Female Whales Undergo Menopause, and Scientists Now Know Why

Drugs.com

WEDNESDAY, March 12, 2024 -- Why humans, five whale species and some chimpanzees are the only known mammals to go through menopause has long been a mystery. Now, researchers at the University of Exeter in the U.K.

article thumbnail

Giant volcano discovered on Mars

Science Daily: Pharmacology News

A deeply eroded giant volcano, active from ancient through recent times and with possible remnants of glacier ice near its base, had been hiding near Mars' equator in plain sight. Its discovery points to an exciting new place to search for life, and a potential destination for future robotic and human exploration.

113
113
article thumbnail

Youth Baseball Can Lead to Overuse Injuries: What Parents Need to Know

Drugs.com

WEDNESDAY, March 13, 2024 -- Baseball season is near, and one orthopedic surgeon is warning young players and their coaches and parents about the very real danger of overuse injuries.Dr. Mark Cohen is a hand, wrist and elbow surgeon at Midwest.

98
article thumbnail

Robot ANYmal can do parkour and walk across rubble

Science Daily: Pharmacology News

The quadrupedal robot ANYmal went back to school and has learned a lot. Researchers used machine learning to teach it new skills: the robot can now climb over obstacles and successfully negotiate pitfalls.

Research 113
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Coordinating the Cell Journey: Essentials in Early Clinical Development

PPD

In every early phase clinical trial, the transportation, chain of custody, environmental monitoring and subsequent analysis of biological samples are the cornerstones of a successful, robust and quality outcome. In combination, they provide confidence in dose escalation or protocol adaptation decisions, which ultimately benefit patients who often have critical and life-limiting diseases.

article thumbnail

What kinds of seismic signals did Swifties send at LA concert?

Science Daily: Pharmacology News

Seattle may have experienced its own Swift Quake last July, but at an August 2023 concert Taylor Swift's fans in Los Angeles gave scientists a lot of shaking to ponder. After some debate, a research team concluded that it was likely the dancing and jumping motions of the audience at SoFi Stadium -- not the musical beats or reverberations of the sound system -- that generated the concert's distinct harmonic tremors.

Research 107
article thumbnail

Using Tap Water for Your Nasal Rinse? Beware Amoeba Dangers

Drugs.com

WEDNESDAY, March 13, 2024 -- Folks with sinus issues often turn to neti pots or "nasal rinsing" to help clear their clogged passages. Unfortunately, too many don't follow standard advice to avoid using tap water, and that's leading to sometimes.

98
article thumbnail

Grounding zone discovery explains accelerated melting under Greenland's glaciers

Science Daily: Pharmacology News

Researchers have conducted the first large-scale observation and modeling study of northwest Greenland's Petermann Glacier. Their findings reveal the intrusion of warm ocean water beneath the ice as the culprit in the accelerated melting it has experienced since the turn of the century, and their computer predictions indicate that potential sea level rise will be much worse than previously estimated.

Research 104
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Cyberattack Leaves Health Care Providers Reeling Weeks Later

Drugs.com

WEDNESDAY, March 13, 2024 -- Following a cyberattack on the largest health insurer in the United States last month, health care providers continue to scramble as insurance payments and prescription orders continue to be disrupted and physicians.

98
article thumbnail

Explaining a supernova's 'string of pearls'

Science Daily: Pharmacology News

Physicists often turn to the Rayleigh-Taylor instability to explain why fluid structures form in plasmas, but that may not be the full story when it comes to the ring of hydrogen clumps around supernova 1987A, research suggests. It looks like the same mechanism that breaks up airplane contrails might be at play in forming the clumps of hydrogen gas that ring the remnant of supernova 1987A.

article thumbnail

1 in 6 Gun Deaths for Women Occur In or Around Pregnancy

Drugs.com

WEDNESDAY, March 13, 2024 -- A woman's risk of intentional death by firearm rises during and shortly after pregnancy, new research shows.About 1 in 6 intentional firearm-related deaths in women of childbearing age occurred during pregnancy or.

article thumbnail

Scientists develop ultra-thin semiconductor fibers that turn fabrics into wearable electronics

Science Daily: Pharmacology News

Scientists have developed ultra-thin semiconductor fibers that can be woven into fabrics, turning them into smart wearable electronics.

107
107
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Weight-Loss Surgery Could Be Lifesaver for Folks Needing New Kidneys

Drugs.com

WEDNESDAY, March 13, 2024 -- Weight-loss surgery may help patients struggling with obesity and kidney failure become eligible for a lifesaving transplant, researchers report.Obesity is a key reason why some kidney patients are turned down for a.

article thumbnail

Cheers! NASA's Webb finds ethanol, other icy ingredients for worlds

Science Daily: Pharmacology News

What do margaritas, vinegar, and ant stings have in common? They contain chemical ingredients that NASA's James Webb Space Telescope has identified surrounding two young protostars known as IRAS 2A and IRAS 23385. Although planets are not yet forming around those stars, these and other molecules detected there by Webb represent key ingredients for making potentially habitable worlds.

91
article thumbnail

Depression May Be Tougher on Women's Hearts Than Men's

Drugs.com

WEDNESDAY, March 13, 2024 — Researchers are zeroing in on the reasons why women who battle depression may be more likely than men to develop heart disease.A study published March 12 in the journal JACC: Asia underscores the need to tailor.

article thumbnail

FDA to focus on ‘early deaths’ in meeting on broader CAR-T use in myeloma

BioPharma Drive: Drug Pricing

Briefing documents posted ahead of Friday’s advisory panel zeroed in on increased rates of early death in tests of cell therapies from Bristol Myers Squibb and Johnson & Johnson.

FDA 92
article thumbnail

Upcoming Webinar: Trends & Better Practices for the Use of Gen AI & LLMs & Round Table, Hosted by 20/15 Visioneers

Collaborative Drug

Upcoming Webinar: Agenda CDD Vault – Susana Tomasio Elucidata – Abhishek Jha Revvity Signals – Pierre Morieux HitchhikersAI – Raminderpal Singh Round Table Discussion with Panelists

79
article thumbnail

Menopause explains why some female whales live so long

Science Daily: Pharmacology News

Females of some whale species have evolved to live drastically longer lives so they can care for their families, new research shows.

article thumbnail

Merck reveals plans to develop newer HPV shots

BioPharma Drive: Drug Pricing

The pharma intends to test a single-dose regimen as well as a shot that may provide broader protection than the current versions of Gardasil that regularly generate billions in annual sales.

73
article thumbnail

New high-speed microscale 3D printing technique

Science Daily: Pharmacology News

A new process for microscale 3D printing creates particles of nearly any shape for applications in medicine, manufacturing, research and more -- at the pace of up to 1 million particles a day.

article thumbnail

Cosmetic Surgery Leaves 1 in 8 Patients With Chronic Post-Op Pain

Drugs.com

WEDNESDAY, March 13, 2024 -- Norwegians are increasingly asking surgeons for a nip, tuck or implant, and many — especially men — have pain that lingers long after their procedure, a new survey shows.Researchers asked 1,746 adults in Norway.

75
article thumbnail

IFM, an unorthodox biotech startup, scores third buyout with Novartis deal

BioPharma Drive: Drug Pricing

With a decision by the Swiss pharma to acquire another one of its subsidiaries, IFM Therapeutics has now sold three spin-offs for $700 million upfront and the potential for billions more in future payments.

67
article thumbnail

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations

Covalent Modifiers

Michael Westberg et al. Sci. Transl. Med. 16 , eadi0979 (2024). DOI: 10.1126/scitranslmed.adi0979 Inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in reducing the severity of COVID-19, but the presence of resistance-conferring mutations in sequenced viral genomes raises concerns about future drug resistance.

article thumbnail

Understanding Group Sequential Designs

Cytel

Group sequential clinical trial designs — a type of adaptive clinical trial design — have emerged as a powerful tool in enhancing the efficiency and ethical conduct of clinical trials, due to the ability to stop the trial early based on accumulating data. Here, I expand on the intricacies of group sequential designs, key design features, applications in clinical trials, their advantages, challenges, and impact on the landscape of clinical trials.

article thumbnail

CDD Vault Update (March 2024)

Collaborative Drug

Redesigned Dose Response Viewer When clicking on a dose response curve from within CDD Vault, a redesigned plot now opens in a new browser tab. In addition to a new look and feel, users may also change the color of any curve displayed within this new window.

64
article thumbnail

The future is likely less skiable, thanks to climate change

Science Daily: Pharmacology News

Annual snow cover days in all major skiing regions are projected to decrease dramatically as a result of climate change, with 1 in 8 ski areas losing all natural snow cover this century under high emission scenarios, according to a new study.

64
article thumbnail

Which pharmaceutical companies have the most insert dosed drugs?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most insert dosed drugs. For a different perspective, see the most popular dosage types. The companies with the most insert dosed drugs… The post Which pharmaceutical companies have the most insert dosed drugs? appeared first on DrugPatentWatch - Make Better Decisions.