Drug Discovery World
MARCH 13, 2024
With government support and strong academic institutions, does Singapore have what it takes to become a global centre for life sciences? DDW’s Diana Spencer explores how the country is turning pioneering science into a successful biotech industry. Thanks to significant investment by the government into research and development, Singapore has become a leading centre for biomedical sciences in Asia.
Science Daily: Pharmacology News
MARCH 13, 2024
An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.
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Drug Discovery World
MARCH 13, 2024
Johnson & Johnson has announced the first data from FRONTIER 2, the long-term extension of the Phase IIb FRONTIER 1 clinical trial evaluating JNJ-2113, the first and only investigational targeted oral peptide designed to block the IL-23 receptor. IL-23 plays a critical role in pathogenic T-cell activation in moderate-to-severe plaque psoriasis (PsO) and underpins the inflammatory response in PsO and other dermatological, rheumatological and gastroenterological IL-23-mediated diseases.
Chemical Biology and Drug Design
MARCH 13, 2024
Administration of melatonin and 3 its bioisosters efficiently normalize VEGF-A and total protein levels and antioxidant activity in vitreous body of newborn rat pups (in oxygen-induced retinopathy model). Novel melatonin analogues could be used as new metabolically stable therapeutic agents for the treatment of retinopathy of prematurity. Abstract We conducted a study on the impact of intraperitoneal injections of melatonin and its three bioisosteres (compounds 1 – 3 ) on the development of oxyg
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
MARCH 13, 2024
UK researchers have highlighted the importance of continued surveillance of emerging SARS-CoV-2 variants and vaccine performance as the virus continues to evolve. The Francis Crick Institute and the National Institute for Health and Care Research Biomedical Research Centre at University College Hospitals London (UCLH) published their study in The Lancet.
Science Daily: Pharmacology News
MARCH 13, 2024
Soil stores 80 percent of carbon on earth, yet with increasing cycles of drought, that crucial reservoir is cracking and breaking down, releasing even more greenhouse gases creating an amplified feedback loop that could accelerate climate change.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
MARCH 13, 2024
Global GDP loss from climate change will increase exponentially the warmer the planet gets when its cascading impact on global supply chains is factored in, finds a new study.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 — Nurses who specialize in anesthesia have issued new guidelines to reduce the risk that patients taking weight-loss drugs like Ozempic or Wegovy throw up during surgery."These medications have exploded in.
Science Daily: Pharmacology News
MARCH 13, 2024
Imagine performing a sweep around an object with your smartphone and getting a realistic, fully editable 3D model that you can view from any angle -- this is fast becoming reality, thanks to advances in AI. Researchers have unveiled new AI technology for doing exactly this. Soon, rather than merely taking 2D photos, everyday consumers will be able to take 3D captures of real-life objects and edit their shapes and appearance as they wish, just as easily as they would with regular 2D photos today.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 12, 2024 -- Why humans, five whale species and some chimpanzees are the only known mammals to go through menopause has long been a mystery. Now, researchers at the University of Exeter in the U.K.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
MARCH 13, 2024
A deeply eroded giant volcano, active from ancient through recent times and with possible remnants of glacier ice near its base, had been hiding near Mars' equator in plain sight. Its discovery points to an exciting new place to search for life, and a potential destination for future robotic and human exploration.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 -- Baseball season is near, and one orthopedic surgeon is warning young players and their coaches and parents about the very real danger of overuse injuries.Dr. Mark Cohen is a hand, wrist and elbow surgeon at Midwest.
Science Daily: Pharmacology News
MARCH 13, 2024
The quadrupedal robot ANYmal went back to school and has learned a lot. Researchers used machine learning to teach it new skills: the robot can now climb over obstacles and successfully negotiate pitfalls.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 -- Folks with sinus issues often turn to neti pots or "nasal rinsing" to help clear their clogged passages. Unfortunately, too many don't follow standard advice to avoid using tap water, and that's leading to sometimes.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
MARCH 13, 2024
Seattle may have experienced its own Swift Quake last July, but at an August 2023 concert Taylor Swift's fans in Los Angeles gave scientists a lot of shaking to ponder. After some debate, a research team concluded that it was likely the dancing and jumping motions of the audience at SoFi Stadium -- not the musical beats or reverberations of the sound system -- that generated the concert's distinct harmonic tremors.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 -- Following a cyberattack on the largest health insurer in the United States last month, health care providers continue to scramble as insurance payments and prescription orders continue to be disrupted and physicians.
Science Daily: Pharmacology News
MARCH 13, 2024
Researchers have conducted the first large-scale observation and modeling study of northwest Greenland's Petermann Glacier. Their findings reveal the intrusion of warm ocean water beneath the ice as the culprit in the accelerated melting it has experienced since the turn of the century, and their computer predictions indicate that potential sea level rise will be much worse than previously estimated.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 -- A woman's risk of intentional death by firearm rises during and shortly after pregnancy, new research shows.About 1 in 6 intentional firearm-related deaths in women of childbearing age occurred during pregnancy or.
Science Daily: Pharmacology News
MARCH 13, 2024
Physicists often turn to the Rayleigh-Taylor instability to explain why fluid structures form in plasmas, but that may not be the full story when it comes to the ring of hydrogen clumps around supernova 1987A, research suggests. It looks like the same mechanism that breaks up airplane contrails might be at play in forming the clumps of hydrogen gas that ring the remnant of supernova 1987A.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 -- Weight-loss surgery may help patients struggling with obesity and kidney failure become eligible for a lifesaving transplant, researchers report.Obesity is a key reason why some kidney patients are turned down for a.
Science Daily: Pharmacology News
MARCH 13, 2024
Scientists have developed ultra-thin semiconductor fibers that can be woven into fabrics, turning them into smart wearable electronics.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 — Researchers are zeroing in on the reasons why women who battle depression may be more likely than men to develop heart disease.A study published March 12 in the journal JACC: Asia underscores the need to tailor.
Science Daily: Pharmacology News
MARCH 13, 2024
What do margaritas, vinegar, and ant stings have in common? They contain chemical ingredients that NASA's James Webb Space Telescope has identified surrounding two young protostars known as IRAS 2A and IRAS 23385. Although planets are not yet forming around those stars, these and other molecules detected there by Webb represent key ingredients for making potentially habitable worlds.
BioPharma Drive: Drug Pricing
MARCH 13, 2024
Briefing documents posted ahead of Friday’s advisory panel zeroed in on increased rates of early death in tests of cell therapies from Bristol Myers Squibb and Johnson & Johnson.
Collaborative Drug
MARCH 13, 2024
Upcoming Webinar: Agenda CDD Vault – Susana Tomasio Elucidata – Abhishek Jha Revvity Signals – Pierre Morieux HitchhikersAI – Raminderpal Singh Round Table Discussion with Panelists
Science Daily: Pharmacology News
MARCH 13, 2024
Females of some whale species have evolved to live drastically longer lives so they can care for their families, new research shows.
BioPharma Drive: Drug Pricing
MARCH 13, 2024
With a decision by the Swiss pharma to acquire another one of its subsidiaries, IFM Therapeutics has now sold three spin-offs for $700 million upfront and the potential for billions more in future payments.
Science Daily: Pharmacology News
MARCH 13, 2024
A new process for microscale 3D printing creates particles of nearly any shape for applications in medicine, manufacturing, research and more -- at the pace of up to 1 million particles a day.
Drugs.com
MARCH 13, 2024
WEDNESDAY, March 13, 2024 -- Norwegians are increasingly asking surgeons for a nip, tuck or implant, and many — especially men — have pain that lingers long after their procedure, a new survey shows.Researchers asked 1,746 adults in Norway.
Cytel
MARCH 13, 2024
Group sequential clinical trial designs — a type of adaptive clinical trial design — have emerged as a powerful tool in enhancing the efficiency and ethical conduct of clinical trials, due to the ability to stop the trial early based on accumulating data. Here, I expand on the intricacies of group sequential designs, key design features, applications in clinical trials, their advantages, challenges, and impact on the landscape of clinical trials.
Collaborative Drug
MARCH 13, 2024
Redesigned Dose Response Viewer When clicking on a dose response curve from within CDD Vault, a redesigned plot now opens in a new browser tab. In addition to a new look and feel, users may also change the color of any curve displayed within this new window.
Science Daily: Pharmacology News
MARCH 13, 2024
Annual snow cover days in all major skiing regions are projected to decrease dramatically as a result of climate change, with 1 in 8 ski areas losing all natural snow cover this century under high emission scenarios, according to a new study.
Covalent Modifiers
MARCH 13, 2024
Michael Westberg et al. Sci. Transl. Med. 16 , eadi0979 (2024). DOI: 10.1126/scitranslmed.adi0979 Inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) such as nirmatrelvir (NTV) and ensitrelvir (ETV) have proven effective in reducing the severity of COVID-19, but the presence of resistance-conferring mutations in sequenced viral genomes raises concerns about future drug resistance.
Drug Patent Watch
MARCH 13, 2024
Annual Drug Patent Expirations for TIROSINT Tirosint is a drug marketed by Ibsa and is included in two NDAs. It is available from three suppliers. There are five patents protecting… The post New patent expiration for IBSA drug TIROSINT appeared first on DrugPatentWatch - Make Better Decisions.
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