Sat.Jun 29, 2024

article thumbnail

DrugPatentWatch Week in Review

Drug Patent Watch

Patent Expirations and Generic Competition This week saw several major blockbuster drugs facing patent expirations, potentially opening the market for […] Source

article thumbnail

Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells

Covalent Modifiers

Cai, G., Bao, Y., Li, Q. et al. Commun Chem 7 , 144 (2024). [link] Serine–arginine (SR) proteins are splicing factors that play essential roles in both constitutive and alternative pre-mRNA splicing. Phosphorylation of their C-terminal RS domains by SR protein kinases (SRPKs) regulates their localization and diverse cellular activities. Dysregulation of phosphorylation has been implicated in many human diseases, including cancers.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

Tips to Safely Helping Your Baby Through Teething Pain

Drugs.com

SATURDAY, June 29, 2024 -- Tending to a teething baby is tough: Parents want to help, but might not be sure how.Teething typically begins around 4 to 7 months of age, as the 20 or so "baby teeth" that will emerge by the age of 3 begin to form. The.

59
article thumbnail

RETURN TO ARTICLES ASAPPREVARTICLENEXT N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study

Covalent Modifiers

Bert L. H. Beerkens, Vasiliki Andrianopoulou, Xuesong Wang, Rongfang Liu, Gerard J. P. van Westen, Willem Jespers, Adriaan P. IJzerman, Laura H. Heitman, and Daan van der Es ACS Chemical Biology 2024 DOI: 10.1021/acschembio.4c00210 Small molecular tool compounds play an essential role in the study of G protein-coupled receptors (GPCRs). However, tool compounds most often occupy the orthosteric binding site, hampering the study of GPCRs upon ligand binding.

59
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 59
article thumbnail

Development of a Dual Factor Activatable Covalent Targeted Photoacoustic Imaging Probe for Tumor Imaging

Covalent Modifiers

Jiho Song , Tianqu Zhai , Heung Sik Hahm , Yuancheng Li , Hui Mao , Xueding Wang , Janggun Jo , Jae Won Chang , Angew. Chem. Int. Ed. 2024 , e202410645. [link] Photoacoustic imaging (PAI) is an emerging modality in biomedical imaging with superior imaging depth and specificity. However, PAI still has significant limitations, such as the background noise from endogenous chromophores.

55

More Trending

article thumbnail

Which pharmaceutical companies have the most drug patents in Australia?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Australia. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

article thumbnail

Understanding Java Enum ConditionType in Katalon Studio. Pt2

Perficient: Drug Development

Introduction In this follow-up blog, we will explore the remaining condition types available in the ConditionType enum. Understanding these additional condition types will further enhance your ability to create robust and flexible test automation scripts in Katalon Studio. Each condition type serves a unique purpose in defining criteria for identifying and interacting with web elements, ensuring the reliability and accuracy of your automated tests.

52
article thumbnail

Navigating Salesforce Record Types: A Beginner’s Guide

Perficient: Drug Development

Hello Trailblazers… In today’s world which is full of innovations and technologies, Salesforce is a powerful customer relationship management (CRM) platform that offers numerous customization options to fit the unique needs of businesses. One of the essential features that allow for such customization is “Record Types.” Record Types in Salesforce enable organizations to manage different business processes, page layouts, and picklist values for various users.

52