Chemical Biology and Drug Design

OCTOBER 8, 2023

33 novel derivatives of bensulfuron methyl were prepared and structure–activity relationships were investigated as antifungal agents against Candida auris. Abstract With the emergence of the human pathogen Candida auris as a threat to human health, there is a strong demand to identify effective medicines to prevent the harm caused by such drug-tolerant human fungi.

Drugs 100

Drugs Research 100

Drugs.com

OCTOBER 8, 2023

SUNDAY, Oct. 8, 2023 -- Catching breast cancer early is key to making it easier to treat and survive, according to the American Cancer Society (ACS). The organization aims to highlight early detection, noting that screening with mammography has.

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Chemical Biology and Drug Design

OCTOBER 8, 2023

Quercetin 3,7-dirhamnoside (QDR), a quercetin flavonoid from Pouzolzia zeylanica (L.) Benn, is the main component for quality standardization. Through an assessment of pharmacology-based method, we found that QDR significantly inhibited lipopolysaccharides-induced inducible nitric oxide synthase expression, nitric oxide release and the generation of proinflammatory cytokines IL-6, IL-1β, and TNF-α by regulating the expression of AKT1, mTOR, and NOS to against inflammatory.

Immune Response 100

Immune Response Regulations Research 100

Drugs.com

OCTOBER 8, 2023

SATURDAY, Oct. 7, 2023 -- It’s time to get the flu shot. They’re important not just for adults, but also for children, and keeping the whole family safe, according to an expert in pediatrics. “You never know how bad a flu season.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Covalent Modifiers

OCTOBER 8, 2023

Bracken, A.; Gekko, C.; Suss, N.; Lueders, E.; Cui, Q.; Fu, Q.; Anderson, E.; Zhang, S.; Abbasov, M. ChemRxiv 2023 [link] Natural products perennially serve as prolific sources of drug leads and chemical probes, fueling the development of numerous therapeutics. Despite their scarcity, natural products that modulate protein function through covalent interactions with lysine residues hold immense potential to unlock new therapeutic interventions and advance our understanding of the biological proc

Government 65

Government Production Drugs 65

FDA Law Blog: Biosimilars

OCTOBER 8, 2023

By Karla L. Palmer — On Friday, October 6, 2023, DEA announced a second extension of telemedicine flexibilities concerning the prescribing of controlled substances, which were originally set to expire after the end of the COVID-19 pandemic emergency. As a reminder, back in February 2023, HPM blogged about DEA’s two proposed rules for prescribing (1) controlled substances generally and (2) for buprenorphine use in opioid treatment.

Compliance 64

Compliance Government Treatment Drugs 64

BioPharma Drive: Drug Pricing

OCTOBER 8, 2023

Mirati shareholders could also receive another $1 billion should an experimental cancer drug the biotech is developing make it to U.S. regulators’ desks.

Drug Development 62

Drug Development Regulations Drugs 62

Perficient: Drug Development

OCTOBER 8, 2023

As we have discussed about Schema.org in Sitecore and it’s benefits in my previous blog. We will be exploring the implementation of schema.org on components. In this blog, I am taking a scenario where I will be implementing Schema.org on the Custom Breadcrumb component in Sitecore. Prerequisites: Sitecore 9.1 and above SXA I am creating a clone of Breadcrumb (Out of the box) rendering in SXA and will modify the rendering to implement Schema.org in it.

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SCIENMAG: Medicine & Health

OCTOBER 8, 2023

Type of work: Peer-reviewed / experimental study / people Credit: Design by Dr. Anne Bjertrup via Canva Type of work: Peer-reviewed / experimental study / people Up to a third of mothers don’t bond well with their babies after birth, causing intense emotional distress to both mother and baby1.

Research 52

Research 52

Drug Patent Watch

OCTOBER 8, 2023

This chart shows the pharmaceutical companies with the most patents in Ecuador. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Ecuador? appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies 59

Pharmaceutical Companies Pharmaceuticals Drugs 59

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Clinical Trials

SCIENMAG: Medicine & Health

OCTOBER 8, 2023

Type of work: peer-reviewed/randomised controlled trial/people Credit: (credit: Marc Dingman, Neuroscientifically Challenged (www.neurochallenged.com). Type of work: peer-reviewed/randomised controlled trial/people SSRI antidepressants normally take a few weeks before any showing mental health benefits, but how come it takes so long?

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Trials 52