Wed.Feb 14, 2024

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Sage offers details on launch of new postpartum depression pill

BioPharma Drive: Drug Pricing

The company and partner Biogen say signs from payers and doctors suggest the launch of Zurzuvae, the first oral therapy for PPD, is off to a good start.

Doctors 125
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Oregon Man Struck by Bubonic Plague Likely Got It From Pet Cat

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- An Oregonian who was diagnosed with the bubonic plague -- the disease that killed millions of Europeans in the Middle Ages -- probably got it from an infected pet cat, health officials said. The patient and all close.

Disease 119
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Hunting a non-opioid painkiller, a biotech startup reveals plans to chase Vertex

BioPharma Drive: Drug Pricing

Latigo Biotherapeutics has raised $135 million to develop drugs that block NaV1.8, a target shared by a Vertex therapy that just succeeded in Phase 3 testing.

Therapies 124
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By growing animal cells in rice grains, scientists dish up hybrid food

Science Daily: Pharmacology News

From lab-grown chicken to cricket-derived protein, these innovative alternatives offer hope for a planet struggling with the environmental and ethical impacts of industrial agriculture. Now, scientists add a new recipe to the list -- cultured beef rice -- by growing animal muscle and fat cells inside rice grains. The method results in a nutritious and flavorful hybrid food that, once commercialized, could offer a more affordable protein alternative with a smaller carbon footprint.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Perficient’s Thoughts on use of GenAI in Commerce Solutions

Perficient: Drug Development

Revolutionizing B2C Commerce: The Impact of Generative AI In the dynamic landscape of commerce and consumer-driven markets, Business-to-Consumer (B2C) organizations are increasingly turning to generative AI to revolutionize their operations and enhance customer experiences. Generative AI, a subset of artificial intelligence, empowers these organizations to create content, personalize interactions, and optimize various aspects of their business processes.

Marketing 115

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Acupuncture May Lower Stroke Risk in Rheumatoid Arthritis Patients

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- Acupuncture may protect people with rheumatoid arthritis (RA) from stroke, new research suggests.The study indicates that a course of acupuncture treatment may lower blood levels of inflammatory proteins called.

Treatment 111
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Finding the Right Fit—Is Your Respirator “The One”?

NIOSH Science Blog: Drugs

Finding the right fit is one of the most important parts of a relationship. You don’t just grab any old fish from the sea that swims by and hope for the best. First, it’s necessary to test the waters and ensure you’re simpatico before settling on a partner. It’s Valentine’s Day, and yes, this advice could apply to your romantic life, but we also love to use today to show our love of respirators and we love to play matchmaker on your behalf as well.

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CDD Receives Malaria Antibody Data Management Grant

Collaborative Drug

Burlingame, California - February 14, 2024 - Collaborative Drug Discovery (CDD) has received a $300,000 grant from the Bill & Melinda Gates Foundation to provide advanced, collaborative informatics capabilities to accelerate preclinical discovery and prioritization of effective antimalarial antibodies.

Drugs 102
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Synthesis and in vitro evaluation of antibacterial and antibiofilm activities of novel triphenylphosphonium?functionalized substituted pyrimidines

Chemical Biology and Drug Design

In this study, triphenylphosphonium-containing substituted pyrimidines were synthesized and evaluated for their antibacterial and antibiofilm activities against S. aureus 222 , E. coli 311 , and P. aeruginosa 449. Compounds 2a and 11 showed a significant reduction in biofilm formation of S. aureus 222 and E. coli 311 by 76.5%–99.1%. Abstract The increase in the prevalence of antibiotic-resistant pathogens leads to a decrease in the number of antimicrobial agents for the treatment of infections a

Treatment 100
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Being Bullied in Childhood More Than Triples Risk of Mental Health Struggles Later

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- When bullies destroy a young victim's trust, mental health problems are likely to follow them into adulthood, a new study warns."There are few public health topics more important than youth mental health right now," said.

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Design, synthesis, and anticancer evaluation of alkynylated pyrrole derivatives

Chemical Biology and Drug Design

The discovery of alkynylated pyrrole derivatives as anticancer agents. Abstract A series of alkynylated pyrrole derivatives were meticulously designed, drawing inspiration from the structure of 3-alkynylpyrrole-2,4-dicarboxylates, which were synthesized via a cyclization process involving methylene isocyanides and propiolaldehydes under mild conditions.

Research 100
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Man Dies in First Fatal Case of Alaskapox

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- Alaska health officials say a man in that state has died after contracting Alaskapox, a rare virus that mostly infects small mammals.In a statement, the Alaska Section of Epidemiology said the patient was “an elderly.

Virus 98
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Altermagnetism proves its place on the magnetic family tree

Science Daily: Pharmacology News

There is now a new addition to the magnetic family: researchers have demonstrated the existence of altermagnetism. The experimental discovery of this new branch of magnetism signifies new fundamental physics, with major implications for spintronics.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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CDC May Consider Loosening COVID Isolation Guidance

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- New, proposed guidance being weighed by the U.S. Centers for Disease Control and Prevention recommends that Americans who test positive for COVID-19 no longer need to routinely stay home for five days.This is the first.

Disease 97
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Biomanufacturing using chemically synthesized sugars enables sustainable supply of sugar without competing with food

Science Daily: Pharmacology News

Researchers have succeeded in biomanufacturing from chemically synthesized sugar for the first time in the world. With refinement of this technology, one can envision a future society in which the sugar required for biomanufacturing can be obtained 'anytime, anywhere, and at high rate'. In the future, biomanufacturing using chemically synthesized sugar is expected to be a game changer in the biotechnology field -- including the production of biochemicals, biofuels, and food, where sugar is an es

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Could Using Scents in Therapy Help Depressed Patients Recover?

Drugs.com

Aromatherapy might be able to improve memory and help treat depressionDepressed individuals better recalled specific personal memories after exposed to scentsThese memories could help them rewire their thought patternsWEDNESDAY, Feb. 14, 2024 --.

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Accelerating Drug Discovery at Receptor.AI with NVIDIA BioNeMo Cloud APIs

Nvidia Developer: Drug Discovery

The quest for new, effective treatments for diseases that remain stubbornly resistant to current therapies is at the heart of drug discovery. This traditionally. The quest for new, effective treatments for diseases that remain stubbornly resistant to current therapies is at the heart of drug discovery. This traditionally long and expensive process has been radically improved by AI techniques like deep learning, empowered by the rise of accelerated computing.

Drugs 90
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Combo of Hot Flashes, Migraine Sends Heart Risks Sky High

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- As if painful migraines, hot flashes and night sweats weren't bad enough, many women in menopause are facing a significantly bigger threat.New research suggests that women with both migraines and vasomotor symptoms (hot.

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Gargling away the 'bad' bacteria in type 2 diabetes

Science Daily: Pharmacology News

Researchers have found that gargling with an antiseptic mouthwash can reduce so-called 'bad' bacteria in the mouths of patients with type 2 diabetes. Notably, this reduction in bacteria was accompanied by improved blood-sugar control in some patients. Given that the oral diseases caused by these bacteria have been linked to many other serious inflammation-associated diseases, such as cardiovascular disease and Alzheimer's disease, this simple treatment may have widespread effects.

Disease 89
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Ipsen drug approved by FDA for early pancreatic cancer

BioPharma Drive: Drug Pricing

The clearance of Onivyde for first-line pancreatic adenocarcinoma triggers a $225 million payment to Merrimack, from whom Ipsen bought the drug.

FDA 87
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Anthropologists' research unveils early stone plaza in the Andes

Science Daily: Pharmacology News

Located at the Callacpuma archaeological site in the Cajamarca Basin of northern Peru, the plaza is built with large, vertically placed megalithic stones -- a construction method previously unseen in the Andes.

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Significantly fewer births on weekends and holidays than weekdays, data analysis of over 21 million births from 1979-2018 in Japan shows

SCIENMAG: Medicine & Health

Significantly more babies were born on a weekday instead of weekend day or holiday, reveals a large-scale analysis of 21 million births in Japan over almost four decades published February 14, 2024 in the open-access journal PLOS ONE by Miho Sassa from the University of Tokyo, Japan, and colleagues.

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A 'quantum leap' at room temperature

Science Daily: Pharmacology News

Scientists have achieved a milestone by controlling quantum phenomena at room temperature.

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The program of the 17th World Congress on Polyphenols Applications 2024 is now released: Advancing polyphenols research

SCIENMAG: Medicine & Health

The 17th World Congress on Polyphenols Applications 2024, scheduled for September 19-20, 2024, at Università degli Studi di Milano Statale in Italy, has revealed its program. This congress aims to bridge the latest scientific research on polyphenols with their potential to promote health.

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Live from the brain: Visual cues inform decision to cooperate

Science Daily: Pharmacology News

By combining behavioral and wireless eye tracking and neural monitoring, a team of scientists studied how pairs of freely moving macaques interacting in a naturalistic setting use visual cues to guide complex, cooperative behavior.

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Discovery of a subset of human short introns that are spliced out by a novel mechanism

SCIENMAG: Medicine & Health

In humans, the length of pre-mRNA varies extensively (from 30 to 1,160,411 nucleotides by recent studies). The fundamental mechanism of splicing has been studied with model pre-mRNAs including 158- and 231-nt introns, for historical instance, that are spliced very efficiently in vitro and in vivo. Such an ideal pre-mRNA contains good splicing signal sequences, i.e.

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A new optical metamaterial makes true one-way glass possible

Science Daily: Pharmacology News

Researchers have discovered how to make an optical metamaterial that would underpin a variety of new technologies.