Thu.Aug 15, 2024

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Cleaning up the aging brain: Scientists restore brain's trash disposal system

Science Daily: Pharmacology News

Scientists have restored the brain's waste-clearing process in aging mice, offering potential new treatment for Alzheimer's and Parkinson's using existing drugs.

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Exploring the Mechanism of Myrrh in the Treatment of Breast Cancer Based on Network Pharmacology and Cell Experiments

Chemical Biology and Drug Design

The findings reveal the active constituents, key targets, and molecular mechanisms of myrrh in BC treatment, providing scientific evidence that supports the role of myrrh in BC therapy. ABSTRACT This study aimed to investigate the mechanism of action of myrrh in breast cancer (BC) treatment and identify its effective constituents. Data on the compounds and targets of myrrh were collected from the TCMSP, PubChem, and Swiss Target Prediction databases.

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Brain wiring is guided by activity even in very early development

Science Daily: Pharmacology News

In humans, the process of learning is driven by different groups of cells in the brain firing together. For instance, when the neurons associated with the process of recognizing a dog begin to fire in a coordinated manner in response to the cells that encode the features of a dog -- four legs, fur, a tail, etc. -- a young child will eventually be able to identify dogs going forward.

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Medicare reveals results of drug price negotiations

BioPharma Drive: Drug Pricing

The agency said the first round of pricing talks, which involved drugs like the blood thinners Eliquis and Xarelto, will result in $6 billion in savings for taxpayers.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Looking for Symptoms to Catch Ovarian Cancer Early

Drugs.com

THURSDAY, Aug. 15, 2024 -- Ovarian cancer is known as a "silent killer," since by the time symptoms arise the disease has often already spread.But in certain cases of aggressive ovarian cancer, symptoms do arise in the tumor's early stages. In.

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The Marina Orth Foundation and The Last Mile Education Fund Receive Perficient Global Grant

Perficient: Drug Development

At Perficient, we take immense pride in igniting positive change around the world. Since Perficient’s Giving Employee Resource Group (ERG) launching the Perficient Global Grants Program earlier this year, we have seen remarkable enthusiasm and commitment from our global colleagues, each championing their favorite charitable causes with passion and purpose.

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Lykos to cut 75% of staff after FDA rejection of MDMA-based therapy

BioPharma Drive: Drug Pricing

The layoffs are part of a larger reorganization that will also see the departure of Lykos’ founder, the psychedelics advocate Rick Doblin.

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High Blood Pressure Raises Odds for Alzheimer's Disease

Drugs.com

THURSDAY, Aug. 15, 2024 -- Untreated high blood pressure in your 60s could raise your risk for Alzheimer's disease later, new research shows.The good news: Simple steps can ease hypertension, researchers said.The global study found that "taking.

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Zebrafish use surprising strategy to regrow spinal cord

Science Daily: Pharmacology News

A new study maps out a detailed atlas of all the cells involved in regenerating the zebrafish spinal cord. In an unexpected finding, the researchers showed that survival and adaptability of the severed neurons themselves is required for full spinal cord regeneration. Surprisingly, the study showed that stem cells capable of forming new neurons play a complementary role but don t lead the process.

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Work Stress May Help Bring on A-Fib

Drugs.com

THURSDAY, Aug. 15, 2024 -- Low-paid employees under crushing work stress have a nearly doubled risk of developing a dangerous heart rhythm disorder, a new study finds.White-collar workers with high-stress, low-reward jobs have a 97% increased risk.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Intelligent soft robotic clothing for automatic thermal adaptation in extreme heat

Science Daily: Pharmacology News

As global warming intensifies, people increasingly suffer from extreme heat. For those working in a high-temperature environment indoors or outdoors, keeping thermally comfortable becomes particularly crucial. A team has now developed thermally-insulated and breathable soft robotic clothing that can automatically adapt to changing ambient temperatures, thereby helping to ensure worker safety in hot environments.

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1 in 4 Brain Injured Patients Who Seem Unresponsive Have 'Covert' Consciousness

Drugs.com

THURSDAY, Aug. 15, 2024 -- Some comatose patients with severe brain injury might be paying closer attention to their surroundings than previously thought, a new study says.About 1 in 4 patients respond to instructions covertly, with their brains.

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Why do plants wiggle? New study provides answers

Science Daily: Pharmacology News

Decades after his voyage on the HMS Beagle, Charles Darwin became fascinated by why plants move as they grow -- spinning and twisting into corkscrews. Now, more than 150 years later, a new study may have solved the riddle.

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Need a Low-Cost Eye Exam, Glasses? The State You Live In Is Key

Drugs.com

THURSDAY, Aug. 15, 2024 -- When it comes to Medicaid and vision care, how much coverage people get depends on the state in which they live, a new study finds.Most Medicaid enrollees have at least some routine vision coverage, but an estimated 6.5.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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CDD Vault Update (August 2024)

Collaborative Drug

Inventory Search Interface: The new CDD Vault Inventory tab can be enabled by the CDD Support Team. If you wish to enable this tab in your Vault please have your vault administrator contact support@collaborativedrug.com.

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Frequent Coffee Drinkers Could Put Their Hearts at Risk

Drugs.com

THURSDAY, Aug. 15, 2024 -- Chugging coffee, swilling colas or pounding down energy drinks could cause heart damage over time, a new study warns. All of these drinks contain caffeine, and a new study finds that folks who drink more than 400.

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The Collaboration Between Industry and Academia in Drug Development

DrugBank

Drug development is challenging, including not only the complexities of biomolecular drug mechanisms but also the convolutions of regulatory pathways and commercialization strategies. To effectively navigate this ecosystem and expedite the development of new therapies, collaboration between the pharmaceutical industry and academia is proving increasingly vital.

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Workplace Mistreatment Takes Tougher Mental Toll on Black Employees

Drugs.com

THURSDAY, Aug. 15, 2024 -- Black employees in a toxic workplace are more susceptible to depression and sleep loss than whites are, according to new research.Black workers being mistreated by employers got an estimated 100 fewer minutes of sleep per.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Great Results Start with Great Standard Curves

addgene Blog

What do a viral vector production facility, food allergy testing lab, and the grad student down the hall from you have in common? All of them rely on standard curves in their day-to-day work. Indeed, viral vector production facilities frequently use qPCR with a standard curve to titer their viruses; food allergy labs use standard curves with ELISAs to measure allergen concentrations in food; and your friend the grad student relies on a standard in their bicinchoninic acid assay (BCA) to normaliz

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FDA Moves to Further Reduce Salt Levels in Food

Drugs.com

THURSDAY, Aug. 15, 2024 -- Emboldened by success in its initial efforts to cut dietary salt intake by Americans, the U.S. Food and Drug Administration on Thursday announced Phase II of the endeavor. U.S. Dietary Guidelines recommend that a person.

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Incyte builds out its arsenal of post-transplant drugs

BioPharma Drive: Drug Pricing

The approval of Niktimvo in graft-versus-host disease hands Incyte another immune system-regulating medicine that analysts see as valuable, especially if use is broadened through additional clearances.

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Brain-Computer Combo Lets Mute Man With ALS 'Talk' Again

Drugs.com

THURSDAY, Aug. 15, 2024 -- Casey Harrell was losing his ability to speak due to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.“Not being able to communicate is so frustrating and demoralizing. It is like you are trapped,” s.

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FDA clears Gilead drug acquired in $4.3B buyout

BioPharma Drive: Drug Pricing

Livdelzi, which Gilead inherited through its acquisition of CymaBay, will now compete with medicines for primary biliary cholangitis that are currently marketed by Ipsen and Alfasigma.

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Kids' Bedtimes Might Influence Odds for Drug, Alcohol Use as Teens

Drugs.com

THURSDAY, Aug. 15, 2024 -- Regular bedtimes won't just help your child be alert for a busy school day; they might also help keep them from abusing drugs or alcohol as a teen, new research suggests.Youth who'd had early bedtimes in childhood and.

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Heterogeneous and curated biobank of live-cell tumor samples retains highly reproducible drug response data for drug and biomarker discovery

Predictive Oncology

White paper validates highly reproducible drug response data. Results enable AI platform to model and predict patient outcomes on historical samples Leveraging more than 20 years of longitudinal patient and drug response data, Predictive Oncology verified and validated that the cryopreserved tumor samples preserved in the company’s live-cell biobank continue to produce accurate drug response data that is consistent with their initial clinical testing results with 100% concordance.

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Which pharmaceutical drugs have the most drug patents in European Patent Office?

Drug Patent Watch

This chart shows the drugs with the most patents in European Patent Office. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

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Heterogeneous and curated biobank of live-cell tumor samples retains highly reproducible drug response data for drug and biomarker discovery

Predictive Oncology

White paper validates highly reproducible drug response data. Results enable AI platform to model and predict patient outcomes on historical samples Leveraging more than 20 years of longitudinal patient and drug response data, Predictive Oncology verified and validated that the cryopreserved tumor samples preserved in the company’s live-cell biobank continue to produce accurate drug response data that is consistent with their initial clinical testing results with 100% concordance.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Environmental, Social and Governance (ESG) and Climate Risk Investing – You must be kidding me?!

Perficient: Drug Development

“As if there weren’t enough jargons and complex terms to remember for an investor, you are telling me I need to now know about ESG and Climate Risk – You must be kidding me!!” – These are the exact words (with a couple of expletives, that I cannot quote here) – a senior fund administrator from a large investment firm uttered when we were presenting about environment aware financial risk management.

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New patent expiration for Janssen Prods drug PREZCOBIX

Drug Patent Watch

Annual Drug Patent Expirations for PREZCOBIX Prezcobix is a drug marketed by Janssen Prods and is included in one NDA. It is available from two suppliers. There are four patents protecting this drug.

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Creating a Sound A/B Test Hypothesis

Perficient: Drug Development

A Hypothesis is important for understanding what you are trying to prove with your A/B test. A well-formed hypothesis acts as a test guide. A hypothesis is going to challenge an assumption you have about your website’s performance and/or visitor behavior. What is the assumption you want to validate as right or wrong? Ask yourself these questions when coming up with your test hypothesis: What assumption are you addressing?

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New patent expiration for Janssen Prods drug PREZISTA

Drug Patent Watch

Annual Drug Patent Expirations for PREZISTA Prezista is a drug marketed by Janssen Prods and is included in two NDAs. It is available from one supplier.

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Perficient Insights: Dreamforce 2024 with Jonathan Rademacher

Perficient: Drug Development

At Perficient, we take pride in the talent and leadership that make up our team. Today, we are excited to speak with Jonathan Rademacher—though you may know him better as JR—our Principal for the Salesforce practice. With an impressive career that spans over two decades, Jonathan’s journey is a testament to his dedication to innovation and customer success.

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