Drug Discovery World

AUGUST 15, 2024

Scale Biosciences (Scale Bio) has launched the ‘100 Million Cell Challenge’, which hopes to push the boundaries of single-cell genomics research, in collaboration with Ultima Genomics and NVIDIA. The programme calls on researchers worldwide to submit proposals for large-scale single cell projects, with the goal of collectively analysing 100 million cells or more across diverse biological systems and research areas.

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Research Disease Drugs 147

Science Daily: Pharmacology News

AUGUST 15, 2024

Scientists have restored the brain's waste-clearing process in aging mice, offering potential new treatment for Alzheimer's and Parkinson's using existing drugs.

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Treatment Drugs 145

Drug Discovery World

AUGUST 15, 2024

OpenFold, a non-profit artificial intelligence (AI) research consortium focused on developing free and open-source software tools for biology and drug discovery, has added six new industry members. Joining the consortium are Astex Pharmaceuticals, Biogen, Congruence Therapeutics, Polaris Quantum Biotech, Psivant Therapeutics, and SandboxAQ. “This expansion marks a significant stride forward in advancing AI-driven solutions for healthcare and life sciences,” said Christina Taylor, Senior Science

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Research Laboratories Drugs Science 147

Science Daily: Pharmacology News

AUGUST 15, 2024

In humans, the process of learning is driven by different groups of cells in the brain firing together. For instance, when the neurons associated with the process of recognizing a dog begin to fire in a coordinated manner in response to the cells that encode the features of a dog -- four legs, fur, a tail, etc. -- a young child will eventually be able to identify dogs going forward.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 15, 2024

A Phase IIa clinical trial has begun evaluating the safety and efficacy of Pelage Pharmaceuticals’ PP405, a novel topical small molecule, for the treatment of androgenetic alopecia (pattern baldness). The company is enrolling 60 women and men for the clinical study. PP405 is designed to reactivate dormant hair follicle stem cells to stimulate hair growth.

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Small Molecule Medical Schools Clinical Trials Pharmaceuticals 147

Chemical Biology and Drug Design

AUGUST 15, 2024

The findings reveal the active constituents, key targets, and molecular mechanisms of myrrh in BC treatment, providing scientific evidence that supports the role of myrrh in BC therapy. ABSTRACT This study aimed to investigate the mechanism of action of myrrh in breast cancer (BC) treatment and identify its effective constituents. Data on the compounds and targets of myrrh were collected from the TCMSP, PubChem, and Swiss Target Prediction databases.

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Treatment Therapies Disease Drugs 100

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Ovarian cancer is known as a "silent killer," since by the time symptoms arise the disease has often already spread.But in certain cases of aggressive ovarian cancer, symptoms do arise in the tumor's early stages. In.

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Disease 110

BioPharma Drive: Drug Pricing

AUGUST 15, 2024

The layoffs are part of a larger reorganization that will also see the departure of Lykos’ founder, the psychedelics advocate Rick Doblin.

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Therapies FDA 120

Science Daily: Pharmacology News

AUGUST 15, 2024

A new study maps out a detailed atlas of all the cells involved in regenerating the zebrafish spinal cord. In an unexpected finding, the researchers showed that survival and adaptability of the severed neurons themselves is required for full spinal cord regeneration. Surprisingly, the study showed that stem cells capable of forming new neurons play a complementary role but don t lead the process.

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Research 115

Perficient: Drug Development

AUGUST 15, 2024

At Perficient, we take immense pride in igniting positive change around the world. Since Perficient’s Giving Employee Resource Group (ERG) launching the Perficient Global Grants Program earlier this year, we have seen remarkable enthusiasm and commitment from our global colleagues, each championing their favorite charitable causes with passion and purpose.

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Engineering 105

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

AUGUST 15, 2024

As global warming intensifies, people increasingly suffer from extreme heat. For those working in a high-temperature environment indoors or outdoors, keeping thermally comfortable becomes particularly crucial. A team has now developed thermally-insulated and breathable soft robotic clothing that can automatically adapt to changing ambient temperatures, thereby helping to ensure worker safety in hot environments.

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Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- The World Health Organization on Wednesday made the rare move of declaring an ongoing African outbreak of mpox a global health emergency.A new clade (strain) of the virus, plus its troubling spread throughout the.

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Virus 105

Science Daily: Pharmacology News

AUGUST 15, 2024

Decades after his voyage on the HMS Beagle, Charles Darwin became fascinated by why plants move as they grow -- spinning and twisting into corkscrews. Now, more than 150 years later, a new study may have solved the riddle.

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Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Untreated high blood pressure in your 60s could raise your risk for Alzheimer's disease later, new research shows.The good news: Simple steps can ease hypertension, researchers said.The global study found that "taking.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Collaborative Drug

AUGUST 15, 2024

Inventory Search Interface: The new CDD Vault Inventory tab can be enabled by the CDD Support Team. If you wish to enable this tab in your Vault please have your vault administrator contact support@collaborativedrug.com.

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Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Low-paid employees under crushing work stress have a nearly doubled risk of developing a dangerous heart rhythm disorder, a new study finds.White-collar workers with high-stress, low-reward jobs have a 97% increased risk.

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DrugBank

AUGUST 15, 2024

Drug development is challenging, including not only the complexities of biomolecular drug mechanisms but also the convolutions of regulatory pathways and commercialization strategies. To effectively navigate this ecosystem and expedite the development of new therapies, collaboration between the pharmaceutical industry and academia is proving increasingly vital.

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Drug Development Clinical Trials Drugs Therapies 82

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Some comatose patients with severe brain injury might be paying closer attention to their surroundings than previously thought, a new study says.About 1 in 4 patients respond to instructions covertly, with their brains.

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addgene Blog

AUGUST 15, 2024

What do a viral vector production facility, food allergy testing lab, and the grad student down the hall from you have in common? All of them rely on standard curves in their day-to-day work. Indeed, viral vector production facilities frequently use qPCR with a standard curve to titer their viruses; food allergy labs use standard curves with ELISAs to measure allergen concentrations in food; and your friend the grad student relies on a standard in their bicinchoninic acid assay (BCA) to normaliz

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Virus Production 77

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- When it comes to Medicaid and vision care, how much coverage people get depends on the state in which they live, a new study finds.Most Medicaid enrollees have at least some routine vision coverage, but an estimated 6.5.

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BioPharma Drive: Drug Pricing

AUGUST 15, 2024

The approval of Niktimvo in graft-versus-host disease hands Incyte another immune system-regulating medicine that analysts see as valuable, especially if use is broadened through additional clearances.

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Regulations Disease Drugs 70

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Chugging coffee, swilling colas or pounding down energy drinks could cause heart damage over time, a new study warns. All of these drinks contain caffeine, and a new study finds that folks who drink more than 400.

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BioPharma Drive: Drug Pricing

AUGUST 15, 2024

Livdelzi, which Gilead inherited through its acquisition of CymaBay, will now compete with medicines for primary biliary cholangitis that are currently marketed by Ipsen and Alfasigma.

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FDA Drugs Marketing 67

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Black employees in a toxic workplace are more susceptible to depression and sleep loss than whites are, according to new research.Black workers being mistreated by employers got an estimated 100 fewer minutes of sleep per.

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Predictive Oncology

AUGUST 15, 2024

White paper validates highly reproducible drug response data. Results enable AI platform to model and predict patient outcomes on historical samples Leveraging more than 20 years of longitudinal patient and drug response data, Predictive Oncology verified and validated that the cryopreserved tumor samples preserved in the company’s live-cell biobank continue to produce accurate drug response data that is consistent with their initial clinical testing results with 100% concordance.

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Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Emboldened by success in its initial efforts to cut dietary salt intake by Americans, the U.S. Food and Drug Administration on Thursday announced Phase II of the endeavor. U.S. Dietary Guidelines recommend that a person.

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FDA Drugs 98

Predictive Oncology

AUGUST 15, 2024

White paper validates highly reproducible drug response data. Results enable AI platform to model and predict patient outcomes on historical samples Leveraging more than 20 years of longitudinal patient and drug response data, Predictive Oncology verified and validated that the cryopreserved tumor samples preserved in the company’s live-cell biobank continue to produce accurate drug response data that is consistent with their initial clinical testing results with 100% concordance.

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Drugs Drug Development 52

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Casey Harrell was losing his ability to speak due to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease.“Not being able to communicate is so frustrating and demoralizing. It is like you are trapped,” s.

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Disease 97

Drug Patent Watch

AUGUST 15, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs Marketing 52

Drugs.com

AUGUST 15, 2024

THURSDAY, Aug. 15, 2024 -- Regular bedtimes won't just help your child be alert for a busy school day; they might also help keep them from abusing drugs or alcohol as a teen, new research suggests.Youth who'd had early bedtimes in childhood and.

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Drugs Research 92

Drug Patent Watch

AUGUST 15, 2024

Annual Drug Patent Expirations for PREZCOBIX Prezcobix is a drug marketed by Janssen Prods and is included in one NDA. It is available from two suppliers. There are four patents protecting this drug.

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Drugs Marketing 52

Perficient: Drug Development

AUGUST 15, 2024

“As if there weren’t enough jargons and complex terms to remember for an investor, you are telling me I need to now know about ESG and Climate Risk – You must be kidding me!!” – These are the exact words (with a couple of expletives, that I cannot quote here) – a senior fund administrator from a large investment firm uttered when we were presenting about environment aware financial risk management.

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Drug Patent Watch

AUGUST 15, 2024

Annual Drug Patent Expirations for PREZISTA Prezista is a drug marketed by Janssen Prods and is included in two NDAs. It is available from one supplier.

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Drugs Marketing 52

Perficient: Drug Development

AUGUST 15, 2024

A Hypothesis is important for understanding what you are trying to prove with your A/B test. A well-formed hypothesis acts as a test guide. A hypothesis is going to challenge an assumption you have about your website’s performance and/or visitor behavior. What is the assumption you want to validate as right or wrong? Ask yourself these questions when coming up with your test hypothesis: What assumption are you addressing?

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