Drug Discovery World

DECEMBER 20, 2023

Using a novel approach, researchers from The Institute of Cancer Research, London have uncovered details of secondary breast cancer in the brain and spinal cord that may help with developing effective treatments. The study revealed for the first time that breast cancer leptomeningeal metastasis (BCLM) cells spread early from the primary breast tumour and that they acquire features typically associated with lobular breast cancer, which develops in the glands that produce breast milk.

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Molecular Biology Drugs DNA Treatment 265

BioPharma Drive: Drug Pricing

DECEMBER 20, 2023

The Healey center is at the front of ALS research and care, earning acclaim from patients, doctors and scientists. Still, the complexities of the disease and of drug development have brought hard-felt losses.

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Drug Discovery World

DECEMBER 20, 2023

In this Case Study you will learn: How Professor Deepak Srivastava’s lab at King’s College London are working to unpick the complex bio logy of neuronal synapses to help us better understand neurological disorders like schizophrenia. How the researchers in Professor Srivastava’s lab have been able to generate publishable data on schizophrenia risk factors in just 12 weeks by optimising their students’ time at the bench.

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Chemical Biology and Drug Design

DECEMBER 20, 2023

Triptolide can effectively inhibit proliferation and invasion as well as promote apoptosis of HT29 cells. Its mechanism of action may be related to the inhibition of Nrf2 signaling. As such, triptolide is expected to be a potential drug for colorectal cancer treatment. Abstract Triptolide (TPL), the main active ingredient of Tripterygium wilfordii , has anti-inflammatory, immunomodulatory, and antitumor actions.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Discovery World

DECEMBER 20, 2023

A new resource is now available to download for free from sponsors Bit Bio: ‘ Speeding up neuroscience research: Generating publishable data in 12 weeks ‘ In this Case Study you will learn: How Professor Deepak Srivastava’s lab at King’s College London are working to unpick the complex bio logy of neuronal synapses to help us better understand neurological disorders like schizophrenia.

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Research Drugs 130

Science Daily: Pharmacology News

DECEMBER 20, 2023

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists have recently uncovered a fascinating aspect of this process known as 'replication timing' (RT) and how special this is when life commences.

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DNA 119

Broad Institute

DECEMBER 20, 2023

With AI, researchers identify a new class of antibiotic candidates By Tom Ulrich December 20, 2023 Breadcrumb Home With AI, researchers identify a new class of antibiotic candidates New compounds can kill methicillin-resistant Staphylococcus aureus (MRSA), an often-lethal bacterial pathogen By Anne Trafton, MIT News Office December 20, 2023 Methicillin-resistant Staphylococcus aureus (gold) on the remains of an immune cell (red) Related people James Collins Related programs Infectious Disease an

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Drug Discovery World

DECEMBER 20, 2023

The US Food and Drug Administration (FDA) has approved antibody-drug conjugate (ADC) enfortumab vedotin-ejfv (Padcev) in combination with pembrolizumab (Keytruda) for patients with locally advanced or metastatic urothelial cancer (la/mUC). The approval is based on clinical data which found that Padcev plus pembrolizumab nearly doubled median overall survival compared to standard of care platinum-based chemotherapy.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

Conventional wisdom suggests that searching online to evaluate the veracity of misinformation would reduce belief in it. But a new study by a team of researchers shows the opposite occurs: Searching to evaluate the truthfulness of false news articles actually increases the probability of believing misinformation.

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Research 110

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- The new COVID variant known as JN.1 was named a "variant of interest" by the World Health Organization on Tuesday, which means health officials are now closely tracking its rapid spread across the globe.So far, the.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

Focusing on the Lake Titicaca Basin in the Andes mountains, anthropologists found through analysis of 1,179 projectile points that the rise of archery technology dates to around 5,000 years ago. Previous research held that archery in the Andes emerged around 3,000 years ago. The new research from UC Davis indicates that the adoption of bow-and-arrow technology coincided with both the expansion of exchange networks and the growing tendency for people to reside in villages.

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Research 103

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Women struggling with fertility and using in vitro fertilization (IVF) to conceive sometimes turn to supplements for help.Unfortunately, a new study finds only weak evidence to support that strategy.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

An artificial intelligence-driven system has autonomously learned about certain Nobel Prize-winning chemical reactions and designed a successful laboratory procedure to make them. The AI did so in just a few minutes and correctly on its first attempt. According to the authors, this is the first time that a non-organic intelligence planned, designed and executed this complex reaction that was invented by humans.

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Laboratories 108

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Beyond a myriad of other consequences, childhood trauma appears to raise the specter of chronic pain in adulthood, new research shows.Researchers pored over 75 years' worth of data involving more than 826,000 people.

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Clinical Trials

SCIENMAG: Medicine & Health

DECEMBER 20, 2023

A new study from Lawson Health Research Institute and Western University published in the journal Microbiome has found changes in the microbiome in multiple locations in the body are linked to the formation of kidney stones.

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Research 92

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Many patients with advanced colon cancers who are successfully treated with immunotherapy and then stop those treatments appear to face little risk of tumor progression two years later.That's the main finding from a.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

Researchers develop transistor that simultaneously processes and stores information like the human brain. Transistor goes beyond categorization tasks to perform associative learning. Transistor identified similar patterns, even when given imperfect input. Previous similar devices could only operate at cryogenic temperatures; new transistor operates at room temperature, making it more practical.

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Research 93

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 — Warmer weather linked to climate change is likely to cause rampaging clouds of mosquitos in the future, a new study forecasts.Rising temperatures can make it tougher for the predators that feast on mosquito larvae to.

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Science Daily: Pharmacology News

DECEMBER 20, 2023

A research team has uncovered a previously undetected mechanism in mice -- starring the genetic molecule RNA -- that could explain how each sensory cell, or neuron, in mammalian noses becomes tailored to detect a specific odor chemical.

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RNA Research 90

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Anxiety, depression and post-traumatic stress are common among people caring for the victim of a recent stroke, a new study has found.Nearly 30% of caregivers of severe stroke patients experience stress and emotional.

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SCIENMAG: Medicine & Health

DECEMBER 20, 2023

Having high cholesterol and high blood pressure before the age of 55 has a lasting impact on your risk of heart disease in later life – even if you subsequently lower your levels Credit: geralt, Pixabay, CC0 ([link] Having high cholesterol and high blood pressure before the age of 55 has a lasting impact on […]

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Disease 73

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Early research in mice could be getting closer to the roots of what causes Parkinson's disease.A "pathological" form of a common brain protein, alpha-synuclein, could play a role in the death of dopamine-rich brain.

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Treatment Research 105

Science Daily: Pharmacology News

DECEMBER 20, 2023

Using artificial intelligence, researchers discovered a class of compounds that can kill methicillin-resistant Staphylococcus aureus (MRSA), a drug-resistant bacterium that causes more than 10,000 deaths in the U.S. each year.

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Research Drugs 73

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Long left to the fringes of the recreational drug culture, psilocybin -- the hallucinatory ingredient in "magic mushrooms" — has recently been making inroads as a legitimate (and fast-acting) antidepressant.Research.

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Drugs 103

SCIENMAG: Medicine & Health

DECEMBER 20, 2023

UTICA, N.Y. – Jason R. McCarthy, Ph.D., associate professor of biomedical research and translational medicine and scientific operations director at MMRI, recently published an innovative manuscript titled, Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Post-Myocardial Infarction.

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Research 71

Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 — What's even more nerve-wracking than paying taxes?The holidays, according to a majority of Americans, who say it takes them weeks to recover from seasonal stress. "The holidays are an easy time to justify putting.

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Drug Channels

DECEMBER 20, 2023

Happy New Year, everyone! It has been another wild year for our ever-evolving healthcare system. Thank you, dear readers, for welcoming Drug Channels into your inboxes, browsers, and apps. I’m proud of the diverse and thoughtful audience who follows and comments on our unique content. The Drug Channels community now encompasses 50,000+ LinkedIn followers , 25,000+ email subscribers , and 17,000+ Twitter/X followers.

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Drugs 98

Science Daily: Pharmacology News

DECEMBER 20, 2023

Researchers have identified a species of frog new to science. The Indonesian amphibian is the size of a quarter, unlike its two-pound cousins, and has tiny fangs. Nearly uniquely among amphibians, they lay their eggs on the leaves of trees, and the males guard and tend to the nests.

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Science Research 74

BioPharma Drive: Drug Pricing

DECEMBER 20, 2023

The Dutch biotech’s star product has lost some luster after a second failed Phase 3 trial in two months, this time for a skin condition called pemphigus.

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Trials Production Drugs 70

Science Daily: Pharmacology News

DECEMBER 20, 2023

Supercomputer helped astronomers develop PRIYA, the largest suite of hydrodynamic simulations yet made of large-scale structure in the universe.

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Cytel

DECEMBER 20, 2023

Perspectives covers a wide range of topics related to real-world evidence and real-world data, from overcoming health inequalities in product development to the use of externally controlled trials to the expanding role of artificial intelligence, and much more.

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Trials Production Clinical Development FDA 64

Drug Patent Watch

DECEMBER 20, 2023

Annual Drug Patent Expirations for BENDEKA Bendeka is a drug marketed by Eagle Pharms and is included in one NDA. It is available from one supplier. There are sixteen patents… The post New patent for Eagle Pharms drug BENDEKA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

DECEMBER 20, 2023

WEDNESDAY, Dec. 20, 2023 -- Exposure to a common chemical group found in many household products may delay or even prevent a woman from becoming pregnant, a new study says.Phthalates can lower a woman’s odds of becoming pregnant by up to 18% in.

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Production 59

Drug Patent Watch

DECEMBER 20, 2023

Icosapent ethyl is the generic ingredient in two branded drugs marketed by Apotex, Dr Reddys, Hikma, Strides Pharma, Teva Pharms Usa, Zydus, and Amarin Pharms and, and is included in… The post New tentative approval for Ascent Pharms drug icosapent ethyl appeared first on DrugPatentWatch - Make Better Decisions.

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