Mon.Jun 24, 2024

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Myths about intermittent fasting, debunked

Science Daily: Pharmacology News

Research shows that the increasingly popular weight-loss strategy is safe. Intermittent fasting has become an increasingly popular way to lose weight without counting calories. And a large body of research has shown it s safe. Still, several myths about fasting have gained traction.

Research 127
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Twice-a-Year Injection Gives Women Full Protection Against HIV, Trial Finds

Drugs.com

MONDAY, June 24, 2024 -- Just two injections a year of a new HIV drug protected young women in Africa from infection with the sexually transmitted disease, new trial results show.In announcing the findings, Gilead Sciences Inc. said its HIV.

Trials 111
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Carbon dioxide's heavy stamp on temperature: Doubling CO2 may mean 7 to 14 degree increase

Science Daily: Pharmacology News

A doubling of the amount of CO2 in the atmosphere could cause an increase in the average temperature on earth from 7 to even a maximum of 14 degrees. That is shown in the analysis of sediments from the Pacific Ocean off the coast of California.

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FDA's Move to OK First Menthol Vapes Is Big Mistake, Health Advocates Say

Drugs.com

MONDAY, June 24, 2024 -- The U.S. Food and Drug Administration's decision to authorize the first menthol-flavored e-cigarettes has drawn the the ire of health advocates who say the decision undermines efforts to end the youth vaping epidemic in.

FDA 105
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Facial recognition linked to close social bonds, not social butterflies

Science Daily: Pharmacology News

Do you have trouble recognizing faces, or do you never forget a face? The better you are at facial recognition, the more supportive relationships you are likely to have, regardless of your personality type.

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Timing of Chemo Could Be Key to Pancreatic Cancer Outcomes

Drugs.com

MONDAY, June 24, 2024 -- Giving people with pancreatic cancer chemotherapy both before and after a tumor-removing surgery brought better outcomes than if they got the drugs only after the surgery, new research shows.Researchers at the Yale Cancer.

More Trending

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Anti- Seizure Meds Are Crucial, But Can Trigger Severe Reactions

Drugs.com

MONDAY, June 24, 2024 -- Specific steps can be taken to reduce the risk of potentially fatal reactions to anti-seizure medications, researchers report in a new review.Performing blood tests, asking patients about risk factors and modifying dosages.

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New study confirms forever chemicals are absorbed through human skin

Science Daily: Pharmacology News

A study of 17 commonly used synthetic 'forever chemicals' has shown that these toxic substances can readily be absorbed through human skin.

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Older Americans in Senior Housing Have Better Health Than Those Living at Home

Drugs.com

MONDAY, June 21, 2024 -- Independent living is important for seniors, but a new study shows it might not be the best thing for their health.Older adults living in senior housing tended to have better health than those who remain in their own homes.

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Star clusters observed within a galaxy in the early Universe

Science Daily: Pharmacology News

The history of how stars and galaxies came to be and evolved into the present day remains among the most challenging astrophysical questions to solve yet, but new research brings us closer to understanding it. New insights about young galaxies during the Epoch of Reionization have been revealed. Observations with the James Webb Space Telescope (JWST) of the galaxy Cosmic Gems arc (SPT0615-JD) have confirmed that the light of the galaxy was emitted 460 million years after the big bang.

Research 104
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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The Next Generation of Vaccine Mega Trials

PPD

In the realm of vaccine development, mega trials — studies enrolling 5,000 subjects or more — have been instrumental in the fight against many pathogens, including influenza, rotavirus, malaria, RSV and most recently in the rapid development of vaccines against COVID-19. The landscape of these trials is evolving, influenced by technological advancements, changing industry standards and innovative clinical trial designs.

Vaccine 97
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A hidden treasure in the Milky Way -- Astronomers uncover ultrabright x-ray source

Science Daily: Pharmacology News

Astronomers uncovered that a well-known X-ray binary, whose exact nature has been a mystery to scientists until now, is actually a hidden ultraluminous X-ray source.

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Inhaled Insulin Could Help Folks With Type 1 Diabetes Avoid Needles

Drugs.com

MONDAY, June 24, 2024 -- Inhaled insulin could be a better option than injections or pumps for some patients with type 1 diabetes, a new clinical trial shows.Patients using inhaled insulin (Afrezza) plus long-lasting insulin degludec injections had.

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Geologists expect Chang'e-6 lunar surface samples to contain volcanic rock and impact ejecta

Science Daily: Pharmacology News

On June 25, China's Chang'e-6 (CE-6) lunar probe is set to return to Earth, carrying the first surface samples collected from the farside of the Moon. In anticipation of this historic event, scientists are publishing their predictions for the unique materials that may be found in the CE-6 samples.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Leveraging 505(b)(2) to Innovate Beyond Existing Drug Patents

Drug Patent Watch

The 505(b)(2) regulatory pathway provides an attractive avenue for drug developers to bring new products to market by leveraging existing data on approved drugs. This pathway allows modifications and improvements to be made to existing drugs, while potentially reducing development costs and timelines compared to the traditional new drug application (NDA) route.

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U.S. Supreme Court Agrees to Hear Case on Medical Care for Transgender Youth

Drugs.com

MONDAY, June 24, 2024 -- The U.S. Supreme Court announced Monday that it would hear a case on a Tennessee law that bans transgender minors from receiving certain medical treatments in that state.The banned treatments include puberty-blocking drugs.

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CDD Vault Update (June 2024 #2)

Collaborative Drug

Learn about the latest update in CDD Vault's Sample Management feature, allowing you to track samples, manage inventory, and create hierarchies of locations. Find out how to create, edit, and delete samples and events, and get helpful hints for managing multiple samples. Discover how to import assay data and maintain compatibility with legacy batch-level inventory features.

Drugs 82
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Part one: what can scientists do with LLMs today?

Drug Target Review

LLMs, or deep learning models, have been around since the 1990s, but it wasn’t until the 2010s that their use became more popular. They have been used as the basis for AI assistants like Apple’s Siri and ChatGPT. Because of their ability to process vast sets of data there have been attempts to use them to accelerate progress across a range of industries.

Science 69
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Novo fills in positive picture for preventive hemophilia drug

BioPharma Drive: Drug Pricing

Phase 3 trial results should support an approval application for the drug, which analysts view as a potential competitor to Roche’s blockbuster medicine Hemlibra.

Drugs 60
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AWS Systems Manager (SSM)

Perficient: Drug Development

It provides a unified interface for viewing and controlling your infrastructure, automating tasks, and managing configurations. Here are some key features and components of AWS Systems Manager AWS Systems Manager Core Components : Run Command : Executes commands on instances. State Manager : Maintains desired state configurations. Parameter Store : Stores configuration data and secrets.

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Obesity drugs from Altimmune, Hengrui show potential; Lilly details Zepbound sleep apnea data

BioPharma Drive: Drug Pricing

The American Diabetes Association’s annual meeting provided a forum for early trial results on several would-be weight loss drug competitors.

Drugs 60
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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs. There are three patents protecting this compound. Drug patent litigation for DABIGATRAN ETEXILATE MESYLATE. Nine suppliers are listed for this compound.

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HPM Director Dara Katcher Levy to Present Webinar on AMCP Format for Formulary Submissions v5.0

FDA Law Blog: Biosimilars

This afternoon Hyman, Phelps & McNamara, P.C. (HPM) Director Dara Katcher Levy will present an informative webinar on the newly released AMCP Format for Formulary Submissions version 5.0. The event, titled “New and Improved – AMCP Format for Formulary Submissions v5.0,” aims to educate pharmaceutical manufacturers and other healthcare stakeholders on the latest updates and best practices in dossier development.

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New patent for Gilead Sciences drug VEKLURY

Drug Patent Watch

Annual Drug Patent Expirations for VEKLURY Veklury is a drug marketed by Gilead Sciences Inc and is included in one NDA. It is available from one supplier. There are fourteen patents protecting this drug. The generic ingredient in VEKLURY is remdesivir. One supplier is listed for this compound.

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Advanced API Testing Part 1: Payloads & Rest Assured Framework

Perficient: Drug Development

Introduction to Rest Assured Framework In today’s API-driven development landscape, testing RESTful APIs is a critical aspect of ensuring application functionality and performance. The Rest Assured framework is a powerful and easy-to-use Java library that simplifies testing REST APIs. Leveraging a fluent API allows developers to write readable and maintainable tests.

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Cathinones

Common Sense for Drug Policy Blog

Cathinones "The phenomenon of new psychoactive substances (NPS) is an ongoing problem in modern forensic toxicology. One of the most important groups among NPS are synthetic cathinones, which are derivatives of cathinone, a natural alkaloid found in the shrub Catha edulis. This substance has been shown to have psychoactive properties, with a widespread centuries-old tradition among the Arabian Peninsula population of chewing the leaves of this plant for recreational purposes [ 1 , 2 , 3 ].

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Advanced API Testing Part 2: JSON Schema Validation, Serialization & Deserialization Techniques

Perficient: Drug Development

Welcome to Part 2 of our series on Advanced API Testing with Rest Assured. In this segment, we delve into three critical aspects of API testing: JSON Schema Validation, Serialization, and Deserialization. These advanced techniques empower developers and testers to ensure the reliability and efficiency of their APIs. Let’s explore how Rest Assured simplifies these processes, enhancing the quality of your API tests and boosting confidence in your applications JSON Schema Validation JSON Sche

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Growth of New Psychoactive Substances on the Unregulated Market

Common Sense for Drug Policy Blog

Growth of New Psychoactive Substances on the Unregulated Market "The NPS phenomenon remains a considerable challenge due to its evolving nature. The range of compounds currently on the drug market is constantly changing, with new and previously unknown substances entering the market every year. Despite the implementation of regulatory countermeasures and the development of extensive early warning systems and their adaptation to the current situation, NPS including synthetic cathinones are still

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Covalent Modifiers - Untitled Article

Covalent Modifiers

Nickolas J. Serniuck, Eden Kapcan, Duane Moogk, Allyson E. Moore, Benjamin P.M. Lake, Galina Denisova, Joanne A. Hammill, Jonathan L. Bramson, Anthony F. Rullo, Molecular Therapy: Oncology , 2024 , 200842, [link] Proximity-induction of cell-cell interactions via small molecules represents an emerging field in basic and translational sciences. Covalent anchoring of these small molecules represents a useful chemical strategy to enforce proximity, however it remains largely unexplored for driving c

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Synthetic Cathinones

Common Sense for Drug Policy Blog

Synthetic Cathinones "In general, synthetic cathinones are classified as stimulants or amphetamine-type stimulants [ 109 , 110 ]. However, the pharmacological effects of individual derivatives are strictly dependent on the type of substituents and their location, and the differences in pharmacological profiles between individual cathinone derivatives are considerable.

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Predictive Analytics in Clinical Trials

Vial

The fields of artificial intelligence (AI) and machine learning (ML) are increasingly influencing clinical research and development (R&D). Contract research organizations (CROs) and pharmaceutical companies can leverage these cutting-edge technologies to streamline clinical trials and introduce automation in drug discovery. This article explores the numerous benefits that AI and ML offer in clinical R&D settings, focusing on how predictive analytics can bring precision and efficiency to

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An Integrated End-to-End Approach to Antibody Drug Conjugate Development and Manufacturing

Fierce BioTech

An Integrated End-to-End Approach to Antibody Drug Conjugate Development and Manufacturing In this white paper, Lonza experts delve into the common challenges encountered by ADC developers. They explore new drug product capabilities in relation to cytotoxic drug development and manufacturing, therefore fully completing Lonza’s integrated ADC offering.

Drugs 52
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Rates of Distress, Depression Have Doubled Among Transgender Americans Since 2014

Drugs.com

MONDAY, June 24, 2024 -- The rate of self-reported mental distress and depression among American adults who identify as transgender or gender-diverse (TGD) has more than doubled between 2014 and 2022, an analysis of federal health data.

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