Chemical Biology and Drug Design

FEBRUARY 15, 2024

Role of serotonin, dopamine, and norepinephrine in neural functions and symptoms involved during their altered levels. Abstract Depression is not similar to daily mood fluctuations and temporary emotional responses to day-to-day activities. Depression is not a passing problem; it is an ongoing problem. It deals with different episodes consisting of several symptoms that last for at least 2 weeks.

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Research Drugs 189

Drug Discovery World

FEBRUARY 15, 2024

DDW Editor Reece Armstrong speaks to Tracy M Woody , President and Chief Executive Officer of Cessation Therapeutics, about the company’s goal to develop an antibody therapy to prevent fentanyl overdoses. Cessation Therapeutics is a pharmaceutical company that is developing antibody therapies to prevent and reverse overdosing caused by fentanyl. Recently, the company was awarded an additional grant from the National Institute on Drug Abuse (NIDA) to support the development of its anti- fentanyl

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Therapies FDA Approval FDA Government 148

Science Daily: Pharmacology News

FEBRUARY 15, 2024

Our brains are 'programmed' to learn more from people we like -- and less from those we dislike. This has been shown by researchers in cognitive neuroscience in a series of experiments.

Research 140

Research 140

Drug Discovery World

FEBRUARY 15, 2024

Hosted by DDW and sponsored by Astrea Biosciences “ Cell and gene therapies – how can market growth be sustained to maximise on opportunities ” – will be free to attend on 28 February at 7AM PST / 10AM EST / 3PM GMT / 4PM CET. Join this free webinar and learn about some of the key opportunities that are available to drug discovery and development companies following growth in the cell and gene therapy market.

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Therapies RNA Science Marketing 130

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

FEBRUARY 15, 2024

Analysts pressed Alnylam executives on the reasons for the changes to HELIOS-B, a Phase 3 study in ATTR amyloidosis with cardiomyopathy that is important to the company’s future.

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Drug Trials Trials Drugs 128

Drug Discovery World

FEBRUARY 15, 2024

The strengths of etherna’s lipid based nanoparticle (LNP) platform have been showcased in a peer-reviewed paper in Advanced Functional Materials. etherna’s Vice President, Technology & Innovation, Stefaan De Koker described the paper as a “landmark” for the company and its technology. The RNA technology company conducted the work in collaboration with the lab of Professor De Geest at Ghent University, and describes how delivery of mRNA encoded antigens in LNPs comprising a novel class

Immune Response 130

Immune Response Vaccine RNA Pharmaceutical Companies 130

Drug Discovery World

FEBRUARY 15, 2024

Join DDW for this free event, Implementing rapid microbial identification in biotherapy manufacturing: Enhancing quality control and regulatory compliance , which is supported by Thermo Fisher Scientific. The event will take place on 26 February 3 pm GMT / 4 pm CET / 10 am EST / 7 am PST It will be presented by Phil Tuckett, BS, RM(NRCM, Department Scientist, Nelson Laboratories and Michelle Thai, Technical Sales Specialist, Pharma Analytics BioProduction Group, Thermo Fisher Scientific.

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Production Compliance Laboratories Vaccine 130

Science Daily: Pharmacology News

FEBRUARY 15, 2024

New research reveals the scale of inappropriate reforestation projects across Africa. A new study reveals that an area the size of France is threatened by forest restoration initiatives, such as the AFR100 initiative (African Forest Landscape Restoration Initiative), due to inappropriate restoration in the form of tree-planting.

Research 108

Research 108

Drug Discovery World

FEBRUARY 15, 2024

Alys Pharmaceuticals has launched with an R&D pipeline enabled by multiple platform technologies and a $100 million financing by Medicxi. The company originates from the aggregation of six Medicxi companies. Co-founded by Medicxi and several dermatology and scientific experts, including John Harris (UMass Chan Medical School), Brian Kim (Icahn School of Medicine at Mount Sinai), Lars French (LMU, Munich), Nobel Prize winner Craig Mello (UMass Chan Medical School), Eric Deutsch (Gustave Rou

Medical Schools 130

Medical Schools Pharmaceuticals Laboratories Disease 130

Science Daily: Pharmacology News

FEBRUARY 15, 2024

A team found evidence for hydrothermal or metamorphic activity within the icy dwarf planets Eris and Makemake, located in the Kuiper Belt. Methane detected on their surfaces has the tell-tale signs of warm or even hot geochemistry in their rocky cores, which is markedly different than the signature of methane from a comet.

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Clinical Trials

Drugs.com

FEBRUARY 15, 2024

Good-tasting tea depends on soil microbes found in the plant’s roots, a new study says Microbes influence the production of theanine, an amino acid that contributes to tea flavor Synthetically produced microbial colonies boosted.

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Production 105

Drug Patent Watch

FEBRUARY 15, 2024

Elevate your excipient business strategies with the comprehensive Drug Excipient Business Development Reports from DrugPatentWatch. Designed for excipient manufacturers seeking lucrative opportunities in the pharmaceutical industry, these reports offer invaluable… The post Drug Excipient Business Development Reports now Available on Amazon appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 105

Drugs Pharmaceuticals 105

Drugs.com

FEBRUARY 15, 2024

THURSDAY, Feb. 15, 2024 -- More than two dozen toddlers and at least 128 pregnant women received RSV vaccines they should not have gotten, U.S. health officials say. The mixup, reported by the U.S.

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Vaccine Disease 105

Science Daily: Pharmacology News

FEBRUARY 15, 2024

Researchers report that ancient viruses may be to thank for myelin -- and, by extension, our large, complex brains. The team found that a retrovirus-derived genetic element or 'retrotransposon' is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed 'RetroMyelin,' is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred sepa

Virus 105

Virus Production Research 105

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Clinical Trials

Drugs.com

FEBRUARY 15, 2024

THURSDAY, Feb. 15, 2024 -- Philip Day loved playing soccer so much that the 35-year-old software engineer founded a website – FootballMatcher.com – to help people connect for pickup games.The fun went on pause when Day developed joint pain so.

Engineering 98

Engineering Drugs 98

Science Daily: Pharmacology News

FEBRUARY 15, 2024

A geologist has revealed intriguing insights into the volcanic activity on Mars. He proposes that Mars has significantly more diverse volcanism than previously realized, driven by an early form of crust recycling called vertical tectonics. The findings shed light on the ancient crust of Mars and its potential implications for understanding early crustal recycling on both Mars and Earth.

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SCIENMAG: Medicine & Health

FEBRUARY 15, 2024

First-year Hackensack Meridian School of Medicine (HMSOM) student Elizabeth Titova leveraged her background in phlebotomy and scientific research to publish a new clinical study around COVID-19 vaccination in Microbiology Spectrum, a peer-reviewed, open-access ASM Journal.

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Vaccine Research 91

NIOSH Science Blog: Drugs

FEBRUARY 15, 2024

The American Journal of Public Health recently published a special supplement with 15 articles focusing on health worker mental health. This special issue of the journal was sponsored and edited by the National Institute for Occupational Safety and Health (NIOSH) and stems from the health worker mental health initiative from the Centers for Disease Control and Prevention and NIOSH.

Disease 88

Disease Research 88

addgene Blog

FEBRUARY 15, 2024

Addgene was built on the concept of accessibility: making plasmids more accessible to scientists around the world. In 2004, that was a fairly simple goal… and we had no idea how much our understanding of what accessibility is would change over the next twenty years. But learn we did!

Science 86

Science 86

Science Daily: Pharmacology News

FEBRUARY 15, 2024

Researchers have discovered a solid material that rapidly conducts lithium ions. Consisting of non-toxic earth-abundant elements, the new material has high enough Li ion conductivity to replace the liquid electrolytes in current Li ion battery technology, improving safety and energy capacity. The research team have synthesized the material in the laboratory, determined its structure and demonstrated it in a battery cell.

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Laboratories Research 88

SCIENMAG: Medicine & Health

FEBRUARY 15, 2024

It is not uncommon for people to “hit the wall” at work and experience burnout for short or long periods of time. Credit: Photo: NTNU It is not uncommon for people to “hit the wall” at work and experience burnout for short or long periods of time.

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Science Daily: Pharmacology News

FEBRUARY 15, 2024

You'd think the complex flavor in a quality cup of tea would depend mainly on the tea varieties used to make it. But a new study shows that the making of a delicious cup of tea depends on another key ingredient: the collection of microbes found on tea roots. By altering that assemblage, the authors showed that they could make good-quality tea even better.

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SCIENMAG: Medicine & Health

FEBRUARY 15, 2024

For the first time, the Mount Sinai Health System has been named the official medical service provider for the International Sumo League—the world’s largest league of sumo wrestlers.

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International 76

PLOS: DNA Science

FEBRUARY 15, 2024

I love the spectacular symbiosis of my vegetable garden as harvest time approaches. Beanstalks spiral up cornstalks, their tendrils teasing nearby tomato stems. Below, broad leaves protect ballooning squashes from the slugs that appear, seemingly from nowhere, after a rain, while providing water for passing furry creatures. The synergism of a garden is an ancient and somewhat obvious idea.

Science 75

Science DNA Laboratories Virus 75

BioPharma Drive: Drug Pricing

FEBRUARY 15, 2024

The partnership will use Intellia's "DNA writing” technology, and initially focus on people with the lung disease who have limited or no available treatment options.

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DNA Treatment Disease 73

Science Daily: Pharmacology News

FEBRUARY 15, 2024

If gravitational condensate stars (or gravastars) actually existed, they would look similar to black holes to a distant observer. Two theoretical physicists have now found a new solution to Albert Einstein's theory of general relativity, according to which gravitational stars could be structured like a Russian matryoshka doll, with one gravastar located inside another.

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Drugs.com

FEBRUARY 15, 2024

THURSDAY, Feb. 15, 2024 -- The U.S. Food and Drug Administration (FDA) on Wednesday approved the first treatment for severe frostbite. Known as Aurlumyn (iloprost), the injected medication lowers the risk of finger or toe amputation in cases of.

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FDA Approval FDA Treatment Drugs 72

SCIENMAG: Medicine & Health

FEBRUARY 15, 2024

A new antibiotic created by Harvard researchers overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.

Drugs 72

Drugs Research 72

BioPharma Drive: Drug Pricing

FEBRUARY 15, 2024

Armed with $94 million in funding, the biotech is marrying antibody-drug conjugates with protein degraders to create a new kind of cancer medicine.

Drugs 78

Drugs 78

Drugs.com

FEBRUARY 15, 2024

THURSDAY, Feb. 15, 2024 -- Nearly half of health care workers nationwide say they’ve seen discrimination against patients while on the job, a new report reveals.While 47% of health workers said they’ve witnessed discrimination against patients.

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Covalent Modifiers

FEBRUARY 15, 2024

Davis H. Chase, Adrian M. Bebenek, Pengju Nie, Saul Jaime-Figueroa, Arseniy Butrin, Danielle A. Castro, John Hines, Brian M. Linhares, Craig M. Crews Angew. Chem. Int. Ed. 2024 , e202316496. [link] Brachyury is an oncogenic transcription factor whose overexpression drives chordoma growth. The downmodulation of brachyury in chordoma cells has demonstrated therapeutic potential, however, as a transcription factor it is classically deemed “undruggable”.

Small Molecule 59

Small Molecule FDA Approval FDA Therapies 59

Drugs.com

FEBRUARY 15, 2024

THURSDAY, Feb. 15, 2024 -- Mick worked in a factory boiler room in the 1970s, where he was exposed to asbestos. He didn’t think much of it until 2018, when he began to feel ill and dropped more than 40 pounds. The diagnosis: malignant.

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Treatment 64

Drug Patent Watch

FEBRUARY 15, 2024

Annual Drug Patent Expirations for TARPEYO Tarpeyo is a drug marketed by Calliditas and is included in one NDA. It is available from one supplier. There is one patent protecting… The post New patent for Calliditas drug TARPEYO appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Agency IQ

FEBRUARY 15, 2024

BY CHELSEY MCINTYRE, PHARMD , ALEXANDER GAFFNEY, MS, RAC The FDA is set to be very, very busy in 2024. AgencyIQ has analyzed the agency’s guidance agendas, user fee commitment letters, statutory obligations and international efforts to determine which guidance documents the agency is actively working on this year (and in some cases, in the years ahead as well).

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FDA International 59