Drug Discovery World

DECEMBER 28, 2023

Oxford Target Therapeutics, a company developing a promising therapy for triple negative breast cancer, is one of three UK life science companies awarded research prizes by the Rosalind Franklin Institute, based in Oxfordshire, UK. The prizes, awarded in collaboration with the Science and Technology Facilities Council (STFC), a part of UKRI, enable the winners to benefit from the Franklin’s top-level technologies and support to move their work forward.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- A common stomach bug may play a part in Alzheimer's disease risk.New research found that older folks infected with Helicobacter pylori (H. pylori) had greater odds for developing Alzheimer's, the most common type of.

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Drug Discovery World

DECEMBER 28, 2023

Paediatric oncologist Gauri Sunkersett shares her unique background and research approach at AbbVie to help find answers for the youngest blood cancer patients. When I was a second-year resident training as a paediatric oncologist at Nicklaus Children’s Hospital, I met a teenage boy diagnosed with Hodgkin’s Lymphoma. He was admitted to the hospital for weekly chemotherapy.

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Chemical Biology and Drug Design

DECEMBER 28, 2023

LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. Abstract The acquired resistance of cancer to cisplatin (DDP) limits the efficacy of chemotherapy. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- A class of sedatives called benzodiazepines, which include meds like Ativan, Valium and Xanax, could be linked to higher odds for miscarriage if taken during pregnancy, new research finds.The findings held even after.

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Research 105

Chemical Biology and Drug Design

DECEMBER 28, 2023

A schematic description of the effects of Platycodin D on diabetic retinopathy. Abstract Diabetic retinopathy (DR) is one of the most frequently occurring diabetic complications associated with inflammation and oxidative stress. Platycodin D (PLD) is a bio-active saponin that has been reported to exhibit anti-inflammation, anti-oxidative, and antidiabetic activities.

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Chemical Biology and Drug Design

DECEMBER 28, 2023

N-acetylcysteine is a recommended drug for treating acetaminophen intoxication. The low bioavailability is one of the important limitations of N-acetylcysteine. PR-NAC can decrease hepatic serum enzymes in hepatotoxicity induced by acetaminophen. PR-NAC effectiveness can be associated with an improvement of oxidant/antioxidant balance in liver. Abstract N-acetylcysteine (NAC) is a recommended drug for treating acetaminophen (APAP) intoxication.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- As Americans travel far and wide to see family and friends this holiday season, a new COVID variant named JN.1 has become dominant across the country.A descendant of the variant BA.2.86, JN.1 now accounts for 44.

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Chemical Biology and Drug Design

DECEMBER 28, 2023

Formononetin significantly induced cell apoptosis, whereas dramatically inhibited cell proliferation and clonal formation in H1975 Osimertinib-resistant NSCLC cells. Abstract Formononetin is one of the main isoflavone components, which has strong anti-cancer effects in non-small cell lung cancer (NSCLC). However, the potentials and the mechanisms of Formononetin to counteract the Osimertinib resistance in NSCLC are unclear.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- New research offers yet more evidence that veggies, whole grains and low-fat dairy products are good for you in the long run."Our study goes beyond the simple question of, 'To carb or not to carb?'" said lead study author.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

SCIENMAG: Medicine & Health

DECEMBER 28, 2023

The nomination of the new generation of FGFR2/3 inhibitor for the treatment of tissue-agnostic solid tumors, bringing the total number of PCCs nominated by Insilico in 2023 to six.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- In preliminary findings, Swedish researchers say taking a cholesterol-lowering statin could also slow the progression of Alzheimer's disease.The study can't prove cause-and-effect, but might pave the way to a trial that.

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Drug Patent Watch

DECEMBER 28, 2023

Annual Drug Patent Expirations for NOCDURNA Nocdurna is a drug marketed by Ferring Pharms Inc and is included in one NDA. It is available from one supplier. There are ten… The post New patent expiration for Ferring Pharms drug NOCDURNA appeared first on DrugPatentWatch - Make Better Decisions.

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Perficient: Drug Development

DECEMBER 28, 2023

Organizations are overwhelmed with the volume of generative artificial intelligence (genAI) tools in the market today. Sequoia and Meritech Capital released the latest version of their AI50 in April of 2023. The map visualizes their top 50 privately held companies in the AI space. Since the updated version was released, a large volume of generative AI tools have come onto the market.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Patent Watch

DECEMBER 28, 2023

Annual Drug Patent Expirations for HEPZATO Hepzato is a drug marketed by Delcath Systems Inc and is included in one NDA. It is available from one supplier. There are nine… The post New patent for Delcath Systems drug HEPZATO appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28 -- As the New Year approaches, many will commit to a trend called "Dry January," where you stop drinking for a month to get more healthy.For years, it's been a tall order to abstain from alcohol when going out, but with a plethora.

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Perficient: Drug Development

DECEMBER 28, 2023

INTRODUCTION: In the ever-evolving landscape of e-commerce, adopting modern technologies is essential to stay competitive and deliver a seamless online shopping experience. HCL Commerce, a robust e-commerce platform, can be further empowered by integrating with Spring Boot—a powerful framework for building Java-based microservices. In this blog post, we’ll explore the synergy between HCL Commerce and Spring Boot, unravelling the benefits and reasons why Spring Boot is a valuable addition t

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The Premier Consulting Blog

DECEMBER 28, 2023

An investigational device exemption (IDE) allows an investigational device to be used in a clinical study to collect safety and effectiveness data. [1] However, if certain criteria are met, many in vitro diagnostic (IVD) devices are released from IDE regulations. This blog post discusses how device studies are classified and explores scenarios where DVDs qualify for exclusion from IDE regulations.

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Perficient: Drug Development

DECEMBER 28, 2023

Organizations are overwhelmed with the volume of generative artificial intelligence (genAI) tools in the market today. Sequoia and Meritech Capital released the latest version of their AI50 in April of 2023. The map visualizes their top 50 privately held companies in the AI space. Since the updated version was released, a large volume of generative AI tools have come onto the market.

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International Marketing 52

The Premier Consulting Blog

DECEMBER 28, 2023

An investigational device exemption (IDE) allows an investigational device to be used in a clinical study to collect data on its safety and effectiveness. [1] This exemption applies to the conduct of trials necessary for developing new medical devices. Clinical studies are often conducted to support a Premarket Approval (PMA) application, though some 510(k) submissions may require clinical data.

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Perficient: Drug Development

DECEMBER 28, 2023

At Perficient, we revolutionize the world’s leading brands, how they engage with their customers, and propel their business forward. Our global footprint across the U.S., Latin America, and India empowers us to redefine excellence throughout the industry. Behind these transformative journeys are our thousands of skilled strategists and technologists, each individually equipped with a wealth of expertise.

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The Premier Consulting Blog

DECEMBER 28, 2023

Significant risk studies of medical devices require an investigational device exemption (IDE), which allows the device to be used in a clinical study to collect data on its safety and effectiveness. [1] Often, device developers wonder whether—and how—the cost of those investigational devices might be covered not only to offset the cost of development but also to enable access and accelerate innovation.

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Perficient: Drug Development

DECEMBER 28, 2023

The Consumer Financial Protection Bureau (CFPB) has narrowed its focus on what it terms “junk fees” targeting financial industry practices. Understanding the CFPB’s recurrent theme and deciphering its message from the recent press releases provides insights into potential enforcement actions over the next 12-24 months and how banks can reassess their current fee structures.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- Two types of mental health treatment are equally effective in treating fibromyalgia patients, Swedish researchers report.They compared traditional cognitive behavioral therapy (CBT) to what is known as exposure-based.

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Perficient: Drug Development

DECEMBER 28, 2023

With 2023 coming to a close, it’s important to reflect on our accomplishments over the past year. Being named a U.S. Top Workplace this year was an incredible source of pride for Perficient. As an award-winning workplace, Perficient colleagues collaborate with experts from across industries and time zones to strategize, test, and build end-to-end solutions for the world’s biggest brands and largest enterprises.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 — New research suggests the effects of high blood pressure during pregnancy may be long-lasting.Researchers found that women who developed high blood pressure during pregnancy had tell-tale signs of abnormal heart.

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ProRelix Research

DECEMBER 28, 2023

Considering the crucial role that the information generated from clinical trials play in the approval of new drugs, biological, and medical devices, it is only logical that the data garnered […] The post Clinical Data Standardization in Clinical Trials: FDA Compliance in Clinical Data Management appeared first on ProRelix Research.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- The prognosis is poor for many cancer patients who develop serious urinary blockages, but researchers say less than half receive palliative care.Palliative care aims to relieve pain and other symptoms of serious illness.

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Perficient: Drug Development

DECEMBER 28, 2023

INTRODUCTION: In the fast-paced world of e-commerce, businesses are constantly seeking robust and scalable solutions to provide seamless online shopping experiences. One such solution that has gained prominence is HCL Commerce, an innovative platform designed to meet the diverse needs of modern e-commerce. At the heart of HCL Commerce lies its common architecture, a carefully crafted framework that ensures flexibility, scalability, and performance.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- Hormone therapy is the usual go-to when women develop painful uterine fibroids, but researchers report they are zeroing in on new avenues for treatment.A University of Cincinnati team found that fibroid cells respond to.

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Common Sense for Drug Policy Blog

DECEMBER 28, 2023

Contribution of Excessive Alcohol Consumption to Deaths and Years of Potential Life Lost in the US "From 2006 through 2010, excessive alcohol consumption accounted for nearly 1 in 10 deaths and over 1 in 10 years of potential life lost among working-age adults in the United States. Furthermore, an average of 2 out of 3 AAD and 8 out of 10 alcohol-attributable YPLL involved working-age adults.

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Drugs.com

DECEMBER 28, 2023

THURSDAY, Dec. 28, 2023 -- Stroke patients often suffer from "spatial neglect" -- an inability to see things on the side of the body opposite to where the brain injury occurred.Now, new research suggests that spatial neglect can also affect folks.

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Drug Patent Watch

DECEMBER 28, 2023

This chart shows the drugs with the most patents in Costa Rica. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical drugs have the most drug patents in Costa Rica? appeared first on DrugPatentWatch - Make Better Decisions.

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Common Sense for Drug Policy Blog

DECEMBER 28, 2023

Low Prevalence of Alcohol Dependence Among US Adult Drinkers "This study found that about 9 of 10 adult excessive drinkers did not meet the diagnostic criteria for alcohol dependence. About 90% of the adults who drank excessively reported binge drinking, and the prevalence of alcohol dependence was similar among excessive drinkers and binge drinkers across most sociodemographic groups.

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