Chemical Biology and Drug Design
DECEMBER 28, 2023
LINC00460 knockdown contributed to DDP sensitivity of cervical cancer by regulating TGFBI, providing a novel mechanism underlying the acquisition of DDP sensitivity. Abstract The acquired resistance of cancer to cisplatin (DDP) limits the efficacy of chemotherapy. The prognostic value of long noncoding RNA (lncRNA) LINC00460 has been reported in cervical cancer.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- A common stomach bug may play a part in Alzheimer's disease risk.New research found that older folks infected with Helicobacter pylori (H. pylori) had greater odds for developing Alzheimer's, the most common type of.
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Chemical Biology and Drug Design
DECEMBER 28, 2023
A schematic description of the effects of Platycodin D on diabetic retinopathy. Abstract Diabetic retinopathy (DR) is one of the most frequently occurring diabetic complications associated with inflammation and oxidative stress. Platycodin D (PLD) is a bio-active saponin that has been reported to exhibit anti-inflammation, anti-oxidative, and antidiabetic activities.
Drug Target Review
DECEMBER 28, 2023
During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Chemical Biology and Drug Design
DECEMBER 28, 2023
N-acetylcysteine is a recommended drug for treating acetaminophen intoxication. The low bioavailability is one of the important limitations of N-acetylcysteine. PR-NAC can decrease hepatic serum enzymes in hepatotoxicity induced by acetaminophen. PR-NAC effectiveness can be associated with an improvement of oxidant/antioxidant balance in liver. Abstract N-acetylcysteine (NAC) is a recommended drug for treating acetaminophen (APAP) intoxication.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- A class of sedatives called benzodiazepines, which include meds like Ativan, Valium and Xanax, could be linked to higher odds for miscarriage if taken during pregnancy, new research finds.The findings held even after.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- As Americans travel far and wide to see family and friends this holiday season, a new COVID variant named JN.1 has become dominant across the country.A descendant of the variant BA.2.86, JN.1 now accounts for 44.
SCIENMAG: Medicine & Health
DECEMBER 28, 2023
The nomination of the new generation of FGFR2/3 inhibitor for the treatment of tissue-agnostic solid tumors, bringing the total number of PCCs nominated by Insilico in 2023 to six.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- New research offers yet more evidence that veggies, whole grains and low-fat dairy products are good for you in the long run."Our study goes beyond the simple question of, 'To carb or not to carb?'" said lead study author.
Drug Patent Watch
DECEMBER 28, 2023
Annual Drug Patent Expirations for NOCDURNA Nocdurna is a drug marketed by Ferring Pharms Inc and is included in one NDA. It is available from one supplier. There are ten… The post New patent expiration for Ferring Pharms drug NOCDURNA appeared first on DrugPatentWatch - Make Better Decisions.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- In preliminary findings, Swedish researchers say taking a cholesterol-lowering statin could also slow the progression of Alzheimer's disease.The study can't prove cause-and-effect, but might pave the way to a trial that.
Drug Patent Watch
DECEMBER 28, 2023
Annual Drug Patent Expirations for HEPZATO Hepzato is a drug marketed by Delcath Systems Inc and is included in one NDA. It is available from one supplier. There are nine… The post New patent for Delcath Systems drug HEPZATO appeared first on DrugPatentWatch - Make Better Decisions.
Perficient: Drug Development
DECEMBER 28, 2023
Organizations are overwhelmed with the volume of generative artificial intelligence (genAI) tools in the market today. Sequoia and Meritech Capital released the latest version of their AI50 in April of 2023. The map visualizes their top 50 privately held companies in the AI space. Since the updated version was released, a large volume of generative AI tools have come onto the market.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28 -- As the New Year approaches, many will commit to a trend called "Dry January," where you stop drinking for a month to get more healthy.For years, it's been a tall order to abstain from alcohol when going out, but with a plethora.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Perficient: Drug Development
DECEMBER 28, 2023
INTRODUCTION: In the ever-evolving landscape of e-commerce, adopting modern technologies is essential to stay competitive and deliver a seamless online shopping experience. HCL Commerce, a robust e-commerce platform, can be further empowered by integrating with Spring Boot—a powerful framework for building Java-based microservices. In this blog post, we’ll explore the synergy between HCL Commerce and Spring Boot, unravelling the benefits and reasons why Spring Boot is a valuable addition t
Common Sense for Drug Policy Blog
DECEMBER 28, 2023
Low Prevalence of Alcohol Dependence Among US Adult Drinkers "This study found that about 9 of 10 adult excessive drinkers did not meet the diagnostic criteria for alcohol dependence. About 90% of the adults who drank excessively reported binge drinking, and the prevalence of alcohol dependence was similar among excessive drinkers and binge drinkers across most sociodemographic groups.
Perficient: Drug Development
DECEMBER 28, 2023
Organizations are overwhelmed with the volume of generative artificial intelligence (genAI) tools in the market today. Sequoia and Meritech Capital released the latest version of their AI50 in April of 2023. The map visualizes their top 50 privately held companies in the AI space. Since the updated version was released, a large volume of generative AI tools have come onto the market.
The Premier Consulting Blog
DECEMBER 28, 2023
An investigational device exemption (IDE) allows an investigational device to be used in a clinical study to collect safety and effectiveness data. [1] However, if certain criteria are met, many in vitro diagnostic (IVD) devices are released from IDE regulations. This blog post discusses how device studies are classified and explores scenarios where DVDs qualify for exclusion from IDE regulations.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Perficient: Drug Development
DECEMBER 28, 2023
At Perficient, we revolutionize the world’s leading brands, how they engage with their customers, and propel their business forward. Our global footprint across the U.S., Latin America, and India empowers us to redefine excellence throughout the industry. Behind these transformative journeys are our thousands of skilled strategists and technologists, each individually equipped with a wealth of expertise.
The Premier Consulting Blog
DECEMBER 28, 2023
An investigational device exemption (IDE) allows an investigational device to be used in a clinical study to collect data on its safety and effectiveness. [1] This exemption applies to the conduct of trials necessary for developing new medical devices. Clinical studies are often conducted to support a Premarket Approval (PMA) application, though some 510(k) submissions may require clinical data.
Perficient: Drug Development
DECEMBER 28, 2023
The Consumer Financial Protection Bureau (CFPB) has narrowed its focus on what it terms “junk fees” targeting financial industry practices. Understanding the CFPB’s recurrent theme and deciphering its message from the recent press releases provides insights into potential enforcement actions over the next 12-24 months and how banks can reassess their current fee structures.
The Premier Consulting Blog
DECEMBER 28, 2023
Significant risk studies of medical devices require an investigational device exemption (IDE), which allows the device to be used in a clinical study to collect data on its safety and effectiveness. [1] Often, device developers wonder whether—and how—the cost of those investigational devices might be covered not only to offset the cost of development but also to enable access and accelerate innovation.
Perficient: Drug Development
DECEMBER 28, 2023
With 2023 coming to a close, it’s important to reflect on our accomplishments over the past year. Being named a U.S. Top Workplace this year was an incredible source of pride for Perficient. As an award-winning workplace, Perficient colleagues collaborate with experts from across industries and time zones to strategize, test, and build end-to-end solutions for the world’s biggest brands and largest enterprises.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- Two types of mental health treatment are equally effective in treating fibromyalgia patients, Swedish researchers report.They compared traditional cognitive behavioral therapy (CBT) to what is known as exposure-based.
ProRelix Research
DECEMBER 28, 2023
Considering the crucial role that the information generated from clinical trials play in the approval of new drugs, biological, and medical devices, it is only logical that the data garnered […] The post Clinical Data Standardization in Clinical Trials: FDA Compliance in Clinical Data Management appeared first on ProRelix Research.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 — New research suggests the effects of high blood pressure during pregnancy may be long-lasting.Researchers found that women who developed high blood pressure during pregnancy had tell-tale signs of abnormal heart.
Perficient: Drug Development
DECEMBER 28, 2023
INTRODUCTION: In the fast-paced world of e-commerce, businesses are constantly seeking robust and scalable solutions to provide seamless online shopping experiences. One such solution that has gained prominence is HCL Commerce, an innovative platform designed to meet the diverse needs of modern e-commerce. At the heart of HCL Commerce lies its common architecture, a carefully crafted framework that ensures flexibility, scalability, and performance.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- The prognosis is poor for many cancer patients who develop serious urinary blockages, but researchers say less than half receive palliative care.Palliative care aims to relieve pain and other symptoms of serious illness.
Drug Patent Watch
DECEMBER 28, 2023
This chart shows the drugs with the most patents in Costa Rica. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical drugs have the most drug patents in Costa Rica? appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- Hormone therapy is the usual go-to when women develop painful uterine fibroids, but researchers report they are zeroing in on new avenues for treatment.A University of Cincinnati team found that fibroid cells respond to.
Common Sense for Drug Policy Blog
DECEMBER 28, 2023
Contribution of Excessive Alcohol Consumption to Deaths and Years of Potential Life Lost in the US "From 2006 through 2010, excessive alcohol consumption accounted for nearly 1 in 10 deaths and over 1 in 10 years of potential life lost among working-age adults in the United States. Furthermore, an average of 2 out of 3 AAD and 8 out of 10 alcohol-attributable YPLL involved working-age adults.
Drugs.com
DECEMBER 28, 2023
THURSDAY, Dec. 28, 2023 -- Stroke patients often suffer from "spatial neglect" -- an inability to see things on the side of the body opposite to where the brain injury occurred.Now, new research suggests that spatial neglect can also affect folks.
Drug & Device Law
DECEMBER 28, 2023
It is not uncommon that terms are used without knowledge of their origin and that the origin is instructive about the meaning or proper application of the term. We offer two examples. Many lawyers who at least dabble in product liability litigation have heard the term “Bradford Hill criteria.” Was it named after two different people like Smoot and Hawley or Hatch and Waxman?
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